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Hla Type 2 Diabetes

Hla-dq Genotypes In Classic Type 1 Diabetes And In Latent Autoimmune Diabetes Of The Adult

Hla-dq Genotypes In Classic Type 1 Diabetes And In Latent Autoimmune Diabetes Of The Adult

In 19931996, islet autoantibodies, C-peptide, and HLA-DQ genotypes were evaluated in 345 insulin-treated diabetic patients of all ages from the Skaraborg Diabetes Registry 56 years after their diagnosis and in 216 control subjects from the Skaraborg County, Sweden, population. The aims of this study were to clarify the importance of age at diagnosis of diabetes for HLA-DQ associations in patients with classic type 1 diabetes and whether patients considered to have latent autoimmune diabetes of the adult differed in their human leukocyte antigen (HLA) associations. An abnormally low fasting C-peptide value was used as the definition of type 1 diabetes, found in 182 of 345 (53%) patients. No major associations between age at diagnosis and HLA susceptibility or protective genotypes were detected in type 1 diabetic patients. Among the 163 patients with preserved -cell function, the frequency of HLA protective genotypes was clearly decreased (5% vs. 42%) in the 46 of 163 with islet antibodies compared with the 117 of 163 antibody-negative patients. The authors conclude that there were no major effects of age at diagnosis on HLA-DQ associations in classic type 1 diabetic patients, whereas lack of HLA-DQ protective genotypes was a feature of patients with slow-progressing type 1 diabetes (latent autoimmune diabetes of the adult). Abbreviations: Ab+, with islet antibodies; Ab, without islet antibodies; CI, confidence interval; CPEP-LOW, fasting serum C-peptide level of less than or equal to 0.24 nmol/liter; CPEP-NORM, fasting serum C-peptide level of greater than 0.24 nmol/liter; HLA, human leukocyte antigen; LADA, latent autoimmune diabetes in the adult; OR, odds ratio; SD, standard deviation. Received for publication November 14, 2001; accepted for publication June 19, 2002. Continue reading >>

Association Of The Hla-dqa1 And Hla-dqb1 Alleles In Type 2 Diabetes Mellitus And Diabetic Nephropathy In The Han Ethnicity Of China

Association Of The Hla-dqa1 And Hla-dqb1 Alleles In Type 2 Diabetes Mellitus And Diabetic Nephropathy In The Han Ethnicity Of China

Association of the HLA-DQA1 and HLA-DQB1 Alleles in Type 2 Diabetes Mellitus and Diabetic Nephropathy in the Han Ethnicity of China 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Key Laboratory of Hormone and Development (Ministry of Health), Metabolic Disease Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300070, China Received 1 January 2013; Revised 29 January 2013; Accepted 29 January 2013 Copyright 2013 Ze-Jun Ma et al. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. HLA gene system is one of the most polymorphic regions of the human genome. The association of HLA class II genes in T1DM pathogenesis has been reported for several ethnicities. Associations of HLA class II genes with T2DM have revealed inconsistent results. Moreover, correlations between DN and HLA alleles remain unclear. We carried out DNA typing chip by specific medium resolution typing probes in 310 T2DM subjects (including 210 patients with DN and 100 patients without DN) in addition to 100 healthy controls. Differences were found between patients with T2DM and the control group in the frequencies of the HLA-DQA1*0301 (15.5% versus 8.0%, ) and the HLA-DQA1*0501 alleles (16.6% versus 8.5%, ). Differences were found between patients with DN and without DN in the frequencies of the HLA-DQA1*0302 (6.9% versus 13.5%, ) and HLA-DQB1*0501 alleles (5.8% versus 14.5%, ). Diabetes duration and systolic blood pressure were independent risk factors associated with DN ( ), whereas the HLA-DQB1*0501 llele had a protective effect on DN ( ). These data suggest the HLA-DQA1*0301 and HLA- Continue reading >>

Hla-drb1 Reduces The Risk Of Type 2 Diabetes Mellitus By Increased Insulin Secretion

Hla-drb1 Reduces The Risk Of Type 2 Diabetes Mellitus By Increased Insulin Secretion

N2 - Aims/hypothesis: We sought to identify the physiological implications of genetic variation at the HLA-DRB1 region in full-heritage Pima Indians in Arizona. Methods: Single-nucleotide polymorphisms from the HLA region on chromosome 6p were tested for association with skeletal muscle mRNA expression of HLA-DRB1 and HLA-DRA, and with type 2 diabetes mellitus and prediabetic traits. Results: The A allele at rs9268852, which tags HLA-DRB1 02(1602), was associated both with higher HLA-DRB1 mRNA expression (n = 133, p = 4.27 10-14) and decreased risk of type 2 diabetes (n = 3,265, OR 0.723, p = 0.002). Among persons with normal glucose tolerance (n = 266) this allele was associated with a higher mean acute insulin response during an intravenous glucose tolerance test (p = 0.005), higher mean 30 min insulin concentration during an oral glucose tolerance test (p = 0.017) and higher body fat percentage (p = 0.010). The polymorphism was not associated with HLA-DRA mRNA expression or insulin sensitivity. Conclusions/interpretation: HLA-DRB1 02 is protective for type 2 diabetes, probably by enhancing self tolerance, thereby protecting against the autoimmune-mediated reduction of insulin secretion. 2011 Springer-Verlag (outside the USA). AB - Aims/hypothesis: We sought to identify the physiological implications of genetic variation at the HLA-DRB1 region in full-heritage Pima Indians in Arizona. Methods: Single-nucleotide polymorphisms from the HLA region on chromosome 6p were tested for association with skeletal muscle mRNA expression of HLA-DRB1 and HLA-DRA, and with type 2 diabetes mellitus and prediabetic traits. Results: The A allele at rs9268852, which tags HLA-DRB1 02(1602), was associated both with higher HLA-DRB1 mRNA expression (n = 133, p = 4.27 10-14) and decreased Continue reading >>

The Relationships Between Hla Class Ii Alleles And Antigens With Gestational Diabetes Mellitus: A Meta-analysis

The Relationships Between Hla Class Ii Alleles And Antigens With Gestational Diabetes Mellitus: A Meta-analysis

The relationships between HLA class II alleles and antigens with gestational diabetes mellitus: A meta-analysis Scientific Reports volume 6, Articlenumber:35005 (2016) Gestational diabetes mellitus (GDM) is defined as glucose intolerance with onset or first recognition during pregnancy. It is associated with an increased risk of pregnancy complications. Susceptibility to GDM is partly determined by genetics and linked with type 1 diabetes-associated high risk HLA class II genes. However, the evidence for this relationship is still highly controversial. In this study, we assessed the relationship between HLA class II variants and GDM. We performed meta-analysis on all of literatures available in PubMed, Embase, Web of Science and China National Knowledge Infrastructure databases. The odds ratio and 95% confidence interval of each variant were estimated. All statistical analyses were conducted using the Comprehensive Meta Analysis 2.2.064 software. At the allelic analysis, DQB1*02, DQB1*0203, DQB1*0402, DQB1*0602, DRB1*03, DRB1*0301 and DRB1*1302 reached a nominal level of significance, and only DQB1*02, DQB1*0602 and DRB1*1302 were statistically significant after Bonferroni correction. At the serological analysis, none of DQ2, DQ6, DR13 and DR17 was statistically significant following Bonferroni correction although they reached a nominal level of significance. In sum, our meta-analysis demonstrated that there were the associations between HLA class II variants and GDM but more studies are required to elucidate how these variants contribute to GDM susceptibility. Gestational diabetes mellitus (GDM) is defined as glucose intolerance with onset during pregnancy 1 . The manifestation of GDM is reportedly influenced by age 2 , ethnicity 3 , BMI 4 , and family history of GDM Continue reading >>

Type 1 And Type 2 Diabetes

Type 1 And Type 2 Diabetes

What Do They Have in Common? Abstract Type 1 and type 2 diabetes frequently co-occur in the same families, suggesting common genetic susceptibility. Such mixed family history is associated with an intermediate phenotype of diabetes: insulin resistance and cardiovascular complications in type 1 diabetic patients and lower BMI and less cardiovascular complications as well as lower C-peptide concentrations in type 2 diabetic patients. GAD antibody positivity is more common in type 2 diabetic patients from mixed families than from common type 2 diabetes families. The mixed family history is associated with more type 1–like genetic (HLA and insulin gene) and phenotypic characteristics in type 2 diabetic patients, especially in the GAD antibody–positive subgroup. Leaving out the extreme ends of diabetes phenotypes, young children progressing rapidly to total insulin deficiency and strongly insulin-resistant subjects mostly with non-Europid ethnic origin, a large proportion of diabetic patients may have both type 1 and type 2 processes contributing to their diabetic phenotype. Diabetes in most cases is caused by a loss of the physical or functional β-cell mass, mostly due to an autoimmune process (type 1 etiological process) and/or increased need for insulin due to insulin resistance (type 2 process) (1). Both of these major diabetes types are believed to include different stages of disease, ranging from non–insulin-requiring to insulin-requiring for control or survival. According to this classification adopted by the World Health Organization, it is quite possible that both processes would operate in a single patient and contribute to the phenotype of the patient. Also, factors other than autoimmunity can lead to a defective insulin response to glucose. Both major diab Continue reading >>

Hla-associated Susceptibility To Type 2 (non-insulin-dependent) Diabetesmellitus: The Wadena City Health Study.

Hla-associated Susceptibility To Type 2 (non-insulin-dependent) Diabetesmellitus: The Wadena City Health Study.

HLA-associated susceptibility to type 2 (non-insulin-dependent) diabetesmellitus: the Wadena City Health Study. Rich SS(1), French LR, Sprafka JM, Clements JP, Goetz FC. (1)Department of Laboratory Medicine and Pathology, Minnesota Department of Health, Minneapolis. Epidemiologic data suggest that a parental history of Type 2(non-insulin-dependent) diabetes mellitus increases the risk of Type 1(insulin-dependent) diabetes in siblings of a Type 1 diabetes proband. Thisincrease in risk is consistent with a shared genetic susceptibility between Type 1 and Type 2 diabetes. We have previously reported evidence that HLA-DR4-linkedfactors may represent a homogeneous subset of diabetes susceptibility. First,HLA-DR4 frequency was higher in Type 1 diabetic study subjects with a Type 2diabetic parent than in Type 1 diabetic subjects whose parents were not diabetic.Second, a DR4-haplotype was transmitted from the Type 2 diabetic parent to theType 1 offspring more often than expected. These data are consistent with thehypothesis that families with a Type 2 diabetic parent and Type 1 diabetic child,heavily determined by HLA-DR4 linked factors, may represent a homogeneous subset of diabetes susceptibility. In this report, we further explore the relationshipbetween the high-risk HLA antigen (HLA-DR4) in study subjects with differingglycaemic status (National Diabetes Data Group criteria). In this community-basedstudy, we find evidence that HLA-DR4 is increased in study subjects with Type 2diabetes and may be a marker for Type 2 diabetes susceptibility. Continue reading >>

Diabetic Retinopathy And Hla Antigens In Type 2 Diabetes Mellitus

Diabetic Retinopathy And Hla Antigens In Type 2 Diabetes Mellitus

Diabetic retinopathy and HLA antigens in type 2 diabetes mellitus PURPOSE. Diabetic retinopathy is the most common complication of diabetes mellitus. No single predisposing factor has been identified, and genetic factors may play a role in the development of severe retinopathy. In this study, we investigated the association between diabetic retinopathy and HLA antigens in type 2 diabetes mellitus. METHODS. This study was conducted at the retina unit of the Department of Ophthalmology of Ondokuz Mayis University between October 1999 and March 2000, and included 46 diabetics with non-proliferative retinopathy and 30 with proliferative retinopathy, with 30 non-diabetic controls. HLA class I (A, B, C) antigens were studied by Terasakis microlymphocytotoxicity test and HLA class II (DR, DQ) typing was carried out using a polymerase chain reaction-sequence specific primer. RESULTS. HLA-DR4 and DQ8 frequencies were higher in patients with non-proliferative retinopathy than those with proliferative retinopathy, and HLA-DR7 frequency was higher in patients with proliferative retinopathy than non-proliferative cases (p>0.05). No significant differences in HLA antigens were found between patient groups and controls. CONCLUSIONS. The differences in HLA antigen frequencies between patients with and without proliferative retinopathy suggest a genetic contribution to diabetic retinopathy. (Eur J Ophthalmol 2002; 12: 89-93) A. Birinci, H. Birinci, R. Abidinoglu, B. DurupInar, I. Oge Continue reading >>

Genetic Analysis Of Hla, Na And Hpa Typing In Type 2 Diabetes And Aso

Genetic Analysis Of Hla, Na And Hpa Typing In Type 2 Diabetes And Aso

Genetic analysis of HLA, NA and HPA typing in type 2 diabetes and ASO *The First Department of Internal Medicine The Second Department of Internal Medicine Department of Blood Transfusion, Kansai Medical University, Osaka, Japan Shosaku Nomura, The First Department of Internal Medicine, Kansai Medical University, 10-15 Fumizonocho, Moriguchi, Osaka 570-8507, Japan. Tel: + 81 6 6992 1001; Fax: + 81 725 32 1113; E-mail: [email protected] Received 2004 Dec 6; Revised 2005 Jul 11; Accepted 2005 Dec 22. Copyright 2006 The Authors Journal compilation 2006 Blackwell Publishing Ltd Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation. We examined the genetic status of human leucocyte antigens (HLA), human platelet alloantigens (HPA) and neutrophil-specific antigens (NA) in patients with type 2 diabetes mellitus and diabetic arteriosclerosis obliterans (ASO). To our knowledge, the present study is the first report showing the relationship among three genetic factors in type 2 diabetes mellitus and ASO patients. HLA typing was performed by the polymerase chain reaction (PCR)restriction fragment length polymorphism method. HPA-typing and NA-typing were by a PCR-sequence-specific primer method. The incidence of HLA-DRB1* 1501 was found to be significant in type 2 diabetes and non-diabetic, particularly ASO-positive patients, compared to control subjects. There were no differences in NA1/NA2 between the control and diabetic or non-diabetic ASO groups. However, the frequency of NA2/NA2 in ASO-positive diabetes and non-diabetic ASO patients was significantly higher than controls. The a/b genotype of HPA-5a/5b was significantly lower in type 2 diabetes and non-diabetic ASO-positive patien Continue reading >>

Association Of Selective Hla Class Ii Susceptibility-conferring And Protective Haplotypes With Type 2 Diabetes In Patients From Bahrain And Lebanon

Association Of Selective Hla Class Ii Susceptibility-conferring And Protective Haplotypes With Type 2 Diabetes In Patients From Bahrain And Lebanon

The association of HLA class II with type 2 diabetes (T2DM) was investigated in Bahraini and Lebanese subjects. DRB1*070101 (Lebanese and Bahraini) and DQB1*0201 (Lebanese) were susceptibility-conferring alleles, and unique susceptibility-conferring/protective haplotypes were found in both patient groups. Regression analysis confirmed that DRB1*070101-DQB1*0201 (Bahraini) and DRB1*110101-DQB1*0201 (Lebanese) were susceptibility-conferring haplotypes. Type 2 (non-insulin-dependent) diabetes mellitus (T2DM) is the most common diabetes form ( 19 ), and susceptibility to it is determined by environmental and genetic factors ( 9 , 19 ), the latter being complex and poorly defined ( 5 , 19 ). While the association of HLA class II genes in type 1 diabetes pathogenesis was reported for several ethnicities ( 1 , 14 ), studies on HLA class II association with T2DM provided inconsistent results, since an association ( 16 ), no association ( 7 ), or a weak link between HLA class II and T2DM has been reported. A number of studies focused on the association of HLA with T2DM morbidity and mortality ( 17 ), highlighted by increased frequency of HLA-DR3 and -DR4 in islet cell autoantibody (ICA)-positive patients refractory to oral anti-diabetic drugs as reported by some ( 11 ) but not others ( 20 ), and association of HLA-DRB1*1502 with T2DM in anti-glutamic acid decarboxylase (GAD)-positive patients ( 10 ). We previously reported on the distribution of HLA class II alleles and haplotypes among T2DM patients in the Bahraini population ( 16 ), an Arab Peninsula population with a high prevalence (24% of the adult population) of T2DM ( 2 ). In view of the heterogeneity of Arabs with distinct ethnic backgrounds and racial origins ( 3 ), this study addresses the association of HLA-DRB1 and Continue reading >>

"the Association Of Human Leukocyte Antigen (hla) Alleles And Type 2 Di" By Kantibhai Motiram Patel

Kantibhai Motiram Patel, University of Texas at El Paso The epidemic of type 2 diabetes mellitus (T2DM) is ranked as a major public health priority across the United States and especially in the El Paso, Texas region. The risk for the development of T2DM is greater in minority groups, particularly among Mexican Americans (MA) who comprise approximately 78% of El Paso's population. The growing incidence of T2DM in this group is typically attributed to increase in weight (obesity). The incidence of diabetes may also be influenced by genetic factors that are unique to this group. ^ Several earlier studies have identified genetic markers for type 1 diabetes mellitus (T1DM). These markers, which reside in the major histocompatibility complex (MHC), are known as the human leukocyte antigens (HLA). These are divided into Class I (HLA-A, B, C loci) and Class II (HLA-DR and DQ loci) antigens. Although some antigens are purported to be protective, other antigens are indicated for possible susceptibility with T2DM, particularly among MA. This includes the association of Class II alleles and T2DM in this ethnic population. However, there are only a few studies that have explored the association of HLA and T2DM among MAs. Given the limited study and information available, genetic markers for susceptibility and protective effects for MA with and without T2DM would be merited. This study is guided by the following research questions: (1) What is the relationship between HLA Class I (HLA-A, B, C loci) antigens and T2DM among MA?; (2) What is the relationship between HLA Class II (HLA-DR and DQ loci) antigens and T2DM among MA?; and (3) What is the relationship between specific HLA Class II (HLA-DRB1*, DQA1*, DQB1* loci) alleles and T2DM among MA? ^ The genetic testing proposed for thi Continue reading >>

Hla Class Ii Alleles And Risk For Peripheral Neuropathy In Type 2 Diabetes Patients Marzban A, Kiani J, Hajilooi M, Rezaei H, Kahramfar Z, Solgi G - Neural Regen Res

Hla Class Ii Alleles And Risk For Peripheral Neuropathy In Type 2 Diabetes Patients Marzban A, Kiani J, Hajilooi M, Rezaei H, Kahramfar Z, Solgi G - Neural Regen Res

The potential impact of human leukocyte antigen (HLA) genotype variations on development of diabetic peripheral neuropathy (DPN) is not well determined. This study aimed to identify the association of HLA class II alleles with DPN in type 2 diabetes (T2D) patients. Totally 106 T2D patients, 49 with DPN and 57 without DPN, and 100 ethnic-matched healthy controls were analyzed. Both groups of the patients were matched based on sex, age, body mass index (BMI) and duration of T2D. Polyneuropathy was diagnosed using electrodiagnostic methods. HLA-DRB1 and DQB1 genotyping was performed in all subjects by the polymerase chain reaction with sequence-specific primers (PCR-SSP) method. T2D patients with DPN showed higher frequencies of HLA-DRB1*10 and DRB1*12 alleles compared to control group (P = 0.04). HLA-DQB1*02 allele and HLA-DRB1*07-DQB1*02 haplotype were associated with a decreased risk for developing DPN in T2D patients (P = 0.02 and P = 0.05 respectively). Also, patients with severe neuropathy showed higher frequencies of DRB1*07 (P = 0.003) and DQB1*02 (P = 0.02) alleles than those with mild-to-moderate form of neuropathy. The distribution of DRB1 and DQB1 alleles and haplotypes were not statistically different between all patients and healthy controls. Our findings implicate a possible protective role of HLA-DQB1*02 allele and HLA-DRB1*07-DQB1*02 haplotype against development of peripheral neuropathy in T2D patients. Therefore, variations in HLA genotypes might be used as genetic markers for prediction and potentially management of neuropathy in T2D patients. Keywords:nerve regeneration; HLA-DRB1; HLA-DQB1; alleles; genotypes; haplotypes; peripheral neuropathy; type 2 diabetes; neural regeneration Marzban A, Kiani J, Hajilooi M, Rezaei H, Kahramfar Z, Solgi G. HLA cla Continue reading >>

Hla-associated Susceptibility To Type 2 (non-insulin-dependent) Diabetes Mellitus: The Wadena City Health Study

Hla-associated Susceptibility To Type 2 (non-insulin-dependent) Diabetes Mellitus: The Wadena City Health Study

, Volume 36, Issue3 , pp 234238 | Cite as HLA-associated susceptibility to Type 2 (non-insulin-dependent) diabetes mellitus: the Wadena City Health Study Epidemiologic data suggest that a parental history of Type 2 (non-insulin-dependent) diabetes mellitus increases the risk of Type 1 (insulin-dependent) diabetes in siblings of a Type 1 diabetes proband. This increase in risk is consistent with a shared genetic susceptibility between Type 1 and Type 2 diabetes. We have previously reported evidence that HLA-DR4-linked factors may represent a homogeneous subset of diabetes susceptibility. First, HLA-DR4 frequency was higher in Type 1 diabetic study subjects with a Type 2 diabetic parent than in Type 1 diabetic subjects whose parents were not diabetic. Second, a DR4-haplotype was transmitted from the Type 2 diabetic parent to the Type 1 offspring more often than expected. These data are consistent with the hypothesis that families with a Type 2 diabetic parent and Type 1 diabetic child, heavily determined by HLA-DR4 linked factors, may represent a homogeneous subset of diabetes susceptibility. In this report, we further explore the relationship between the high-risk HLA antigen (HLA-DR4) in study subjects with differing glycaemic status (National Diabetes Data Group criteria). In this community-based study, we find evidence that HLA-DR4 is increased in study subjects with Type 2 diabetes and may be a marker for Type 2 diabetes susceptibility. GeneticsType 2 (non-insulin-dependent) diabetes mellitusHLA Newman B, Selby JV, King MC, Slemenda C, Fabsitz R, Friedman GD (1987) Concordance for type 2 (non-insulin-dependent) diabetes mellitus in male twins. Diabetologia 30: 763768 CrossRef PubMed Google Scholar Chern MM, Anderson VE, Barbosa J (1982) Empirical risk for insulin-de Continue reading >>

Human Leukocyte Antigen

Human Leukocyte Antigen

The human leukocyte antigen (HLA) system or complex is a gene complex encoding the major histocompatibility complex (MHC) proteins in humans. These cell-surface proteins are responsible for the regulation of the immune system in humans. The HLA gene complex resides on a 3 Mbp stretch within chromosome 6p 21. HLA genes are highly polymorphic , which means that they have many different alleles , allowing them to fine-tune the adaptive immune system . The proteins encoded by certain genes are also known as antigens , as a result of their historic discovery as factors in organ transplants. Different classes have different functions: HLAs corresponding to MHC class I ( A , B , and C ) present peptides from inside the cell. For example, if the cell is infected by a virus, the HLA system brings fragments of the virus to the surface of the cell so that the cell can be destroyed by the immune system. These peptides are produced from digested proteins that are broken down in the proteasomes . In general, these particular peptides are small polymers , about 9 amino acids in length.[ citation needed ] Foreign antigens presented by MHC class I attract killer T-cells (also called CD8 positive- or cytotoxic T-cells) that destroy cells. MHC class I proteins associate with 2-microglobulin , which unlike the HLA proteins is encoded by a gene on chromosome 15 . HLAs corresponding to MHC class II ( DP , DM , DOA , DOB , DQ , and DR ) present antigens from outside of the cell to T-lymphocytes. These particular antigens stimulate the multiplication of T-helper cells (also called CD4 positive T cells), which in turn stimulate antibody -producing B-cells to produce antibodies to that specific antigen. Self-antigens are suppressed by regulatory T cells . HLAs corresponding to MHC class III enc Continue reading >>

Increased Frequency Of Hla A2/dr4 And A2/dr8 Haplotypes In Young Saskatchewan Aboriginal People With Diabetic End-stage Renal Disease

Increased Frequency Of Hla A2/dr4 And A2/dr8 Haplotypes In Young Saskatchewan Aboriginal People With Diabetic End-stage Renal Disease

Original Article: Patient-Oriented, Translational Research Increased Frequency of HLA A2/DR4 and A2/DR8 Haplotypes in Young Saskatchewan Aboriginal People with Diabetic End-Stage Renal Disease Department of Medicine, Royal University Hospital Aims: To determine the association of HLA with diabetic end-stage renal disease (DESRD) in Saskatchewan aboriginal people. Methods: This was a retrospective study of HLA profiles in four groups of Saskatchewan residents with ESRD diagnosed from 1980 to 1998: aboriginal people with and without DESRD, and non-aboriginal people with and without DESRD. The aboriginal DESRD group was also subdivided into those 50 and >50 years of age. Frequencies of individual and combinations of HLA antigens were compared between groups and subgroups. Results: HLA data were available for 634 subjects. Young aboriginal people with DESRD had a higher frequency of HLA-A2 than older AB DESRD subjects (69 vs. 36%; p = 0.03), and of HLA-DR4 and/or DR8 compared to older AB DESRD subjects (91 vs. 68%; p = 0.07) and AB non-DESRD subjects (91 vs. 67%; p = 0.03). Over 65% of young AB DESRD subjects had either an A2/DR4 or A2/DR8 haplotype (odds ratio 5.09 [confidence intervals 1.35, 20.15] versus older AB DESRD subjects; odds ratio 3.32 [confidence intervals 1.20, 9.3] versus AB non-DESRD subjects). Forty percent of young AB DESRD subjects were homozygous for at least one of A2, DR4 or DR8. Conclusions: Our findings suggest that DESRD in young AB subjects with T2DM has a genetic basis related to HLA. Canadian aboriginal people are experiencing an epidemic of diabetic end-stage renal disease (DESRD) [ 1 ]that cannot be wholly explained by increased rates of type 2 diabetes mellitus (T2DM) [ 2 ]. After adjusting for differences in rates of diabetes, for example, w Continue reading >>

Susceptible And Protective Human Leukocyte Antigen Class Ii Alleles And Haplotypes In Bahraini Type 2 (non-insulin-dependent) Diabetes Mellitus Patients

Susceptible And Protective Human Leukocyte Antigen Class Ii Alleles And Haplotypes In Bahraini Type 2 (non-insulin-dependent) Diabetes Mellitus Patients

Susceptible and Protective Human Leukocyte Antigen Class II Alleles and Haplotypes in Bahraini Type 2 (Non-Insulin-Dependent) Diabetes Mellitus Patients We are experimenting with display styles that make it easier to read articles in PMC. The ePub format uses eBook readers, which have several "ease of reading" features already built in. The ePub format is best viewed in the iBooks reader. You may notice problems with the display of certain parts of an article in other eReaders. Generating an ePub file may take a long time, please be patient. Susceptible and Protective Human Leukocyte Antigen Class II Alleles and Haplotypes in Bahraini Type 2 (Non-Insulin-Dependent) Diabetes Mellitus Patients Ayesha A. Motala, Marc Busson, [...], and Wassim Y. Almawi Whereas the genetic risk for type 1 diabetes is linked to human leukocyte antigen (HLA) class II genes, the HLA association in type 2 (non-insulin-dependent) diabetes is less clear. The association between HLA class II genotypes and type 2 diabetes was examined in adult Bahrainis, an Arab population with a high prevalence of type 2 diabetes. HLA-DRB1* and -DQB1* genotyping of 86 unrelated type 2 diabetes patients (age, 51.6 8.2 years; mean duration of diabetes, 7.7 7.1 years) who had a strong family history of diabetes (52 of 72 versus 0 of 89 for controls, P < 0.001) and 89 healthy subjects was done by PCR-sequence-specific priming. DRB1*040101 (0.1221 versus 0.0562, P = 0.019) and DRB1*070101 (0.2151 versus 0.0843, P < 0.001) were positively associated, while DRB1*110101 (0.0698 versus 0.1461, P = 0.014) and DRB1*160101 (0.0640 versus 0.1236, P = 0.038) were negatively associated with type 2 diabetes. DRB1*040101-DQB1*0302 (0.069 versus 0.0007; P = 0.004), DRB1*070101-DQB1*0201 (0.178 versus 0.0761, P = 0.007), DRB1*07010 Continue reading >>

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