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Genetic Determinants Of Diabetes

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Impact Of Common Genetic Determinants Of Hemoglobin A1c On Type 2 Diabetes Risk And Diagnosis In 1 Ancestrally Diverse Populations: A Transethnic Genome-wide Meta-analysis

Impact of Common Genetic Determinants of Hemoglobin A1c on Type 2 Diabetes Risk and Diagnosis in 1 Ancestrally Diverse Populations: A Transethnic Genome-Wide Meta-Analysis Wong, A; (2017) Impact of Common Genetic Determinants of Hemoglobin A1c on Type 2 Diabetes Risk and Diagnosis in 1 Ancestrally Diverse Populations: A Transethnic Genome-Wide Meta-Analysis. PLoS Medicine 10.1371/journal.pmed.1002383 . BACKGROUND: Glycated hemoglobin (HbA1c) is used to diagnose type 2 diabetes (T2D) and assess glycemic control in patients with diabetes. Previous genome-wide association studies (GWAS) have identified 18 HbA1c-associated genetic variants. These variants proved to be classifiable by their likely biological action as erythrocytic (also associated with erythrocyte traits) or glycemic (associated with other glucose-related traits). In this study, we tested the hypotheses that, in a very large scale GWAS, we would identify more genetic variants associated with HbA1c and that HbA1c variants implicated in erythrocytic biology would affect the diagnostic accuracy of HbA1c. We therefore expanded the number of HbA1c-associated loci and tested the effect of genetic risk-scores comprised of ery Continue reading >>

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  1. avg

    I am preparing for gastric bypass surgery, I started with an A1C of 11.1 october of 2010. I have been diabetic for many years now and was hesitant to go on insulin. Surgeons will not consider you a candidate for procedure unless your A1C is 7.5 or lower, so I started to see a local diabetic specialist at the medical center, In Jan. 2011. I saw him 1 time and have been seeing his N.P. every month since. She has adjusted my lantus insulin doses several times, but left my oral meds as they have alwyas been. Each month they run an A1C and evey time it has come down. In May Iwas finally 7.5 in June Iwas 7.3. my BS have been much better 65-100 fasting before breakfast. I have my surgical consult tomorrow, so I had an A1c done this afternoon, the nurse asked me what I thought my numbers would be and I figured 7.1. He asked me to stand, showed me the computer print out and I began to cry with happiness. It was 6.8 the nurse gave me a great big hug and sai " you have done wonderful this month good luck and keep up the good work". What a fantastic feeling. A n A1c of 14.1 is extremely high and still needs a lot of work, but if that is an improvement from the last check the congrats. Good Luck.

  2. Jeannie Holmes

    Good luck with your surgery. I would love to get gastic bypass, but my insurance won't pay for it.

  3. MarkS

    Hi LexaDelly, an optimal HbA1c is determined by your physician. Typically, the lower the number the better. I believe that a normal HbA1c is less than 6 while the ideal standard for a diabetic is less than 7, which equates to an average daily blood sugar of about 150. The danger with trying to get your HbA1c low is the hypolycemia that follows. I know because that's one of my challenges, and I wear a continuous glucose monitor that helps me to adjust on a real time basis.

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Dr Raymond Noordam, Genetic Determinants For Insulin-dependent Type 2 Diabetes Mellitus

Dr Raymond Noordam, Genetic determinants for insulin-dependent type 2 diabetes mellitus Dr Raymond Noordam, Genetic determinants for insulin-dependent type 2 diabetes mellitus Principal Investigator: Dr Raymond Noordam Tags: 22474 , diabetes , genetics , insulin-depedent 1a: Type 2 diabetes mellitus (T2D) is a heterogeneous disease caused by different mechanisms, including insulin resistance and pancreatic malfunction. Of the patients diagnosed with T2D, a fair amount of the patients requires insulin analogs shortly (e.g., within 1 year) after diagnoses, which is indicative of a major role for pancreatic malfunction already at the moment of diagnosis. Malfunction of the pancreas results in an insulin-dependent T2D phenotype. In this project, we will investigate genetic determinants for insulin-dependent type 2 diabetes mellitus as defined by the use of insulin analogs within 1 year after diagnosis. 1b: The prevalence and incidence of type 2 diabetes mellitus is increasing. After diagnosis, patients with type 2 diabetes are often prescribed oral glucose-lowering drugs, but treatment response is often insufficient or associated with serious adverse drug reactions. A better understan Continue reading >>

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  1. Lance_Parsons

    I hve heard the the policy on diabetes at the NMC is that you must show a history of continous control of your diabetes eg. a1c - a Hg1c of under 8, in order to be elgible for a renewal of your Masters License. Can anyone expand on this?

  2. injunear

    When I renewed almost 2 years ago, under the new guidelines, my Dr. wrote a letter listing my A1Cs for the previous year. I had 3 A1Cs including the one for the renewal physical. They also asked for an eye exam from an ophthalmologist.

    On renewal, my waiver stated I was required to submit my A1Cs annually to the NMC. A year later, I sent a letter from my dr. showing 2 A1Cs to the NMC. The NMC then rescinded the annual requirement with the stipulation that I notify them of any changes in my blood work.

  3. Lance_Parsons

    Injunear, thanks for the input. When I renewed last time I got the letter saying I was required to report any changes in my status. I spent quite a lot of time yesterday and managed to dig out some guidelines from the NMC, so I hope for minimal slow down in the renewal process come Jan. 2013. Lance

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Genetic Determinants Of Albuminuria And Renal Disease In Diabetes Mellitus

Genetic determinants of albuminuria and renal disease in diabetes mellitus Correspondence and offprint requests to: Barry I. Freedman, MD, Department of Internal Medicine, Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1053, USA. Email: [email protected] Search for other works by this author on: Nephrology Dialysis Transplantation, Volume 21, Issue 1, 1 January 2006, Pages 1316, Michle M. Sale, Barry I. Freedman; Genetic determinants of albuminuria and renal disease in diabetes mellitus, Nephrology Dialysis Transplantation, Volume 21, Issue 1, 1 January 2006, Pages 1316, albuminuria , chronic kidney failure , diabetes mellitus , genetics Type 2 diabetes mellitus (T2DM) is increasing in epidemic proportions. The worldwide prevalence of diabetes was estimated to be 171 million cases in 2000 and is projected to rise to 366 million cases by 2030 [ 1 ]. Given current trends, the lifetime risk for developing T2DM is 30% in European Americans born in 2000, contrasted with 40% in African American males and 49% in African American females [ 2 ]. This global epidemic will clearly increase the development of diabetic neph Continue reading >>

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Popular Questions

  1. lukesgirls

    My new endo wants me to consider a Medtronic 630G + CGM. I'm currently on MDI. She is suggesting this one because it turns off the insulin if one goes low. Does anyone have any experience with this? I've not worn a pump before so any words of wisdom/opinions would be appreciated.

  2. T1nunya

    It's a pretty new pump! I have only seen 2 user reviews and 1 hates it and the other loves it. I do recommend an insulin pump as long as one knows how to use it. The pumper needs to be the one that manages all things that happen with it so I would not connect this 630 pump to me. I do not want my pump to make decisions regarding turning off my insulin.

  3. i don't know about this.
    I have a pump and a separate CGM.
    Is this pump/CGM covered by Medicare or a Medicare supplement?
    thanks,
    Susan

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