
Hypoglycemic Effect Of Catalpol On High-fat Diet/streptozotocin-induced Diabetic Mice By Increasing Skeletal Muscle Mitochondrial Biogenesis
Hypoglycemic effect of catalpol on high-fat diet/streptozotocin-induced diabetic mice by increasing skeletal muscle mitochondrial biogenesis Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education Jiangsu Center for Pharmacodynamics Research and Evaluation Jiangsu Center for Pharmacodynamics Research and Evaluation Correspondence address. Tel: +86-25-83271043; Fax: + ; E-mail: [email protected] (T.W.)/ [email protected] (L.Z.) Search for other works by this author on: State Key Laboratory of Natural Medicines Correspondence address. Tel: +86-25-83271043; Fax: + ; E-mail: [email protected] (T.W.)/ [email protected] (L.Z.) Search for other works by this author on: Acta Biochimica et Biophysica Sinica, Volume 46, Issue 9, 1 September 2014, Pages 738748, Xia Li, Zhimeng Xu, Zhenzhou Jiang, Lixin Sun, Jinzi Ji, Jingshan Miao, Xueji Zhang, Xiaojie Li, Shan Huang, Tao Wang, Luyong Zhang; Hypoglycemic effect of catalpol on high-fat diet/streptozotocin-induced diabetic mice by increasing skeletal muscle mitochondrial biogenesis, Acta Biochimica et Biophysica Sinica, Volume 46, Issue 9, 1 September 2014, Pages 738748, Catalpol, an iridoid glycoside, exists in the root of Radix Rehmanniae. Some studies have shown that catalpol has a remarkable hypoglycemic effect in the streptozotocin-induced diabetic model, but the underlying mechanism for this effect has not been fully elucidated. Because mitochondrial dysfunction plays a vital role in the pathology of diabetes and because improving mitochondrial function may offer a new approach for the treatment of diabetes, this study was designed. Catalpol was orally administered together with metformin to high-fat diet/streptozotocin (HFD/STZ)-induced diabetic mice daily for 4 weeks. Body weight (BW), fast Continue reading >>

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