Glucosamine And Metformin

Can I Keep Taking Anti-inflammatories Like Ibuprofen If I Go On Glucosamine And Chondroitin?

Can I keep taking anti-inflammatories like ibuprofen if I go on glucosamine and chondroitin? The brief answer is... Yes. Some people take Celebrex®, Aleve®, Advil®, ibuprofen or other non-steroidal anti-inflammatory drugs (NSAIDs) chronically for pain control. I advise patients to stay on their NSAID while taking both glucosamine and chondroitin, or ASU. After taking the supplements for a few weeks, and if your doctor approves, you can try to slowly wean off of the anti-inflammatory medication. Try to decrease the medication dose slowly, perhaps about 10% per week. this is often performed by skipping an occasional doses or using a lower dose tablet over time. In my patients, I consider it a great victory to eventually eliminate the medication. Fortunately, large numbers of people are able to either reduce or eliminate their reliance on these drugs by following the principles in my nine-step treatment program. Using chondroitin alone (not even in combination) showed a 67% reduction in NSAID use in a large study of 11,000 people. ASU can also reduce the need for chondroitin. As reported on several sections of this website, these anti-inflammatory medications are not at all benign drugs. About 10% of anti-inflammatory users develop high blood pressure from the medication, a substantial portion develop kidney and liver damage, blood disorders, bleeding, serious interactions with other medications and even death. Most people are surprised to learn that over 16,500 people in the U.S. each year die from the complications of anti-inflammatory medications. That's about 45 people every day, on average. And these are 1998 numbers - the values might be much higher today since millions more take these drugs due to heavy advertising. I warned people that the COX-2 inhibitor NSAIDs Continue reading >>

Glucosamine-induced Insulin Resistance In L6 Muscle Cells.

Glucosamine-induced insulin resistance in L6 muscle cells. School of Life and Health Sciences, Aston University, Birmingham, UK. [email protected] Glucosamine increases flux through the hexosamine pathway, causing insulin resistance and disturbances similar to diabetic glucose toxicity. This study examines the effect of glucosamine on glucose uptake by cultured L6 muscle cells as a model of insulin resistance. Glucose uptake by L6 myotubes was measured using the non-metabolized glucose analogue 2-deoxy-d-glucose after incubation with glucosamine for 4 and 24 h, with and without insulin and several other agents (metformin, peroxovanadium and d-pinitol) that improve glucose uptake in diabetic states. After 4 h, high concentrations of glucosamine (5 x 10(-3) and 10(-2) M) reduced basal and insulin-stimulated glucose uptake by up to 50%. After 24 h, the effect of insulin was completely abolished by 10(-2) M glucosamine and reduced over 50% by 5 x 10(-3) M glucosamine. Lower concentrations of glucosamine did not significantly alter glucose uptake. The effect of glucosamine could not be attributed to cytotoxicity assessed by the Trypan Blue test. Metformin, peroxovanadium and d-pinitol, each of which increased glucose uptake by L6 cells, did not prevent the decrease in glucose uptake with glucosamine. Glucosamine decreased insulin-stimulated glucose uptake by L6 muscle cells, providing a potential model of insulin resistance with similarities to glucose toxicity. Insulin resistance induced by glucosamine was not reversed by three agents (metformin, peroxovanadium and d-pinitol) known to enhance or partially mimic the effects of insulin. Continue reading >>

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Fortamet

FORTAMET® (metformin hydrochloride) Extended-Release Tablets DESCRIPTION FORTAMET® (metformin hydrochloride) Extended-Release Tablets contain an oral antihyperglycemic drug used in the management of type 2 diabetes. Metformin hydrochloride (N, Ndimethylimidodicarbonimidic diamide hydrochloride) is a member of the biguanide class of oral antihyperglycemics and is not chemically or pharmacologically related to any other class of oral antihyperglycemic agents. The empirical formula of metformin hydrochloride is C4H11N5•HCl and its molecular weight is 165.63. Its structural formula is: Metformin hydrochloride is a white to off-white crystalline powder that is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. The pKa of metformin is 12.4. The pH of a 1% aqueous solution of metformin hydrochloride is 6.68. FORTAMET® Extended-Release Tablets are designed for once-a-day oral administration and deliver 500 mg or 1000 mg of metformin hydrochloride. In addition to the active ingredient metformin hydrochloride, each tablet contains the following inactive ingredients: candellila wax, cellulose acetate, hypromellose, magnesium stearate, polyethylene glycols (PEG 400, PEG 8000), polysorbate 80, povidone, sodium lauryl sulfate, synthetic black iron oxides, titanium dioxide, and triacetin. FORTAMET® meets USP Dissolution Test 5. System Components And Performance FORTAMET® was developed as an extended-release formulation of metformin hydrochloride and designed for once-a-day oral administration using the patented single-composition osmotic technology (SCOT™). The tablet is similar in appearance to other film-coated oral administered tablets but it consists of an osmotically active core formulation that is surrounded by a semipermeable membra Continue reading >>

Miglitol Combined With Metformin Improves Glycaemic Control In Type 2 Diabetes.

Miglitol combined with metformin improves glycaemic control in type 2 diabetes. Department of Endocrinology, Metabolism and Clinical Nutrition, Faculty of Medicine, Universitaire Instelling Antwerpen, Wilrijkstraat 10, B-2650 Antwerp, Belgium. [email protected] To investigate the efficacy and safety of miglitol vs. placebo in type 2 diabetic outpatients insufficiently controlled (HbA1c between 7.5 and 10.5%) with diet and metformin. Patients treated with diet and metformin (1500-2250 mg/day) were randomized to receive additional treatment with either miglitol or placebo for 32 weeks. The dosages were force-titrated: 4 weeks at 25 mg miglitol t.i.d., 12 weeks at 50 mg miglitol t.i.d., and 16 weeks at 100 mg miglitol t.i.d. or matching placebo. If the highest dosage could not be tolerated, patients could be down-titrated to 50 mg t.i.d. The primary efficacy criterion was the change in glycated haemoglobin (HbA1c). Secondary efficacy parameters included fasting and 1 h postprandial blood glucose, serum insulin, and fasting and 1 h postprandial triglyceride levels. Safety and tolerability were evaluated by the incidence of adverse events and changes in vital signs or routine biochemical and haematological parameters. One hundred and fifty-two patients were valid for the intent-to-treat (ITT) analysis. There was a significant decrease in HbA1c on adding miglitol to metformin compared to adding placebo (miglitol treatment effect, - 0.21%; placebo treatment effect, + 0.22%; p = 0.011). Postprandial blood glucose declined in both the miglitol/metformin and placebo/metformin groups with a statistically significant difference in favour of miglitol/metformin (end of treatment adjusted means 13.8 mmol/l for miglitol vs. 15.8 mmol/l for placebo, p = 0.0007). Adverse events Continue reading >>

Metformin : Interactions With Other Medicines

It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with metformin. Similarly, check with your doctor or pharmacist before taking any new medicines while taking metformin, to make sure that the combination is safe . There may be an increased risk of developing lactic acidosis if you take medicines that can affect your kidney function with metformin. These include the following: non-steroidal anti-inflammatory drugs (NSAIDs) such asibuprofenornaproxen.It's best to check with your doctor before taking this type of painkiller with metformin. If you are prescribedany of the following medicines withmetformin you may be more likely to get low blood sugar (hypoglycaemia),so your doctor may want you to monitor your blood sugar levels more frequently if you start treatment with one of these: MAOI antidepressants, such asphenelzine,tranylcypromineorisocarboxazid other antidiabetic medicines, such as sulphonylureas (eg gliclazide, glibenclamide) or insulin. Medicines that canincrease blood sugar levels as a side effect may make all antidiabetic medicines, including metformin, less effective at controlling blood sugar. Medicines that can increase blood sugar levels include the following: antipsychotic medicines, such as chlorpromazine, olanzapine, risperidone beta-2-agonists, such as salbutamol, salmeterol oestrogens and progestogens, such as thosein oral contraceptives thiazide diuretics, such as bendroflumethiazide. Your doctor may want to monitor your blood sugar if you start or stop treatment with any of these while taking metformin, and if necessary your doctor may alter your dose of metformin. Octreotide and lanreotide may also affect blood suga Continue reading >>

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Glucosamine: Does It Affect Blood Sugar?

Even though glucosamine is technically a type of sugar, it doesn't appear to affect blood sugar levels or insulin sensitivity. Some early research had suggested that glucosamine might worsen insulin resistance, which can contribute to increases in blood sugar in people with type 2 diabetes. But later studies refuted these findings. Glucosamine is one of the most popular dietary supplements sold in the United States, although study results have been mixed regarding its ability to reduce osteoarthritis pain. Although glucosamine doesn't appear to affect glucose levels or insulin sensitivity, it can interact with other medications you might be taking — such as warfarin (Coumadin, Jantoven), a blood thinner. As is important with any dietary supplement, talk to your doctor before you add glucosamine to your daily regimen. Continue reading >>

Is Glucosamine Safe For Me?

I am 71 years old, and I have type 2 diabetes. Last year I developed joint problems in both shoulders. Doctors have prescribed physical therapy, which has helped some but not very much. The supplement glucosamine has helped several people I know who have similar shoulder problems. However, these people don't have diabetes. I want to try the supplement, but I have read that glucosamine may contribute to insulin resistance. Elwin Beck, Rio Vista, California Craig Williams, PharmD, responds: Glucosamine is definitely safe to try. While there are anecdotal reports of patients with diabetes experiencing slight elevations in blood glucose with either glucosamine hydrochloride or glucosamine sulfate, in the few human studies that have been carefully done, no effect can be detected. These studies are often based on glycated hemoglobin (hemoglobin with glucose attached to itnot a direct measure of glucose levels), and the studies pool the results from many patients, so it is always possible that some individual patients may experience slight changes in blood glucose. Monitoring would obviously be prudent. But again, we consider it safe to try in patients with diabetes. However, glucosamine being safe doesn't mean that it's effective. Controlled clinical trials have not found a significant positive effect, but some individual patients do seem to experience a benefit. Glucosamine is important for the repair and maintenance of healthy cartilage in joints, but taking it in an oral form may not get it to where it needs to be in an amount that will do any real good. Much of it is broken down in the stomach and digestive tract. Even short trials where similar compounds are injected directly into arthritic joints have not found a significant benefit, and a large study published in the Continue reading >>

Glucosamine And Metformin Interaction | Treato

My wife was already taking Glucosamine and a poster here ... "On Sun, 09 Sep 2007 10:46:42 -0400, William Wagner observations suggest that glucosamine at commonly consumed doses does not have significant effects on glycemic control, lipid profile or levels of apolipoprotein AI in diabetic subjects after 2 weeks of My dose is 1500mg. During my last trip I found I was in increasing pain from my wrist while driving the manual car through Europe. Initially I put it down to the read more... different arrangement of the controls and gearshift in the left-hand-drive car but it gradually dawned on me that I had It got bad enough that I had difficulty carrying bags in airports and had to be very careful when pulling or pushing on doors. If my wrist was at the wrong angle or I made sudden movements the pain was quite sharp and high. My wife was already taking Glucosamine and a poster here (JDA or Eskimo Joe) was enthusiastic about the stuff so I started on it myself when we got home. After three months of 1500mg daily the pain became a memory and now I only get an I'm unsure about the value of my other supplements - but not Everything in Moderation - Except Laughter. Continue reading >>

Metformin And Glucosamine Drug Interactions - From Fda Reports - Ehealthme

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. ( latest outcomes from Metformin 248,689 users ) Glucosamine has active ingredients of glucosamine. It is often used in joint pain. ( latest outcomes from Glucosamine 6,828 users ) Interactions between Metformin and drugs from A to Z a b c d e f g h i j k l m n o p q r s t u v w x y z Interactions between Glucosamine and drugs from A to Z a b c d e f g h i j k l m n o p q r s t u v w x y z Browse all drug interactions of Metformin and Glucosamine Related publications that referenced our studies Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders" , Indian journal of endocrinology and metabolism, 2012 Jan . UPANI KRMEK DU, BRAJKOVI I, BEKI D, KRNI A, JURKOVI P, PAVLOVI T, "CALCIFIED DEEP VEIN THROMBOSIS IN A PATIENT WITH RECURRENT DEEP VEIN THROMBOSIS AND SARCOIDOSIS" , Acta Medica Croatica, 2014 Mar . Lee IS, Kim KS, Kim KH, Park J, Jeong HS, Kim Y, Na YC, Chung WS, Ahn KS, Lee SG, Um JY, "Antihyperglycemic and Antiobesity Effects of JAL2 on db/db Mice" , Evidence-Based Complementary and Alternative Medicine, 2016 Mar . Continue reading >>

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Suppression Of Phosphatase And Tensin Homolog Protects Insulin-resistant Cells From Apoptosis

Suppression of phosphatase and tensin homolog protects insulin-resistant cells from apoptosis Affiliations: Department of Geriatric Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China Published online on: May 12, 2015 Metrics: HTML 0 views | PDF 0 views Cited By (CrossRef): 0 citations In the present study, a glucosamine-induced model of insulin-resistant skeletal muscle cells was established in order to investigate the effect of inhibition of phosphatase and tensin homolog (PTEN)/5'-adenosine monophosphate-activated protein kinase (AMPK) on these cells. The glucosamineinduced insulinresistant skeletal muscle cells were produced and the rate of glucose uptake was measured using the glucose oxidaseperoxidase method. The expression levels of PTEN and phosphorylated PTEN (pPTEN) were assessed using western blotting. Glucose transporter4 (GLUT4) translocation was detected by immunofluorescence. Cell apoptosis was evaluated using flow cytometry. Following insulin stimulation, the rate of glucose uptake was significantly reduced in the cells with glucosamineinduced insulinresistance in comparison with those in the control group. The expression and translocation of GLUT4 were reduced in the insulinresistant muscle cells. By contrast, the expression of PTEN and pPTEN as well as apoptosis were significantly increased. Following treatment with bisperoxopicolinatooxovanadate (BPV) or metformin in the insulinresistant skeletal muscle cells, there was an increase in the rate of glucose uptake, an increase in GLUT4 expression and its translocation, a reduction in the expression of PTEN and pPTEN, and a decrease in cell apoptosis compared with untreated insulinresistant cells. Glucosamine may be used to produce an effective Continue reading >>

Glucosamine: The New Metformin? | Interview With Dr. Michael Ristow (part Ii)

Last week when we heard from Dr. Ristow , he turned the outdated notion of the free radical theory of aging on its head, and demonstrated that antioxidants like vitamin A and vitamin C arent all theyre cracked up to be. But if those supplements cant help us, what can? Perhaps, says Ristow, the answer can be found in the mitohormetic effects of an inexpensive over-the-counter compound, one with enough promise that it may someday rival metformin as the darling of the anti-aging set. So weve discussed this effect called hormesis, where substances that are toxic at high doses can actually be helpful in low doses. Theres a related word that pops up a lot in your research, mitohormesiswhat is that? Its an abbreviation of mitochondrial hormesis, and it essentially translates this hormesis principle, which normally applies to compounds and drugs, to whatever comes out the mitochondria. So mitochondria send out signals that promote health and lifespan at low doses, and at higher doses these signals do the opposite. The most well-established signal from the mitochondria is reactive oxygen species, but there are also other signals, small peptides that some groups have started working on like humanin and MOTS-c. And then there are metabolites, like beta hydroxybutyrate, which is produced a lot by the mitochondria if youre on a ketogenic diet. Beta hydroxybutyrate also has mitohormetic effects, so it signals to other compartments of the cell and promotes health. Does free radical production become a problem as mitochondria get older and start producing more free radicals? While older mitochondria do produce more free radicals, its unclear whether that really accelerates aging. I think it does at very high, artificial doses. For example, one very artificial mouse model showed that m Continue reading >>

Do Glucosamine And Chondroitin Worsen Blood Sugar Control In Diabetes?

Despite theoretical risks based on animal models given high intravenous doses, glucosamine/chondroitin (1500 mg/1200 mg daily) does not adversely affect short-term glycemic control for patients whose diabetes is well-controlled, or for those without diabetes or glucose intolerance (SOR: A, consistent, good-quality patient-oriented evidence). Some preliminary evidence suggests that glucosamine may worsen glucose intolerance for patients with untreated or undiagnosed glucose intolerance or diabetes (SOR: C, extrapolation from disease-oriented evidence). Long-term effects are unknown; however, no compelling theoretical or incidental data suggest that long-term results should be different (SOR: C, expert opinion). Further studies are required to clarify the effects of glucosamine on patients with poorly controlled diabetes or glucose intolerance. These products seem to be a safe alternative to NSAIDs Lisa Brandes, MD University of Wyoming, Cheyenne Glucosamine/chondroitin is a popular over-the-counter supplement used by many patients; it appears to be without any serious adverse affects or drug interactions. It does not seem to have much effect on blood sugar for patients with diabetes. It may relieve symptoms for some patients with pain due to osteoarthritis. As such, glucosamine/chondroitin seems to be a safe alternative to nonsteroidal antiinflammatory drugs (NSAIDs) for patients with osteoarthritis. I would monitor blood sugars more frequently for patients with diabetes given the low numbers in the studies cited above. I would avoid glucosamine/chondroitin during pregnancy and lactation for the younger symptomatic female patient. The cost of this product varies widely, and this can be a factor for patients since they are paying out of pocket. Diabetes mellitus and osteo Continue reading >>