Dipsogenic Diabetes Insipidus Definition

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Chapter 26 Diabetes Insipidus And Hyperosmolar Syndromes

CHAPTER 26 DIABETES INSIPIDUS AND HYPEROSMOLAR SYNDROMES Principles and Practice of Endocrinology and Metabolism CHAPTER 26 DIABETES INSIPIDUS AND HYPEROSMOLAR SYNDROMES PETER H. BAYLIS AND CHRISTOPHER J. THOMPSON Definitions Diabetes Insipidus Etiology Clinical Features Differential Diagnosis Thirst in Hypothalamic Diabetes Insipidus Diabetes Insipidus and Pregnancy Treatment Hyperosmolar Syndromes Etiology Clinical Features Osmoregulatory Defects in Chronic Hypernatremia Treatment Chapter References Blood osmolality in healthy persons is maintained within narrow limits by a series of mechanisms that are described in detail in Chapter 25. Adjustments in water balance determine the constancy of blood osmolality, which is mediated by delicate alterations in thirst appreciation (with consequent promotion of drinking) plus the enormous capacity of the kidney to alter urine flow rates and urine osmolality in response to relatively small changes in the plasma vasopressin concentration (see Chap. 206). Thus, healthy humans are able to conserve their osmotic internal milieu despite extremes in climatic conditions, sustained severe exertion, or, to a certain degree, an inadequate supply of Continue reading >>

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Popular Questions

  1. Suzzyy

    I began metformin yesterday. My doctor prescribed the extended release because he said it will be easier on my stomach. I am to take 500mg 4 times a day however he said to begin slowly. So yesterday I took one with breakfast and one with dinner. I have had explosive diarrhea all day and such pains in my stomach. He did tell me that could happen and 10 years ago when I took metformin, I got a little of this but nothing like yesterday. Could it be coincidental and I might just have a stomach bug or is this what I have to put up with for a few days?? I want so badly to get my weight and my health under control. If this is what I have to do, then of course I will do it but I am not a happy camper. I can't leave the house !!! I might send my husband out for some imodium so I can go to work tomorrow. Any suggestions?

  2. zinkemomx2

    I would only start with 500mg a day for the first week. I took mine with dinner as it was my largest meal of the day. I've also heard that taking it in the evening when you first start sometimes helps avoid those symptoms.

  3. Iconoclast at Large

    Suzzyy -- I started Metformin about 2 and a half months ago. I experienced the same side effect you're experiencing. With me, it lasted a week. And then it was completely gone.
    The doctor prescribed it as I had just learned I was diabetic. He also scheduled me to visit with a dietician two weeks later. When I went to see her, she asked if the doctor had started me on Metformin. I told her "Yes. 2 x 500 mg pills per day". She said "have you already started taking them?" I said "Yes. 2 weeks ago". She said, "Oh, so you've already finished with the side effects.... I would have told you to start slowly - one per day - and eventually move to 2 per day to avoid that particular side effect."
    So, yes -- it is well known.... it is not pleasant, but it was over in a week, if that helps at all!

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