Fish Oil And Type 1 Diabetes

Omega-3 May Lower Type 1 Diabetes Risk

Diet Rich in Omega-3 Fatty Acids May Help Body Fight Inflammation That Leads to Diabetes Sept. 25, 2007 -- Eating a diet rich in omega-3 fats may help keep high-risk children from developing type 1 diabetes , early research suggests. Dietary intake of omega-3 fatty acids was associated with a lower incidence of autoantibodies in the blood that signal the immune system to attack insulin -producing cells in the pancreas . Omega-3 fatty acids are known to have anti-inflammatory properties, and inflammation is believed to play a major role in the development of type 1 diabetes through destruction of these insulin -producing cells. "The thinking is that omega-3 may increase the body's ability to fight the inflammation that leads to type 1 diabetes ," researcher Jill M. Norris, MPH, PHD, tells WebMD. The University of Colorado professor of preventive medicine adds that the findings, while intriguing, do not prove omega-3-rich foods protect against type 1 diabetes . The study appears in the Sept. 27 issue of TheJournal of the American Medical Association. "This is a preliminary study," she says. "We really can't make dietary recommendations based on these findings." In adults, omega-3 rich diets are believed to lower cardiovascular risk, and in babies the fatty acid is believed to boost brain development. A 2003 study from Norway was one of the first human trials to suggest a protective role for omega-3 fatty acids in type 1 diabetes . Researchers reported a lower incidence of omega-3-rich cod liver oil supplementation during infancy in children with diabetes , compared to children without the disease. The newly published study included 1,770 children -- from birth to age 3 -- at increased risk for developing type 1 diabetes, followed for an average of six years. These childr Continue reading >>

Omega-3s May Help To Treat Type 1 Diabetes

Type 1 diabetes is an incurable autoimmune disorder of unknown origin. New research, however, may pave the way for novel, more efficient therapies for type 1 diabetes, as omega-3 fatty acids are found to reduce the autoimmune responses typical of the disease. Type 1 diabetes is an autoimmune disorder that affects approximately 1.25 million adults and children in the United States. In type 1 diabetes, the body's immune system does not recognize its own beta cells, so it attacks and destroys them. Beta cells are responsible for creating insulin. The body needs insulin to transport glucose into cells, where it is needed for producing energy. Without insulin-producing beta cells, the glucose builds up in the blood stream, and the body cannot use it for energy. It is not yet known what causes type 1 diabetes, and there is currently no cure for the illness. The most common treatment option is administering insulin, but the ultimate goal of the medical research community is to stop the body's immune system from attacking its own beta cells, or reversing this process. New research, published in The Journal of Clinical Investigation, investigates the benefits of adding omega-3 fatty acids to the diet of mice with type 1 diabetes. Omega-3s are a class of polyunsaturated fatty acids (PUFAs). They are typically found in fish, seafood, and some vegetable oils, as well as in dietary supplements. These fatty acids are important for the good functioning of several organs, as these beneficial fats improve the activity of muscles, prevent blood clotting, help digestion, and aid the division and growth of cells. The health benefits of omega-3s have been investigated in several studies. Some research has suggested that omega-3s protect against cardiovascular events and rheumatoid arthritis Continue reading >>

Study Sheds 'new Light' On Role Of Omega-3 In Type 1 Diabetes Protection

Study sheds 'new light' on role of omega-3 in type 1 diabetes protection New light has been shed on the role of fatty acids and milk feeding in helping protect against type 1 diabetes and further testing could help prove that nutritional intervention can help prevent a disease which impacts millions across the world. This is the verdict of one of the researchers on a research paper, which suggests that omega-3 might reduce childrens risk of type 1 diabetes. The research, published in the European Association for the Study of Diabetes (EASD), was carried out at the National Institute of Health and Welfare, Helsinki. It scrutinised whether serum fatty acid levels during childhood are linked to the development of autoimmunity among children at increased genetic risk of developing type 1 diabetes. Specifically, researchers scrutinised whether high levels of omega-3 polyunsaturated fatty acids curtailed the risk of autoimmune responses associated with type 1 diabetes. Prior to this research, it was thought that fatty acids could play a role in the development of type 1 diabetes-associated autoimmunity, as they had shown to modulate the immune system and inflammatory reactions. Nearly 8,000 children predisposed to type 1 diabetes tested In total, 7,782 children predisposed to type 1 diabetes were recruited between 1997 and 2004. The children were monitored for islet autoimmunity and blood samples were taken at regular intervals up to the age of 15. The study found that fatty acids may play a role in the development of type 1 diabetes and that fish-derived fatty acids may be protective, particularly during infancy, against the disease. In particular, the results revealed that higher serum levels of fish-derived fatty acids were linked with a lower risk of early autoimmunity. Continue reading >>

Can Omega-3 Prevent Type 1 Diabetes?

D.D. Family T1 Since 18 Aug 2006, now T2? aug 2010 Researchers are claiming that consuming omega-3, the fatty acids often found in fish oils, can prevent Type 1 diabetes in some children who are at high risk of developing the condition. Scientists in Colarado followed the diet of 1,770 young children between 1994 and 2006. They wanted to see if omega-3 could affect the development of auto-antibodies to the insulin-producing beta cells in children with an increased risk, such as a family history of Type 1 diabetes. It is being reported today that dietary intake of omega-3 can lower these childrens chances of developing the condition by around 55 per cent. Cathy Moulton, Care Advisor at Diabetes UK, said: This is an interesting new study. Diabetes UK recommends that people follow a healthy, balanced diet that includes portions of oily fish, such as tuna, mackeral and sardines - which are naturally rich in a variety of fatty acids and vitamin D - rather than taking additional supplements. More research needs to be done to find out how beneficial fish oil can be in reducing the risk of developing Type 1 diabetes. I am a Diabetes Daily Guide. You can ask me questions about how to use the forum. Feb 2010 6.2%, October 09 5.8%, July 09 5.4%, April 09 5.1%,Jan 09 5.7, July 08 5.2, March 08 5.4%,A1C 5.6% Jan 2008,A1C 5.4% Nov 2007, A1C 5.7% June 2007, A1c,5.2% March 2007, A1c 5.6% December 2006, A1c 13% September 2006 DX Aug 2006, bg67 A1c 22%......The past now For Pictures of the Leeds meet click here Omega-3 Polyunsaturated Fatty Acid Intake and Islet Autoimmunity in Children at Increased Risk for Type 1 Diabetes full text of this is free online. This appears to be the Colarado research they are talking about. As it was published some time ago I'm surprised it's being discuss Continue reading >>

Pilot Study On Omega-3 Fatty Acids In Type I Diabetes Mellitus.

Pilot study on omega-3 fatty acids in type I diabetes mellitus. Landgraf-Leurs MM, et al. Diabetes. 1990. Department of Internal Medicine, Innenstadt, University of Munich, Federal Republic of Germany. Patients with diabetes mellitus are prone to develop vascular complications. Because omega-3 polyunsaturated fatty acid (omega 3FA) intake has a potential protective effect on cardiovascular disease, we studied the influence of omega 3FA supplementation (5.4 g eicosapentaenoic acid and 2.3 g docosahexaenoic acid daily) for 4 wk in 13 well-controlled type I (insulin-dependent) diabetic subjects on a vascular risk profile. Each subject served as his/her own control in a pre- and post-omega 3FA-intake phase. In plasma and platelets, phospholipids eicosapentaenoic acid and docosahexaenoic acid increased at the expense of arachidonic acid and linoleic acid. There was no significant change in blood pressure and glycosylated proteins. Only small changes were noted in blood glucose levels and insulin dose. Side effects were not noted. Triglycerides decreased significantly in the first 14 days, and total cholesterol increased slightly, probably because of an elevation of high-density lipoprotein cholesterol, although low-density lipoprotein cholesterol remained unchanged. Platelet aggregation induced by low doses of ADP and collagen, which was higher in diabetic than nondiabetic subjects, decreased during omega 3FA intake to levels of healthy control subjects. Thromboxane production after ADP- and collagen-induced platelet aggregation decreased significantly. Thromboxane liberation during clotting of whole blood and urinary excretion of thromboxane were markedly lowered during omega 3FA supplementation. The results show that even short-term intake of omega 3FAs leads to beneficia Continue reading >>

Omega-3 Therapy May Help Reverse Type 1 Diabetes: Study - Global Times

Omega-3 therapy may help reverse type 1 diabetes: study Source:Xinhua Published: 2017/4/5 8:10:39 Chinese researchers said Tuesday they have developed a gene therapeutic approach that may allow the body to produce enough omega-3 fatty acids to reverse the onset of type 1 diabetes. The work, led by Professor Allan Zhao of the Guangdong University of Technology and published in the Journal of Clinical Investigation, may offer the hope of curing this autoimmune condition that affects millions of children and young adults worldwide. Type 1 diabetes develops when the body is unable to produce insulin, a substance required to regulate blood sugar levels by moving glucose out of the blood and into cells to be used for energy. It is an autoimmune disease, where the body's immune system that normally protects against infections attacks and destroys the insulin-producing cells within the pancreatic islets. "For decades, scientists have tried to come up with a way to help the patients fight the autoimmunity and regenerate functional islets to completely cure diabetes," Zhao said. There are, however, currently no therapies that can successfully reverse the damage or progression of autoimmune attacks in type 1 diabetes, and patients have to inject insulin daily. Zhao's work was inspired by previous studies that those with a family history of type 1 diabetes who start an omega-3 fish oil supplement from infancy will have a significant reduction in the risk of developing the disease. They first tested the omega-3 therapy using mice to show that intervention with dietary supplementation of two fatty acids, known as EPA and DHA, does significantly reduce the incidence of type 1 diabetes. Then, they developed a gene-therapeutic technology that took advantage of a US Food and Drug Admini Continue reading >>

Fish Oil May Help With Diabetic Neuropathy

Omega-3 fatty acids in found to improved nerve damage in mice with type 1 and type 2… Approximately 50 percent of patients with diabetes suffer from nerve damage, or neuropathy. No cure exists, and the most effective treatment, keeping blood sugar in control, only slows neuropathy. But a new study shows that fish oil supplements can restore the condition of nerves damaged from diabetes in mice. “Diabetic neuropathy is a very costly and debilitating complication of diabetes. It is the leading cause of foot ulcers and nontrauma-related amputations, and the impact of diabetic neuropathy on the patient and family are unmeasurable,” said Mark Yorek of the VA Medical Center in Iowa City, the study’s lead investigator. Fish oil is an attractive treatment approach because “supplements are considered very safe and could be easily translated into everyday care. Fish oil would be easy to take, like a vitamin, and should have few side effects when combined with other medications,” explained Yorek. Previous studies of obesity and diabetes have reported better blood sugar handling, liver function and reduced inflammation with omega-3 fatty acids treatment. The health benefits were attributed to protective molecules produced from omega-3 fatty acids, including one type called resolvins. The research group had previously observed that diets enriched with omega-3 fatty acids from fish oil improved diabetic neuropathy in mice with type 1 and type 2 diabetes, and in this new study they examined why. Researchers used a mouse model of diabetes to study the effect of fish oil. Diabetic mice were fed a high-fat diet and treated with daily injections of resolvin or given a high-fat diet in which half the fat came from fish oil. The results were compared to healthy, non-diabetic mic Continue reading >>

Diabetes, Type 1

What is type 1 diabetes? Type 1 diabetes is an autoimmune disorder that accounts for five to 10 percent of all cases of diabetes. It initially develops most often in children and young adults. With type 1 diabetes, the pancreas produces little or no insulin, the hormone needed to transport glucose into cells where it can be converted into energy. For this reason, if you have type 1 diabetes you will need to take insulin daily throughout your life. This form of diabetes has also been called juvenile or insulin-dependent diabetes. What are the symptoms? Some of the symptoms of diabetes, such as persistent thirst or irritability, can seem relatively benign, which is one of the reasons why diagnosis may be delayed. With type 1 diabetes, however, symptoms may come on suddenly. Early detection and treatment can decrease the odds of developing the acute complications that can stem from type 1 diabetes. Common symptoms of diabetes include: Frequent urination Excessive thirst Extreme hunger Unusual weight loss Increased fatigue Irritability Blurry vision If high blood sugar levels are not brought quickly under control via treatment, acute complications of type 1 diabetes include severe dehydration and development of diabetic ketoacidosis. This is a metabolic state characterized by high concentrations of ketone bodies, which are byproducts of fatty acid breakdown, and can render the body’s tissues dangerously acidic. Symptoms of diabetic ketoacidosis include nausea, vomiting and abdominal pain, which in turn can lead to shock, coma, and even death. Longer term complications of type 1 diabetes – which are also common to those with type 2 diabetes – include: Eye damage: People with diabetes have a 40 percent higher than normal risk of developing glaucoma, increased pressure w Continue reading >>

Omega-3s Could Present Novel Treatment For Type 1 Diabetes

Omega-3s Could Present Novel Treatment for Type 1 Diabetes Omega-3 supplementation could lead to beta cell regeneration. In the United States alone, approximately 1.25 million adults have been diagnosed with type 1 diabetes. The condition is characterized by an immune attack on the bodys own insulin-producing beta cells, which results in a build-up of glucose in the blood. The cause of type 1 diabetes is unknown, and there currently are no cures. While insulin can be effective in managing the condition, researchers have been searching for a way to inhibit the immune system from killing beta cells or finding a way to reverse the process. A new study published by The Journal of Clinical Investigation found that adding omega-3 fatty acids to mice models of type 1 diabetes was effective. Omega-3s are polyunsaturated fatty acids found in fish, seafood, vegetable oils, and supplements. Multiple studies have shown that the fatty acids can protect against cardiovascular events and dementia. They are also crucial for organ function, and can improve muscle activity, reduce blood clots, and aid digestion and cell growth. Since omega-3s can stop inflammation, the authors of the current study investigated whether they could also prevent or reduce disease activity. Non-obese diabetic mice were either fed a regular diet or a diet enriched with polyunsaturated fatty acids. The authors also increased omega-3 levels through genetic modification. Every 3 months, the mice were tested for glucose and insulin tolerance and insulin serum. Mice were also examined for insulitis, which is the infiltration of immune cells to the pancreas, and is common among patients with type 1 diabetes. The authors discovered that mice fed the enriched diet showed significant improvement in the metabolism of g Continue reading >>

Omega-3 Linked To Lower Risk Of Type 1 Diabetes Risk, Says Study

Omega-3 linked to lower risk of type 1 diabetes risk, says study Omega-3 linked to lower risk of type 1 diabetes risk, says study Adolescents with good type 1 diabetes control have better long-term health outcomes 02 May 2017 A link between omega-3 consumption through breast milk and lower cases of type 1 diabetes has been found in a new study. Researchers from Finland believe breastfeeding mothers who consume omega-3, a polyunsaturated fatty acid, could reduce the risk of their newborn babies developing type 1 diabetes . Commonly found in fish, nuts , vegetable oils as well as leafy vegetables, omega-3 fats have been subject to much research in recent decades. In this new study, scientists from the National Institute of Health and Welfare based in Helsinki wanted to explore whether high levels of omega-3 was associated with autoimmunity development. They looked at almost 8,000 infants aged between 3-24 months who were deemed to be genetically at risk of type 1 diabetes. Blood samples were taken regularly until the age of 15 to measure islet cell (pancreatic beta cell) autoantibodies. The researchers also tracked the use of breastfed milk and formula, the two main sources of fatty acids for infants. They found that higher levels of omega-3 fatty acids correlated with a lower risk of insulin autoimmunity, adding that omega-3 consumption could offer protective qualities against type 1 diabetes during infancy. A link was also observed between fatty acids and the type of milk infants were fed, with the research team suggesting that "the quantity of breast milk consumed per day was inversely associated with primary insulin autoimmunity, while the quantity of cows milk consumed per day was directly associated". The study team believes that the fatty acids consumed during bre Continue reading >>

Omega-3 Fatty Acids Shown To Reverse Islet Autoimmunity In Mice

Omega-3 fatty acids shown to reverse islet autoimmunity in mice Omega-3 fatty acids shown to reverse islet autoimmunity in mice Newer oral treatments show risk-reduction benefits for people with type 2 diabetes 30 March 2017 A new study has shown that sufficiently high intakes of omega-3 polyunsaturated fatty acids (PUFAs) might stop the body's immune system from attacking its own beta cells and even reverse this process. Previous research found that dietary intake of omega-3s, as found in oily fish and fish oil, is associated with a reduced risk of developing islet autoimmunity in children at increased genetic risk for type 1 diabetes. Here, researchers at the Guangdong University of Technology, in China, tested whether higher levels of omega-3s could stop the progression of islet autoimmunity from escalating to type 1 diabetes. They supplemented young mice with high levels of the omega-3s eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) for 35 weeks. In addition to that, they also increased the levels of omega-3s in these mice by way of a genetic modification that spontaneously convert certain substrates, like the omega-6 arachidonic acid (AA), into EPA. Researchers compared these mice to two other groups of mice: one fed a regular diet and another given a diet supplemented with high levels of AA. Looking at the mice's nonfasting blood sugar levels between groups, 80 per cent or more of the mice either on the regular or high omega-6 diet went onto developing type 1 diabetes . In contrast, only 33 per cent of the mice fed an EPA/DHA-enriched diet did. Another notable finding is that the DHA plus EPA group had a significantly reduced incidence of insulitis compared to mice on the AA or regular diet. Insulitis is where islet cells in the pancreas get infiltrat Continue reading >>

Omega-3 Therapy May Help Reverse Type 1 Diabetes: Study

Omega-3 therapy may help reverse type 1 diabetes: study Source: Xinhua| 2017-04-05 04:56:46|Editor: Mu Xuequan WASHINGTON, April 4 (Xinhua) -- Chinese researchers said Tuesday they have developed a gene therapeutic approach that may allow the body to produce enough omega-3 fatty acids to reverse the onset of type 1 diabetes. The work, led by Professor Allan Zhao of the Guangdong University of Technology and published in the Journal of Clinical Investigation, may offer the hope of curing this autoimmune condition that affects millions of children and young adults worldwide. Type 1 diabetes develops when the body is unable to produce insulin, a substance required to regulate blood sugar levels by moving glucose out of the blood and into cells to be used for energy. It is an autoimmune disease, where the body's immune system that normally protects against infections attacks and destroys the insulin-producing cells within the pancreatic islets. "For decades, scientists have tried to come up with a way to help the patients fight the autoimmunity and regenerate functional islets to completely cure diabetes," Zhao said. There are, however, currently no therapies that can successfully reverse the damage or progression of autoimmune attacks in type 1 diabetes, and patients have to inject insulin daily. Zhao's work was inspired by previous studies that those with a family history of type 1 diabetes who start an omega-3 fish oil supplement from infancy will have a significant reduction in the risk of developing the disease. They first tested the omega-3 therapy using mice to show that intervention with dietary supplementation of two fatty acids, known as EPA and DHA, does significantly reduce the incidence of type 1 diabetes. Then, they developed a gene-therapeutic technology tha Continue reading >>

Omega-3s Guard Against Type 1 Diabetes

Yahoo!-ABC News Network | 2018 ABC News Internet Ventures. All rights reserved. TUESDAY, Sept. 25 (HealthDay News) -- Youngsters at high risk for developing type 1 diabetes might be able to prevent the disease by eating foods rich in omega-3 fatty acids, a new study suggests. Reporting in the Sept. 26 issue of the Journal of the American Medical Association, researchers from the University of Colorado found that high-risk children with the highest omega-3 intake had up to a 55 percent reduced risk of type 1 diabetes. "The kids with more omega-3 in their diets were about half as likely to develop type 1 diabetes than those with less," said study author Jill Norris, a professor in the department of preventive medicine and biometrics at the Barbara David Center for Childhood Diabetes at the University of Colorado at Denver and Health Sciences Center. Omega-3 fatty acids are found in fish, walnuts and certain plant oils, such as canola and olive. Omega-3 fatty acids have anti-inflammatory properties and are believed to help reduce the incidence of heart disease. Type 1 diabetes is an autoimmune disease in which the body mistakenly attacks the islet cells in the pancreas. Insulin, which regulates blood sugar levels, is produced by the islet cells. In past research, scientists discovered that Norwegian children who were regularly given cod liver oil supplements, which are rich in omega-3 fatty acids and vitamin D, had a lower incidence of type 1 diabetes. It wasn't clear, however, whether the vitamin D or the omega-3 was responsible for the reduced risk. To assess the affect of omega-3 and omega-6 fatty acids on the risk of type 1 diabetes, Norris and her colleagues recruited 1,770 children who were at high risk for developing type 1 diabetes, either because they had a famil Continue reading >>

Could Fish Oil Help T1d Complications? | Type 1 Diabetes Blog - Jdrf Australia

Published on May 12, 2015 By JDRF Australia Researchers from the US have found that taking fish oil every day was able to slow the development of T1D-related nerve damage in mice, and even reversed the damage that had already occurred. In the study, mice had their insulin-producing beta cells chemically destroyed to model type 1 diabetes, and were divided into different dietary groups. The first group were fed a standard diet for 16 weeks to see how neuropathy, or nerve damage, normally develops. The next group were fed a diet supplemented with fish oil immediately after the onset of diabetes, and continued for the entire 16 weeks to see how much of the neuropathy could be prevented. The third group were fed a standard diet for 8 weeks, followed by the fish oil diet for the remaining 8 weeks to see if the neuropathy that developed during the first 8 weeks could be reversed. The diabetic mice fed a standard diet had significant nerve damage such as slow nerve conduction, a reduced ability to feel heat pain, and poor sensitivity of the skin and cornea. These complications were prevented to a large extent in the mice that were fed the fish oil for 16 weeks, and began to be reversed in mice that were fed the fish oil after neuropathy had already developed. The fish oil had no effect on blood glucose control. Neuropathy is shown to affect around 60-70% of people with diabetes at some point in their lives ( reference ). Tight glucose control can help slow or delay the development of neuropathy, but this can be difficult to achieve and cannot prevent neuropathy completely. This study has shown that simply taking fish oil may be able slow or reverse the development of neuropathy. The next steps for this research will be to further investigate the benefits of fish oil in preven Continue reading >>

Cod Liver Oil Reduces Risk For Type 1 Diabetes

Home / Resources / Articles / Cod Liver Oil Reduces Risk for Type 1 Diabetes Cod Liver Oil Reduces Risk for Type 1 Diabetes Taking cod liver oil early in life appears to reduce the chances that children will develop insulin-dependent (type 1) diabetes, by 26%, researchers report. The protection may possibly come from the anti-inflammatory effects of long-chain n-3 fatty acids found in cod liver oil. "In Norway, cod liver oil is an important source of dietary vitamin D and the long-chain n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)," according to Dr. Lars C. Stene, of the Norwegian Institute of Public Health, in Oslo, and colleagues. All these nutrients "have biological properties of potential relevance for the prevention of type 1 diabetes.". The researchers looked to see if intake of dietary cod liver oil by mothers or by children during their first year of life was tied to a lower risk of type 1 diabetes among children. The nationwide study in Norway included 545 cases of childhood-onset type 1 diabetes and 1668 control subjects. Families completed questionnaires on the use of cod liver oil, other vitamin D supplements, and other factors. The team found that the use of cod liver oil in the first year of life reduced the risk of diabetes by 26 percent. No such effect was found with the use of other vitamin D supplements life or with maternal intake of cod liver oil or other vitamin D supplements during pregnancy. These results point to the fatty acids EPA and DHA as the beneficial components. "These fatty acids may influence gene expression, have anti-inflammatory effects, and have been shown to be relevant in the prevention and treatment of several chronic diseases," Stene and colleagues write. They hope to repeat the findings in childre Continue reading >>