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Triple Fixed Drug Combinations In Type 2 Diabetes

Triple Fixed Drug Combinations In Type 2 Diabetes

Type 2 diabetes is characterized by progressive beta-cell failure that results in sequential adding of different oral and injectable medications to achieve optimal glycemic control.[1,2] This necessitates administration of multiple tablets or pills to achieve good glycemic control as the disease progresses.[2] In addition, subjects with type 2 diabetes may have other co-morbidities such as dyslipidemia, hypertension and cardiovascular disease, which further increase the burden of medications. Polypharmacy with increased pill burden and dosing frequency is identified as one of the factors responsible for poor adherence to oral hypoglycemic therapy.[3] Even in countries with high access to healthcare, only 39% of patients reported good medication adherence.[4] In a study of 2741 patients on oral antidiabetic drug (OAD), there was an inverse relationship between OAD adherence and HbA1c; controlling for baseline HbA1c and therapy regimen, each 10% increase in oral diabetes medication adherence was associated with a 0.1% HbA1c decrease (P = 0.0004), suggesting that adherent patients are more likely to achieve glycemic control than the nonadherent ones.[5] Go to: One method to improve drug adherence is to use fixed drug combinations (FDC).[6] United States Food and Drugs Administration (USFDA) defines FDC as “two or more drugs may be combined in a single dosage form when each component makes a contribution to the claimed effects and the dosage of each component (amount, frequency, duration) is such that the combination is safe and effective for a significant patient population requiring such con-current therapy as defined in the labeling for the drug.”[7] The rationality of FDCs should be based on certain aspects such as: The drugs in the combination should act by differe Continue reading >>

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What Is The Effect Of Combination Of Voglibose+ Metformin+glimipride Drug In Diabetes?

What Is The Effect Of Combination Of Voglibose+ Metformin+glimipride Drug In Diabetes?

what is the effect of combination of Voglibose+ metformin+Glimipride Drug in diabetes? The doctor will decide what is right for you based on your medical history.Without knowing the medical history if you follow somebody's advise,it will be like going on a blind path. Voglibose is an alpha-glucosidase inhibitor used for lowering post-prandial blood glucose levels in people with diabetes mellitus. Voglibose delays the absorption of glucose thereby reduces the risk of macrovascular complications. Metformin is used alone or with other medications, including insulin, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Metformin is in a class of drugs called biguanides. Metformin helps to control the amount of glucose (sugar) in your blood. It decreases the amount of glucose you absorb from your food and the amount of glucose made by your liver. Metformin also increases your body's response to insulin, a natural substance that controls the amount of glucose in the blood. Glimepiride is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Glimepiride lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. This medication will only help lower blood sugar in people whose bodies produce insulin naturally. Continue reading >>

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Glimepiride Metformin Voglibose Combination Brands In India

Glimepiride Metformin Voglibose Combination Brands In India

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Glimepiride Metformin Voglibose Combination Brands In India

Glimepiride Metformin Voglibose Combination Brands In India

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