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Glipizide For Diabetes

Glipizide Needed To Meet Growing Numbers Of Patients With Type 2 Diabetes

Glipizide Needed To Meet Growing Numbers Of Patients With Type 2 Diabetes

Glipizide, CAS number 29094-61-9, is also known as Glucotrol XL, which is marketed by Pfizer. With the patent due to expire in January of 2014, glipizide is set up for success as a generic alternative treatment for patients with type 2 diabetes. As an oral blood-glucose-lowering drug of the sulfonylurea class, glipizide is offered in five and ten milligram tablets. Serious adverse reactions from patients who have taken glucotrol, or glipizide, have been rarely reported. Side effects include mild dizziness, drowsiness and minor headache. Generally well tolerated, LGM Pharma is a provider of the API glipizide, and offers complete and extensive support for researchers and developers. Designed for patients who are non insulin dependent, glipizide is effective when used alongside diet and exercise. Glipizide works as it aids the pancreas in making more insulin, and also helping the cells respond better to insulin. This in turn helps to lower blood sugar and keep it under better control for patients with type 2 diabetes. Facts from The National Diabetes Association reveal astounding statistics regarding the prevalence of type 2 diabetes. For example, type 2 diabetes is the most common form of diabetes, and it is more common in African Americans, Latinos, Native Americans, Asian Americans, Native Pacific Islanders, as well as the elderly population. Diabetic Retinopathy is the leading cause of blindness in patients with type 2 diabetes, ages 20-74. In addition to this grave news, type 2 diabetes is the leading cause of kidney failure, accounting for 44% of adult cases in 2008. These alarming statistics are quite telling, and act as a message to the medical community that there is a need for a greater availability of generic drugs to combat this disease. Products currently cove Continue reading >>

Glipizide-induced Prevention Of Diabetes And Autoimmune Events In The Bb Rat.

Glipizide-induced Prevention Of Diabetes And Autoimmune Events In The Bb Rat.

Glipizide-induced prevention of diabetes and autoimmune events in the BB rat. Hosszufalusi N(1), Reinherz L, Takei S, Chan E, Charles MA. (1)Diabetes Research Program, University of California, Irvine 92717. To determine whether glipizide, a sulfonylurea, can prevent diabetes in thediabetic-prone BB rat model, rats were studied from 35 to 240 days of age.Treated animals received oral glipizide (10 or 100 mg/kg/day) from 35 to 200 daysof age, and control rats received oral placebo. From 80 to 135 days of age atboth drug doses, glipizide decreased the incidence of diabetes, thus delayingdisease onset (P < 0.02). At the higher dose of glipizide, a diabetes preventive effect was observed (P < 0.025). There were no significant differences in bodyweights between the treated and control groups. At 240 days, i.e. 40 days afterstopping glipizide and placebo treatments, diabetes incidence remained stable in the two groups; thus the effect of glipizide persisted after discontinuation ofthe drug. Serum glucose and insulin levels measured at 90 and 200 days did notreveal differences between the glipizide treated and control groups. To determinewhether the sulfonylurea affected autoimmune events, the prevalence and severity of islet inflammation were examined. In glipizide-treated BB rats at 240 days,only 44% of rats had islet inflammation compared to 86% in the control group (P <0.01). At both 90 and 240 days the severity of islet inflammation was decreasedin the glipizide treatment groups compared with the control groups (P < 0.01).These data indicate that glipizide (a) prevents diabetes in the diabetic-prone BBrat strain, (b) decreases the prevalence and severity of islet inflammation even after drug withdrawal and (c) may dampen autoimmune events leading to diabetesonset. Diabet Continue reading >>

Sitagliptin, Glipizide Safe, Effective For Diabetic Dialysis Patients

Sitagliptin, Glipizide Safe, Effective For Diabetic Dialysis Patients

Sitagliptin, Glipizide Safe, Effective for Diabetic Dialysis Patients Sitagliptin, Glipizide Safe, Effective for Diabetic Dialysis Patients Sitagliptin and glipizide monotherapy is safe and effective in patients with type 2 diabetes and end-stage renal disease (ESRD) requiring dialysis , researchers reported online ahead of print in the American Journal of Kidney Diseases. Patients with type 2 diabetes mellitus and ESRD on dialysis therapy have limited therapeutic options to manage hyperglycemia, the researchers noted. Furthermore, few randomized controlled studies have evaluated or compared antihyperglycemic agents in this patient population. These are the findings of a 54-week, randomized, double-blind study conducted by Juan C. Arjona Ferreira, MD, of Merck Sharp & Dohme Corp., in Whitehouse Station, N.J., and colleagues. The trial included 129 patients with type 2 diabetes and ESRD requiring dialysis. At baseline, patients had a hemoglobin A1c (HbA1c) level of 7%-9%. Of the 129 patients, 64 were assigned to treatment with sitagliptin and 65 were assigned to treatment with glipizide. For the study, patients received sitagliptin 25 mg daily or glipizide initiated with 2.5 mg daily and titrated up to a potential maximum dose of 10 mg twice daily or down to avoid hypoglycemia. After 54 weeks, mean HbA1c levels declined significantly from baseline by 0.72% and 0.87% with sitagliptin and glipizide, respectively. Fasting plasma glucose levels declined significantly by 26.6 mg/dL and 31.2 mg/dL, respectively. The incidences of symptomatic hypoglycemia were 6.3% in the sitagliptin group compared with 10.8% in the glipizide group, but the between-group difference was not significant. Severe hypoglycemia occurred in 7.7% of the glipizide-treated patients but not in any of the Continue reading >>

Description And Brand Names

Description And Brand Names

Drug information provided by: Micromedex US Brand Name Metaglip Descriptions Glipizide and Metformin combination is used to treat high blood sugar levels that are caused by a type of diabetes mellitus or sugar diabetes called type 2 diabetes. Normally, after you eat, your pancreas releases insulin to help your body store excess sugar for later use. This process occurs during normal digestion of food. In type 2 diabetes, your body does not work properly to store the excess sugar and the sugar remains in your bloodstream. Chronic high blood sugar can lead to serious health problems in the future. Proper diet is the first step in managing type 2 diabetes but often medicines are needed to help your body. With two actions, the combination of glipizide and metformin helps your body cope with high blood sugar. Glipizide stimulates the release of insulin from the pancreas, directing your body to store blood sugar. Metformin has three different actions: it slows the absorption of sugar in your small intestine; it also stops your liver from converting stored sugar into blood sugar; and it helps your body use your natural insulin more efficiently. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: Tablet Copyright © 2018 Truven Health Analytics Inc. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Continue reading >>

Oral Hypoglycemic Drugs (glipizide)

Oral Hypoglycemic Drugs (glipizide)

How they work Dogs versus cats Treatment Adverse reactions Personal stories Drugs like glipizide (trade name Glucotrol) and glyburide (trade name Micronase or Diabea) can sometimes be used to control hyperglycemia. Although the exact mechanism of action is not known, it is believed that these drugs work in several ways. Their strongest method of action is to stimulate the beta cells of the pancreas to produce insulin. They also increase the sensitivity of other tissues to insulin, either by causing insulin to bind to the insulin receptor more easily, or by causing the cell to respond more strongly to the insulin, once it is bound to the receptor. These drugs also have other effects on glucose metabolism. But the end result is that blood glucose is lowered. Here's a refresher on basic information about diabetes, insulin, and insulin receptors. Since their main method of action is to stimulate the pancreas to produce insulin, the pancreas must have functioning beta cells. These drugs will not work for a Type I insulin-dependent diabetic where the pancreas does not produce insulin. Remember, in Type I diabetes the pancreatic beta cells do not produce insulin and Type I diabetes is always insulin dependent (IDDM). In Type II diabetes, there may be decreased responsiveness of the body's cells to insulin, or, the beta cells may be functioning improperly. Type II diabetes may be either insulin dependent (IDDM) or non-insulin dependent (NIDDM) Dogs versus cats Because the majority of dogs are Type I insulin-dependent diabetics, oral hypoglycemic drugs are usually ineffective, and usually not even tried as therapy. Some cats are Type I insulin-dependent diabetics and oral hypoglycimic drugs will not work for these cats. Many cats are Type II diabetics. For those that are non-ins Continue reading >>

Minodiab

Minodiab

Take glipizide tablets about half an hour before a meal (usually breakfast). Remember to follow any advice you have been given about what you should or shouldn't eat, and try to take some regular exercise. Make sure you know how to recognise the symptoms of low blood sugar. These include feeling shaky or anxious, sweating, looking pale, feeling hungry, having a feeling that your heart is pounding (palpitations), and feeling dizzy. In this article About glipizide Type of medicine Sulfonylurea antidiabetic medicine Used for Type 2 diabetes mellitus Also called Minodiab® Available as Tablets Insulin is a hormone that is made naturally in your body, in the pancreas. It helps to control the levels of sugar in your blood. If your body does not make enough insulin to meet its needs, or if it does not use the insulin it makes effectively, this results in the condition called sugar diabetes (diabetes mellitus). People with diabetes need treatment to control the amount of sugar in their blood. This is because good control of blood sugar (glucose) levels reduces the risk of complications later on. Some people can control the sugar in their blood by making changes to the food they eat but for other people, medicines like glipizide are given alongside the changes in diet. Glipizide works by increasing the amount of insulin that your pancreas produces. It can be given on its own or alongside other antidiabetic medicines or insulin. Before taking glipizide Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking glipizide it is important that your doctor or pharmacist knows: If you are pregnant, trying for a baby or breast-feeding. If you have kidney or liver proble Continue reading >>

Which Diabetes Drug Is Best For Diabetics With Kidney Disease?

Which Diabetes Drug Is Best For Diabetics With Kidney Disease?

Highlights Sitagliptin is as effective as glipizide at lowering blood sugar levels in patients with type 2 diabetes and chronic kidney disease. Sitagliptin is less likely than glipizide to cause dangerously low blood sugar levels. Patients on sitagliptin tend to lose weight, while those on glipizide gain weight. Some blood-sugar-lowering drugs have caused kidney problems in patients with type 2 diabetes, so physicians are especially cautious when prescribing these agents to diabetics who also have chronic kidney disease (CKD). Previous research indicates that the diabetes drugs sitagliptin and glipizide may not cause considerable kidney damage. New clinical trial results presented during the American Society of Nephrology's Annual Kidney Week compared the two drugs. Sitagliptin and glipizide act on different targets but generate the same result--they boost the effects of insulin, which lowers blood sugar levels. Juan Arjona Ferreira, MD, (MSD Corp.) and his colleagues conducted a 54-week study to compare the efficacy and safety of sitagliptin and glipizide in patients with type 2 diabetes and moderate or severe CKD who were not on dialysis. The researchers randomized 426 patients to receive sitagliptin or glipizide. Among the major findings at the end of the study: Blood glucose levels dropped to a similar extent in patients in both groups. Patients receiving sitagliptin were less likely to experience hypoglycemia--or dangerously low blood sugar levels--than patients receiving glipizide (6.2% vs 17.0%). Patients who took sitagliptin tended to lose a small amount of weight, while most patients who took glipizide experienced a slight weight gain. Study authors for "Efficacy and Safety of Sitagliptin vs. Glipizide in Patients with Type 2 Diabetes and Moderate to Severe Chr Continue reading >>

How Glipizide Might Help With Your Type 2 Diabetes Management

How Glipizide Might Help With Your Type 2 Diabetes Management

Glipizide is an oral medication that is used to treat Type 2 diabetes. The drug is available in immediate-release tablets and extended-release tablets. Patients who currently take the medication as part of their diabetes treatment state that Glipizide has helped with lowering their blood sugar levels, and it seems that the extended-release tablets are favored over the immediate-release tablets. One of the main benefits from the drug is that it helps to lower your A1C levels by 1-2%. We will discuss the benefits and the downsides of Glipizide in more detail below. What is Glipizide? Glipizide is an oral medication used in the treatment of Type 2 diabetes. It is available in brand-name form as well as generic form, with the brand-names being Glucotrol and Glucotrol XL. Glipizide works by helping your pancreas produce more of your body’s natural insulin, which in turn regulates your blood sugar levels. Glipizide is used in conjunction with diet and exercise as part of a diabetes management plan. Glipizide is part of a class of diabetes drugs known as Sulfonylureas, which are designed to help your body’s pancreas to produce more of the body’s natural insulin. Diabetes medication aren’t designed to cure your Type 2 diabetes, but instead they are designed to treat the symptoms of diabetes, including blurry vision, excessive hunger, excessive thirst, frequent urination and sores that won’t heal. Further reading: Usually, the first diabetes medication that your doctor may prescribe is Metformin. However, many times, Glipizide is a popular choice for doctors to prescribe because many patients find that their bodies tolerate Glipizide better than Metformin. What are the Benefits of Glipizide? Glipizide can help lower your A1C levels by an average of 1-2%. Since Glipizid Continue reading >>

Glipizide

Glipizide

Glipizide is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Glipizide is in a class of medications called sulfonylureas. Glipizide lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. This medication will only help lower blood sugar in people whose bodies produce insulin naturally. Glipizide is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may occur if high blood sugar is not treated). Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes. Glipizide comes as tablets and extended-release (long-acting) tablets to take by mouth. The regular tablet is usually taken one or more times a day, 30 minutes before breakfast Continue reading >>

Glipizide And Metformin (oral Route)

Glipizide And Metformin (oral Route)

Precautions Drug information provided by: Micromedex Your doctor will want to check your progress at regular visits , especially during the first few weeks that you take this medicine. Under certain conditions, too much glipizide and metformin can cause lactic acidosis. Symptoms of lactic acidosis are severe and quick to appear and usually occur when other health problems not related to the medicine are present and are very severe, such as a heart attack or kidney failure. Symptoms of lactic acidosis include abdominal or stomach discomfort; decreased appetite; diarrhea; fast, shallow breathing; general feeling of discomfort; muscle pain or cramping; and unusual sleepiness, tiredness, or weakness. If symptoms of lactic acidosis occur, you should get immediate emergency medical help. It is very important to follow carefully any instructions from your health care team about: Alcohol—Drinking alcohol may cause severe low blood sugar. Discuss this with your health care team. Other medicines—Do not take other medicines unless they have been discussed with your doctor. Counseling—Other family members need to learn how to prevent side effects or help with side effects if they occur. Also, patients with diabetes may need special counseling about diabetes medicine dosing changes that might occur because of lifestyle changes, such as changes in exercise and diet. Furthermore, counseling on contraception and pregnancy may be needed because of the problems that can occur in patients with diabetes during pregnancy. Travel—Keep a recent prescription and your medical history with you. Be prepared for an emergency as you would normally. Make allowances for changing time zones and keep your meal times as close as possible to your usual meal times. In case of emergency—There may Continue reading >>

Glipizide Side Effects

Glipizide Side Effects

Generic Name: glipizide (GLIP i zide) Brand Names: GlipiZIDE XL, Glucotrol, Glucotrol XL What is glipizide? Glipizide is an oral diabetes medicine that helps control blood sugar levels by helping your pancreas produce insulin. Glipizide is used together with diet and exercise to treat type 2 diabetes. Glipizide may also be used for purposes not listed in this medication guide. Important information You should not use glipizide if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). Before taking glipizide, tell your doctor if you have kidney or liver disease, chronic diarrhea or a blockage in your intestines, glucose-6-phosphate dehydrogenase deficiency (G6PD), a disorder of your pituitary or adrenal glands, a history of heart disease, or if you are malnourished. Glipizide is only part of a complete program of treatment that may also include diet, exercise, weight control, and testing your blood sugar. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels. Before taking this medicine You should not use this medicine if you are allergic to glipizide, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). To make sure glipizide is safe for you, tell your doctor if you have: liver or kidney disease; chronic diarrhea or a blockage in your intestines; an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD); a disorder of your pituitary or adrenal glands; a history of heart disease; or if you are malnourished. Certain oral diabetes medications may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the r Continue reading >>

Glipizide - An Overview | Sciencedirect Topics

Glipizide - An Overview | Sciencedirect Topics

Christof Schaefer, in Drugs During Pregnancy and Lactation (Second Edition) , 2007 Insulin as a proteohormone does not reach the mother's milk, and is not absorbed intestinally. Any effect on the infant can therefore be ruled out. Neither glibenclamide nor glipizide were detected in the breastmilk of three mothers. Hypoglycemia was not observed in any of the children. In another eight women receiving a single dosage of glibenclamide, no substance was found in milk. A high protein-binding of 98% could explain these results (Feig 2005). Only small amounts of metformin are found in mothers milk; the weight-adjusted dose for a fully breastfed child is 0.10.7% (Briggs 2005, Gardiner 2003, Hale 2002). Hypoglycemia was not reported in breastfed infants. Metformin concentrations in breast milk remained stable over the time of observation. Growth, motor-social development, and illness requiring a pediatrician's visit were assessed in 61 nursing infants (21 male, 40 female) and 50 formula-fed infants (19 male, 31 female) born to 92 mothers with polycystic ovary syndrome (PCOS) taking a median of 2.55g metformin per day throughout pregnancy and lactation. At 3 and 6 months of age, the weight, height, and motor-social development did not differ between breast- and formula-fed infants. No infants had retardation of growth, or of motor or social development. Intercurrent illnesses did not differ (Glueck 2006). Up to 16.2% of the weight-related dosage of tolbutamide can pass into the milk (Moiel 1967). There are no data on the other oral antidiabetics, acarbose, glibornuride, gliclazide, glimepiride, gliquidone, glisoxepide, miglitol, pioglitazone, repaglinide, and rosiglitazone. There is also insufficient experience on the antihypoglycemics glucagon and diazoxide. Insulin and metfor Continue reading >>

What Is Glipizide? - Goodrx

What Is Glipizide? - Goodrx

Glipizide discount prices start at just $6.02! Commonly Used Brand Name(s)Glucotrol, Glucotrol XL Glipizide is used to treat high blood sugar levels caused by a type of diabetes mellitus (sugar diabetes ) called type 2 diabetes . In type 2 diabetes , your body does not work properly to store excess sugar and the sugar remains in your bloodstream. Chronic high blood sugar can lead to serious health problems in the future. Proper diet is the first step in managing type 2 diabetes , but often medicines are needed to help your body. Glipizide belongs to a class of drugs called sulfonylureas. It stimulates the release of insulin from the pancreas, directing your body to store blood sugar. This helps lower blood sugar and restore the way you use food to make energy. This medicine is available only with your doctor's prescription. Find big savings at pharmacies near you with GoodRx discount coupons Follow carefully the special meal plan your doctor gave you. This is the most important part of controlling your condition, and is necessary if the medicine is to work properly. Also, exercise regularly and test for sugar in your blood or urine as directed. This medicine comes with a patient information insert. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions. Swallow the extended release tablet whole. Do not split, crush, or chew it. If you are taking the extended release tablet, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is differe Continue reading >>

Why Some Diabetics Gain Weight - And What You Can Do To Drop The Pounds

Why Some Diabetics Gain Weight - And What You Can Do To Drop The Pounds

One of the worst things a diabetic can do is gain weight. Unfortunately, that?s exactly what many of them do - even if they eat right, get plenty of exercise, and take their medications. What they don?t realize is that those medications may be the reason they?re gaining weight. Weight gain is a common side effect from oral anti-diabetic drugs. These include Glucotrol or glipizide. Glipizide triggers the pancreas to secrete insulin and use it efficiently. This lowers your blood sugar levels. The good news is you can avoid this weight gain or melt away those extra pounds by taking enough of a safe supplement. And you can find it in any health food store. The nutrient is chromium. You may be familiar with using chromium to help regulate blood sugar. In fact, you?re probably taking a few hundred micrograms of it already. But this isn?t nearly enough to cancel out this weight gain. You may need to take much more. In a study published in Diabetes Care, researchers followed a few dozen patients with type-2 diabetes. All of them were taking glipizide. They gave half of them 1,000 mcg of chromium picolinate a day for six months. Most multivitamins have only 200 mcg. They gave the control group a placebo along with glipizide. Continued Below... How to beat almost any health problem... by rejuvenating every single cell in your body! This European breakthrough can reverse the effects of aging in your body's cells. Studies show it leads to healthier cholesterol, a sharper memory, a stronger liver and more. At the end of the study, the patients who took glipizide with the placebo gained about five pounds. They also had substantially more abdominal and body fat. Those who took the chromium gained either nothing or up to two pounds, had a significant loss of body fat, and had lower blo Continue reading >>

Glucotrol, Glucotrol Xl, Glipizide Diabetes Treatment - Glucotrol, Glipizide Patient Information

Glucotrol, Glucotrol Xl, Glipizide Diabetes Treatment - Glucotrol, Glipizide Patient Information

Glucotrol, Glucotrol XL, Glipizide Diabetes Treatment - Glucotrol, Glipizide Patient Information Glucotrol, Glicotrol XL, glipizide, full prescribing information What is Glucotrol and why is Glucotrol prescribed? Glucotrol is an oral antidiabetic medication used to treat type 2 (non-insulin-dependent) diabetes. In diabetics either the body does not make enough insulin or the insulin that is produced no longer works properly. There are actually two forms of diabetes: type 1 insulin-dependent and type 2 non-insulin-dependent. Type 1 usually requires insulin injections for life, while type 2 diabetes can usually be treated by dietary changes and/or oral antidiabetic medications such as Glucotrol. Apparently, Glucotrol controls diabetes by stimulating the pancreas to secrete more insulin. If you suffer from type 1 diabetes, you will need to use insulin and will not be able to use Glucotrol. Occasionally, type 2 diabetics must take insulin injections on a temporary basis, especially during stressful periods or times of illness. Always remember that Glucotrol is an aid to, not a substitute for, good diet and exercise. Failure to follow a sound diet and exercise plan can lead to serious complications, such as dangerously high or low blood sugar levels. Remember, too, that Glucotrol is not an oral form of insulin, and cannot be used in place of insulin. In general, to achieve the best control over blood sugar levels, Glucotrol should be taken 30 minutes before a meal. However, the exact dosing schedule as well as the dosage amount must be determined by your physician. Glucotrol XL should be taken with breakfast. Swallow the tablets whole; do not chew, crush, or divide them. Do not be alarmed if you notice something that looks like a tablet in your stoolit will be the empty she Continue reading >>

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