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How Does A Glucose Meter Work?

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Other Types: Gestational Diabetes During Pregnancy

Diabetes is a chronic metabolic disease effecting millions worldwide. Diabetes is categorized by: Type I (Juvenile Diabetes): Pancreas produces very little or no insulin Type II (Insulin Resistant): Pancreas does not produce enough insulin or does not use produced insulin effectively (insulin resistant) Insulin is a circulating hormone that helps the body use and store glucose. At low levels of insulin, the body stores less nutrients in the formof glucose After eating, blood glucose rises as food is broken down. High blood glucose levels damage the eyes, kidneys, nerves, and heart over time. Diabetics aim to keep their blood glucose level within normal range (82 to 110 mg/dL). Insulin therapy is a common method in which exogenous insulin analogs are injected when blood gluose are high Example home glucometer At home glucometers allow diabetic patients to monitor their blood glucose levels with a minimal amount of sample blood. Glucometers utilize disposable electrochemical cells. Type I diabetics check their blood glucose levels about 4 times a day. Type II diabetics check their blood glucose levels about 2 times a day. Components of a typical galvanic electrochemical cell: Working Continue reading >>

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Popular Questions

  1. Sidhedevil

    I believe that the research is suggesting that Seroquel affects the functioning of the pancreas, which is responsible for insulin regulation.
    Insulin disruptions can lead to many things, including food cravings, diabetes, and weight gain.
    You should also be watchful of pancreatitis--something that I have noticed anecdotally is that people who generally have a hard time gaining weight are more prone to pancreatitis as a side-effect of medication that seems to give the pancreas a hard time than they are to either weight gain or diabetes.

  2. decathecting

    The answer is, truly, nobody knows for sure. Here are a few theories that are frequently floated, along with reasons to question them:
    1) Seroquel makes people want to eat more, which causes weight gain, and overweight people are more likely to have diabetes. However, the increased rate of diabetes is seen in patients of all weights who take Seroquel, not only those who gain substantial weight or change their diets. Moreover, some studies have shown increased risk even when weight or weight gain are controlled for. And as well, the direct evidence that eating too much or eating too much sugar causes diabetes is suspect.
    2) Seroquel has some effect on blood sugar levels directly. Patients who take the drug tend to have higher blood sugar levels generally. However, we don't really know why that happens. There are theories about glucose metabolism and about the drug's effect on pancreatic serotonin receptors, but nothing has been conclusively proved.
    3) Patients who have schizophrenia have higher rates of diabetes regardless of their course of treatment, so it may be that the disease, not the drug, is correlated with the diabetes. However, Seroquel patients who are not schizophrenic have also been found in some studies to have increased risk.
    4) Patients who take Seroquel are under the direct care of a doctor and are getting regular checkups and blood tests, so it may be that their rate of diabetes is not higher than that of the general population, but merely that their rate of diagnosis is higher because going to the doctor means that the condition is more likely to be noticed and treated. Rates of diagnosis have been going up for everyone, so there's some merit to this hypothesis. But the rate of diagnosis for schizophrenic patients taking Seroquel is higher than for patients with other diagnoses being monitored for other drugs, so this doesn't seem to fully explain the difference.
    So basically, the answer is that there are some reasons to be wary, but that you and your doctor have to weigh the risks and benefits of the drug given your condition and needs.

  3. nathan v

    I've been warned, by doctors and other patients, that Seroquel not only causes weight gain, but also diabetes. Having not noticed either of these side-effects myself, it makes me wonder.
    When people say things like that, what they mean is that a sizeable number of people taking Seroquel suffered diabetes and/or weight gain. How sizeable? This page says 23% of patients receiving Seroquel in all studies suffered weight gain, as opposed to 6% of patients receiving only placebo. (My go-to for drug info, www.rxlist.com, says more along the lines of 5% vs 1%, but then, I think that's just going off of published studies.) This page says that between 1% and 0.1% of patients receiving the drug in trials developed diabetes.
    You can see, looking at this, that it's to be expected that you won't experience unpleasant weight gain or diabetes. Part of the reason for drug testing is to discover relatively unlikely adverse reactions.
    (Regarding the rest of what you're asking: well, it looks like the consensus is just "mechanism unknown." That's how it is for most of this stuff. It would be pretty expensive to figure out if people on Seroquel with fixed calorie diets gained weight, and wouldn't be of much use to know, so nobody's going to bother to figure it out.)

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