Diabetic Ketoacidosis Pathophysiology

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Pathophysiology Of Diabetic Ketoacidosis

Diabetic ketoacidosis is one of the potentially life-threatening acute complications of diabetes mellitus. In the past, diabetic ketoacidosis was considered as the hallmark of Type I diabetes, but current data show that it can be also diagnosed in patients with type II diabetes mellitus. It is often seen among patients who are poorly compliant to insulin administration during an acute illness. It is commonly precipitated by an acute stressful event such as the development of infection leading to overt sepsis, organ infarction such as stroke and heart attack, burns, pregnancy or intake of drugs that affect carbohydrate metabolism such as corticosteroids, anti-hypertensives, loop diuretics, alcohol, cocaine, and ecstasy. The presence of these stressful conditions incite the release of counter-regulatory hormones such as glucagon, catecholamines and growth hormone. These hormones induce the mobilization of energy stores of fat, glycogen and protein. The net effect of which is the production of glucose. As a result of absent or deficient insulin release, diabetic ketoacidosis present with the following metabolic derangements: profound hyperglycemia, hyperketonemiaand metabolic acidosis Continue reading >>

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Popular Questions

  1. dkellis

    What is the best time of day to take insulin ?

    I it better to take long acting insulin in the morning or in the evening? I take 50 units of Levemir at night before bed and my numbers are starting to run high the next morning.

  2. msann

    i take mine 14 units at around 10 and 6 in the morning i been diabetic 17 yrs it working good getting under 8 for a1c!!

  3. Gabby

    I was recommended to take my dose 12 hour apart. So it kind of depends on when I take the first one of the day. I usually do a 7:00 am and a before dinner dose.
    If you are getting high numbers in the morning it could be that the dose is too much and you drop low over night and your body kicks in. It is something I would talk to the doctor about. See if splitting it helps. I don't take Levemir, so I am not sure how it is supposed to be used. Many of them now come with different kids of dosing instructions.

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