Diagnostic Criteria For Diabetes Mellitus According To American Diabetes Association

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Diagnosis Of Type 2 Diabetes Mellitus

There is a continuum of risk for poor patient outcomes as glucose tolerance progresses from normal to overt type 2 diabetes. AACE-defined glucose tolerance categories are listed in Table 1.1 Table 1. Glucose Testing and Interpretation1 Normal High Risk for Diabetes Diabetes FPG < 100 mg/dL IFG FPG ≥100-125 mg/dL FPG ≥126 mg/dL 2-hour PG <140 mg/dL (measured with an OGTT performed 2 hours after 75 g oral glucose load taken after 8-hour fast) IGT 2-hour PG ≥140-199 mg/dL 2-hour PG ≥200 mg/dL Random PG ≥200 mg/dL plus symptoms of diabetes (polyurea, polydipsia, or polyphagia) A1C < 5.5% 5.5% to 6.4% For screening of prediabetesa ≥6.5% Secondaryb Abbreviations: A1C = hemoglobin A1C; FPG = fasting plasma glucose; IFG = impaired fasting glucose; IGT = impaired glucose tolerance; PG = plasma glucose. a A1C should be used only for screening prediabetes. The diagnosis of prediabetes, which may manifest as either IFG or IGT, should be confirmed with glucose testing. b Glucose criteria are preferred for the diagnosis of DM. In all cases, the diagnosis should be confirmed on a separate day by repeating glucose or A1C testing. When A1C is used for diagnosis, follow-up glucose testin Continue reading >>

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Popular Questions

  1. TheImmortalPeacock

    Hello r/longevity, I have a question regarding which age is appropriate to begin Metformin for anti-aging effects. Is it a case of the sooner, the better, or should one wait until a certain age and then begin taking Metformin?
    I ask because I'm in my mid-20s and have access to Metformin. I've researched the recommended dosages for anti-aging and possible side effects.
    The clinical trials begin next winter I believe, and will take 6-7 years just for that. Who knows how much longer until it becomes FDA-approved and available for general public usage.
    Any help or additional information regarding this would be greatly appreciated, thanks!

  2. LongevityMan

    Life extension benefits are based on mortality reduction in type 2 diabetics found during meta analysis studies of over 10,000 people. For example there is a 37% reduction in cancer in type 2 diabetics over 10 years. Normally type 2 diabetes shortens lifespan by around 8 years but people who took metformin lived longer than non-diabetics. You have to remember though that it is unknown if the benefits will occur in healthy individuals. One benefit that will likely transfer to non-diabetics is that it will likely delay the onset of diabetes in people who would have had or will eventually get type 2 diabetes.
    Metformin has been studied for decades and is generally seen as safe. Clearly nothing is without side effects but eating red meat is probably more dangerous than metformin when you read the various studies on both. The main side effects are diarrhea in medium to high dosages and B12 deficiency which has been found in 10-30% of the people who take it. I would feel comfortable with someone in my family taking a low dose metformin who was their 30s as long as they supplemented with B12. One of the biggest problems with health care today, in my opinion, is that we wait decades for the damage to build up and then try to fix it. It is much better to start preventing damage in your 30s than wait until your 65.
    Edit: better results found when starting younger and taken for a longer period of time.
    "Meta-regression showed a significant correlation of the effect of metformin on cardiovascular events with trial duration and with minimum and maximum age for inclusion, meaning that the drug appeared to be more beneficial in longer trials enrolling younger patients. It is likely that metformin monotherapy is associated with improved survival (MH-OR: 0.801[0.625–1.024], p = 0.076)."

  3. TheImmortalPeacock

    Interesting. Thanks for the detailed reply backed by sources! I intend to do more research myself on this subject when I have more time to do so.

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