Genetic Determinants Of Type 2 Diabetes Mellitus.
Genetic determinants of type 2 diabetes mellitus. (1)John P. Robarts Research Institute, London, Ontario, Canada N6A 5K8. Type 2 diabetes refers to a group of disparate metabolic diseases, which aretypically characterized by insulin resistance in peripheral tissues, togetherwith impaired insulin secretion from pancreatic beta-cells. The complexity oftype 2 diabetes is related to factors such as genetic heterogeneity, interactionsbetween genes, and the modulating role played by the environment. Recent progresshas included defining the molecular basis of monogenic forms of type 2 diabetes, such as familial partial lipodystrophy and the subtypes of maturity-onsetdiabetes of the young (MODY), and also the identification of chromosomal regions that may harbor type 2 diabetes susceptibility genes. Many common variants infunctional and positional candidate genes, including ADRB3, PPARG, ENPP1, andCAPN10, have also been studied for their possible role as determinants of type 2 diabetes, with varying levels of agreement between studies. The availability of arelatively complete sequence of the human genome will increase the amount ofgenetic information that can be used to evaluate hypothese Continue reading >>