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Gallbladder Pain Metformin

Metformin, The Liver, And Diabetes

Metformin, The Liver, And Diabetes

Most people think diabetes comes from pancreas damage, due to autoimmune problems or insulin resistance. But for many people diagnosed “Type 2,” the big problems are in the liver. What are these problems, and what can we do about them? First, some basic physiology you may already know. The liver is one of the most complicated organs in the body, and possibly the least understood. It plays a huge role in handling sugars and starches, making sure our bodies have enough fuel to function. When there’s a lot of sugar in the system, it stores some of the excess in a storage form of carbohydrate called glycogen. When blood sugar levels get low, as in times of hunger or at night, it converts some of the glycogen to glucose and makes it available for the body to use. Easy to say, but how does the liver know what to do and when to do it? Scientists have found a “molecular switch” called CRTC2 that controls this process. When the CRTC2 switch is on, the liver pours sugar into the system. When there’s enough sugar circulating, CRTC2 should be turned off. The turnoff signal is thought to be insulin. This may be an oversimplification, though. According to Salk Institute researchers quoted on RxPG news, “In many patients with type II diabetes, CRTC2 no longer responds to rising insulin levels, and as a result, the liver acts like a sugar factory on overtime, churning out glucose [day and night], even when blood sugar levels are high.” Because of this, the “average” person with Type 2 diabetes has three times the normal rate of glucose production by the liver, according to a Diabetes Care article. Diabetes Self-Management reader Jim Snell brought the whole “leaky liver” phenomenon to my attention. He has frequently posted here about his own struggles with soarin Continue reading >>

Metformin (glucophage) Side Effects & Complications

Metformin (glucophage) Side Effects & Complications

The fascinating compound called metformin was discovered nearly a century ago. Scientists realized that it could lower blood sugar in an animal model (rabbits) as early as 1929, but it wasn’t until the late 1950s that a French researcher came up with the name Glucophage (roughly translated as glucose eater). The FDA gave metformin (Glucophage) the green light for the treatment of type 2 diabetes in 1994, 36 years after it had been approved for this use in Britain. Uses of Generic Metformin: Glucophage lost its patent protection in the U.S. in 2002 and now most prescriptions are filled with generic metformin. This drug is recognized as a first line treatment to control blood sugar by improving the cells’ response to insulin and reducing the amount of sugar that the liver makes. Unlike some other oral diabetes drugs, it doesn’t lead to weight gain and may even help people get their weight under control. Starting early in 2000, sales of metformin (Glucophage) were challenged by a new class of diabetes drugs. First Avandia and then Actos challenged metformin for leadership in diabetes treatment. Avandia later lost its luster because it was linked to heart attacks and strokes. Sales of this drug are now miniscule because of tight FDA regulations. Actos is coming under increasing scrutiny as well. The drug has been banned in France and Germany because of a link to bladder cancer. The FDA has also required Actos to carry its strictest black box warning about an increased risk of congestive heart failure brought on by the drug. Newer diabetes drugs like liraglutide (Victoza), saxagliptin (Onglyza) and sitagliptin (Januvia) have become very successful. But metformin remains a mainstay of diabetes treatment. It is prescribed on its own or sometimes combined with the newer d Continue reading >>

Possible Medication Induced Pancreatitis?

Possible Medication Induced Pancreatitis?

Hi all, I'm new here. So, about 4 years ago I was diagnosed with polycystic ovarian syndrome, and educated to lose 50 pounds, and I was put on metformin for insulin resistance. About 6 months after starting metformin, I began having random pains in my mid chest, right under my sternum that would radiate around my right side, up my esophagus and into my right jaw, and pierce through my back. I let this pain go on for about 2 years because it would only last a few days. About 2 years ago, I got sick of it, decided it was my gallbladder and had that removed. I felt great for about 9 months, then I had all the same symptoms come back, and I thought this cant be, I had my gallbladder out... why in the eff do I feel this pain again. Once again, it lasted about 4 days, I wouldnt eat anything then the pain would go away. I went to the doctor, drew some labs, had an ultrasound, upper endoscopy...the works. They decided I must be having esophogeal spasms. SO... I have had about 4 attacks since then, they all last for about 3-5 days and as long as I dont eat or drink carbonated things I'm ok. This last one started 4 days ago, and it dawned on me that I am horribly nauseated and have pain that goes onto the left and right side now, and have nasty loose stools that are bright yellow. I'm also very, very tender under my sternum and along my bottom left rib cage (not to mention fatigued). Holy crap, maybe I have pancreatitis. I am a nurse, and I dont know why it took me so long to realize that! *worlds worst patient right here* Anyways, I got to researching about how different medications can cause pancreatititis, and I ran into a few articles on how people developed pancreatitits due to taking metformin because it overstimulates the pancreas. I rarely drink (maybe a few drinks 1-2 t Continue reading >>

Metformin And Gallbladder Problems

Metformin And Gallbladder Problems

If this is your first visit, be sure tocheck out the FAQ by clicking thelink above. You may have to register before you can post: click the register link above to proceed. To start viewing messages,select the forum that you want to visit from the selection below. I just want this out there to maybe help others avoid surgery. I had a lot of stomach problems with met from day one (such as diarhea, stomach spasms, extreme admoninal pain and cold sweats in middle of night followed by explosions (use your imagination). I tolerated this all for the overwhelming desire to conceive. About 8 weeks into taking this I experienced terrible pain in my chest, neck, throat and back. I went to pcp and told him I suspected the met but he said no and ordered, bloodwork, xrays and ultrasound. (about $5000 plus in tests) I was told I had sludge in my gallbladder and immediately sent to a surgeon to have it removed. He also said that the ultrasound revealed I had complex cysts in my left ovary and needed a MRI (another $4000 ) I told him that it was normal for me to have cysts due to PCOS but he isisted on the test. He had nurse call me back in a week to reveal that OMG, I have PCOS!!!. I told him before he did this 2 hour MRI that I had PCOS. Now to the surgeon, The week before I saw him, I stopped taking the Met because I figured if I really had to have surgery, I didnt want to get pregnant yet anyway and for my own peace of mind, I wanted to rule out the Met as cause of the intense pain. The pain went away 3 days after I stopped the met and has remained gone since. The surgeon scheduled another ultrasound and a hapabilary scan (spelling stinks) (another $3000. in tests) that revealed that sludge was gone and my gallbladder function was fine. My advise is that if you have terrible chest Continue reading >>

Gallbladder Referred Pain, Constipation, & Gallstones

Gallbladder Referred Pain, Constipation, & Gallstones

Home / Health Articles / Digestive Health / Gallbladder Health Part I: Be Good to Your Gallbladder Its There For a Reason Gallbladder Health Part I: Be Good to Your Gallbladder Its There For a Reason Gallbladder problems including gallbladder attacks are very common reasons for which people seek medical care. The pain and discomfort can unfortunately result in the removal of the little green organ followed by dietary restrictions (often low fat). But of course, all of our organs are there for one reason or another and although we can live without the gallbladder, removing it is simply removing a symptom of a problem, not the actual cause. In this two-part article on the gallbladder Ill discuss why you have a gallbladder, why you should want to keep it (and keep it healthy), warning signs that your gallbladder isnt working well, risk factors, and natural treatments and lifestyle changes you can make to improve your gallbladder and overall health; yeah! If I can just save one more gallbladder Ill be a happy guy. Gallbladder Physiology: Bile is so Good for You Lets take a brief lesson in gallbladder physiology here, and Ill make it interesting and relevant to your everyday health. The gallbladder is a small organ that sits tucked up underneath the liver in the upper right side of your abdomen. It concentrates and stores bile produced by the liver, and along with the enzyme lipase secreted by the pancreas, it aids in the digestion of fats in the gut. When fats from food enter the digestive tract they stimulate the secretion of a type of hormone called cholecystokinin (CCK) in the upper part of the small intestine the duodenum. This, along with the stomachs secretion of hydrochloric acid, signals the gallbladder to release some of its approximately 50mL of bile into the gut Continue reading >>

Side Effects Of Metformin

Side Effects Of Metformin

Metformin ("Glucophage") has a broad array of possible side effects and implications for your health. Has your doctor discussed with you all of the possible problems associated with metformin? Malaise Did you know that 10%- 25% of women who take Glucophage just don't feel well? They experience a general malaise, fatigue and occasional achiness that lasts for varying lengths of time. Malaise a warning signal for your doctor to closely monitor your body systems, including liver, kidneys, and GI tract. GI Disturbance About one third of women on metformin experience gastrointestinal disturbances, including nausea, occasional vomiting and loose, more frequent bowel movements, or diarrhea. This problem occurs more often after meals rich in fats or sugars, so eating a healthier diet will help. The symptoms lessen over time, so if you can tolerate the GI upset for a few weeks, it may go away. Some women have found it helps to start with a very low dose and gradually increase it. Vitamin B12 Malabsorption Most people think that aside from possible gastrointestinal upset, there are no side effects from taking metformin, and thus you can take it for a very long time. This is not true! The sneakiest side effect of all is a vitamin B12 insufficiency. A substance formed in the stomach called "intrinsic factor" combines with B12 so that it can be transferred into the blood. Metformin interferes with the ability of your cells to absorb this intrinsic factor-vitamin B12 complex.(12) Over the long term, vitamin B12 insufficiency is a significant health risk. B12 is essential to the proper growth and function of every cell in your body. It's required for synthesis of DNA and for many crucial biochemical functions. There is also a link between B12 insufficiency and cardiovascular disease. Continue reading >>

Avoid The Metformin Bandwagon

Avoid The Metformin Bandwagon

From diabetes to cancer, berberine matches - or beats - this patent medicine every time! As many know, metformin is the number one prescription medication for type-2 diabetes. The patent for the name-brand of this patent medicine, Glucophage®, expired years ago and as a result generic-brand competition (metformin) brought this patent medicine’s price down so that it’s relatively inexpensive, especially when compared with nearly any other medication still covered by a patent. Mainstream medical research has found other uses for this un-natural molecule, including (but not limited to) lipid, blood pressure, and insulin resistance lowering effects, anti-cancer effects, improvement of polycystic ovarian syndrome, combatting Alzheimer’s disease, and extending life span in mice. Surprising guests on the metformin bandwagon Some proponents of natural therapies – including, surprisingly, two nationally and internationally circulated health magazines – have climbed on the metformin bandwagon, writing articles about the “health benefits” of metformin, and even advocating that otherwise healthy people take this patent medicine every day as a preventive. They admit that there are known side effects, but write that these are few, and that the benefits outweigh the risks. If there aren’t any natural treatment alternatives that are as effective, or more effective, than a patent medicine or other un-natural molecule – especially in serious or life-threatening situations – then the use of a patent medication of course makes sense. But when there are natural alternatives that work just as well or better, the rule is – and always should be – to “Copy Nature.” Human bodies are formed from the molecules of planet Earth, and powered by the energies of this planet Continue reading >>

Anyone Experiencing Pain From Taking Metformin?

Anyone Experiencing Pain From Taking Metformin?

Anyone Experiencing Pain From Taking Metformin? Thank you. I've tried time release, regular & the liquid, Riomet. I seem to have trouble no matter the version. HEALTH_NOW There is another post on here, she said she was giving time release and that almost completely took care of her problems. Yes I've had some of those symptoms & others. Problem with taking many medications is figuring out the ones causing the problem & wondering if it is the combination rather than just one med. Very frustrating especially since no doctor helping so I'm trying to do it on my own. This has been an interesting week. I had my diabetes class tuesday and it was really good. I ended up asking about all of these symptoms I have been having for 3 years and the doctor said all these symptoms aren't from diabetes..He told me to stop Metformin for 2 weeks and see how I feel? The next day a lot of the symptoms went away! Wow! I have been going through this for 3 years. Since I have been eating good and have lost 7 lbs now, my A1C went from 7.5 to 7. I went to the doctor today and that was an interesting experience, different doctor than the doctor at my diabetes class. It turns out I have asthma. My echocardiogram was good. Here are some of the symptoms I was having numb or cold feeling in your arms and legs feeling dizzy, light-headed, tired, or very weak diarrhea, or a metallic taste in the mouth may occur. actic acidosis. Symptoms include: tiredness. unusual muscle pain. trouble breathing. unusual sleepiness. dizziness or lightheadedness. ... low blood sugar. Symptoms include: headache. weakness. confusion. shaking or feeling jittery. drowsiness. dizziness. I know this is an old post, but I've been suffering all year with feeling hot even in winter & with ac in summer, burning back sensation, b Continue reading >>

Newly Diagnosed/liver Pain

Newly Diagnosed/liver Pain

Registration is fast, simple and absolutely free so please,join our community todayto contribute and support the site. This topic is now archived and is closed to further replies. I am new here and was just diagnosed with Diabetes related to Chronic pancreatitis. So you just might see me here often asking a lot of questions. My problem now is that I started on Metformin and about 2 weeks afterwards I started having servere upper abdominal and upper back pain. I had my blood drawn and my liver enzymes and Alk Phos were elevated. I had the pain and elevated liver enzymes for about 2 weeks after the first episode. I ended up in the ER but they didn't tell me much. However, I called my Endo because I had to take prendisone prior to an MRI and so my bcs were really high. I mentioned to him about the liver and he took me off the metformin because it could be causing my liver problems. I have had gallstones in the past and know what it feels like when the bile duct gets blocked. This is what the pain felt like. MY question for anyone is.....I know you can get elevated liver enzymes from the medication and just diabetes alone. But I haven't heard of anyone complaining about pain coming along with the elevated liver enzymes. I am trying to figure out if I had another stone blocking my bile duct or if it was from the medication. So, any information would be really helpful. glad to see you here, and please ask away. I don't know the answer to your question, however my liver enzymes were elavated at diagnosis. I had an ultrasound of my liver, they said I had "fatty liver disease" which meant I was so fat that my liver was full of fat, disgusting. anyway, I lost wieght and then the fatty liver and liver ezymes went away. Just FYI, i don't think that is uncommon where there is type Continue reading >>

Will You Have Gallstones With Metformin - From Fda Reports - Ehealthme

Will You Have Gallstones With Metformin - From Fda Reports - Ehealthme

A study for a 56 year old man who takes Calcium Carbonate, Dexilant NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk. You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088). If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. Continue reading >>

Cholecystitis - Liver And Gallbladder Disorders - Merck Manuals Consumer Version

Cholecystitis - Liver And Gallbladder Disorders - Merck Manuals Consumer Version

Cholecystitis is inflammation of the gallbladder, usually resulting from a gallstone blocking the cystic duct. Typically, people have abdominal pain that lasts more than 6 hours, fever, and nausea. Ultrasonography can usually detect signs of gallbladder inflammation. The gallbladder is removed, often using a laparoscope. Cholecystitis is the most common problem resulting from gallbladder stones. It occurs when a stone blocks the cystic duct, which carries bile from the gallbladder (see Figure: View of the Liver and Gallbladder ). Cholecystitis is classified as acute or chronic. Acute cholecystitis begins suddenly, resulting in severe, steady pain in the upper abdomen. The pain usually lasts more than 6 hours. At least 95% of people with acute cholecystitis have gallstones . The inflammation almost always begins without infection, although infection may follow later. Inflammation may cause the gallbladder to fill with fluid and its walls to thicken. Rarely, a form of acute cholecystitis without gallstones ( acalculous cholecystitis ) occurs. However, the gallbladder may contain sludge (microscopic particles of materials similar to those in gallstones). Acalculous cholecystitis is more serious than other types of cholecystitis. It tends to occur after the following: Critical illnesses such as serious injuries, severe burns , or a bloodstream infection ( sepsis ) Acute acalculous cholecystitis can occur in young children, perhaps developing from a viral or another infection. Chronic cholecystitis is gallbladder inflammation that has lasted a long time. It almost always results from gallstones and from prior attacks of acute cholecystitis . Chronic cholecystitis is characterized by repeated attacks of pain (biliary colic) that occur when gallstones periodically block the c Continue reading >>

Diabetes Drug Class Linked To Bile Duct And Gallbladder Disease

Diabetes Drug Class Linked To Bile Duct And Gallbladder Disease

A popular class of drugs used to treat type 2 diabetes may increase the risk of bile duct and gallbladder disease. The class, GLP-1 (glucagon-like peptide 1) receptor agonists, is given via an injection and includes Byetta (exenatide), Victoza (liraglutide) and Trulicity (dulaglutide). Health records of more than 1.5 million patients with type 2 diabetes in the United States, the United Kingdom and Canada who were taking an antidiabetic medication were examined in the study, which was published in JAMA Internal Medicine. GLP-1s were shown to cause a 79% increased risk of developing symptoms associated with bile duct and gallbladder disease compared to those not on any diabetes drug. Put another way, about 3 more patients per 1,000 exhibited symptoms compared to those not taking the medication. The most common adverse effect seen in this population were gallstones. Another class of diabetes drugs, DPP-4 (dipeptidyl peptidase 4) inhibitors, which are given as a pill and act in a similar way as GLP-1s, did not have the increased risk of bile duct and gallbladder disease. DPP-4s on the market include Januvia (sitagliptin), Onglyza (saxagliptin) and Tradjenta (linagliptin). However, both GLP-1s and DPP-4s were not associated with an increased risk of acute pancreatitis. “It’s important that clinicians and patients alike be well informed about possible adverse effects,” Laurent Azoulay, PhD, a senior investigator at the Lady Davis Institute at the Jewish General Hospital in Montreal and the study’s lead author, said in a statement. “As a result of the gallbladder finding, it would be prudent for doctors to warn their patients to seek treatment if they experience symptoms, such as pain in their right side.” Jonathan Block is MedShadow’s content editor. He has pre Continue reading >>

Can Metformin Cause Gallbladder Pain?

Can Metformin Cause Gallbladder Pain?

Metformin question? Hi everyone,Has anyone had ... Hi everyone,Has anyone had rigth upper quadrant cramping, like gallbladder pain (that is no longer in there - YEAH!) after stopping Metformin? I had a my first stubborn BG low yesterday of 61 (I waited too long to eat lunch). Ate four little pieces of chocolate (15 carbs), waited 15 minutes and BG went to 55. Drank chocolate Silk milk, waited 15 minutes and it went to 64. Ate a small banana, waited 15 minutes and it went to 69. Drank more Chocolate Silk milk and it went to 74. read more... Ate an orange and waited 15 minutes and it went to 94, WHEW!! I was so full by then I didn't want to eat anything else. One hour later ate a big mac and didn't take my Metformin then. Two hours later BG was only at 119. Ate late dinner of grilled cheese on cracked wheat sourdough and low carb soup and didn't take Metformin then either. Four hours later BG was 121. Thought it was safer to be a little high then hit another low. Anyway, after I ate the big mac (definitely a big no, no and haven't had one since diagnosed) I began having right upper abdomen cramping similar to gallbladder problems, but like I said I know longer have my gallbladder. Had cramping all night. Back on schedule today with all meds, still a little crampy. Has anyone who stopped taking metformin, even temporarily, had any liver pain or cramping or colic????My blood work a month ago was ok, and my liver biopsy when I had the gallbladder out and was REALLY jaundice came back ok.Thanks everyone, happy holidays.Char" Continue reading >>

Metformin And Pancreatitis | Diabetic Connect

Metformin And Pancreatitis | Diabetic Connect

I was misdiagnosed with type 2 diabetes and prescribed metformin. 4 days after starting the prescription I ended up in hospital fighting for my life with pancreatitis. Doctor should have advised me not to eat or drink after midnight before taking the test. I've had 3 other Doctors agree I never had type 2 diabetes. Now the tail of my pancreas is necrotic. They are trying to say it wasn't the metformin, but when I drank alcohol 25yrs earlier was the cause. I call B.S. can't get a real diagnosis of reason I got pancreatitis. Then I read this article, any help would be appreciated since my pancreas will continue to die slowly. I was diagnosed with type 2 diabetes in 2009. I was started on 500 mg Metformin twice daily but had a bad reaction to it so was taken off it. Five years later, a new doctor wanted me to try taking it again, this time extended release. I only took 500 mg once daily as I was afraid to approach my previous dosage for fear of the same reaction. I was on Metformin for only a year, at which time I contracted acute pancreatitis and sepsis. Was admitted to the hospital, had a seizure (presumably because of the sepsis) and I experienced cardiac arrest. My heart was restarted with CPR. I experienced kidney failure and my lungs started to fill up with fluid. Was on a respirator for several days then when they tried to extubate me. I went into cardiac arrest again. I stayed on the respirator for several more days until they were finally able to get me off it and I started to wake up and kidneys started to function again. Since that time I have been on only insulin, no oral medications of any kind. I had NONE of the risk factors for pancreatitis, except oral medications for diabetes (which IS a risk factor). But I didn't know it at the time. I just trusted the d Continue reading >>

Will You Have Gallbladder Attack With Metformin - From Fda Reports - Ehealthme

Will You Have Gallbladder Attack With Metformin - From Fda Reports - Ehealthme

A study for a 53 year old man who takes Suboxone, Nitrostat NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk. You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088). If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. Continue reading >>

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