Diabetes May Have Five Separate Types, Not Two, Study Says | Time
For many years, diabetes cases have largely been classified as either type 1 or type 2. But a new study suggests that there may actually be five different types of the disease—some of which may be more dangerous than others. A new classification system could help doctors identify the people most at risk for complications, the study authors say, and could pave the way for more personalized and effective treatments. The research article, published in The Lancet: Diabetes & Endocrinology , calls attention to the need for an updated diabetes classification system. The current system “has not been much updated during the past 20 years,” the authors wrote in their paper, “and very few attempts have been made to explore heterogeneity of type 2 diabetes”—despite calls from expert groups over the years to do so. Meanwhile, they wrote, diabetes is the fastest-increasing disease worldwide, and existing treatments have been unable to stem the tide or prevent the development of chronic complications in many patients. One explanation, they say, is that diabetes diagnosis is based on only one measurement—how the body metabolizes glucose—when the disease is actually much more complex, and much more individual. Currently, diabetes is classified based mainly on age of diagnosis (younger people often have type 1) and on the presence or absence of antibodies that attack beta cells, which release insulin. People with type 1 diabetes have these antibodies—and therefore cannot make insulin on their own—while people with type 2 do not. Their bodies make insulin but don’t use it the right way. Based on these criteria, between 75% and 85% of people with diabetes are classified with type 2, the authors wrote in their paper. A third subgroup of diabetes, known as latent auto Continue reading >>
Are There Actually 5 Types Of Diabetes?
"Diabetes is actually five separate diseases," reports BBC News on a study looking at nearly 9,000 people with diabetes in Sweden and Finland. The researchers analysed certain characteristics such as body weight, blood sugar control and presence of antibodies against the likelihood of disease complications and need for insulin. Based on their results, they came up with 5 sub-types or clusters of diabetes. Cluster 1 corresponds to what could be called classic type 1 diabetes, while clusters 4 and 5 correspond to type 2 diabetes. Clusters 2 and 3 can be thought of as falling between the two extremes. This study is valuable in improving our understanding of diabetes. For example, the researchers found that people who had cluster 2 or 3 diabetes had a higher risk of kidney disease or vision problems (retinopathy) than people in the other clusters. However, the diagnosis and management of diabetes isn't going to change overnight. Further research is needed to see whether these 5 clusters hold true for non-Scandinavian populations. The study was carried out by researchers from Lund University, Uppsala University and the University of Gothenburg in Sweden; and Vaasa Health Centre and the University of Helsinki in Finland. Funding was provided by the Swedish Research Council, European Research Council, Vinnova, the Academy of Finland, Novo Nordisk Foundation, Scania University Hospital, Sigrid Juslius Foundation, the European Union Innovative Medicines Initiative 2 Joint Undertaking, Vaasa Hospital, Jakobstadsnejden Heart Foundation, Folkhlsan Research Foundation, the Ollqvist Foundation and the Swedish Foundation for Strategic Research. The study was published in the peer-reviewed medical journal The Lancet. The UK media provided accurate coverage of the study. This study ana Continue reading >>
Type 1 And Type 2 Diabetes: What’s The Difference?
If your child or someone you know has been recently diagnosed with type 1 diabetes, you may be wondering how the disease differs from type 2 diabetes — the form people tend to know more about. What causes type 1 versus type 2 diabetes? Are the symptoms the same? And how is each treated? Here to clear up the confusion with an overview of key differences — and similarities — between these two types of diabetes are experts Julie Settles, M.S.N., A.C.N.P.-B.C., C.E.N., a clinical research scientist at Lilly Diabetes, and Rosemary Briars, N.D., P.N.P.-B.C., C.D.E., C.C.D.C., clinical director and program co-director of the Chicago Children’s Diabetes Center at La Rabida Children’s Hospital. Causes Diabetes, or diabetes mellitus, as it’s formally known in medical terms, describes a group of metabolic diseases in which a person develops high blood glucose (blood sugar). The underlying health factors causing the high blood sugar will determine whether someone is diagnosed with type 1 or type 2 diabetes. Type 1 diabetes is an autoimmune disease in which “the body’s immune system starts to make antibodies that are targeted directly at the insulin-producing cells of the pancreas (islet cells),” explains Briars. Over time, the immune system “gradually destroys the islet cells, so insulin is no longer made and the person has to take insulin every day, from then on,” she says. As for why this happens, Settles notes, “The immune system normally fights off viruses and bacteria that we do not want in our body, but when it causes diabetes, it is because something has gone wrong and now the body attacks its own cells.” Triggering this autoimmune response is a complex mix of genetic and environmental factors that researchers are still trying to fully understand. O Continue reading >>
Type 1 Diabetes Vs Type 2
National Diabetes Month is coming to a close. Unfortunately, diabetes isn’t going away any time soon. According to the American Diabetes Association, 1.4 million Americans are diagnosed with diabetes each year. And 86 million people in the United States with prediabetes are headed towards developing Type 2 diabetes. Diabetes isn’t unique to the United States: It’s a global issue, affecting hundreds of millions of people worldwide. Many people describe diabetes as being a pandemic. When people are diagnosed with diabetes, they often have many questions, especially about the differences between Type 1 and Type 2 diabetes. There are, in fact, multiple different forms of diabetes (too many to get into in this week’s posting!), but the more common forms are Type 1 and Type 2. Let’s take a look at these this week and hopefully clear up any confusion or questions you may have. Type 1 diabetes Name: Type 1 diabetes was formerly known as “juvenile diabetes” and “insulin-dependent diabetes.” These terms are inaccurate and obsolete. We know that it’s not just “juveniles” who get Type 1 diabetes — adults get Type 1, too, and many people who have Type 2 diabetes must take insulin. So, Type 1 diabetes is the correct term. Definition: Type 1 diabetes (also known as Type 1 diabetes mellutis, or T1DM) is an autoimmune condition. This means that the body’s immune system turns on itself; in this case, it attacks the beta cells of the pancreas. These are the cells that produce insulin. As a result, the pancreas produces very little, if any, insulin. Causes: Scientists don’t exactly know what causes Type 1 diabetes. However, it’s likely that genetics and environmental factors, such as certain types of viruses, play a role. Prevalence: Type 1 diabetes accounts Continue reading >>
Difference Between Type 1 And Type 2 Diabetes | Prevention
When people hear that you have diabetes , they start to make assumptions that aren't always accurate. A lot of the confusion stems from the fact that there are two main types, yet many people don't understand how they're different. (Want to pick up some healthier habits? Sign up to get daily healthy living tips delivered straight to your inbox!) As someone with type 1 diabetesI was diagnosed with it nearly 40 years agoI'm all too familiar with the disease. I lived with it as a child, teen, and adult, and when I decided to have kids I had to figure out how to manage the condition while being pregnant. (I even wrote a book about it, Balancing Pregnancy With Pre-Existing Diabetes: Healthy Mom, Healthy Baby .) Having type 1 diabetes means I'm in the minority: Of the approximately 29 million Americans who have diabetes, only 1.25 million have type 1. Most have type 2, which is a totally different form. "Comparing type 1 to type 2 is like comparing apples to tractors," says Gary Scheiner, a Pennsylvania-based certified diabetes educator and author of Think Like a Pancreas . "The only thing they really have in common is that both involve an inability to control blood sugar levels." Here are 5 important distinctions. MORE: 7 Reasons You're Tired All The Time 1. Type 1 is an autoimmune disease; type 2 isn't. Diabetes happens when your body has trouble with insulin, a hormone that helps convert sugar from the food you eat into energy. When there isnt enough insulin in your body, sugar builds up in the bloodstream and can make you sick. People with type 1 and type 2 both face this problem, but how they arrived there is quite different. If you have type 1, you don't make any insulin at all. That's because type 1 is an autoimmune disease in which your immune system attacks and dest Continue reading >>
What Is Diabetes?
Diabetes is a disease that occurs when your blood glucose, also called blood sugar, is too high. Blood glucose is your main source of energy and comes from the food you eat. Insulin, a hormone made by the pancreas, helps glucose from food get into your cells to be used for energy. Sometimes your body doesn’t make enough—or any—insulin or doesn’t use insulin well. Glucose then stays in your blood and doesn’t reach your cells. Over time, having too much glucose in your blood can cause health problems. Although diabetes has no cure, you can take steps to manage your diabetes and stay healthy. Sometimes people call diabetes “a touch of sugar” or “borderline diabetes.” These terms suggest that someone doesn’t really have diabetes or has a less serious case, but every case of diabetes is serious. What are the different types of diabetes? The most common types of diabetes are type 1, type 2, and gestational diabetes. Type 1 diabetes If you have type 1 diabetes, your body does not make insulin. Your immune system attacks and destroys the cells in your pancreas that make insulin. Type 1 diabetes is usually diagnosed in children and young adults, although it can appear at any age. People with type 1 diabetes need to take insulin every day to stay alive. Type 2 diabetes If you have type 2 diabetes, your body does not make or use insulin well. You can develop type 2 diabetes at any age, even during childhood. However, this type of diabetes occurs most often in middle-aged and older people. Type 2 is the most common type of diabetes. Gestational diabetes Gestational diabetes develops in some women when they are pregnant. Most of the time, this type of diabetes goes away after the baby is born. However, if you’ve had gestational diabetes, you have a greater chan Continue reading >>
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There May Be Five Types Of Diabetes
Diabetes is currently said to exist in essentially two variations: Type 1 and Type 2. But a group of medical scientists believe that division is overly simplistic. Writing in a study published by The Lancet: Diabetes & Endocrinology this month, a team of international researchers propose that there are actually five types of diabetes, and that the distinctions between them could mean that some people are taking diabetes medications they dont need, while others arent being treated sufficiently at time of diagnosis. They believe the nuances of diabetes ought to be reconsidered, especially as diabetes has become the worlds fastest growing disease. In 2014, 422 million people globally had diabetes, up from 108 million in 1980, according to the World Health Organization . A person develops diabetes when his or her body either doesnt produce insulin or doesnt use the amount it produces properly. Insulin is a hormone that acts like a traffic cop for glucose levels in the bloodstream. When all is well, it can maintain glucose levels at the right amounts. When the system is failing, either because the pancreatic cells that produce insulin, called beta cells, are under attack from antibodies, or because your cells have become insulin-resistant, youre at risk of developing diabetes. Living with the condition can lead to blindness, kidney failure, or lower limb amputation, all while increasing your likelihood of heart attack or stroke. The way we designate diabetes as Type 1 or Type 2 is largely related to two factors: How old someone is when they develop diabetes, and whether the antibodies that attack insulin-producing beta cells are present. Type 1 diabetes is the type that often, but not always, begins in childhood, and it is characterized by the presence of the antibodies tha Continue reading >>
The 5 'new' Types Of Diabetes, Explained
Credit: Bochkarev Photography/Shutterstock Diabetes just got a little more complicated, or clearer, depending on your perspective. Researchers in Scandinavia have proposed classifying diabetes as five types of disease, rather than two types, according to a new study. But what are these different types, and why did the researchers make this decision? Having diabetes means that a person's blood sugar (glucose) levels are too high. It's an increasingly common disease; about 30 million people in the U.S. have diabetes, according to the Centers for Disease Control and Prevention. In people with type 1 diabetes , which most often appears in childhood, the body cannot make insulin a hormone that helps glucose get into cells. This condition occurs because the body's immune system attacks the cells in the pancreas that make insulin. In type 2 diabetes , the body does not make or use insulin well. Often, this condition begins with insulin resistance, which means cells aren't responding to insulin, even though the body is still making the hormone. The condition often occurs in middle-age or older adults and is thought to be related to lifestyle factors and obesity . But in the new study , which was published yesterday (March 1) in the journal The Lancet Diabetes & Endocrinologyl, researchers found that diabetes patients in Sweden and Finland fell into five clusters. One of the clusters was similar to type 1 diabetes, while the other four clusters were "subtypes" of type 2. Three of the clusters were considered severe forms of the disease, while two clusters were considered mild forms. [ 5 Diets That Fight Diseases ] Dr. Kathleen Wyne, an endocrinologist at The Ohio State University Wexner Medical Center, who was not involved with the study, said that the new classification could Continue reading >>
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Diabetes: The Differences Between Types 1 And 2
Diabetes, or diabetes mellitus (DM), is a metabolic disorder in which the body cannot properly store and use sugar. It affects the body's ability to use glucose, a type of sugar found in the blood, as fuel. This happens because the body does not produce enough insulin, or the cells do not correctly respond to insulin to use glucose as energy. Insulin is a type of hormone produced by the pancreas to regulate how blood sugar becomes energy. An imbalance of insulin or resistance to insulin causes diabetes. Diabetes is linked to a higher risk of cardiovascular disease, kidney disease, vision loss, neurological conditions, and damage to blood vessels and organs. There is type 1, type 2, and gestational diabetes. They have different causes and risk factors, and different lines of treatment. This article will compare the similarities and differences of types 1 and 2 diabetes. Gestational diabetes occurs in pregnancy and typically resolves after childbirth. However, having gestational diabetes also increases the risk of developing type 2 diabetes after pregnancy, so patients are often screened for type 2 diabetes at a later date. According to the Centers for Disease Control and Prevention (CDC), 29.1 million people in the United States (U.S.) have diabetes. Type 2 diabetes is much more common than type 1. For every person with type 1 diabetes, 20 will have type 2. Type 2 can be hereditary, but excess weight, a lack of exercise and an unhealthy diet increase At least a third of people in the U.S. will develop type 2 diabetes in their lifetime. Both types can lead to heart attack, stroke, nerve damage, kidney damage, and possible amputation of limbs. Causes In type 1 diabetes, the immune system mistakenly attacks the insulin-producing pancreatic beta cells. These cells are destro Continue reading >>
Differences Between Type 1 And Type 2
Tweet Whilst both type 1 and type 2 diabetes are characterised by having higher than normal blood sugar levels, the cause and development of the conditions are different. Confused over which type of diabetes you have? It's not always clear what type of diabetes someone has, despite what many people think. For instance, the typical assumption is that people with type 2 diabetes will be overweight and not inject insulin, while people with type 1 diabetes will be, if anything, underweight. But these perceptions just aren't always true. Around 20% of people with type 2 diabetes are of a healthy weight when diagnosed, and many of them are dependent on insulin. Similarly, people with type 1 diabetes will in some cases be overweight. Because both types of diabetes can be so varied and unpredictable, it's often difficult to know which type of diabetes someone has. It's not safe to assume that an overweight person with high blood glucose levels has type 2 diabetes, because the cause of their condition might in fact be attributable to type 1. In some cases, when the type of diabetes is in doubt, your health team may need to carry out specialised tests to work out which type of diabetes you have. This way, they can recommend the most appropriate treatment for your diabetes. Common differences between type 1 and type 2 diabetes Despite the uncertainty that often surrounds a diagnosis of diabetes, there are a few common characteristics of each diabetes type. Please note that these differences are based on generalisations - exceptions are common. For instance, the perception of type 1 diabetes isn't strictly true: many cases are diagnosed in adulthood. This table should be seen as a rough guide to the differences between type 1 and type 2 diabetes, rather than hard and fast rules. Co Continue reading >>
Types Of Diabetes Mellitus
Diabetes mellitus (or diabetes) is a chronic, lifelong condition that affects your body's ability to use the energy found in food. There are three major types of diabetes: type 1 diabetes, type 2 diabetes, and gestational diabetes. All types of diabetes mellitus have something in common. Normally, your body breaks down the sugars and carbohydrates you eat into a special sugar called glucose. Glucose fuels the cells in your body. But the cells need insulin, a hormone, in your bloodstream in order to take in the glucose and use it for energy. With diabetes mellitus, either your body doesn't make enough insulin, it can't use the insulin it does produce, or a combination of both. Since the cells can't take in the glucose, it builds up in your blood. High levels of blood glucose can damage the tiny blood vessels in your kidneys, heart, eyes, or nervous system. That's why diabetes -- especially if left untreated -- can eventually cause heart disease, stroke, kidney disease, blindness, and nerve damage to nerves in the feet. Type 1 diabetes is also called insulin-dependent diabetes. It used to be called juvenile-onset diabetes, because it often begins in childhood. Type 1 diabetes is an autoimmune condition. It's caused by the body attacking its own pancreas with antibodies. In people with type 1 diabetes, the damaged pancreas doesn't make insulin. This type of diabetes may be caused by a genetic predisposition. It could also be the result of faulty beta cells in the pancreas that normally produce insulin. A number of medical risks are associated with type 1 diabetes. Many of them stem from damage to the tiny blood vessels in your eyes (called diabetic retinopathy), nerves (diabetic neuropathy), and kidneys (diabetic nephropathy). Even more serious is the increased risk of hea Continue reading >>
What's The Difference Between Type 1 And Type 2 Diabetes?
Type 1 and type 2 diabetes share the problem of high levels of blood sugar. The inability to control blood sugar causes the symptoms and the complications of both types of diabetes. But type 1 diabetes and type 2 diabetes are two different diseases in many ways. According to the latest (2014) estimates from the Centers for Disease Control and Prevention (CDC), 29.1 million people, or 9.3 percent of the U.S. population, have diabetes. Type 1 diabetes affects just 5 percent of those adults, with type 2 diabetes affecting up to 95 percent. Here’s what else you need to know to be health-savvy in the age of the diabetes epidemic. What Causes Diabetes? "Type 1 diabetes is an autoimmune disease — the body's immune system attacks the cells in the pancreas that make insulin," a hormone, says Andjela Drincic, MD, associate professor of internal medicine in the division of diabetes, endocrinology, and metabolism at the University of Nebraska Medical Center in Omaha. The exact cause is not known, but it's probably a combination of the genes a person is born with and something in the environment that triggers the genes to become active. "The cause of type 2 diabetes is multifactorial," says Dr. Drincic. "People inherit genes that make them susceptible to type 2, but lifestyle factors, like obesity and inactivity, are also important. In type 2 diabetes, at least in the early stages, there is enough insulin, but the body becomes resistant to it." Risk factors for type 2 diabetes include a family history of the disease, a poor diet, a sedentary lifestyle, and obesity. African-Americans, Latin Americans, and certain Native American groups have a higher risk of type 2 diabetes than Caucasian Americans. Juvenile or Adult-Onset: When Does Diabetes Start? Usually, type 1 diabetes in dia Continue reading >>
What Are The Different Types Of Diabetes?
What are the different types of diabetes? Diabetes is a group of diseases in which the body either doesn’t produce enough or any insulin, does not properly use the insulin that is produced, or a combination of both. When any of these things happens, the body is unable to get sugar from the blood into the cells. That leads to high blood sugar levels. Glucose, the form of sugar found in your blood, is one of your chief energy sources. Lack of insulin or resistance to insulin causes sugar to build up in your blood. This can lead to many health problems. The three main types of diabetes are: type 1 diabetes type 2 diabetes gestational diabetes Type 1 diabetes Type 1 diabetes is believed to be an autoimmune condition. It happens when your immune system mistakenly attacks and destroys the beta cells in your pancreas that produce insulin. The damage is permanent. What prompts the attack isn’t clear. There may be both genetic and environmental components. Lifestyle factors aren’t thought to play a role. Type 2 diabetes Type 2 diabetes starts as insulin resistance. This means your body can’t use insulin efficiently. That stimulates your pancreas to produce more insulin until it can no longer keep up with demand. Insulin production decreases, which leads to high blood sugar. The exact cause is unknown. Contributing factors may include genetics, lack of exercise, and being overweight. There may also be other health factors and environmental reasons. Gestational diabetes Gestational diabetes is due to insulin blocking hormones produced during pregnancy. This type of diabetes only occurs during pregnancy. Learn more: What you should know about pregestational diabetes » General symptoms of diabetes include: excessive thirst and hunger frequent urination drowsiness or fatigue Continue reading >>
Types Of Diabetes
Elevated blood sugar has many causes. Diabetes is classified by type, based on causes. Knowing what type of diabetes you have will help you manage it. Diabetes is defined as an elevated blood sugar, but there are many causes of an elevated blood sugar. Diabetes is classified into different types, based on the various causes. The treatment will vary, depending on what is causing the problem. It is important to know what type of diabetes you have because your type of diabetes might need to be managed differently from someone else’s. This section will help you learn about what kind of diabetes you have. In this section, you will learn about: Type 1 Diabetes: when the body loses the ability to make insulin or can only make a very small amount of insulin. Type 1 diabetes is usually caused by an autoimmune process, and your body’s immune system mistakenly destroys the insulin-producing cells. About 10% of individuals with diabetes have type 1 diabetes. Type 2 Diabetes: caused by a dual defect of resistance to the action of insulin combined with an inability to make enough insulin to overcome the resistance. Type 2 diabetes is the most common form of diabetes and represents 80% to 90% of diabetes worldwide. Other Types of Diabetes: a miscellaneous category that includes unusual or rare inherited or acquired causes of diabetes. This represents the minority of people with diabetes. Continue reading >>
Diabetes Symptoms, (type 1 And Type 2)
Diabetes type 1 and type 2 definition and facts Diabetes is a chronic condition associated with abnormally high levels of sugar (glucose) in the blood. Insulin produced by the pancreas lowers blood glucose. Absence or insufficient production of insulin, or an inability of the body to properly use insulin causes diabetes. The two types of diabetes are referred to as type 1 and type 2. Former names for these conditions were insulin-dependent and non-insulin-dependent diabetes, or juvenile onset and adult onset diabetes. Symptoms of type 1 and type 2 diabetes include increased urine output, excessive thirst, weight loss, hunger, fatigue, skin problems slow healing wounds, yeast infections, and tingling or numbness in the feet or toes. Some of the risk factors for getting diabetes include being overweight or obese, leading a sedentary lifestyle, a family history of diabetes, hypertension (high blood pressure), and low levels of the "good" cholesterol (HDL) and elevated levels of triglycerides in the blood. If you think you may have prediabetes or diabetes contact a health-care professional. Diabetes mellitus is a group of metabolic diseases characterized by high blood sugar (glucose) levels that result from defects in insulin secretion, or its action, or both. Diabetes mellitus, commonly referred to as diabetes (as it will be in this article) was first identified as a disease associated with "sweet urine," and excessive muscle loss in the ancient world. Elevated levels of blood glucose (hyperglycemia) lead to spillage of glucose into the urine, hence the term sweet urine. Normally, blood glucose levels are tightly controlled by insulin, a hormone produced by the pancreas. Insulin lowers the blood glucose level. When the blood glucose elevates (for example, after eating food Continue reading >>