Glyburide / Metformin Dosage
-As Initial Therapy in Patients with Inadequate Glycemic Control on Diet and Exercise Alone: Starting dose: 1.25 mg-250 mg orally once a day -Consider a starting dose of 1.25 mg-250 mg orally twice a day for patients with fasting blood glucose (FBG) greater than 200 mg/dL or HbA1c greater than 9% Maintenance Dose: Increase in increments of 1.25 mg-250 mg per day every 2 weeks up to the minimum effective dose to achieve glycemic control Maximum Initial Dose: 10 mg-2000 mg per day -Patients with Inadequate Glycemic Control on a Glyburide (or another Sulfonylurea) and/or Metformin: Initial dose: 2.5 mg-500 mg or 5 mg-500 mg orally twice a day Maintenance Dose: Increase in increments of no more than 5 mg-500 mg to the minimum effective dose to achieve adequate blood glucose control Continue reading >>
When Do I Take Metformin For My Diet: Morning Or Night?
Metformin helps control blood sugar and increase your body's sensitivity to insulin. The drug is available only by prescription and sold under several different brand names, including Fortamet, Glumetza, Riomet, Glucophage and Glucophage XR. Your dosage will depend on your normal diet and exercise habits -- too much metformin can lead to low blood sugar and hypoglycemia. Always follow your doctor's directions for taking your medication. Video of the Day Metformin works by limiting your liver's production of glucose and stopping your body from absorbing some of the glucose in your bloodstream. Additionally, metformin increases your body's sensitivity to insulin, allowing your pancreas to produce less insulin. Keeping blood sugar levels stable can decrease hunger and food cravings, leading to weight loss. Metformin is not an appetite suppressant, nor does it boost metabolism; to lose weight, you'll still need to pay close attention to your diet and increase your physical activity. Standard vs. Extended Release Options The amount of metformin you'll take depends on why you are using the medication, how often you take the medicine, other medications you might be taking and the time between doses. The National Institutes of Health explains that metformin is available as a tablet or a liquid solution. Tablets come in an extended release dose -- Glucophage XR -- or in a standard release option. Extended release pills are designed to be taken once daily, with your evening meal. Standard tablet and liquid solutions may be taken once or multiple times daily -- with meals. Metformin should be taken with food. Always follow your doctor's orders. It's typical to start with a 500 milligram dose once daily, then increase both the amount of medication and the frequency. If you're using Continue reading >>
Diabetes Drugs: Metformin
Editor’s Note: This is the second post in our miniseries about diabetes drugs. Tune in on August 21 for the next installment. Metformin (brand names Glucophage, Glucophage XR, Riomet, Fortamet, Glumetza) is a member of a class of medicines known as biguanides. This type of medicine was first introduced into clinical practice in the 1950’s with a drug called phenformin. Unfortunately, phenformin was found to be associated with lactic acidosis, a serious and often fatal condition, and was removed from the U.S. market in 1977. This situation most likely slowed the approval of metformin, which was not used in the U.S. until 1995. (By comparison, metformin has been used in Europe since the 1960’s.) The U.S. Food and Drug Administration (FDA) required large safety studies of metformin, the results of which demonstrated that the development of lactic acidosis as a result of metformin therapy is very rare. (A finding that has been confirmed in many other clinical trials to date.) Of note, the FDA officer involved in removing phenformin from the market recently wrote an article highlighting the safety of metformin. Metformin works primarily by decreasing the amount of glucose made by the liver. It does this by activating a protein known as AMP-activated protein kinase, or AMPK. This protein acts much like an “energy sensor,” setting off cellular activities that result in glucose storage, enhanced entry of glucose into cells, and decreased creation of fatty acids and cholesterol. A secondary effect of the enhanced entry of glucose into cells is improved glucose uptake and increased storage of glycogen (a form of glucose) by the muscles. Additionally, the decrease in fatty acid levels brought about by metformin may indirectly improve insulin resistance and beta cell func Continue reading >>
Half A Tablet Of Metformin...what Shell I Do??
half a tablet of METFORMIN...what shell i do?? People starting off at 250 mg [half a tablet] of Metformin have a very good chances of eliminating the drug from their lifestyle. That is your dose, right? A half a tablet also means 425 mg or 500 mg. At this level it is a little more difficult to reverse the condition. You left out the part of maintaining proper body weight. Along with sticking to a diabetic diet/nutrition plan, and daily physical exercise being overweight contributes greatly to diabetes. Keep your cholesterol, triglycerides and blood pressure at normal levels too. Doing all helps lower and maintain proper glucose levels. Purchase a reputable home glucose test meter, test before each meal [preprandial] - to get a baseline measurement. Then test 2-3 hrs after each meal [postprandial] - to see how the foods you consumed affected your glucose levels. Post back if you don't know the acceptable ranges or read other threads on this forum as it has been mentioned quite often. Good luck Continue reading >>
Metformin, Oral Tablet
Metformin oral tablet is available as both a generic and brand-name drug. Brand names: Glucophage, Glucophage XR, Fortamet, and Glumetza. Metformin is also available as an oral solution but only in the brand-name drug Riomet. Metformin is used to treat high blood sugar levels caused by type 2 diabetes. FDA warning: Lactic acidosis warning This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects. Lactic acidosis is a rare but serious side effect of this drug. In this condition, lactic acid builds up in your blood. This is a medical emergency that requires treatment in the hospital. Lactic acidosis is fatal in about half of people who develop it. You should stop taking this drug and call your doctor right away or go to the emergency room if you have signs of lactic acidosis. Symptoms include tiredness, weakness, unusual muscle pain, trouble breathing, unusual sleepiness, stomach pains, nausea (or vomiting), dizziness (or lightheadedness), and slow or irregular heart rate. Alcohol use warning: You shouldn’t drink alcohol while taking this drug. Alcohol can affect your blood sugar levels unpredictably and increase your risk of lactic acidosis. Kidney problems warning: If you have moderate to severe kidney problems, you have a higher risk of lactic acidosis. You shouldn’t take this drug. Liver problems warning: Liver disease is a risk factor for lactic acidosis. You shouldn’t take this drug if you have liver problems. Metformin oral tablet is a prescription drug that’s available as the brand name drugs Glucophage, Glucophage XR, Fortamet, and Glumetza. Glucophage is an immediate-release tablet. All of the other brands are extended-r Continue reading >>
Buy Glycomet 250 Mg Tablet Online - Find Uses, Side Effects, Substitutes, Dosage On | Practo
Contraindications of Glycomet 250 MG Tablet This medicine is not recommended for use in patients with a severe impairment of kidney function due to the increased risk of serious adverse effects. This medicine is not recommended for use in patients with a known allergy to metformin or any other biguanides. This medicine is not recommended for use in patients with metabolic acidosis since it may worsen the patient's condition. Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up for the missed dose. Contact a doctor immediately if an overdose is suspected. Some overdosages could lead to Lactic Acidosis which requires immediate medical intervention. All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine. - Consumption of alcohol while taking this medicine may increase the risk of Lactic Acidosis which is a severe condition requiring immediate medical intervention. - Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects. - This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition. - This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition. - This medicine may cause lactic Continue reading >>
What Is Glucovance (glyburide And Metformin)?
Glucovance is the brand name for a combination prescription drug that contains glyburide and metformin. It's used along with diet and exercise to help lower blood-sugar levels by people who have type 2 diabetes. If you have type 2 diabetes, your body doesn't make or use the hormone insulin normally, so it can't control the amount of sugar, or glucose, in the blood. Glyburide belongs to a class of drugs known as sulfonylureas. It makes the pancreas produce insulin, which directs your body's cells to store sugar, lowering the amount of glucose in your blood. Metformin belongs to a class of drugs known as biguanides. Biguanides lower blood-sugar levels in three ways: decreasing the glucose produced by your liver; slowing absorption of sugar in the digestive system; and increasing the amount of sugar that muscle cells absorb. Taking Glucovance, along with adopting a healthy lifestyle, can decrease your risk of developing the serious or life-threatening complications of type 2 diabetes. These may include cardiovascular diseases, such as heart attack, stroke, and problems related to blood circulation; nerve damage; kidney disease; or eye conditions. The medicine is manufactured by Bristol Myers Squibb and was approved by the Food and Drug Administration (FDA) in 2000. Glucovance Warnings The FDA requires a black-box warning for Glucovance, because it may cause a rare but serious condition called lactic acidosis (a buildup of lactic acid in the blood). Stop taking the drug and call your doctor immediately or get emergency help if you experience any of the following side effects: Extreme weakness, fatigue, or discomfort Nausea, vomiting, or stomach pain Decreased appetite Deep and rapid breathing or shortness of breath Dizziness or lightheadedness Fast or slow heartbeat Flushin Continue reading >>
Glyburide And Metformin (oral Route)
Follow carefully the special meal plan your doctor gave you. This is the most important part of controlling your diabetes, and is necessary if the medicine is to work properly. Also, exercise regularly and test for sugar in your blood or urine as directed. This medicine comes with a patient information insert. Read and follow the instructions carefully. Ask your doctor if you have any questions. Glyburide and metformin combination should be taken with meals to help reduce the stomach adverse effects that may occur during the first few weeks of treatment. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. AdultsAt first, 1.25 milligrams (mg) of glyburide and 250 mg of metformin one or two times a day with meals. Your doctor may increase your dose a little at a time every two weeks until your blood sugar is controlled. However, the dose is usually not more than 20 mg of glyburide and 2000 mg of metformin per day. ChildrenUse and dose must be determined by your doctor. For patients previously treated with a sulfonylurea antidiabetic agent and/or metformin: AdultsAt first, 2.5 milligrams (mg) of glyburide and 500 mg of metformin or 5 mg of glyburide and 500 mg of metformin two times a day, with the morning and evening meals. Your doctor may increase your dose a little at a time Continue reading >>
What Are The Possible Side Effects Of Glyburide And Metformin (glucovance)?
GLUCOVANCE® (glyburide and metformin hcl) Tablets, 1.25 mg/250 mg, 2.5 mg/500 mg, 5 mg/500 mg DESCRIPTION GLUCOVANCE® (Glyburide and Metformin HCl) Tablets contain 2 oral antihyperglycemic drugs used in the management of type 2 diabetes, glyburide and metformin hydrochloride. Glyburide is an oral antihyperglycemic drug of the sulfonylurea class. The chemical name for glyburide is 1-[[p-[2-(5-chloro-o-anisamido)ethyl]phenyl]sulfonyl]-3-cyclo-hexylurea. Glyburide is a white to off-white crystalline compound with a molecular formula of C23H28ClN3O5S and a molecular weight of 494.01. The glyburide used in GLUCOVANCE has a particle size distribution of 25% undersize value not more than 6 μm, 50% undersize value not more than 7 to 10 μm, and 75% undersize value not more than 21 μm. The structural formula is represented below. Metformin hydrochloride is an oral antihyperglycemic drug used in the management of type 2 diabetes. Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide monohydrochloride) is not chemically or pharmacologically related to sulfonylureas, thiazolidinediones, or α-glucosidase inhibitors. It is a white to off-white crystalline compound with a molecular formula of C4H12ClN5 (monohydrochloride) and a molecular weight of 165.63. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. The pKa of metformin is 12.4. The pH of a 1% aqueous solution of metformin hydrochloride is 6.68. The structural formula is as shown: GLUCOVANCE is available for oral administration in tablets containing 1.25 mg glyburide with 250 mg metformin hydrochloride, 2.5 mg glyburide with 500 mg metformin hydrochloride, and 5 mg glyburide with 500 mg metformin hydrochloride. In addition, each tablet contains the f Continue reading >>
Apotex Metformin Tablets Cannot Be Accurately Halved
Apotex metformin tablets cannot be accurately halved Healthcare professionals are advised that the Apotex brand of metformin 500mg and 850mg tablets are not scored and cannot be accurately halved. This advice follows recent reports sent to CARM describing problems halving the 500mg tablet. The recommended starting dose for metformin is 500mg once or twice daily; however Medsafe is aware that some patients are being prescribed a starting dose of 250mg to minimise gastrointestinal side effects. Diarrhoea, nausea and vomiting occur in more than 10% of patients starting metformin but usually resolve over a short period of time. Medsafe has obtained expert advice on metformin dosing and has been informed that a 250mg daily dose is likely to be subtherapeutic. This means any small differences in dose resulting from inaccurate halving of a 500mg tablet are unlikely to be clinically relevant. Similarly, any small differences from inaccurate halving are unlikely to affect the development of gastrointestinal tolerance. Prescribers are also advised to consider the difculties associated with halving a 500mg tablet and remember that an 850mg tablet is available before titrating metformin doses in increments of 250mg. Further information on metformin dosing can be found on the Medsafe website at: www.medsafe.govt.nz/Medicines/infoSearch.asp Continue reading >>
Generic Glucophage | Glycomet 500 Mg, 250 Mg, 850 Mg & 1000 Mg Tablets | Metformin Hcl Side Effects
Generic Glucophage (Glycomet Tablets) - Product Information Generic Glucophage (Glycomet tablets) is used to treat type 2 diabetes mellitus (non-insulin dependent diabetes) in adults, when a special diet and exercise alone does not result in adequate control of blood glucose levels. Generic Glucophage is also used for the treatment of polycystic ovary syndrome. The active ingredient present in Generic Glucophage Tablets is Metformin Hydrochloride. Metformin Hydrochloride is marketed under trade names such as Fortamet, Actoplus Met, Avandamet, Glucophage, Glumetza, Riomet, Glycomet, Exermet XR and Glycomet SR . Glycomet tablets are manufactured by USV Limited in the strengths of 250 mg, 500 mg, 850 mg and 1000 mg. We also have in stock Generic Amaryl (Glador tablets) which is also used to treat the same indications. We supply original Glycomet tablets manufactured by USV Limited . In our online pharmacy Generic Glucophage is available in strengths of 250 mg, 500 mg, 850 mg and 1000 mg. Active Ingredient present in Glycomet Tablets The active ingredient present in Glycomet Tablets is Metformin Hydrochloride. Each tablet of Glycomet 500 mg contains 500 mg of Metformin Hydrochloride equivalent IP Each tablet of Glycomet 850 mg contains 850 mg of Metformin Hydrochloride equivalent IP Each tablet of Glycomet 250 mg contains 250 mg of Metformin Hydrochloride equivalent IP Each tablet of Glycomet 1000 mg contains 1000 mg of Metformin Hydrochloride equivalent IP Uses of Diabetes Medicine Generic Glucophage (Glycomet Tablets) Glycomet tablets (Generic Glucophage), is used along with diet and exercise, to improve glycaemic control in adults with type 2 diabetes mellitus. Generic Glucophage can be used concomitantly with a sulphonylurea or insulin to improve glycaemic control in a Continue reading >>
Metformin Makes Headline News
Metformin is the first-line drug of choice in the treatment of type II diabetes. It was first approved in Europe in 1958.1 Americans had to wait until 1994 to legally obtain metformin.1 The holdup in approving metformin goes beyond the FDA. It is an indictment of a political/legal system that will forever cause needless suffering and death unless substantively changed. When Life Extension® informed Americans about drugs like metformin in the 1980s, the FDA did everything in its power to incarcerate me and shut down our Foundation.2 FDA propaganda at the time was that consumers needed to be "protected" against "unproven" therapies. As history has since proven, the result of the FDA's embargo has been unparalleled human carnage. So called "consumer protection" translated into ailing Americans being denied access to therapies that the FDA now claims are essential to saving lives. Today's major problem is not drugs available in other countries that Americans can't access. Instead, it is a political/legal system that suffocates medical innovation. Headline news stories earlier this year touted the anti-cancer effects of metformin, data that Foundation members were alerted to long ago.3 The problem is that it is illegal for metformin manufacturers to promote this drug to cancer patients or oncologists. It's also illegal to promote metformin to healthy people who want to reduce their risk of cancer, diabetes, vascular occlusion, and obesity. This fatal departure from reality continues unabated, as our dysfunctional political/legal system denies information about metformin that could spare countless numbers of lives. Type II diabetics suffer sharply higher rates of cancer4-7and vascular disease.8-11 The anti-diabetic drug metformin has been shown in numerous scientific studies Continue reading >>
Metformin Hcl Er
Uses Metformin is used with a proper diet and exercise program and possibly with other medications to control high blood sugar. It is used in patients with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. Metformin works by helping to restore your body's proper response to the insulin you naturally produce. It also decreases the amount of sugar that your liver makes and that your stomach/intestines absorb. How to use Metformin HCL ER Read the Patient Information Leaflet if available from your pharmacist before you start taking metformin and each time you get a refill. If you have any questions, consult your doctor or pharmacist. Take this medication by mouth as directed by your doctor, usually once daily with the evening meal. Drink plenty of fluids while taking this medication unless otherwise directed by your doctor. Do not crush or chew this medication. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing. The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To reduce your risk of side effects (such as upset stomach), your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. Take this medication regula Continue reading >>
Metformin Dosage 250mg Is Too Low?
Friend Thin super-active but rising FBG; Mom T2 I felt nothing after one week on 250mg glucostage. Maybe the dosage is too low and too soon to share experience. I read someone saying met needs at least 1000mg to start working, is it true? I am considering raising it to 850mg XR after 90days, when I will do a blood testing At first metformin 500 mg worked but eventually needed more and that is when i couldnt handle the side effects. Also you have to eat low carb with it to work good D.D. Family Getting much harder to control A lot depends on what your eating. Met can not counter act what carbs do. Also it could take 6 weeks to fully work most likely they started you low dose to prevent stomach issues. I started 500mg for first week and then upped to 1000mg. As furball says the initial lower dose is so your body adjusts. 250 does sound a bit low though. I am also taking 2.5mg of glipizide once a day. Friend Thin super-active but rising FBG; Mom T2 I work hard to persuade dr. for even 250mg dosage because in their book the patient is normal unless FBG is 7+ or HBA1c is 6.5%+ After 3 months, I will have the battle to get 850mg XR ... I truely believe Met needs more dosage to work.. 250mg, which is too low, is wasting my kidney and my time.... D.D. Family Getting much harder to control Friend Thin super-active but rising FBG; Mom T2 it's like eating much salt while I am not a salty dinner fan... Met is dumped by my kidney, right? My lovely organ should not "in vain" function, my opinion... D.D. Family Getting much harder to control Met works in the liver and reduces insulin resistance and you been on it only one week it's not like a pancreas stimulating med. D.D. Family diabetic since 1997, on insulin 2000 When I first started metformin, I had to raise it to 2550 mg before Continue reading >>
Metformin Vs Metformin Er
I'm seeing quite a few posts on BBSes from people who are having problems with metformin because of side effects that could be eliminated if they were taking the extended release form of this drug. For some reason, many family doctors don't seem to be aware that there is a ER version of this drug that has such benefits. This is probably because metformin is a cheap generic and isn't promoted by herds of beautiful ex-cheerleaders turned drug company salespushers who "educate" doctors about far more expensive--and less effective--newer drugs. Here are the facts: Metformin (also sold under the brand name Glucophage) comes in a regular version which is taken at meal time, three times a day, and an extended release form (marketed as ER or XR) which is taken once a day. Almost always, when people report diarrhea or intense heartburn with metformin, they are taking regular version. I experienced the heartburn on the regular drug. It was very disturbing because the pain was localized over my heart and felt just like the description of a heart attack you read in articles. My doctor assured me it was coming from the metformin, but that didn't make it any easier to live with because I kept wondering how, if I were having a real heart attack, I'd know it wasn't a pain from the drug? The ER version releases the drug more slowly and this usually eliminates the gastrointestinal problems. The trade off with taking the ER form is that the amount of blood sugar lowering you see might be a bit less than with the regular form as the drug acts in a slower smoother fashion rather than hitting all at once. But if you can't take the regular at all drug because of the side effects, the slight weakening in effect is a reasonable trade off. Plus, you only have to remember to take one dose rather Continue reading >>