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Glipizide Metformin Side Effects

Glipizide/metformin (by Mouth)

Glipizide/metformin (by Mouth)

Glipizide and Metformin combination is used to treat high blood sugar levels that are caused by a type of diabetes mellitus or sugar diabetes called type 2 diabetes . Normally, after you eat, your pancreas releases insulin to help your body store excess sugar for later use. This process occurs during normal digestion of food. In type 2 diabetes, your body does not work properly to store the excess sugar and the sugar remains in your bloodstream. Chronic high blood sugar can lead to serious health problems in the future. Proper diet is the first step in managing type 2 diabetes but often medicines are needed to help your body. With two actions, the combination of glipizide and metformin helps your body cope with high blood sugar. Glipizide stimulates the release of insulin from the pancreas, directing your body to store blood sugar. Metformin has three different actions: it slows the absorption of sugar in your small intestine ; it also stops your liver from converting stored sugar into blood sugar; and it helps your body use your natural insulin more efficiently. This medicine is available only with your doctor's prescription. Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. It is best to take this medicine with food or milk. Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions. Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Ask your doctor or pharmacist before using any other medicine, Continue reading >>

Glipizide-metformin Side Effects

Glipizide-metformin Side Effects

Glipizide and metformin is a combination of two oral diabetes medicines that help control blood sugar levels. Glipizide and metformin is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes. This medicine is not for treating type 1 diabetes. Glipizide and metformin may also be used for purposes not listed in this medication guide. You should not use glipizide and metformin if you have severe kidney disease, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking glipizide and metformin. Some people taking metformin develop a serious condition called lactic acidosis. Stop taking this medicine and get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired. You should not use this medicine if you are allergic to glipizide or metformin, or if you have: severe kidney disease; or metabolic acidosis or diabetic ketoacidosis (call your doctor for treatment). If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking glipizide and metformin. To make sure glipizide and metformin is safe for you, tell your doctor if you have: kidney disease; congestive heart failure, especially if you take digoxin (Lanoxin) or furosemide (Lasix); a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency; liver disease; heart disease; or if you are over 80 years old and have not Continue reading >>

Glipizide And Metformin (oral Route)

Glipizide And Metformin (oral Route)

Precautions Drug information provided by: Micromedex Your doctor will want to check your progress at regular visits , especially during the first few weeks that you take this medicine. Under certain conditions, too much glipizide and metformin can cause lactic acidosis. Symptoms of lactic acidosis are severe and quick to appear and usually occur when other health problems not related to the medicine are present and are very severe, such as a heart attack or kidney failure. Symptoms of lactic acidosis include abdominal or stomach discomfort; decreased appetite; diarrhea; fast, shallow breathing; general feeling of discomfort; muscle pain or cramping; and unusual sleepiness, tiredness, or weakness. If symptoms of lactic acidosis occur, you should get immediate emergency medical help. It is very important to follow carefully any instructions from your health care team about: Alcohol—Drinking alcohol may cause severe low blood sugar. Discuss this with your health care team. Other medicines—Do not take other medicines unless they have been discussed with your doctor. Counseling—Other family members need to learn how to prevent side effects or help with side effects if they occur. Also, patients with diabetes may need special counseling about diabetes medicine dosing changes that might occur because of lifestyle changes, such as changes in exercise and diet. Furthermore, counseling on contraception and pregnancy may be needed because of the problems that can occur in patients with diabetes during pregnancy. Travel—Keep a recent prescription and your medical history with you. Be prepared for an emergency as you would normally. Make allowances for changing time zones and keep your meal times as close as possible to your usual meal times. In case of emergency—There may Continue reading >>

Glipizide, Metformin Hydrochloride: Oral Tablet

Glipizide, Metformin Hydrochloride: Oral Tablet

Take this medicine by mouth with meals. Swallow with a drink of water. Follow the directions on the prescription label. Take your medicine at the same time each day. Do not take more often than directed. Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. Patients over 65 years old may need a smaller dose than younger adults. If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses. Do not take this medicine with any of the following medications: -certain contrast medicines given before X-rays, CT scans, MRI, or other procedures This medicine may also interact with the following medications: -certain antiviral medicines for HIV infection or hepatitis Visit your doctor or health care professional for regular checks on your progress. A test called the HbA1C (A1C) will be monitored. This is a simple blood test. It measures your blood sugar control over the last 2 to 3 months. You will receive this test every 3 to 6 months. Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them. Always carry a quick-source of sugar with you in case you have symptoms of low blood sugar. Examples include hard sugar candy or glucose tablets. Make sure others know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar, such as seizures or unconsciousness. They must get medical help at once. Tell your doctor or health care professional if you have high blood sugar. You might need to change the dose of your medicine. If you are sick or exercising more than usual, you might need to change the dose of your medicine. Do not skip meals. Ask your doctor or health care profession Continue reading >>

Glipizide-metformin

Glipizide-metformin

Uses This diabetes medication is a combination of 2 drugs (glipizide and metformin). It is used along with a diet and exercise program to control high blood sugar in patients with type 2 diabetes. Glipizide is a sulfonylurea and works by stimulating the release of your body's natural insulin and by decreasing the amount of sugar that your liver makes. Metformin is a biguanide and works by decreasing the amount of sugar that your liver makes and that your stomach/intestines absorb. Both of these medications work by helping to restore your body's proper response to the insulin you naturally produce. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. How to use Glipizide-Metformin Read the Patient Information Leaflet available from your pharmacist before you start using this medication and each time you get a refill. If you have any questions, consult your doctor or pharmacist. Take this medication by mouth, usually once or twice a day with meals or as directed by your doctor. Drink plenty of fluids while taking this medication unless otherwise directed by your doctor. The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To reduce your risk of side effects (such as upset stomach), your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. If you are already taking another diabetes drug (e.g., chlorpropamide), follow your docto Continue reading >>

Metaglip, (glipizide-metformin) Dosing, Indications, Interactions, Adverse Effects, And More

Metaglip, (glipizide-metformin) Dosing, Indications, Interactions, Adverse Effects, And More

Discontinue metformin at the time of or before an iodinated contrast imaging procedure in patients with an eGFR between 30-60 mL/minute/1.73 m; in patients with a history of liver disease, alcoholism, or heart failure; or in patients who will be administered intra-arterial iodinate contrast Characterized by elevated blood lactate levels (>5 mmol/L) Rare but serious complication that can occur because of metformin accumulation; increased risk with sepsis, dehydration, excess alcohol intake, hepatic insufficiency, renal impairment, and acute congestive heart failure Subtle onset with nonspecific symptoms (eg, malaise, myalgias, respiratory distress, somnolence, nonspecific abdominal distress) Monitor lab for decreased serum pH, increased anion gap, and elevated blood lactate If suspected, discontinue drug and hospitalize patient immediately Metformin is highly dialyzable (clearance up to 170 mL/min under good hemodynamic conditions); prompt hemodialysis is recommended to correct the acidosis and to remove accumulated metformin Severe renal disease: eGFR <30 ml/min/1.73 m Metabolic acidosis, diabetic ketoacidosis Rare but serious lactic acidosis can occur due to accumulation of metformin Patients with glucose-6-phosphate dihydrogenase deficiency may be at risk of sulfonylurea induced hemolytic anemia Discontinue metformin at the time of or before an iodinated contrast imaging procedure in patients with an eGFR between 30-60 mL/minute/1.73 m; in patients with a history of liver disease, alcoholism, or heart failure; or in patients who will be administered intra-arterial iodinate contrast Reevaluate eGFR 48 hr after the imaging procedure; restart metformin if renal function is stable Continue reading >>

Glipizide/metformin Hcl Tablets Rx

Glipizide/metformin Hcl Tablets Rx

Select the drug indication to add to your list Glipizide/metformin HCl; 2.5mg/250mg, 2.5mg/500mg, 5mg/500mg. Indications for Glipizide/Metformin HCl Tablets: Adjunct to diet and exercise in type 2 diabetes, as initial therapy or as second-line therapy when response to a sulfonylurea or metformin is inadequate. Take with meals. First-line: initially 2.5mg/250mg once daily; or, if fasting plasma glucose is 280320mg/dL, may start at 2.5mg/500mg twice daily. May increase by 1 tab/day every 2 weeks; max 10mg/1000mg or 10mg/2000mg per day in divided doses. Second-line: (previously treated with sulfonylurea or metformin only): 2.5mg/500mg or 5mg/500mg twice daily (AM & PM) (initial dose should not exceed previous daily doses of individual components); may increase by increments of 5mg/500mg up to minimum effective dose or max 20mg/2000mg per day. Previously treated with combination therapy (sulfonylurea plus metformin): may be switched to 2.5mg/500mg or 5mg/500mg (initial dose should not exceed previous daily doses of individual components). Elderly: avoid max doses. Renal disease or dysfunction. Metabolic acidosis, diabetic ketoacidosis with or without coma. Concomitant intravascular iodinated contrast agents (suspend during and for 48hrs). Increased risk of cardiovascular mortality. Discontinue if lactic acidosis, shock, acute CHF, acute MI, sepsis, or hypoxemia occurs. Confirm normal renal function before starting therapy (esp. in patients 80yrs); monitor renal function. Avoid in hepatic disease. G6PD deficiency. Suspend before surgery that requires fasting. Monitor hematology (esp. serum Vit. B12 in susceptible patients). Elderly, debilitated, uncompensated strenuous exercise, malnourished, or deficient caloric intake, adrenal or pituitary insufficiency, alcohol intoxicat Continue reading >>

Glipizide/metformin Hcl Tablets Rx

Glipizide/metformin Hcl Tablets Rx

Select the drug indication to add to your list Glipizide/metformin HCl; 2.5mg/250mg, 2.5mg/500mg, 5mg/500mg. Indications for Glipizide/Metformin HCl Tablets: Adjunct to diet and exercise in type 2 diabetes, as initial therapy or as second-line therapy when response to a sulfonylurea or metformin is inadequate. Take with meals. First-line: initially 2.5mg/250mg once daily; or, if fasting plasma glucose is 280320mg/dL, may start at 2.5mg/500mg twice daily. May increase by 1 tab/day every 2 weeks; max 10mg/1000mg or 10mg/2000mg per day in divided doses. Second-line: (previously treated with sulfonylurea or metformin only): 2.5mg/500mg or 5mg/500mg twice daily (AM & PM) (initial dose should not exceed previous daily doses of individual components); may increase by increments of 5mg/500mg up to minimum effective dose or max 20mg/2000mg per day. Previously treated with combination therapy (sulfonylurea plus metformin): may be switched to 2.5mg/500mg or 5mg/500mg (initial dose should not exceed previous daily doses of individual components). Elderly: avoid max doses. Renal disease or dysfunction. Metabolic acidosis, diabetic ketoacidosis with or without coma. Concomitant intravascular iodinated contrast agents (suspend during and for 48hrs). Increased risk of cardiovascular mortality. Discontinue if lactic acidosis, shock, acute CHF, acute MI, sepsis, or hypoxemia occurs. Confirm normal renal function before starting therapy (esp. in patients 80yrs); monitor renal function. Avoid in hepatic disease. G6PD deficiency. Suspend before surgery that requires fasting. Monitor hematology (esp. serum Vit. B12 in susceptible patients). Elderly, debilitated, uncompensated strenuous exercise, malnourished, or deficient caloric intake, adrenal or pituitary insufficiency, alcohol intoxicat Continue reading >>

What Are The Possible Side Effects Of Glipizide And Metformin (metaglip)?

What Are The Possible Side Effects Of Glipizide And Metformin (metaglip)?

A A A Medications and Drugs Brand Names: Metaglip Generic Name: glipizide and metformin (Pronunciation: GLIP ih zyd and met FOR min) What is glipizide and metformin (Metaglip)? Glipizide and metformin is a combination of two oral diabetes medicines that help control blood sugar levels. Glipizide and metformin is for people with type 2 diabetes who do not use daily insulin injections. This medication is not for treating type 1 diabetes. Glipizide and metformin may also be used for purposes not listed in this medication guide. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. This medication may cause lactic acidosis (a build-up of lactic acid in the body, which can be fatal). Lactic acidosis can start slowly and get worse over time. Get emergency medical help if you have even mild symptoms of lactic acidosis, such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired. Stop taking this medication and call your doctor at once if you have a serious side effect such as: feeling short of breath, even with mild exertion, swelling or rapid weight gain; pain or burning with urination; nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure). Less serious side effects may include: cold symptoms such as stuffy nose, sneezing, sore throat; headache, dizziness; mild nausea, vomiting, diarrhea, st Continue reading >>

Glipizide And Metformin Overview

Glipizide And Metformin Overview

Glipizide/metformin is a prescription medication used in the management of type 2 diabetes mellitus. It is a single tablet containing 2 medications: glipizide and metformin. Glipizide belongs to a group of drugs called sulfonylureas. These work by stimulating the release of insulin from the pancreas. Metformin belongs to a group of drugs called biguanides. These work by decreasing the amount of glucose absorbed from food and decreasing the amount of glucose that is produced by the liver. This medication comes in tablet form and is taken once or twice daily with meals. Common side effects of glipizide/metformin include stomach pain, nausea or vomiting, diarrhea, and dizziness. Glipizide/metformin can also cause dizziness. Do not drive or operate heavy machinery until you know how glipizide/metformin affects you. Glipizide/metformin is a prescription medication used in the management of type 2 diabetes mellitus. It helps to lower the amount of glucose (sugar) in the blood. This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information. Continue reading >>

Glipizide / Metformin Side Effects

Glipizide / Metformin Side Effects

Visit your doctor or health care professional for regular checks on your progress. A test called the HbA1C (A1C) will be monitored. This is a simple blood test. It measures your blood sugar control over the last 2 to 3 months. You will receive this test every 3 to 6 months. Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them. Always carry a quick-source of sugar with you in case you have symptoms of low blood sugar . Examples include hard sugar candy or glucose tablets. Make sure others know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar , such as seizures or unconsciousness. They must get medical help at once. Tell your doctor or health care professional if you have high blood sugar. You might need to change the dose of your medicine. If you are sick or exercising more than usual, you might need to change the dose of your medicine. Do not skip meals. Ask your doctor or health care professional if you should avoid alcohol. Many nonprescription cough and cold products contain sugar or alcohol. These can affect blood sugar. This medicine may cause ovulation in premenopausal women who do not have regular monthly periods. This may increase your chances of becoming pregnant. You should not take this medicine if you become pregnant or think you may be pregnant. Talk with your doctor or health care professional about your birth control options while taking this medicine. Contact your doctor or health care professional right away if think you are pregnant. This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or sun tanning beds/booths. Wear a medical ID br Continue reading >>

What Are The Side Effects Of Glipizide And Metformin?

What Are The Side Effects Of Glipizide And Metformin?

Glipizide and metformin may cause side effects that may be severe for some people. In rare cases, the medication may cause a severe allergic reaction that leads to difficulty breathing, swelling in the face or throat, and hives. If you develop these symptoms, call 911 immediately. Glipizide and metformin may also increase the risk for a serious condition called lactic acidosis, or a buildup of acid in the blood. If you experience symptoms such as shortness of breath, light-headedness, fainting, weakness, slowed heartbeat, feeling cold, muscle or stomach pain, or unusual sleepiness, get emergency medical attention immediately. This medication may also lead to hypoglycemia (low blood sugar), causing symptoms like excessive hunger, headache, dizziness, blurred vision, fast heartbeat, tingling in the hands and feet, cold sweat, shaking, and fainting. Other serious side effects of glipizide and metformin may include unusual bruising and bleeding, severe stomach pain or nausea, yellowing of the skin and eyes, increased blood pressure, and swelling or unusual weight gain. More common side effects include dizziness, headache, joint or muscle pain, mild nausea, diarrhea, upset stomach, sneezing, or cough. Other side effects may be possible, so talk to your doctor if any new or unusual symptoms develop while taking glipizide and metformin. Continue reading >>

How Glipizide Might Help With Your Type 2 Diabetes Management

How Glipizide Might Help With Your Type 2 Diabetes Management

Glipizide is an oral medication that is used to treat Type 2 diabetes. The drug is available in immediate-release tablets and extended-release tablets. Patients who currently take the medication as part of their diabetes treatment state that Glipizide has helped with lowering their blood sugar levels, and it seems that the extended-release tablets are favored over the immediate-release tablets. One of the main benefits from the drug is that it helps to lower your A1C levels by 1-2%. We will discuss the benefits and the downsides of Glipizide in more detail below. What is Glipizide? Glipizide is an oral medication used in the treatment of Type 2 diabetes. It is available in brand-name form as well as generic form, with the brand-names being Glucotrol and Glucotrol XL. Glipizide works by helping your pancreas produce more of your body’s natural insulin, which in turn regulates your blood sugar levels. Glipizide is used in conjunction with diet and exercise as part of a diabetes management plan. Glipizide is part of a class of diabetes drugs known as Sulfonylureas, which are designed to help your body’s pancreas to produce more of the body’s natural insulin. Diabetes medication aren’t designed to cure your Type 2 diabetes, but instead they are designed to treat the symptoms of diabetes, including blurry vision, excessive hunger, excessive thirst, frequent urination and sores that won’t heal. Further reading: Usually, the first diabetes medication that your doctor may prescribe is Metformin. However, many times, Glipizide is a popular choice for doctors to prescribe because many patients find that their bodies tolerate Glipizide better than Metformin. What are the Benefits of Glipizide? Glipizide can help lower your A1C levels by an average of 1-2%. Since Glipizid Continue reading >>

Glipizide/metformin Side Effects In Detail - Drugs.com

Glipizide/metformin Side Effects In Detail - Drugs.com

Applies to glipizide / metformin: oral tablet Metabolic side effects, including lactic acidosis, which is a potentially fatal metabolic complication of biguanide therapy, has been reported in patients receiving metformin. The incidence of lactic acidosis has been about 0.03 cases per 1,000 patient years with approximately 0.015 fatal cases per 1,000 patient-years. The risk of lactic acidosis is particularly high in patients with underlying renal insufficiency. Cases of lactic acidosis occurring in patients with normal renal function have been rarely reported. Concomitant cardiovascular or liver disease, sepsis , and hypoxia may also increase the risk of lactic acidosis.[ Ref ] Very Common (10% or more): Hypoglycemia (up to 12.6%) Rare (less than 0.1%): Lactic acidosis[ Ref ] Common (1% to 10%): Nausea/vomiting , abdominal pain [ Ref ] Postmarketing reports: Hemolytic anemia in patients not known to have G6PD deficiency Common (1% to 10%): Subnormal vitamin B12 levels Rare (less than 0.1%): Cholestatic and hepatocellular hepatic injury accompanied by jaundice [ Ref ] Very common (10% or more): Upper respiratory infection (up to 10.3%)[ Ref ] Common (1% to 10%): Urinary tract infection[ Ref ] Very common (10% or more): Headache (up to 12.6%) Common (1% to 10%):: Musculoskeletal pain.[ Ref ] 1. "Product Information. Metaglip (glipizide-metformin)." Bristol-Myers Squibb, Princeton, NJ. Some side effects of glipizide / metformin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA . Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may Continue reading >>

Dailymed - Glipizide And Metformin Hydrochloride- Glipizide And Metformin Hydrochloride Tablet

Dailymed - Glipizide And Metformin Hydrochloride- Glipizide And Metformin Hydrochloride Tablet

After 24 weeks, treatment with Glipizide/Metformin HCl tablets 2.5 mg/250 mg and 2.5 mg/500 mg resulted in significantly greater reduction in HbA1c compared to glipizide and to metformin therapy. Also, Glipizide/Metformin HCl tablets 2.5 mg/250 mg therapy resulted in significant reductions in FPG versus metformin therapy. Increases above fasting glucose and insulin levels were determined at baseline and final study visits by measurement of plasma glucose and insulin for three hours following a standard mixed liquid meal. Treatment with Glipizide/Metformin HCl tablets lowered the three-hour postprandial glucose AUC, compared to baseline, to a significantly greater extent than did the glipizide and the metformin therapies. Compared to baseline, Glipizide/Metformin HCl tablets enhanced the postprandial insulin response, but did not significantly affect fasting insulin levels. There were no clinically meaningful differences in changes from baseline for all lipid parameters between Glipizide/Metformin HCl tablets therapy and either metformin therapy or glipizide therapy. The adjusted mean changes from baseline in body weight were: Glipizide/Metformin HCl tablets 2.5 mg/250 mg, -0.4 kg; Glipizide/Metformin HCl tablets 2.5 mg/500 mg, -0.5 kg; glipizide, -0.2 kg; and metformin, -1.9 kg. Weight loss was greater with metformin than with glipizide and metformin hydrochloride. Patients with Inadequate Glycemic Control on Sulfonylurea Monotherapy In an 18-week, double-blind, active-controlled U.S. clinical trial, a total of 247 patients with type 2 diabetes not adequately controlled (HbA1c 7.5% and 12% and FPG < 300 mg/dL) while being treated with at least one-half the maximum labeled dose of a sulfonylurea (e.g. glyburide 10 mg, glipizide 20 mg) were randomized to receive glipizid Continue reading >>

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