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Diabetes Mellitus In Dogs - Overview

This handout provides general information about diabetes mellitus in dogs. For information about its treatment, see the fact sheets "Diabetes Mellitus - Principles of Treatment" and "Diabetes Mellitus - Insulin Treatment". What is diabetes mellitus? Diabetes mellitus is a disease of the pancreas, a small but vital organ located near the stomach. The pancreas has two significant types of cells. One group of cells produces the enzymes necessary for proper digestion. The other group, called beta cells, produces the hormone insulin. Insulin regulates the level of glucose (sugar) in the bloodstream and controls the delivery of glucose to the tissues of the body. In simple terms, diabetes mellitus is caused by the failure of the pancreas to regulate blood sugar. The clinical signs of diabetes mellitus are related to elevated concentrations of blood glucose and the inability of the body to use glucose as an energy source. What are the clinical signs of diabetes and why do they occur? The four main symptoms of uncomplicated diabetes mellitus are increased thirst, increased urination, weight loss, and increased appetite. Glucose is a vital substance that provides much of the energy needed b Continue reading >>

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  1. rabbitsong

    A little history. I've been T2 since 1997. Diet controlled until last fall. Can't tolerate anything with metformin. I had been on Glimiperide (Amaryl) since last May. It was working okay, but we still wanted to bring my numbers down. My average blood sugars were 140s-150s. I had hip surgery last December and have not recovered well. Not able to exercise more than my PT exercises. Can't just go for a walk when I feel like it. Still, the only time my blood sugar was really high was when I have been on prednisone in the past. It only got over 300 once, and that was the first day of a taper.
    Last week, at my annual physical, my GP decided that I needed something else to bring my blood sugar down, so he switched me to Januvia (100mg).
    My last day on Glimiperide, my fasting blood sugar was 148. The morning after my first full day on Januvia, it was 225. I can't explain it. Nothing had changed. I was eating low carb, lean proteins, no sugar, etc. I've been on it four days, and it's climbing higher and higher. Right now it's 401. (11pm) It's only dropped below 200 once, and that was 199.
    I called my GP's office this morning, but they didn't call back.
    Has anyone else had this happen? Is there anything else besides exercise that I can do to bring that 401 down?

  2. Trivettes

    My best friend had that happen, whereas I take Januvia with no problems at all.
    Best I can say is get in touch with your doctor asap. Keep calling and calling them.
    Water will help keep you from being dehydrated and might help your bg a little.
    Also, when your blood glucose is that high it can be dangerous to exercise.
    Diabetes and exercise: When to monitor your blood sugar - Mayo Clinic

    Lower than 100 mg/dL (5.6 mmol/L). Your blood sugar may be too low to exercise safely. Eat a small carbohydrate-containing snack, such as fruit or crackers, before you begin your workout.
    100 to 250 mg/dL (5.6 to 13.9 mmol/L). You're good to go. For most people, this is a safe pre-exercise blood sugar range.
    250 mg/dL (13.9 mmol/L) or higher. This is a caution zone. Before exercising, test your urine for ketones — substances made when your body breaks down fat for energy. Excess ketones indicate that your body doesn't have enough insulin to control your blood sugar. If you exercise when you have a high level of ketones, you risk ketoacidosis — a serious complication of diabetes that needs immediate treatment. Instead, wait to exercise until your test kit indicates absence or a low level of ketones in your urine.
    300 mg/dL (16.7 mmol/L) or higher. Your blood sugar may be too high to exercise safely, as these high glucose levels may increase your risk of dehydration and ketoacidosis. Postpone your workout until your blood sugar drops to a safe pre-exercise range.

  3. rabbitsong

    Thanks Trivettes.
    I did reach my doctor - finally. I asked about going back to the Glimiperide, but he wanted to ADD a new drug called Farxiga. It's very new and very expensive. I doubt insurance will even cover it, but he gave me a coupon. His nurse told me not to google it, because it would scare me.
    Well, I googled. I'm not liking what I see about either Januvia OR Farxiga. (Bloodsugar101.com is a pretty good site that's not affiliated with drug companies or government agencies.)
    I'm not sure what I'm going to do right now. I'm really hesitant to take something that's so new they don't know much about it yet.

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