Beta Blockers And The Risk Of Cv Events In Type 2 Diabetes
Home / Conditions / Type 2 Diabetes / Beta Blockers And the Risk of CV Events in Type 2 Diabetes Beta Blockers And the Risk of CV Events in Type 2 Diabetes Beta-blocker use in patients with T2DM and established CV risk factors associated with increased risk of CV events and severe hypoglycemia, according to recent study. Diabetes mellitus management mainly aims at preventing diabetes mellitusrelated complications. Although appropriate glycemic control prevents complications, the ACCORD trial (Action to Control Cardiovascular Risk in Diabetes) revealed that intensive therapy can increase all-cause and cardiovascular mortalities. A possible explanation for the results is that glucose-lowering therapy increases the frequency of hypoglycemic episodes, which in turn is associated with increased risks for vascular events and death. Patients with diabetes mellitus with severe hypoglycemia face many critical problems, such as severe hypertension, hypokalemia, and QT prolongation, resulting in cardiovascular diseases, fatal arrhythmia, and death. Recent studies have suggested that -blockers may prevent or decrease the adverse effects after the occurrence of severe hypoglycemia, such as severe hypertension and hypokalemia, and may reduce severe hypoglycemia-associated cardiac arrhythmias and death. A recent study revealed that the cardiovascular event rate in patients with diabetes mellitus on -blockers was significantly lower in the intensive therapy group compared with the standard therapy group. Conversely, all-cause and cardiovascular mortalities in patients not on -blockers were significantly higher in the intensive therapy group. The difference of these results between patients on and those not on -blockers may be mainly because of the protective effects of -blockers after Continue reading >>
Beta Blockers And Diabetes: Mechanism And Risks
Beta Blockers and Diabetes: Mechanism and Risks Watch short & fun videos Start Your Free Trial Today Alyssa is an active RN and teaches Nursing and Leadership university courses. She also has a Doctorate in Nursing Practice and a Master's in Business Administration. Log in or sign up to add this lesson to a Custom Course. Custom Courses are courses that you create from Study.com lessons. Use them just like other courses to track progress, access quizzes and exams, and share content. Organize and share selected lessons with your class. Make planning easier by creating your own custom course. Create a new course from any lesson page or your dashboard. Click "Add to" located below the video player and follow the prompts to name your course and save your lesson. Click on the "Custom Courses" tab, then click "Create course". Next, go to any lesson page and begin adding lessons. Edit your Custom Course directly from your dashboard. Name your Custom Course and add an optional description or learning objective. Create chapters to group lesson within your course. Remove and reorder chapters and lessons at any time. Share your Custom Course or assign lessons and chapters. Share or assign lessons and chapters by clicking the "Teacher" tab on the lesson or chapter page you want to assign. Students' quiz scores and video views will be trackable in your "Teacher" tab. You can share your Custom Course by copying and pasting the course URL. Only Study.com members will be able to access the entire course. Beta-blockers are common medications used to control high blood pressure, but can block dangerous signs of low blood sugar in people with diabetes. Read this lesson to learn more about how diabetes is affected by this class of medication. Diabetes occurs when the body creates little t Continue reading >>
Beta Blockers And High Blood Sugar Readings
Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community Beta Blockers and high blood sugar readings I am a 5' 8" female who weighs 135lbs. I exercise routinely, but love my chocolate! lol! I have been on a beta blocker for the past 11 years for a fast heart rate. Over the course of the past 5 years, during routine blood work, my FBS has been ranging anywhere from 102 to 128. (It should also be noted that I checked my own blood sugars one and two hours after eating on a few occasions and found that my readings went in excess of 200. On my most recent blood work a few months ago, my family doctor voiced his concern that I was indeed pre-diabetic and that I should watch what I eat. I ask him about my beta blocker and if it could cause this. He did not feel that it could, as it is a cardo select version. I decided, (with his approval) that I would wean myself off of the beta blocker and see if my blood sugars improved at all. I needed to prove this to myself...is it the medication OR do I in fact have pre-diabetes. If so, I wanted to get "on the ball" and watch my diet better. I have been off of the medication fully now for the past 12 days. My blood sugar readings have DRAMATICALLY lowered, back to the normal range! I was taking a very low dose of beta blocker, Zebeta (bisoprolol) 2.5 mg daily. This was a very welcome surprise as you can imagine. My point....I want people out there to know that this can happen. So many people are placed on beta blockers for high blood pressure etc, and may be diagnosed with diabetes. Perhaps some folks out there in this world may NOT indeed have it! Please talk to your doctor if you take one of these meds! I know that in most people it does not effect readings. This is shown Continue reading >>
Uses For Beta Blockers
Doctors prescribe beta blockers to prevent, treat or improve symptoms in a variety of conditions, such as: High blood pressure Irregular heart rhythm (arrhythmia) Heart failure Chest pain (angina) Heart attacks Migraine Certain types of tremors Beta blockers aren't usually prescribed for blood pressure until other medications, such as diuretics, haven't worked effectively. Your doctor may prescribe beta blockers as one of several medications to lower your blood pressure, including angiotensin-converting enzyme (ACE) inhibitors, diuretics or calcium channel blockers. Beta blockers may not work as effectively for black and older people, especially when taken without other blood pressure medications. Side effects and cautions Side effects may occur in people taking beta blockers. However, many people who take beta blockers won't have any side effects. Common side effects of beta blockers include: Fatigue Cold hands or feet Weight gain Less common side effects include: Shortness of breath Trouble sleeping Depression Beta blockers generally aren't used in people with asthma because of concerns that the medication may trigger severe asthma attacks. In people who have diabetes, beta blockers may block signs of low blood sugar, such as rapid heartbeat. It's important to monitor your blood sugar regularly. Beta blockers can also affect your cholesterol and triglyceride levels, causing a slight increase in triglycerides and a modest decrease in high-density lipoprotein, the "good" cholesterol. These changes often are temporary. You shouldn't abruptly stop taking a beta blocker because doing so could increase your risk of a heart attack or other heart problems. Continue reading >>
Many therapeutic agents can predispose to or precipitate diabetes, especially when pre-existing risk factors are present, and these may cause glucose control to deteriorate if administered to those with existing diabetes. They may act by increasing insulin resistance, by affecting the secretion of insulin, or both. For convenience, these agents may be subdivided into widely used medications that are weakly diabetogenic, and drugs used for special indications that are more strongly diabetogenic. Examples of the former include antihypertensive agents and statins, and examples of the latter include steroids, antipsychotics and a range of immunosuppressive agents. There are also a number of known beta cell poisons including the insecticide Vacor, alloxan and streptozotocin. Introduction A wide range of therapeutic agents may affect glucose tolerance, and the list of known or suspected drugs is lengthy. This entry summarizes evidence concerning the agents most frequently implicated. Widely used medications A number of drugs used to reduce cardiovascular risk also predispose to the development of diabetes. These include the thiazide diuretics, beta-blockers and statins. It should however be appreciated that these are commonly offered to individuals who are at increased risk of diabetes by virtue of risk factors such as obesity and hypertension, and that risk association does not necessarily mean causation. Thiazides: Thiazide diuretics revolutionized the treatment of hypertension in the 1960s, but were soon noted to increase the risk of diabetes. Subsequent experience showed that that this risk is greatly reduced by low-dose therapy, whose benefits therefore outweigh its risks. The thiazides have a weak inhibitory effect upon release of insulin from the beta cell. This eff Continue reading >>
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What Medicines Can Make Your Blood Sugar Spike?
If you have diabetes or high blood sugar, you probably know some of the things that cause your glucose (another name for blood sugar) to go up. Like a meal with too many carbohydrates, or not enough exercise. But other medicines you might take to keep yourself healthy can cause a spike, too. Know Your Meds Medicines you get with a prescription and some that you buy over the counter (OTC) can be a problem for people who need to control their blood sugar. Prescription medicines that can raise your glucose include: Steroids (also called corticosteroids). They treat diseases caused by inflammation, like rheumatoid arthritis, lupus, and allergies. Common steroids include hydrocortisone and prednisone. But steroid creams (for a rash) or inhalers (for asthma) aren’t a problem. Drugs that treat high blood pressure, such as beta-blockers and thiazide diuretics High doses of asthma medicines, or drugs that you inject for asthma treatment OTC medicines that can raise your blood sugar include: Cough syrup. Ask your doctor if you should take regular or sugar-free. How Do You Decide What to Take? Even though these medicines can raise your blood sugar, it doesn’t mean that you shouldn’t take them if you need them. The most important thing is to work with your doctor on the right way to use them. If you have diabetes or you’re watching your blood sugar, ask your doctor before you take new medicines or change any medicines, even if it’s just something for a cough or cold. (Remember, just being sick can raise your blood sugar.) Make sure your doctor knows all the medicines you take -- for diabetes or any other reason. If one of them may affect your blood sugar, she may prescribe a lower dose or tell you to take the medicine for a shorter time. You may need to check your blood s Continue reading >>
Newer Beta-blocker Coreg Safer For Diabetics
The beta-blocker blood pressure medicine Coreg proved significantly better in keeping blood sugar levels from rising in diabetics than metaprolol, another widely used member of the beta-blocker family. The study involved 1,235 high-risk patients with type 2 diabetes and hypertension — two of the biggest risk factors for heart disease. It measured long-term blood sugar levels of those taking Glaxo’s Coreg, or carvedilol, against those taking the generic drug metoprolol for at least five months. Most of those in the study were also taking cholesterol medication. While both drugs were similarly effective in lowering blood pressure to the desired goal of less than 130 over 80, Coreg demonstrated superiority in keeping blood sugar levels from worsening. “Side effects are the big Achilles heel of beta-blockers,” said Dr. George Bakris, director of the hypertension clinical research unit at Rush University Medical Center in Chicago and the lead investigator of the study. Beta-blockers generally do a good job of lowering blood pressure and decreasing some cardiovascular risks, Bakris said. But they tend to raise blood sugar, slow the heart rate and can increase cholesterol problems such as triglycerides. Slow heart rate, for example, was much higher in the metoprolol group, Bakris said. At least 18 million Americans suffer from high blood pressure, type 2 diabetes and high cholesterol, Bakris said, making traditional beta-blockers that raise blood sugar problematic for this patient population. Coreg has been on the market since 1997 as a treatment for hypertension and heart failure with sales of $577 million for the first nine months of this year. Researchers believes the antioxidant activity of Coreg is what separates it from other beta blockers. This study should help Continue reading >>
Beta-blockers 'increase Diabetes Risk By 50 Per Cent'
Beta-blockers 'increase diabetes risk by 50 per cent' Patients taking beta-blockers for their blood pressure have a 50 per cent higher risk of developing diabetes compared to being on newer drugs, researchers have revealed. For the first time, a new study reveals the risk of using the older drugs which are no longer recommended for treating high blood pressure. Patients taking beta-blockers and diuretics - standard medication for over 30 years - are at far greater risk of becoming diabetic. Not only are they less effective than newer medication, but they actually hasten and, in some cases, induce the disease in blood pressure patients - who are already at high risk. This means at least 8,000 Britons taking the older drugs are getting diabetes unnecessarily each year as a result. Until earlier this year, around two million patients have been on beta blocker based treatments at any one time. But new guidance to doctors says newer ace inhibitors and calcium channel blockers should be the first choice treatment for the millions of Britons treated for high blood pressure. The change came after research found the older drugs were only half as effective at stopping strokes and heart attacks. Beta blockers such as atenolol should no longer be prescribed for the problem, said the guidelines from the National Institute for Clinical Excellence. But now a new clinical trial released yesterday show they also bring a 50 per cent higher risk of developing diabetes. Although many patients currently taking them are being switched by their GPs to newer drugs when they go for a scheduled check-up, they remain in wide use. Beta blockers are still considered the best treatment for other conditions such as angina, and doctors have warned patients not to stop taking them without medical advi Continue reading >>
Drug Induced Diabetes
Tweet A number of medications have side effects which include the raising of blood glucose levels. Drug induced diabetes is when use of a specific medication has lead to the development of diabetes. In some cases the development of diabetes may be reversible if use of the medication is discontinued, but in other cases drug-induced diabetes may be permanent. Drug induced diabetes is a form of secondary diabetes, in other words diabetes that is a consequence of having another health condition. Which drugs can induce diabetes? A number of drugs have been linked with an increased risk development of type 2 diabetes. Corticosteroids Thiazide diuretics Beta-blockers Antipsychotics Is diabetes permanent? Diabetes may not be permanent but this can depend on other health factors. With some medications, blood glucose levels may return back to normal once the medication is stopped but, in some cases, the development of diabetes may be permanent. Managing drug induced diabetes If you need to continue taking the medication that has brought on diabetes, it may make your diabetes more difficult to control than would otherwise be the case. If you are able to stop the course of medication, you may find your blood glucose levels become slightly easier to manage. Following a healthy diet and meeting the recommended exercise guidelines will help to improve your chances of managing your blood glucose levels. Can drug induced diabetes be prevented? It may be possible to reduce the risk of developing diabetes by ensuring you to keep to a healthy lifestyle whilst you are on the medication. Being on smaller doses of the medication or shorter periods of time may help to reduce the likelihood of developing high blood sugar levels and diabetes. Doctors will usually try to put you on the smallest e Continue reading >>
Diabetes Update: Beta Blockers Worsen Blood Sugar--may Cause Diabetes
Beta Blockers Worsen Blood Sugar--May Cause Diabetes Many people know that it is a bad idea for anyone who takes insulin or a sulfonylurea drug to take a beta blocker. This is because it has long been known that these drugs block the counter-regulatory response that prevents a dangerous hypo or--if it cannot prevent the hypo--at least gives the victim some warning that one is coming by causing shakes and pounding pulse. Now evidence from a huge study of almost 20,000 people has learned that beta blockers are dangerous to anyone with any blood sugar abnormality. The study is Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA,). It was published in Diabetes Care in May. Determinants of new-onset diabetes among 19,257 hypertensive patients randomized in the Anglo-Scandinavian Cardiac Outcomes Trial--Blood Pressure Lowering Arm and the relative influence of antihypertensive medication. It concluded: "Baseline FPG >5 mmol/l, BMI, and use of an atenolol +/- diuretic regimen were among the major determinants of NOD [Non-insulin dependent diabetes i.e. Type 2] in hypertensive patients." An analysis of the study (which is still only available as an abstract to non-subscribers) published in Irish Medical News explains "Hypertensive patients allocated to amlodipine and perindopril were found 34% less likely to develop NOD [Type 2] compared with those allocated to the -blocker/diuretic combination." Diabetes in Control adds the following: "Says Dr Anoop Misra, director and head (diabetes and metabolic diseases) Fortis Hospitals: "In patients with hypertension, beta blocker drugs are no longer frontline therapy. These drugs may not only increase blood sugar levels in those who don't have diabetes, but may worsen sugar control in those with diabetes an Continue reading >>
New Beta Blocker May Help Diabetic Patients With High Blood Pressure
New beta blocker may help diabetic patients with high blood pressure A medication that is commonly used to control high blood pressure does not raise blood sugar levels in diabetics who also have high blood pressure, according to researchers from Rush University Medical Center . The results of the study appear in the November 10 issue of the Journal of the American Medical Association (JAMA) and were presented today at the 2004 American Heart Association Scientific Sessions. Beta blockers have been shown to be effective at lowering high blood pressure but many physicians have been reluctant to prescribe them to patients with diabetes because some beta-blockers have been shown to raise blood sugar levels in diabetics. Especially at risk are the estimated 47 million people with metabolic syndrome, a combination of several risk factors in one person that includes, but is not limited to, high blood pressure, insulin dependence or glucose intolerance, and obesity. "The results of this study suggest that physicians treating diabetic patients may want to consider the role that a newer beta-blocker such as carvedilol could play in managing certain cardiovascular risk factors and components of the metabolic syndrome ," said Dr. George L. Bakris, director, hypertension research center at Rush University Medical Center. "By improving these crucial risk factors, carvedilol could, theoretically, improve overall outcomes in this high-risk patient population." Bakris was the principal investigator of this 1,235-patient study, which is known as GEMINI (Glycemic Effects in Diabetes Mellitus: Carvedilol - Metoprolol Comparison in Hypertensives). Bakris and colleagues compared the effects of carvedilol to metoprolol tartrate in diabetic, hypertensive patients. Patients were randomized to Continue reading >>
Beta Blocker Drug Therapy
Beta blockers block the effect of adrenaline (the hormone norepinephrine) on the body's beta receptors. This slows down the nerve impulses that travel through the heart. As a result, the resting heart rate is lower, the heart does not have to work as hard and the heart requires less blood and oxygen. Beta blockers can also block the impulses that can cause an arrhythmia (irregular heartbeat). This type of drug is generally prescribed for: If these medications are prescribed, the doctor should be made aware of any other drug, vitamin, mineral or herbal supplement the patient is taking, especially: Drugs for treating asthma , chronic bronchitis and emphysema Insulin and other medicines used to treat diabetes Medicines for high blood pressure, which may increase the effect of beta blockers The doctor should be told if the patient has: A slow heart rate (bradycardia) or heart block Allergies to foods or dyes, which can be made worse by beta blockers Asthma, which beta blockers can make worse Diabetes or hypoglycemia because beta blockers can cause the blood sugar levels to rise or hide the symptoms of low blood sugar Heart disease or poor circulation in the hands or feet Symptoms of hay fever, chronic bronchitis or emphysema Patients should avoid foods and beverages that have caffeine, antacids that have aluminum or over-the-counter cough and cold medications and antihistamines. Alcohol should also be avoided because it can decrease the effects of the beta blockers. To learn more about these types of drugs and their side effects, click on the links below: Continue reading >>
Beta-blockers And Diabetes: The Bad Guys Come Good.
Beta-blockers and diabetes: the bad guys come good. Type 2 diabetes is becoming very common and is closely linked to physical inactivity and obesity. It is associated with clustering of coronary risk factors and 60-80% of cases have hypertension. The first therapeutic action is appropriate adjustment of life style. Anti-hypertensive therapies such as diuretics, ACE inhibitors and calcium antagonists have been effective in reducing cardiovascular events in type 2 diabetes, though calcium antagonists may be less effective than older therapies and ACE-inhibitors in reducing the risk of heart attacks and heart failure (but possibly more effective in stroke reduction). Beta-blockers (BBs) have a poor image as a potential therapy due to apparent adverse effects on surrogate end-points such as insulin-resistance. However large, controlled trials have shown BBs to be highly effective in reducing the risk of cardiovascular events and death in post myocardial infarction patients with diabetes. The UKPDS study in type 2 diabetics with hypertension showed first-line beta-blockade to be at least as effective as ACE-inhibition in preventing all primary macrovascular and microvascular end-points. The active ingredient appears to be beta-1 blockade, acting not only to lower blood pressure but also to prevent sudden death and cardiovascular damage stemming from chronic beta-1 stimulation associated with raised noradrenaline activity. By contrast, in the LIFE study atenolol was less effective than the angiotensin receptor antagonist losartan in reducing cardiovascular events and all-cause mortality in mainly elderly hypertensives with diabetes. Thus the best beta-blocker results in reducing hard cardiovascular end-points occur in hypertension studies (including the UKPDS study) involvin Continue reading >>
Beta blockers, also called beta-adrenergic blocking agents, treat a variety of conditions, such as high blood pressure and migraines. Find out more about this class of medication. Beta blockers, also known as beta-adrenergic blocking agents, are medications that reduce your blood pressure. Beta blockers work by blocking the effects of the hormone epinephrine, also known as adrenaline. When you take beta blockers, your heart beats more slowly and with less force, thereby reducing blood pressure. Beta blockers also help blood vessels open up to improve blood flow. Examples of beta blockers Some beta blockers mainly affect your heart, while others affect both your heart and your blood vessels. Which one is best for you depends on your health and the condition being treated. Examples of oral beta blockers include: Acebutolol (Sectral) Atenolol (Tenormin) Bisoprolol (Zebeta) Metoprolol (Lopressor, Toprol-XL) Nadolol (Corgard) Nebivolol (Bystolic) Propranolol (Inderal LA, InnoPran XL) Doctors prescribe beta blockers to prevent, treat or improve symptoms in a variety of conditions, such as: High blood pressure Irregular heart rhythm (arrhythmia) Heart failure Chest pain (angina) Heart attacks Migraine Certain types of tremors Beta blockers aren't usually prescribed for blood pressure until other medications, such as diuretics, haven't worked effectively. Your doctor may prescribe beta blockers as one of several medications to lower your blood pressure, including angiotensin-converting enzyme (ACE) inhibitors, diuretics or calcium channel blockers. Beta blockers may not work as effectively for black and older people, especially when taken without other blood pressure medications. Side effects and cautions Side effects may occur in people taking beta blockers. However, many peop Continue reading >>
Diabetes And Beta-blockers: What You Need To Know
People with diabetes tend to develop heart disease or stroke at an earlier age than the general population. One reason for this is that high glucose levels increase your risk of high blood pressure (hypertension). According to the American Diabetes Association, almost one in three American adults has high blood pressure. Two out of three people with diabetes have high blood pressure. Type 2 Diabetes and Hypertension High blood pressure doesn’t necessarily cause symptoms. You may feel just fine, but don’t let that fool you. Your heart is working harder than it should. It’s a serious condition, especially for people with diabetes. High blood pressure puts a lot of extra stress on your body. Over time, it can cause hardening of the arteries. It can also damage your brain, kidneys, eyes, and other organs. Treating High Blood Pressure If you have high blood pressure, your doctor may want to try other methods of treating it before turning to beta-blockers. These may include lifestyle changes and taking better control of blood glucose levels. The decision to use medication, including beta-blockers, will depend on your personal medical history. A 2015 study published in the Journal of the American Medical Association recommends drug therapy with a blood pressure reading of above 140 systolic and above 90 diastolic (140/90). For people with diabetes, lowering high blood pressure reduces the risk of developing cardiovascular problems, kidney disease, and neuropathy. Beta-Blockers Beta-blockers (beta-adrenergic blocking agents) are a class of prescription drug. They are used to treat a variety of conditions such as glaucoma, migraines, and anxiety disorders. They are also used to treat heart failure and high blood pressure. High blood pressure can increase your risk for hear Continue reading >>