[use Of Metformin (siofor) In Patients With Gout And Insulin Resistance (pilot 6-month Results)].
Abstract AIM: To evaluate metformin efficacy and safety in patients with gout and insulin resistance (IR). MATERIAL AND METHODS: The trial included 26 patients with gout (criteria of the American collage of rheumatologists) and IR (index HOMA). The inclusion criteria were the following: absence of antigout therapy, normal hepatic and renal function, rejection of alcohol. The drug dose was 1500 mg/day. The study was made of anthropometric and clinical characteristics, 24-h blood pressure monitoring, blood tests for uric acid, glucose, insulin, urea, creatinin, alaninaminotransferase, aspartataminotransferase, lipid spectrum at the first and further visits. RESULTS: A 6-month metformin therapy significantly changed the levels of glucose, insulin, HDLP and LDLP cholesterol, uric acid, HOMA index. Normouricemia was achieved in 11 patients, a significant lowering of uric acid--in 12 patients. The number of affected joints in 23 patients reduced from 4 (1-5) to 1 (0-2), p < 0.01. Seven patients with achieved normouricemia had no arthritis attacks. In 3 of 10 patients with chronic arthritis joint inflammation persisted. Six patients had dyspepsia during the first week of therapy, 1 patient discontinued the drug because of persistent diarrhea. CONCLUSION: Metformin therapy is safe. It reduces IR. The principal result of the study was lowering of uric acid and attenuation of the articular syndrome. Continue reading >>
Have High Uric Acid ( Value= 8) Since Dec'12 , While The Fasting, Pp Values Are Under Control. Request Suggestions To Avoid Medicine
Have been on metformin for 8 years ( 500mg tablet after Breakfast and repeat after dinner) Started Ecospirin AV 75mg given family history of CAD Metformin is an oral diabetes medicine that helps control blood sugar levels. Metformin is for people with type 2 diabetes. Metformin is sometimes used in combination with insulin or other medications, but it is not for treating type 1 diabetes. This is a side effect of your drug which has resulted in high uric acid levels. Ask your doctor for any other alternative which is suitable as per your diabetic history . for lowering Uric Acid levels you may take chandraprabhavati tablets 3 times a days and also take Sansamani vati or Giloy Ghanvati . This will also helpful to you in lowering suger level. take sansamni vati with with cold water (Avoid refrigerator water) . Monitor your diabetes regularly. Continue reading >>
Effects Of Combined Resveratrol Plus Metformin Therapy In Db/db Diabetic Mice
1CINDETEC A.C. Avenida Jurica, Industrial Park Querétaro, Querétaro, México 2Faculty of Pharmacy, Autonomous University of the State of Morelos, Cuernavaca, Morelos, México 3Nucitec, S. A. de C. V. Avenida Jurica, Industrial Park Querétaro, Querétaro, México Citation: Ángel DVM, Antonieta GSM, Rocio GC, Jorge RE, Rosado JL, et al. (2016) Effects of Combined Resveratrol Plus Metformin Therapy in db/db Diabetic Mice. J Metabolic Synd 5: 217. doi: 10.4172/2167-0943.1000217 Copyright: ©2016 Ángel DVM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Visit for more related articles at Journal of Metabolic Syndrome Abstract Background: The worldwide prevalence of Type 2 diabetes mellitus is associated with other conditions that trigger metabolic syndrome. Although several studies on the benefits of resveratrol have been carried out, few have assessed this drug in combination with metformin. Objectives: This study looks at the effects that combined metformin/resveratrol therapy has on body weight gain and liver and renal damage of db/db diabetic mice. It also addresses biochemical findings. Method: Diabetic mice were treated with resveratrol (20 mg/kg/day), metformin (150 mg/kg/day) and combined metformin/resveratrol therapy for 5 weeks. Histopathological tissue analyses and biochemical parameters (glucose, insulin, triglycerides and cholesterol), functional liver enzymes (AP, AST and GGT) and renal parameters (urea and uric acid) were examined. Results: Our data clearly showed that combined metformin/resveratrol treatment reduced obesity, glucose and triglyceride levels, as w Continue reading >>
- Effects of resveratrol on glucose control and insulin sensitivity in subjects with type 2 diabetes: systematic review and meta-analysis
- Effects of resveratrol on glucose control and insulin sensitivity in subjects with type 2 diabetes: systematic review and meta-analysis
- Type 1 diabetes cured in mice using gene therapy
Metformin And Blood Uric Acid Increased - From Fda Reports
Blood uric acid increased is found among people who take Metformin, especially for people who are male, 60+ old , have been taking the drug for 1 - 2 years, also take medication Allopurinol, and have High blood pressure. This review analyzes which people have Blood uric acid increased with Metformin. It is created by eHealthMe based on reports of 199,020 people who have side effects when taking Metformin from FDA , and is updated regularly. What to expect? If you take Metformin and have Blood uric acid increased, find out what symptoms you could have in 1 year or longer. You are not alone! Join a support group for people who take Metformin and have Blood uric acid increased Personalized health information On eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA since 1977. Our tools are simple to use, anonymous and free. Start now >>> * Approximation only. Some reports may have incomplete information. Continue reading >>
[effect Of Metformin On The Clinical Course Of Gout And Insulin Resistance].
Abstract The aim of this prospective study was to evaluate results of metformin (MF) therapy during 1 year of uric acid (UA) metabolism and the clinical course of gout with insulin resistance (IR). The study included 30 patients (28 men and 2 women) of mean age 51 yr and duration of he disease 4-11 yr. IR was diagnosed based on the HOMA index. INCLUSION CRITERIA: the absence of anti-gout therapy, normal renal and hepatic function, abstinence. The patients were given 1500 mg MF/day. The measured parameters included anthropometric and clinical characteristics, 24 hour AP, plasma UA, glucose, insulin, urea, creatinine, ALT, AST, lipid spectrum at the first and subsequent visits. UA clearance and excreted UA fraction were calculated. UA level decreased from 569 +/- 109.5 to 442.8 +/-107.4 mcmol/l (p < 0.01) after 12 months of MF therapy. Normouricemia ( < 360 mcmol/l) was achieved in 11 patients. Fasting insulin level dropped by 35% (from 23.9 to 15.9 mcU/ml, p < 0.01), HOMA index from 6.5 to 3. 7(p < 0.01). Serum glucose, cholesterol, triglycerides, and LDL cholesterol decreased while HDL cholesterol increased. Parameters of renal UA regulation and anthropometry remained unaltered. MF therapy resulted in a decrease of serum UA, insulin, and the degree of IR. The hypouricemic effect of MF was unrelated to renal UA excretion, reduced AP and body weight. It is hypothesized that MF reduces production of UA in patients with gout due to inhibition of synthesis of free fatty acids. Continue reading >>
Gout A Painful Form Of Arthritis
MAYO CLINIC HEALTH LETTER Gout is a form of arthritis that causes sudden, severe attacks of pain, tender- ness, redness, warmth and swelling in joints. It usually affects one joint at a time â€” typically the large joint of the big toe â€” and often at night. You may go to bed feeling fine, but then wake up in the middle of the night feeling like your big toe is on fire. The pain is so bad that you canâ€™t even have a bed sheet covering it. Gout can also affect your ankles, knees, hands and wrists. Some people have just one attack of gout and never have another. Others have recurring attacks and may be at risk of additional problems. Medications and lifestyle changes can usually reduce or eliminate the attacks. Diet is only one factor Gout is caused by excess uric acid in the blood and tissues. Uric acid is a waste product that results from the breakdown of purines. The main source of uric acid is the breakdown of your bodyâ€™s naturally occurring purines. But purines may also come from your diet. Gout was once known as the disease of kings because of its association with a diet rich in meat, seafood and alcohol â€” foods high in purines. However, anyone can get gout, and diet is only one factor. Why some people develop gout and others donâ€™t is unclear, but its prevalence has been increasing over the last few decades, affecting more than 8 million Americans. The rise of conditions that often accompany gout â€” such as high blood pressure, obesity, diabetes, metabolic syndrome and Reliable Information for a Healthier Life Gout is a form of arthritis that causes sudden and severe attacks of pain, tenderness, redness, warmth and swelling in joints. Coming in May EYE REDNESS Beyond antibiotic eyedrops. ENDOMETRIAL CANCER Early signs can Continue reading >>
About This Factmed Analysis Covering Adverse Side Effect Reports Of Metformin Hydrochloride Patients Who Developed Gout.
FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. The below report offers compiled information from Food & Drug Administration and FactMed user submissions. Between January 2004 and October 2012, 23 individuals taking METFORMIN HYDROCHLORIDE reported GOUT to the FDA. A total of 8028 METFORMIN HYDROCHLORIDE drug adverse event reaction reports were made with the FDA during this time period. Often the FDA only receives reports of the most critical and severe cases; these numbers may therefore underrepresent the complication rate of the medication. Toxic Arthritis Food List Limit these foods to decrease arthritis pain and inflammation. naturalhealthreports.net Introduction This page is designed to help you determine the relationship, if any, between METFORMIN HYDROCHLORIDE and GOUT. In doing so, we compare METFORMIN HYDROCHLORIDE with other drugs that cause GOUT, to help you evaluate whether or not METFORMIN HYDROCHLORIDE causes GOUT. Likewise, this page shows the most highly-reported side effects of METFORMIN HYDROCHLORIDE, so you can see if GOUT ranks among METFORMIN HYDROCHLORIDE's most well-known side effects. Summary Statistics Reports of METFORMIN HYDROCHLORIDE causing GOUT: 23 Reports of any side effect of METFORMIN HYDROCHLORIDE : 8028 Percentage of METFORMIN HYDROCHLORIDE patients where GOUT is a reported side effect: 0.2865% FDA reports of any drug causing GOUT : 4844 Average percentage for all medicated patients where GOUT is reported as a complication: 0.0304% Overall opinion for all reports of this drug: In addition to reviewing our up-to-date FDA research, users may interact with the FactMed community - currently one million members Continue reading >>
Gout: Never Have An Attack Again
Gout is a condition that commonly effects both men and women as they age, especially this time of year during the holidays when we all tend to over-indulge in rich foods and alcohol. And now the good news: you never have to suffer from gout again. What it is, and how your other doctor treats it Gout is the deposition of uric acid crystals in joints, most commonly the big toe, and can be debilitating due to the extreme pain it can cause. Uric acid is a breakdown product of purines (see below for the list of foods that contain high levels) and is broken down by an enzyme called xanthine oxidase. Allopurinol is a typical drug used in the treatment of gout as it blocks the action of xanthine oxidase, thereby decreasing the amount of uric acid crystals being produced. NSAID’s are often used for pain management, as is colchicine, for their anti-inflammatory effects. How you can treat it, naturally Even if you do some of the following, you will decrease the severity and frequency of your attacks. Lifestyle Lose some weight and improve your blood pressure – hyperuricemia (elevated levels of uric acid in blood) is associated with abdominal obesity and hypertension Improve your blood lipid and glucose levels- hyperuricemia is also associated with dyslipidemia and insulin resistance. If you’re on a lipid medication (most commonly a statin), or a prescription for type II diabetes (most commonly metformin), then there’s work to be done Diet Increase water intake – not only will this decrease uric acid levels, but it will help with your blood pressure as well Increase consumption of cherries or unsweetened cherry juice – consuming the equivalent 6 cups of cherries daily can reduce your uric acid levels to normal in 3 months Eliminate alcohol – this does not go over well Continue reading >>
Gout And Diabetes
Tweet Gout is a form of arthritis (inflammation of joints) caused by high levels of uric acid. Gout can be a painful condition but one that can be managed to reduce the frequency at which gout attacks occur. Gout is known to affect around 1 in 100 people in the UK and is around four times more common in men than in women. Research shows that people with gout are significantly more likely to develop type 2 diabetes than people without gout. Gout and diabetes A number of research papers have shown associations between gout and type 2 diabetes including a study from Harvard Medical School, published in 2014, which showed gout to be associated with a 70 increased risk of developing type 2 diabetes. A common medication for treating gout, allopurinol, has shown promise for reducing thickening of heart muscle and is currently undergoing testing as a possible medication for reducing risk of diabetic nephropathy (kidney disease). Symptoms of gout Gout is characterised by swelling of joints. The base of the big toe is most commonly affected by gout. More than one joint may be affected by gout in some people. Symptoms can come on quickly, with swelling occurring within a few hours. The swollen joint can be very painful and sensitive to touch. During swelling, skin covering the joint may typically turn red and shiny in appearance. The swelling and symptoms may occur for several days if not treated. Once the inflammation has subsided, the skin on the joint may become itchy and flaky. Causes of gout Gout occurs if high levels of uric acid in the blood leads to crystals of sodium urate forming in and around the joints. If these crystals spill into the joint space, this can cause the joint to become inflamed. Risk factors High levels of uric acid are more likely to build if you have an Continue reading >>
Hypoglycemia And Reduced Feed Intake In Broiler Chickens Treated With Metformin
C. M. Ashwell1 and J. P. McMurtry Growth Biology Laboratory, USDA-ARS, 10300 Baltimore Ave., Beltsville, Maryland 20705 ABSTRACT The bi-guanide metformin is used to treat noninsulin dependent diabetes in obese patients. In addi- tion to having antihyperglycemic effects, metformin is also anorectic and reduces BW. These studies were per- formed to determine if metformin possesses similar prop- erties in chickens. Metformin-HCl was administered to 14-day-old broiler chickens at either 300 or 600 mg/kg per day in the drinking water for 10 d while monitoring BW and feed intake. No changes in water intake were observed, while feed intake and daily gains were only significantly reduced by the 600 mg/kg dose. After oral administration of a single dose of 300 mg/kg metformin- HCl, feed intake was significantly reduced by 4 h and remained suppressed for greater than 24 h relative to (Key words: metformin, appetite, hypoglycemia, insulin, glucagons) 2003 Poultry Science 82:106â€“110 INTRODUCTION Metformin-HCl (Glucophage, Bristol-Meyers Squibb) is regarded as the first choice for therapy of type 2 diabetes that is generally characterized by insulin resistance or specifically obese patients with hyperinsulinaemia (Bray, 1999; Cusi and DeFronzo, 1998). By reducing blood glu- cose without inducing hypoglycemia and further hyper- insulinaemia, as well as reducing feed intake, metformin- HCl provides a suitable antidiabetic treatment (Lee and Morley, 1998; Rouru et al., 1992). Complications can occur with metformin-HCl induction of lactic acidosis (Stum- voll et al., 1995). High levels of fasting blood glucose, insulin resistance, and obesity are not just hallmarks of type 2 diabetes but are also normal physiologic conditions for chickens (Simon, 1989). The regulation of feed int Continue reading >>
The Effect Of A One-year Weight Reduction Program On Serum Uric Acid In Overweight/obese Children And Adolescents.
Abstract Hyperuricemia may underlie obesity and related disorders, but the impact of weight reduction and metformin on serum uric acid (sUA) in Caucasian children/adolescents is unknown.One hundred and thirteen children/adolescents were enrolled (83 completed) into 1-year weight reduction program (diet+exercise) without or with metformin. Anthropometric and biochemical measurements were conducted at baseline and at the end of follow-up (13 ± 3 months).sUA decreased in 86% females and 67% males. Significantly more patients substantially (≥ 10%) reduced their sUA than body mass index (BMI)%. In females, sUA decreased regardless of type of intervention, but more markedly in the metformin group, and ΔsUA correlated positively with ΔBMI%, ΔWHtR (waist-to-height ratio), Δinsulin, ΔHOMA (homeostasis model of assessment), and Δtriglycerides/high density lipoprotein (HDL), but correlated negatively with baseline sUA, HOMA, insulin, and triglycerides/HDL. Of these, metformin treatment, baseline sUA, and ΔBMI% were independent predictors of sUA reduction, explaining 77% of data variability. In males, sUA reduction was significant in the metformin group only, and negatively correlated with ΔWHR (waist-to-hip ratio), ΔWHtR, Δleptin, baseline sUA, and waist circumference. Of these, baseline sUA and ΔBMI% were independent predictors of sUA reduction, explaining 69% of data variability. Except for sUA, females reduced their BMI%, waist circumference, triglycerides, triglycerides/HDL and increased HDL, while males reduced total cholesterol.A longitudinal weight reduction program encompassing diet/exercise with or without metformin was more efficient in reducing sUA than weight and its effect on sUA and other metabolic parameters differed between genders. Weight loss did no Continue reading >>
- Sugar, Uric Acid, and the Etiology of Diabetes and Obesity
- Disparities in Diabetes Deaths Among Children and Adolescents United States, 20002014
- Early Glycemic Control and Magnitude of HbA1c Reduction Predict Cardiovascular Events and Mortality: Population-Based Cohort Study of 24,752 Metformin Initiators
Use Of Metformin (siofor®) In Patients With Gout And Insulin Resistance (pilot 6-month Results)
Abstract To evaluate metformin efficacy and safety in patients with gout and insulin resistance (IR). The trial included 26 patients with gout (criteria of the American collage of rheumatologists) and IR (index HOMA). The inclusion criteria were the following: absence of antigout therapy, normal hepatic and renal function, rejection of alcohol. The drug dose was 1500 mg/day. The study was made of anthropometric and clinical characteristics, 24-h blood pressure monitoring, blood tests for uric acid, glucose, insulin, urea, creatinin, alaninaminotransferase, aspartataminotransferase, lipid spectrum at the first and further visits. A 6-month metformin therapy significantly changed the levels of glucose, insulin, HDLP and LDLP cholesterol, uric acid, HOMA index. Normouricemia was achieved in 11 patients, a significant lowering of uric acid--in 12 patients. The number of affected joints in 23 patients reduced from 4 (1-5) to 1 (0-2), p < 0.01. Seven patients with achieved normouricemia had no arthritis attacks. In 3 of 10 patients with chronic arthritis joint inflammation persisted. Six patients had dyspepsia during the first week of therapy, 1 patient discontinued the drug because of persistent diarrhea. Metformin therapy is safe. It reduces IR. The principal result of the study was lowering of uric acid and attenuation of the articular syndrome. Continue reading >>
What Is It?
What Is It? Gout is a disorder characterized by too much uric acid in the blood and tissues. In gout, crystals of uric acid are deposited in the joints, where they cause a type of arthritis called gouty arthritis. These same crystals can also deposit in the kidneys, where they can cause kidney stones. There are three main causes of the high levels of uric acid that lead to gout: A diet rich in chemicals called purines, because purines are broken down by the body into uric acid. Foods that contain high levels of purines include anchovies; nuts; and organ foods such as liver, kidney and sweetbreads. High production of uric acid by the body. This can happen for unknown reasons. It can also occur in certain inherited genetic metabolic disorders, leukemia and during chemotherapy for cancer. The kidneys do not excrete enough uric acid. This can be caused by kidney disease, starvation and alcohol use, especially binge drinking. This also can occur in people taking medications called diuretics (such as hydrochlorothiazide or furosemide). Obesity or sudden weight gain can cause high uric acid levels because the body's tissues break down more purines. In some people, gout is caused by a combination of these factors. People with a family history of gout are more likely to develop the condition. About 90% of patients with gout are men older than 40. Gout is quite rare in younger women; when women develop gout, they are usually post-menopausal. Symptoms The first attack of gouty arthritis usually involves only one joint, most commonly the big toe. However, it can affect other joints, such as a knee, ankle, wrist, foot or finger. In gouty arthritis, the joint can become red, swollen and extremely tender to the touch. Typically, even a bed sheet brushing against the joint will trigger Continue reading >>
Address Correspondence To:
Hyperuricemia has been linked to metabolic syndrome, cardiovascular disease, and chronic kidney disease. Hyperuricemia and type 2 diabetes mellitus were inter-related, type 2 diabetes mellitus was more at risk of having a higher serum uric acid level, and also individuals with higher serum uric acid had higher risk of developing type 2 diabetes in the future. Insulin resistance seems to play an important role in the causal relationship between metabolic syndrome, type 2 diabetes, and hyperuricemia. Oral diabetic drugs that would have additional beneficial effects on reducing serum uric acid levels are of importance. Selective SGLT2 inhibitors were extensively studied in type 2 diabetes mellitus and were found to have improvement of glycemic control, in addition to their proven metabolic effects on weight and blood pressure. Additional beneficial effect of SGLT2 inhibitors on serum uric acid level reduction is investigated. Recently, data have been accumulating showing that they have additional beneficial effects on serum uric acid reduction. As for the postulated mechanism, serum uric acid decreased in SGLT2 inhibitor users as a result of the increase in the urinary excretion rate of uric acid, due to the inhibition of uric acid reabsorption mediated by the effect of the drug on the GLUT9 isoform 2, located at the collecting duct of the renal tubule. Continue reading >>
Physiology Of Insulin Resistance
In horses, there's little doubt that high-carbohydrate feeding influences the response to insulin, but it's more complicated than in people or other animals. The horse evolved without any sources of concentrated carbohydrate in its diet. When horses are grain fed, their responsiveness to an intravenous injection of insulin drops, i.e., less insulin sensitive, more insulin resistant — yet their ability to keep blood glucose in control is usually well preserved. Insulin Resistance (IR) in ponies was reported almost 40 years ago. IR in horses was recognized less than 15 years ago. However, a 1989 USDA-sponsored survey found that 13% of the owners and equine premises surveyed reported having laminitis problems in the prior 12 months. Laminitis was second only to colic as a reason for seeking veterinary care. Prior to IR and Equine Metabolic Syndrome coming into the limelight as the "disease du jour", it was very common for breeders involved with susceptible breeds to vehemently deny they had any laminitis problems or that there was a genetic link — but insiders knew otherwise. With insulin resistance, circulating levels of insulin are elevated but glucose stays normal. The cells are resistant to insulin's signal to take up glucose, but higher levels get the job done. Horses do not progress to be frankly diabetic as easily as other species do. Diabetes mellitus is when blood sugar is higher than normal. Glucose is the most important, and the most precious, fuel in the body. Every cell needs it, even the ones that can depend heavily on fat as an energy source. The capacity to store glucose in the tissues is low. To compensate for this, many pathways exist for converting other nutrients into glucose if need be. Many amino acids can be converted to glucose. The energy crisi Continue reading >>