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Doxycycline And Diabetes

Effects Of Long-term Doxycycline On Bone Quality And Strength In Diabetic Male Dba/2j Mice - Sciencedirect

Effects Of Long-term Doxycycline On Bone Quality And Strength In Diabetic Male Dba/2j Mice - Sciencedirect

Effects of long-term doxycycline on bone quality and strength in diabetic male DBA/2J mice In DBA/2J mice, diabetic bones have more slender femurs, thinner cortices, decreased trabecular bone, and reduced strength to bending. The diabetic bone phenotype in this model was not improved by doxycycline treatment. Long-term doxycycline exposure was not deleterious to the microarchitecture or biomechanical properties of healthy bone in male DBA/2J mice. In type 1 diabetes, diabetic bone disease (DBD) is characterized by decreased bone mineral density, a state of low bone turnover and an increased risk of fracture. Animal models of DBD demonstrate that acquired alterations in trabecular and cortical bone microarchitecture contribute to decreased bone strength in diabetes. With anti-collagenolytic and anti-inflammatory properties, tetracycline derivatives may prevent diabetes-related decreases in bone strength. To determine if doxycycline, a tetracycline class antibiotic, can prevent the development of DBD in a model of long-term diabetes, male DBA/2J mice, with or without diabetes, were treated with doxycycline-containing chow for 10weeks (dose range, 2892mg/kg/day). Long-term doxycycline exposure was not deleterious to the microarchitecture or biomechanical properties of healthy bones in male DBA/2J mice. Doxycycline treatment also did not prevent or alleviate the deleterious changes in trabecular microarchitecture, cortical structure, and biomechanical properties of bone induced by chronic diabetes. Continue reading >>

Doxycycline: Medlineplus Drug Information

Doxycycline: Medlineplus Drug Information

Doxycycline is used to treat infections caused by bacteria, including pneumonia and other respiratory tract infections; certain infections of the skin or eye; infections of the lymphatic, intestinal, genital, and urinary systems; and certain other infections that are spread by ticks, lice, mites, infected animals, or contaminated food and water. It is also used along with other medications to treat acne. Doxycycline is also used to treat or prevent anthrax (a serious infection that may be spread on purpose as part of a bioterror attack), in people who may have been exposed to anthrax in the air, and to treat plague and tuleramia (serious infections that may be spread on purpose as part of a bioterror attack). It is also used to prevent malaria. Doxycycline can also be used in people who cannot be treated with penicillin to treat certain types of food poisoning. Doxycycline (Oracea) is used only to treat pimples and bumps caused by rosacea (a skin disease that causes redness, flushing, and pimples on the face). Doxycycline is in a class of medications called tetracycline antibiotics. It works to treat infections by preventing the growth and spread of bacteria. It works to treat acne by killing the bacteria that infects pores and decreasing a certain natural oily substance that causes acne. It works to treat rosacea by decreasing the inflammation that causes this condition. Antibiotics such as doxycycline will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. Doxycycline comes as a capsule, delayed-release capsule, tablet, delayed-release tablet, and suspension (liquid) to take by mouth. Doxycycline is usually taken once or twice a day. Drink Continue reading >>

Low-dose Doxycycline May Slow Diabetic Retinopathy

Low-dose Doxycycline May Slow Diabetic Retinopathy

Low-Dose Doxycycline May Slow Diabetic Retinopathy Low-dose doxycycline could slow the progression of diabetic retinopathy (DR), according to a small proof-of concept study by a group of researchers in the United States and Denmark, published online March 6 in JAMA Ophthalmology. "To our knowledge, this is the first observation suggesting a link between a low-dose oral anti-inflammatory agent and subclinical improvement in inner retinal function," write Ingrid U. Scott, MD, MPH, from the Penn State Hershey Eye Center and the Department of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania, and colleagues. At this time, no established therapy exists to slow the progression of nonproliferative DR, the stage of retinopathy that affects most people with diabetes, according to Thomas Gardner, MD, professor of ophthalmology and visual sciences at the University of Michigan Medical School, Ann Arbor, and senior author of the article. Vascular endothelial growth factor inhibitors may slow progression of DR but are not widely used and require multiple intraocular injections. The idea in this study was that low-dose tetracycline could be used to suppress the neuroinflammatory component of DR, Dr. Gardner told Medscape Medical News. Tetracycline has been shown to reduce inflammation, although the exact mechanism is unclear. The study was a 24-month randomized, double-masked, clinical trial involving 30 participants from hospital-based retina clinics in Pennsylvania and Denmark. Participants received financial compensation and were recruited from October 1, 2008, to May 31, 2010. They had either type 1 or type 2 diabetes mellitus and 1 or more eyes affected by nonproliferative DR or non-high-risk proliferative DR, defined according to the Early Treatment Continue reading >>

Doxycycline Could Potentially Prevent Vision Loss In People Living With Type 1 Diabetes

Doxycycline Could Potentially Prevent Vision Loss In People Living With Type 1 Diabetes

Doxycycline Could Potentially Prevent Vision Loss in People Living With Type 1 Diabetes A JDRF-funded study may help to identify an inexpensive treatment for diabetic retinopathy as well as an early biomarker for this common diabetes complication It is estimated that 45 percent of Americans diagnosed with diabetes have some stage of diabetic retinopathy (DR), making it among the most prevalent complications of diabetes and a leading cause of adult blindness. Finding a way to prevent or delay development of DRa condition caused by changes in blood vessels in the retinais a major goal of JDRFs complications therapy research. A new clinical trial is providing hope that a common antibiotic may be useful in preventing this eye disease. The study published in the on-line first edition of JAMA Ophthalmology, was funded in part by a grant from the Penn State-JDRF Center for Mechanism and Intervention of Diabetic Retinopathy under the leadership of former director, Thomas Gardner, MD, MS. It looked at whether doxycycline, an inexpensive generic antibiotic, could delay or prevent deterioration of certain eye functions that may contribute to DR. Researchers at Penn State Hershey Eye Center and Denmarks Glostrup Hospital followed 30 type 1 diabetes (T1D) patients who were randomized into two groups: one receiving 50 mg of doxycycline daily and the other placebo (inert pills). By the end of the 24 month trial, half the patients receiving doxycycline experience improved sensitivity in their fovea a nerve-concentrated region of the retinabut none of the patients receiving placebo experienced this improvement. Projected Incidence of Diabetic Retinopathy (in millions) Chart Source: National Eye Institutewww.nei.nih.gov/eyedata/diabetic.asp#4 Investigators are uncertain how doxycycline Continue reading >>

Doxycycline - Diabetes In Dogs: The K9diabetes.com Forum

Doxycycline - Diabetes In Dogs: The K9diabetes.com Forum

Diabetes Discussion: Your Dog Anything related to your diabetic dog. Has anyone used Doxycycline for uti and experienced insulin sensitivity? Have used doxy and not seen any difference in bg. I have actually never heard of doxy being given for UTI? It is important with doxy not to give with ANY dairy as it negates the effect of the doxy. Just looked it up and it is given for UTI. Interesting as most vets give clavamox, simplicef, baytril etc. My dog started doxy on the 7th of this month. The next morning vomited 1 hr after insulin. He had hypo issues most of the day and could not have insulin at night. He has had vomiting 1 hr after insulin every day since.He took two doses only of doxy and is not on it currently.The problem still persists even though off doxy for 1 day.My vet is now taking him off insulin,just got off the phone with him. He does not think doxy is causing insulin problems but just in case he is off doxy too. Mile is enjoying the Hagen Daz vanilla ice cream and gluten free waffles and syrup for hypo issues. In regards to any antibiotic or medication,I have learned some do effect diabetes in regards to glucose but I have never heard of anything causing insulin sensitivity thus I thought I would see if anyone else has had a problem with doxy. Mile has Cushing's and other issues besides diabetes so he is a mighty warrior. He was doing pretty good until this happened. Although,he does love the ability to indulge in the treats to elevate glucose like Hagan Daz vanilla ice cream. Yes,hypos are scary and staying calm and monitoring with blood glucometer is Again,if anyone has any info on doxy issues please share. Last edited by Ann Renee L.; 01-11-2016 at 12:45 PM. Almost lost Mile tonight. Prayed for help. He was not responding to karo syrup for hypo-LOW read Continue reading >>

Low-dose Doxycycline Effective For Periodontitis In Diabetics

Low-dose Doxycycline Effective For Periodontitis In Diabetics

Home / Specialties / Periodontal / Low-Dose Doxycycline Effective for Periodontitis in Diabetics Low-Dose Doxycycline Effective for Periodontitis in Diabetics A subantimicrobial dose of doxycycline effectively controls periodontitis in diabetics, reducing A1c and resulting in a significant decrease in tooth pocket depth. At the 32nd annual meeting of the American Association of Dental Research in San Antonio, Texas, researchers reported that this treatment is actually more effective in diabetics than nondiabetics with periodontal disease. Dr. Sebastian G. Ciancio of the University of Buffalo presented results of a randomized placebo-controlled trial of 20 adult diabetics with stable blood glucose levels and generalized periodontitis. Half the patients received doxycycline 20 mg bid and the other half placebo bid for 12 weeks. All patients underwent scaling and root planing. Dr. Ciancio reported that not only did doxycycline therapy reduce tooth pocket depth by 1.7 mm, it also reduced glycated hemoglobin levels (HbA1c). Active treatment was 25% more effective in reducing pocket depth than was scaling and root planing alone, he added. In previous studies of nondiabetics with periodontitis, Dr. Ciancio said that sub-antimicrobial doses of doxycycline reduced tooth pocket depth by 0.4 mm. Periostat (doxycycline) achieved results that were 75% better in the diabetics than in nondiabetic patients. This dose of doxycycline inhibits collagenase and elastase, resulting in a strengthening of bone and connective tissue, Dr. Ciancio explained. But he stressed that the dose given in this study is not antibiotic. It is 20 mg per dose, and it must be given twice a day. Otherwise, you get into bacterial problems. Dr. Ciancio and his colleagues have been discussing the possible mechani Continue reading >>

Antibiotics And Insulin Sensitivity

Antibiotics And Insulin Sensitivity

Diabetes Forum The Global Diabetes Community This site uses cookies. By continuing to use this site, you are agreeing to our use of cookies. Learn More. Get the Diabetes Forum App for your phone - available on iOS and Android . Find support, ask questions and share your experiences. Join the community Has anyone noticed any change to their insulin requirements when on antibiotics? I am keen to know if anyone has noticed changes to their requirements / ratios when on antibiotics since I am seeing some odd results right now and would like to hear what other people have seen. Isn't it more likely to be the fact that you're got an infection that's doing it - infections make sugars more unpredictable (usually making them go up or have big spikes, from my experience). Personally I don't think the pills have got anything to do with it. Has anyone noticed any change to their insulin requirements when on antibiotics? I am keen to know if anyone has noticed changes to their requirements / ratios when on antibiotics since I am seeing some odd results right now and would like to hear what other people have seen. when you say 'odd'... what do you mean? Are you finding you had high bgs, adjusted insulin to that and then found yourself sudddenly going hypo? Or some other 'oddness' :wink: ? I did consider the fact that I was slightly ill. I've had a long running sinus issue and am on the second course of antibiotics. The thing I noticed is that before my levels were consistently high and didnt respond as you would expect to correction doses so I had to get very aggressive with correction. I never had ketones above 0.4 on the Optium meter so there was never a huge issue there. I would accept that my levels would come down and even out as I get better but I noticed the increased respons Continue reading >>

Doxycycline (oracea) - Side Effects, Dosage, Interactions - Drugs

Doxycycline (oracea) - Side Effects, Dosage, Interactions - Drugs

Doxycycline is an antibiotic used for treating bacterial infections. The drug is also sold under the brand names Oracea, Doryx, Monodox, Periostat, and Vibramycin. Doxycycline is in a class of medications called tetracyclines, and it's a broad-spectrum antibiotic, which means it works against a wide range of bacteria. Doctors prescribe doxycycline to prevent malaria and treat a wide range of infections, including: Pneumonia and other respiratory tract infections Infections involving the genitals and urinary tract infections (UTI) Doxycycline works by preventing the growth and spread of bacteria. Like all antibiotics , doxycycline will not treat colds, the flu , or other infections caused by viruses or fungi. A 2014 study found that a low dose of 40 milligrams (mg) of slow-release doxycycline daily could be an effective and safe therapy for ocular rosacea, or rosacea that affects the eyes. The drug company Pfizer developed doxycycline in the early 1960s, and the Food and Drug Administration (FDA) approved the drug in 1967 under the brand name Vibramycin. In 1994 the FDA also approved the drug to prevent malaria. For many years, doctors have prescribed doxycycline to treat acne. It's sometimes used as an alternative to another acne drug with more side effects, minocycline . However, a study published in 2015 found that people with acne who used an antibiotic-free facial gel had greatly improved acne, according to MedPage Today . The study suggests that using the facial gel containing adapalene /benzoyl peroxide might be a better alternative than using antibiotics such as doxycycline for acne. There are several important warnings you should know about before taking doxycycline. You should take this medication only to treat bacterial infections, and it's important to take Continue reading >>

Antibiotic Doxycycline

Antibiotic Doxycycline

D.D. Family Type 1 since 1976. Diagnosed at 2yrs. I was prescribed this antibiotic for a sinus infection yesterday. Due to illness, said infection and generally feeling rough, I was on a basal rate of 115-120%. The pharmacist said this drug could interact with Novorapid and cause possible hypo's. My thoughts, OK if anything can bring my numbers down because of this sickness I will be very impressed!! Took 2 tablets to start, then it's 1 every day thereafter, and within 40 minutes a hypo. Thought it quite coincidental to be honest. Within 8 hours I had gone from 120% basal to 105%. We shall see what tomorrow will bring. Just a heads up for anyone else who may be prescribed this antibiotic. It can drops your BG quite significantly and there is nothing in the literature in the box. Pumping with Accu-Chek Combo/Apidra and loving it!! Thanks for the warning, Gillian. I hope you get well soon, this seems to be one mean bug. D.D. Family Getting much harder to control I have been on that stuff a few times, I will have to see how that works next time. D.D. Family T1 for 54 years - on Pump since 03/2008 Hi & glad to hear you have some antibiotics. I never heard of those. Anyway - hope you start feeling better in a day or 2 D.D. Family Type 1 since 1976. Diagnosed at 2yrs. I had never heard of them until yesterday either. Things are still falling today and am about to switch to 100% or regular basal rate, bolus rates normal also. I know I am not making a miraculous recovery because I still feel pants! D.D. Family T2, trying to live a healthy life I didn't realize they used doxy for sinus, got a bottle on the shelf they gave me to treat possible lymne disease. Thing to watch out for with doxy is digestive issues, they can get really bad, really quick. Wife can't take doxy, causes Continue reading >>

Sub-antimicrobial Doxycycline For Periodontitis Reduces Hemoglobin A1c In Subjects With Type 2 Diabetes: A Pilot Study

Sub-antimicrobial Doxycycline For Periodontitis Reduces Hemoglobin A1c In Subjects With Type 2 Diabetes: A Pilot Study

Sub-antimicrobial Doxycycline for Periodontitis Reduces Hemoglobin A1c in Subjects with Type 2 Diabetes: a Pilot Study Department of Periodontology, Stony Brook University School of Dental Medicine, Stony Brook, NY, USA 11794 *Endocrine Care, Pfizer, Inc. New York, NYUSA 10017 Address correspondence to: Steven P. Engebretson, DMD, MS, MS Department of Periodontology 104 Rockland Hall Stony Brook University School of Dental Medicine Stony Brook, NY, 11794-8703 USA Tel: 1-631-632-9443 Fax: 1-631-632-3113 [email protected] The publisher's final edited version of this article is available at Pharmacol Res See other articles in PMC that cite the published article. In vitro and animal studies suggest a possible role for the tetracycline class of drugs in the inhibition of non-enzymatic protein glycation. We conducted a 3-month, randomized placebo-controlled pilot clinical trial of conventional sub-gingival debridement, (periodontal therapy) combined with either a three month regimen of sub-antimicrobial-dose doxycycline (SDD), a two week regimen of antimicrobial-dose doxycycline (ADD), or placebo in 45 patients with long-standing type 2 diabetes (mean duration 9 years) and untreated chronic periodontitis. Subjects were taking stable doses of oral hypoglycemic medications and/or insulin. Treatment response was assessed by measuring hemoglobin A1c (HbA1c),plasma glucose, and clinical periodontal disease measures. At one-month and three-month follow-up, clinical measures of periodontitis were decreased in all groups(data to be presented elsewhere). At three months, mean HbA1c levels in the SDD group were reduced 0.9% unitsfrom 7.2% units 2.2(SD), to 6.3% units 1.1, which represents a 12.5% improvement. In contrast, there was no significant change in HbA1c in the Continue reading >>

The Effect Of A Common Antibiotics Doxycycline On Non-healing Chronic Wound.

The Effect Of A Common Antibiotics Doxycycline On Non-healing Chronic Wound.

Curr Pharm Biotechnol. 2017;18(5):360-364. doi: 10.2174/1389201018666170519095339. The Effect of a Common Antibiotics Doxycycline on Non-Healing Chronic Wound. Department of Microbiology, Immunology & Pathology, Des Moines University, Des Moines, Iowa, 50312, United States. Department of Surgery, University of Missouri School of Medicine, Columbia, MO, 65212, United States. Department of Microbiology, Immunology & Pathology, Des Moines University College of Osteopathic Medicine, Des Moines 50312, Iowa, United States. Up to 25% of diabetic patients will develop a diabetic foot ulcer. Chronic wounds such as diabetic foot ulcers often fail to heal with conventional therapies. In recent years, it has been identified that chronic wounds are usually associated with elevated level of matrix metalloproteinases (MMPs). Doxycycline, a cheap tetracycline antibiotic, has been shown to inhibit MMPs both in vitro and in vivo independent of its antimicrobial property. We undertook a search through PUBMED for peer-reviewed research literature with doxycycline, chronic wound, diabetes, MMPs as key words. Seventy papers were included in the review. This review identified doxycycline is a very promising drug to be used in patients with diabetic foot ulcers because higher efficacy even in a very low dosage, little side effects in a lower dosage, inhibition of MMP as well as prevention/treatment of infection in the ulcers, beneficial to cardiovascular complications and cheap to manufacture. In this review, we provide an overview of the roles of MMPs in the pathogenesis of chronic wounds and explore the potential application of doxycycline as a treatment option in managing chronic wounds such as diabetic foot ulcers. Copyright Bentham Science Publishers; For any queries, please email at epu Continue reading >>

Doxycycline Type 2 Diabetes Mellitus Causes And Reviews

Doxycycline Type 2 Diabetes Mellitus Causes And Reviews

DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information. Doxycycline Type 2 Diabetes Mellitus Causes and Reviews Diabetes means your blood glucose, or blood sugar, levels are too high. With type 2 diabetes, the more common type, your body does not make or use insulin well. Insulin is a hormone that helps glucose get into your cells to give them energy. Without insulin, too much glucose stays in your blood. Over time, high blood glucose can lead to serious problems with your heart, eyes, kidneys, nerves, and gums and teeth. You have a higher risk of type 2 diabetes if you are older, have obesity, have a family history of diabetes, or do not exercise. Having prediabetes also increases your risk. Prediabetes means that your blood sugar is higher than normal but not high enough to be called diabetes. If you are at risk for type 2 diabetes, you may be able to delay or prevent developing it by making some lifestyle changes. The symptoms of type 2 diabetes appear slowly. Some people do not notice symptoms at all. The symptoms can include Blood tests can show if you have diabetes. One type of test, the A1C, can also check on how you are managing your diabetes. Many people can manage their diabetes through healthy eating, physical activity, and blood glucose testing. Some people also need to take diabetes medicines. NIH: National Institute of Diabetes and Digestive and Kidney Diseases Doxycycline Type 2 Diabetes Mellitus Reviews I was taking Doxycycline for meibomitis and a little over 2 weeks after I started I came ill with severe head pressure,tinnitus,chills,nausea,flulike symptoms and after 2 emergency room visits and 6 different doctors (who were trying to treat me for sinuses,unknown reactions,and migraines)I was finally told by my opthalmolo Continue reading >>

Mastery In Diabetes Management: Doxycycline Treatment For Insulin Resistance

Mastery In Diabetes Management: Doxycycline Treatment For Insulin Resistance

Erjola Balliu, MD Erjola Balliu, MD, of Stony Brook Hospital in New York, spoke with MedPage Today at ENDO 2017, the annual meeting of The Endocrine Society, where she reported finding that use of the antibiotic doxycycline was associated with improved fasting glucose when compared to placebo in a proof-of-concept study. Her full poster may be downloaded by clicking here. Following is a transcript of her remarks: Obesity is a state of inflammation and the inflammatory process may be contributing to the development of insulin resistance and the associated metabolic abnormalities such as dyslipidemia, diabetes, hypertension, and cardiovascular disease. We all know that obese individuals compared to normal weight individuals are four times more likely to develop diabetes, about two to four times more likely to develop heart disease, and about two times more likely to die from hypertension-related heart disease. So, it is very important to be able to reduce the prevalence of these health problems associated with obesity. In the past, there have been a lot of trials looking at medications to reduce inflammation, but they've had a lot of serious side effects. They've looked at pioglitazone, but that is associated with bone loss and bladder cancer. They've used TNF-alpha antagonists and they are at increased risk for developing tuberculosis and myocardial infarction. They've used salicylates, but they cause very severe tinnitus and gastrointestinal symptoms. Metformin has shown to improve insulin sensitivity, but in those trials hypertension got worse. So, we're very in need of a medication to be able to prevent the development of these health complications associated with obesity. So, the idea of targeting the inflammatory process could be a noble pharmacological intervention Continue reading >>

Low Dose Doxycycline Decreases Systemic Inflammation And Improves Glycemic Control, Lipid Profiles, And Islet Morphology And Function In Db/db Mice

Low Dose Doxycycline Decreases Systemic Inflammation And Improves Glycemic Control, Lipid Profiles, And Islet Morphology And Function In Db/db Mice

Low dose doxycycline decreases systemic inflammation and improves glycemic control, lipid profiles, and islet morphology and function in db/db mice Scientific Reportsvolume7, Articlenumber:14707 (2017) | Download Citation The aim of this study was to determine whether low dose doxycycline as an anti-inflammatory agent could improve glucose metabolism in diabetic animals. Therefore, doxycycline was supplemented in drinking water to 6-week-old male db/db mice for 10 weeks. Doxycycline reduced perirenal/epididymal fat, Lees index, and liver cholesterol. Blood HDL-cholesterol increased, but total cholesterol and aspartate transaminase decreased. Glucose and insulin tolerances were improved, accompanying with reduced fasting blood glucose, insulin, HOMA-IR and advanced glycation end products. Islet number, -cell percentage and mass increased, while islet size decreased. Consistently, less apoptosis but more -cell proliferation were found in islets of treated mice. Freshly isolated islets from treated mice showed higher insulin content and enhanced glucose stimulated insulin secretion (GSIS). In addition, purified islets of Balb/c mice showed increased GSIS after cultivation in vitro with doxycycline, but not with chloramphenicol and levofloxacin. Inflammation markers, including lipopolysaccharides (LPS) and C-reactive protein (CRP) in serum as well as CD68-positive cells in treated islets, decreased significantly. Finally, LPS stimulated the production of inflammatory factors but inhibited GSIS of MIN6 cells; however, the effects were completely reversed by doxycycline. The results support further study of possible long-term usage of sub-antimicrobial doxycycline in diabetic patients. Type 2 diabetic mellitus (T2DM) is a long term metabolic disorder that is characterized by Continue reading >>

Protective Action Of Doxycycline Against Diabetic Cardiomyopathy In Rats

Protective Action Of Doxycycline Against Diabetic Cardiomyopathy In Rats

Protective action of doxycycline against diabetic cardiomyopathy in rats 1Department of Biophysics, Faculty of Medicine, Ankara University, Ankara, Turkey 2Departments of Pediatrics, Pharmacology and Biochemistry, University of Alberta, Edmonton, AB, Canada 3Department of Pharmacology, Faculty of Pharmacy, Ankara University, Ankara, Turkey *Author for correspondence: [email protected] 4These authors contributed equally as co-first authors. 5These authors contributed equally as co-senior authors. Received 2008 May 6; Revised 2008 Jul 7; Accepted 2008 Aug 18. This article has been cited by other articles in PMC. Reactive oxygen and nitrogen species play an important role in the development of diabetic cardiomyopathy. They can activate matrix metalloproteinases (MMPs), and MMP-2 in particular is known to mediate early consequences of oxidative stress injury in the heart. Therefore, we investigated the role of MMP-2 and the effect of the MMP inhibitor doxycycline on the changes of heart function caused by diabetes. Using streptozotocin-induced diabetic rats, we evaluated the effect of doxycycline on both mechanical and electrical function of isolated hearts, papillary muscle and cardiomyocytes. Doxycycline abolished the diabetes-induced depression in left ventricular developed pressure and the rates of changes in developed pressure in isolated hearts and normalized the prolongation of the action potential in papillary muscles. In cardiomyocytes isolated from doxycycline-treated diabetic rats, the altered kinetic parameters of Ca2+ transients, depressed Ca2+ loading of sarcoplasmic reticulum and basal intracellular Ca2+ level, and the spatio-temporal properties of Ca2+ sparks were significantly restored. Gelatin zymography and western blot data indicated that the d Continue reading >>

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