The following is a list of insulin preparations, grouped by duration of action (short, intermediate and long acting). Each group is sorted according to affordability, computed as the cost per mL of the insulin preparation. The parts of the table are as follows: Centile rank refers to the rank (between 0-100) of the preparation in terms of cost per mL, compared with other available insulin preparations. The lower the number, the lower the cost. Brand name refers to the trade name of the drug. Stock volume refers to the amount of the drug (in mL) per preparation. Unit Price refers to the manufacturer's price. Cost per mL refers to the cost per unit volume (mL) of the insulin preparation. The data may be used by physicians to compare the cost of different insulin preparations. The tabular format provides physicians a quick survey of the comparative prices and cost-per-mLday of using a particular insulin. The data may be used by patients to search for more affordable drugs with the same action and bioavailability as their current prescription drug. Continue reading >>
A Comparison Of Premixed Insulin Preparations In Elderly Patients. Efficacy Of70/30 And 50/50 Human Insulin Mixtures.
A comparison of premixed insulin preparations in elderly patients. Efficacy of70/30 and 50/50 human insulin mixtures. OBJECTIVE: To compare the postprandial hyperglycemic response to a standardbreakfast of two premixed humulin insulin mixtures, 50/50 (50% NPH human insulin and 50% regular human insulin) and 70/30 (70% NPH human insulin and 30% regularhuman insulin) in elderly non-insulin-dependent diabetes mellitus (NIDDM)patients.RESEARCH DESIGN AND METHODS: On two mornings, each patient (n = 20) consumed astandard breakfast after a single dose of 50/50 or 70/30 insulin (0.3 U/kg) wasadministered in a randomized crossover fashion. Plasma glucose and serum freeinsulin concentrations were measured before and for 4 h after insulinadministration.RESULTS: Plasma glucose reached a peak at 60 min and a nadir at 240 min for both types of insulin. No differences in maximum and minimum glucose concentrations,time to maximum and minimum glucose concentrations, or areas under the curve werenoted. Free insulin levels did not differ significantly.CONCLUSIONS: These results suggest that small changes in the composition ofpremixed insulin mixtures in NIDDM patients may not result in improvedpostprandial glycemic control. Continue reading >>
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Insulin Brands And Types
1. Type of Insulin & Brand Names Onset Peak Duration Role in Blood Sugar Management Rapid-Acting Lispro (Humalog) 15-30 min. 30-90 min 3-5 hours Rapid-acting insulin covers insulin needs for meals eaten at the same time as the injection. This type of insulin is often used with longer-acting insulin. Aspart (Novolog) 10-20 min. 40-50 min. 3-5 hours Glulisine (Apidra) 20-30 min. 30-90 min. 1-2½ hours Short-Acting Regular (R) humulin or novolin 30 min. -1 hour 2-5 hours 5-8 hours Short-acting insulin covers insulin needs for meals eaten within 30-60 minutes. Velosulin (for use in the insulin pump) 30 min.-1 hour 1-2 hours 2-3 hours Intermediate-Acting NPH (N) 1-2 hours 4-12 hours 18-24 hours Intermediate-acting insulin covers insulin needs for about half the day or overnight. This type of insulin is often combined with a rapid- or short-acting type. Long-Acting Insulin glargine (Basaglar, Lantus) 1-1½ hour No peak time. Insulin is delivered at a steady level. 20-24 hours Long-acting insulin covers insulin needs for about one full day. This type is often combined, when needed, with rapid- or short-acting insulin. Insulin detemir (Levemir) 1-2 hours 6-8 hours Up to 24 hours Ultra-Long-Acting Insulin degludec (Tresiba) 30-90 min. No Peak onset. 42 hours Ultra-Long-Acting insulin provides steady insulin levels for over 24 hours. Injected once daily to provide base insulin levels. May be combined with short-acting insulin to cover meals. Pre-Mixed* Humulin 70/30 30 min. 2-4 hours 14-24 hours These products are generally taken two or three times a day before mealtime. Novolin 70/30 30 min. 2-12 hours Up to 24 hours Novolog 70/30 10-20 min. 1-4 hours Up to 24 hours Humulin 50/50 30 min. 2-5 hours 18-24 hours Humalog mix 75/25 15 min. 30 min.-2½ hours 16-20 hours *Premixed insu Continue reading >>
Humulin R Classification
humulin r classification Onset of action: Peak level: Duration of action: Comments. Humalog differs from Regular human insulin by its rapid onset of action as well as a shorter duration of activity. When mixing insulin in a syringe, draw up the quickest acting insulin first (e. 38 Vetsulin (porcine insulin zinc suspension) from Merck Animal Health is the only FDA-approved product for diabetes management in both dogs and cats. insulin coverage 1-72. NPH suspen- Humulin70/30 3060 26 hours 1424 hours cloudy Do not mix with other sion/Regular Novolin 70/30 minutes insulins. Interactions: Concomitant thiazolidinediones (TZDs) may cause fluid retention and heart failure; consider dose reduction or discontinue TZDs. hypoglycemia 1-74. The term "sliding scale" refers to the progressive increase in pre-meal or nighttime insulin doses. phenergan Includes Analytical Chemistry, AP Chemistry, Biological Systems, Bonding and Molecule Formation, Chemistry of Biological and Bioactive Organic Composition, Chemistry of Biological Macromolecules, Chemical Engineering, Dynamics, Electrochemistry and Chemical Kinetics, Environmental Chemistry 1 Patient Information Humulin(HU-mu-lin)R insulin human injection (100units per mL) Do not share your syringes with other people, even if the needle has been changed. isophane insulin suspension (NPH) and insulin injection (regular) Humulin 70/30 (70% isophane insulin and 30% insulin injection), Humulin 70/30 PenFill, Novolin 70/30, Novolin The link to Humulin R Insulin 500 units /ml on the Leeds formulary can be found here Drug: Indication: Humulin R (U500) insulin (unlicensed product) Diabetic patients with marked insulin resistance requiring high doses of insulin Classification: Amber Level 2 Monitoring: Routine monitoring for diabetic patients on Continue reading >>
Comparison Of Thrice Daily Biphasic Human Insulin (30/70) Versus Basal Detemir & Bolus Aspart In Patients With Poorly Controlled Type 2 Diabetes Mellitus – A Pilot Study
Go to: Abstract Conventionally, biphasic human insulin (30/70, BHI) is used twice daily for the management of patients with diabetes. However, this regimen is suboptimal to control post-lunch and/or pre-dinner hyperglycaemia in some patients. This study was undertaken to compare the efficacy and safety of thrice-daily biphasic human insulin (30/70, BHI) versus basal detemir and bolus aspart (BB) in patients with poorly controlled type 2 diabetes mellitus (T2DM). In this open labelled randomized pilot study, 50 patients with uncontrolled T2DM on twice-daily BHI and insulin sensitizers were randomized either to BHI thrice-daily or BB regimen. HbA1c, six point plasma glucose profile, increment in insulin dose, weight gain, hypoglycaemic episodes and cost were compared between the two treatment groups at the end of 12 wk. Mean HbAlc (±SD) decreased from 9.0±0.9 per cent at randomization to 7.9±0.8 per cent in BHI (P<0.001) and from 9.4±1.3 to 8.2±1.0 per cent in BB regimen (P<0.001) after 12 wk of treatment. The mean (±SEM) weight gain in patients in the BHI regimen was 1.5±0.33 kg compared to 1.4±0.34 kg in the BB regimen. Insulin dose increment at 12 wk was significantly more in the BB regimen 0.46±0.32 U/kg/day compared to 0.15±0.21 U/kg/day in the BHI regimen (P<0.001). The incidence of major as well as minor hypoglycaemic episodes was not different in both the regimen. The BB regimen was more expensive than the BHI regimen (P<0.001). Interpretation & conclusions: The thrice daily biphasic human insulin regimen is non-inferior to the basal bolus insulin analogue regimen in terms efficacy and safety in patients with poorly controlled T2DM. However, these data require further substantiation in large long term prospective studies. Keywords: Biphasic human insulin Continue reading >>
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How Does 70/30 Insulin Differ From Lantus?
How does 70/30 insulin differ from Lantus? Hello.I'm not a medical professional, just the parent of a kid with diabetes.Lantus is a long acting insulin that starts working within 1 to 2 hours, with a minimal peak in about 6 hours, and lasts 24 hours.You take one shot of it for your long acting insulin, and you still need to take a fast acting insulin to cover your corrections and meals.It is provides a fairly constant basal insulin all day long.70/30 mix has both, fast acting insulin to cover a meal, and long acting to provide that basal between meals. Here is a listing of different types of insulins and their details: To me, the basic difference is variability and flexibility.With Lantus, you know exactly what you are dosing, and you also dose exactly the amount of fast acting you need.With 70/30 there is a lot extra to take into account.I personally don't know many, if any, people who are still using mixed insulin, except in poorer countries where they can't get anything else. Continue reading >>
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Insuget R/insuget N/insuget 70/30
Treatment of patients with type I diabetes mellitus; type II diabetes mellitus either alone or in combination with oral antidiabetic agents; gestational diabetes. Emergency management of diabetic ketoacidosis. The type of formulation, its dose and the frequency of administration should be determined by the physician, according to the needs suitable to the patient. The dose should be adjusted as necessary according to the results of regular monitoring of glucose concentrations in the blood glucose (or occasionally urine concentrations). A total dose in excess of about 80 units daily would be unusual and may indicate the presence of a form of insulin resistance. The average daily requirement for diabetes therapy ranges between 0.5 IU/kg and 0.1 IU/kg, depending on the individual needs of the patient. Optimized metabolic control, including glucose monitoring, is therefore recommended during insulin treatment. Elderly: The primary aim of treatment may be relief of symptoms and avoidance of hypoglycemic events. Insuget R: May be taken 1-4 times daily, before meals and possibly at bedtime. Regular or rapid-acting insulin should be administered 30-45 min before a meal. It can be mixed in the same syringe with intermediate-acting insulins, but in such situations, the regular insulin is drawn first. Insuget R should be given by SC injection but may, although not recommended, also be given by IM injection. It may also be administered IV. Insuget R is administered SC into the thigh or abdominal wall. If convenient, the gluteal or deltoid region may be used. Insuget N (NPH): Administered SC into the thigh or abdominal wall, preferably before meals, 1-2 times daily depending upon the requirement of the individual. If convenient, the gluteal or deltoid region may be used. It should Continue reading >>
Humulin 70-30 (70% human insulin isophane suspension and 30% human insulin) is a man-made form of a hormone that is produced in the body used to treat diabetes. The most common side effect of Humulin 70-30 is low blood sugar (hypoglycemia). Symptoms of low blood sugar may include headache, nausea, hunger, confusion, drowsiness, weakness, dizziness, blurred vision, fast heartbeat, sweating, tremor, trouble concentrating, confusion, or seizure (convulsions). Other side effects of Humulin 70-30 include: injection site reactions (e.g., pain, redness, irritation), skin thickening or pits at the injection site (lipodystrophy), itching, rash, swelling of your hands and feet. Tell your doctor if you have serious side effects of Humulin 70-30 including signs of low potassium level in the blood (such as muscle cramps, weakness, irregular heartbeat). Each patient's diabetes is different, and the injection schedule and use of Humulin 70-30 is individualized. A doctor determines which insulin to use, how much, and when and how often to inject it. Humulin 70-30 may interact with albuterol, clonidine, reserpine, guanethidine, or beta-blockers. Tell your doctor all medications you are taking. Tell your doctor if you are pregnant before using Humulin 70-30. If you are planning pregnancy, discuss a plan for managing your blood sugars with your doctor before you become pregnant. Your doctor may switch the type of insulin you use during pregnancy. This medication does not pass into breast milk. Consult your doctor before breastfeeding. Insulin needs may change while breastfeeding. Our Humulin 70-30 (70% human insulin isophane suspension and 30% human insulin) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this Continue reading >>
Diabetes Mellitus Type I Medication
Automatically changes to Flash or non-Flash embed The presentation is successfully added In Your Favorites . This Presentation is Public Favorites: DIABETES MELLITUS TYPE I MEDICATION Mohamed Zaghbar Pharmacist 1 Al Khabisi Pharmacy Introduction The Hermon Insulin is endogenously released from the B cells of the Pancreas. Patients with Type 1 diabetes mellitus have an absolute deficiency of Insulin. Insulin is required in all type I diabetes patients as a lifelong treatment. Various substitutions on the insulin molecule and other modifications have led to multiple types of insulins Insulins characterized and adminis - tered based on their pharmacodynamic and pharmacokinetic characteristics such as ONSET PEAK DURATION OF ACTOION S ignificantly , they are classified as RAPID-ACTING SHORT-ACTING LONG-ACTING INTEMEDIATE-ACTING Mechanism of Action for the Drug Class Insulin lowers blood glucose by stimulating peripheral glucose uptake, especially in skeletal muscle and fat, and by inhibiting hepatic glucose production . Usage for the Drug Class Type 1 diabetes mellitus, type 2 diabetes mellitus. Dosing for the Drug Class Initial dose : 0.5 to 1 unit/kg per day Sub-Q (high interpatient variability ) Maintenance dose: Adjust doses to achieve premeal and bedtime blood glucose levels of 80140 mg/dl Renal dosage adjustment : CrCl 1050 ml/minute: Administer 75% of normal dose CrCl <10 ml/minute: Administer 2550% of normal dose Adverse Reactions for the Drug Class Most Common Hypoglycemia (anxiety, blurred vision, palpitations, shakiness, slurred speech, sweating), weight gain Rare / Severe/Important seizure/coma), edema, lipoatrophy or lipohypertrophy at injection site Major Drug Interactions for the Drug Class Decreased Hypoglycemic Effect Increased Hypoglycemic Effect Alcohol F Continue reading >>
Humilin 70/30 Vs Novomix 30
Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community I have been administering Humilin 70/30 for the last 10 years. On my request, recently my doctor put me on Novomix 30 recommending the same dose as of Humilin 70/30. In the past by using Humilin 70/30, I had hypos, and BG was somewhat sometime under control especially during the evening time, but Novoflex has not shown me any sign of hypos, also glucose level is not coming under control. I am very much worried about this. Any of my friends on this forum can educate me what are possible reasons and what should I do? Thanks in anticipation for your valuable input. I have been administering Humilin 70/30 for the last 10 years. On my request, recently my doctor put me on Novomix 30 recommending the same dose as of Humilin 70/30. In the past by using Humilin 70/30, I had hypos, and BG was somewhat sometime under control especially during the evening time, but Novoflex has not shown me any sign of hypos, also glucose level is not coming under control. I am very much worried about this. Any of my friends on this forum can educate me what are possible reasons and what should I do? Thanks in anticipation for your valuable input. It might be helpful if you can post some of your readings, doses and meals/snacks to help build a bigger picture? If we know what your results are it can be simpler to spot a pattern that could indicate a good place to start? NovoMix 30 : 32 units in the morning (before breakfast), 30 units in the evening (before dinner). My usual breakfast : at around 7:30 a.m. 2 or 3 slices of bran bread with little margarine (cholesterol free) and 2 or 3 times a week one boiled egg with a cup of low fat milk daily. At around 9:30 a.m. I drink one cu Continue reading >>
Alternate Brands Of Insuget 70/30
Site designed by Pharma Professional Services and developed by Hasan Computing Systems Information provided on this Web site is neither intended nor implied to be a substitute for professional medical advice. You should not use this information on this web site or the information on links from this site to diagnose or treat a health problem or disease without consulting with a qualified healthcare provider. Pharma Professional Services advises you to always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition. You should check with your physician/health care provider before using any of the means or methods presented on this site. If you undertake any treatment methods displayed on this site without such supervision, you are solely and entirely responsible for it's outcome. Pharma Professional Services nor anyone connected with this site cannot be held responsible for your actions nor any conditions resulting thereof. Continue reading >>
Insuget-r / Insuget-n / Insuget 70/30 Product Information | The Filipino Doctor
Renal or hepatic impairment, emotional disturbances, excessive exercise. Pregnancy Risk Category: B. Pregnancy Risk Category by the US FDA: Close A - Adequate and compelling studies in humans do not show any evidence that the product poses a risk to the baby inthe womb. B - Adequate and compelling studies in animals do not show a risk to the baby, but there are not enough compellingstudies in humans. Otherwise, animal studies show a risk but studies on humans do not show any. C - Adequate and compelling studies in animals show a risk to the baby, but there are not enough compelling studiesin humans. However, the product may be used in pregnant women in certain situations despite potential risks. D - Adequate and compelling studies in humans show a risk to the baby. However, the product may be used in pregnantwomen in certain situations despite the potential risks. X - Adequate and compelling studies in animals or humans show a risk to the baby in the womb. Also, use orexperience in humans shows a risk. The danger of using the product in pregnant women clearly outweighs its benefits. Nonselective beta-blockers, oral contraceptives, octerotide, MAOIs, ACE inhibitors, salicylates, alcohol & alcohol steroids, thiazides, glucocorticoids, thyroid hormones & sympathomimetics, danazol. Continue reading >>
Humulin 70/30 And Pregnancy
Diabetes Home > Humulin 70/30 and Pregnancy In most cases, Humulin 70/30 is considered safe to take during pregnancy. Since it is very important for pregnant women with diabetes to control their blood sugar, the benefits of the insulin medication may outweigh any potential risks. If you are using Humulin 70/30 and pregnancy occurs, notify your healthcare provider, as pregnancy may affect your insulin requirements. Can I Take Humulin 70/30 During Pregnancy? Humulin 70/30 (NPH insulin / regular insulin ) is a non-prescription diabetes medication that contains two different types of insulin . As with many types of insulin, Humulin 70/30 is generally considered to be safe for pregnant women. It has been around long enough for healthcare providers to have plenty of experience with the use of this medication during pregnancy. The U.S. Food and Drug Administration (FDA) uses a pregnancy category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category B is given to medicines that have not been adequately studied in pregnant humans but do not appear to cause harm to the fetus in animal studies. Although it was originally thought that insulin molecules are too large to cross the placenta, it is now known that some insulins, in some circumstances, may cross the placenta. In general, most healthcare providers consider Humulin 70/30 to be safe for use during pregnancy. It is very important for pregnant women with diabetes (including gestational diabetes ) to control their blood sugar, and Humulin 70/30 can be useful to help keep blood sugar under control. The most significant risk to a pregnant woman (or to anyone, for that matter) due to the use of insulin is dangerously low blood sugar. Be sure to check your blood su Continue reading >>
Nearest Equivalent Insulin To Mixtard 30
Home IDDT News Withdrawal of Mixtard 30 Nearest equivalent insulin to Mixtard 30 Marketing of insulin a missed opportunity Nearest equivalent insulin to Mixtard 30 Mixtard 30 is human premixed insulin 30% of which is short-acting insulin and 70% is intermediate-acting, isophane insulin. Humulin M3 is the nearest equivalent insulin to Mixtard 30. It is made by Eli Lilly and is also human premixed insulin made up of 30% short-acting insulin and 70% intermediate-acting, isophane insulin. The only pre-mixed insulin that will be available from Novo Nordisk is NovoMix 30, an analogue premixed insulin 30% of rapid-acting NovoRapid [aspart] insulin and 70% protamine insulin aspart. This is not the same, nor even similar as NovoMix 30 has a very different peak and duration of action to Mixtard 30, as the chart below clearly demonstrates. The chart also demonstrates that Humulin M3 is more similar to Mixtard 30 than NovoMix 30. So if you are forced to change from Mixtard 30, then the nearest equivalent insulin is Humulin M3. Clearly, Novo Nordisk will want people to stay with their brand of insulin, in this case NovoMix 30, and you may be advised to do this but remember, this is not the same. IDDTs advice is to discuss your options with your diabetes team and if you want the nearest equivalent insulin, then ask to change to Humulin M3 and not NovoMix 30. Duration of the peak of action of premixed insulins Continue reading >>
Humulin70/30, Novolin 70/30 (insulin Isophane Human/insulin Regular Human) Dosing, Indications, Interactions, Adverse Effects, And More
insulin isophane human/insulin regular human Ketones moderate or less: 0.5 U/kg/day SC Typically, 50-75% of total daily dose is given as intermediate- or long-acting insulin May use this combination product if the dosage ratio of NPH (isophane) to regular is 2:1 Suggested guidelines for beginning dose; adjust according to blood glucose levels Initial dose: 0.5-1 units/kg/day in divided doses Typically, 50-75% of total daily dose is given as intermediate- or long-acting insulin May use this combination product if the dosage ratio of NPH (isophane) to regular is 2:1 Ratio of regular insulin to NPH (isophane) insulin 1:2 Administer within 15 min before a meal or immediately after a meal Store unopened vials/pens refrigerated; do not freeze Opened (in-use) product may be stored at ambient room temperature (below 86F [30C]) and away from heat and light Dosage of human insulin, which is always expressed in USP units, must be based on the results of blood and urine glucose tests and must be carefully individualized to optimal effect Dose adjustments should be based on regular blood glucose testing (See Dosage Adjustment Strategies) Adjust to achieve appropriate glucose control Look for consistent pattern in blood sugars for >3 days Compare blood glucose for same time each day For each time of day: calculate blood glucose range Consider eating and activity patterns during day If all blood sugars are high (within 2.75 mmol/L [50 mg/dL]): correct morning fasting blood glucose 1st Many sliding scales exist to determine exact insulin dose based on frequent blood glucose monitoring - Commonly written for q4hr blood glucose test - Sliding scale coverage usually begins after blood glucose >11 mmol/L (200 mg/dL) - If coverage is needed q4hr x 24 hr, then base insulin dose is adjusted Continue reading >>