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Diabetic Ketoacidosis Etiology

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What is DIABETIC KETOACIDOSIS? What does DIABETIC KETOACIDOSIS mean? DIABETIC KETOACIDOSIS meaning - DIABETIC KETOACIDOSIS definition - DIABETIC KETOACIDOSIS explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/... license. SUBSCRIBE to our Google Earth flights channel - https://www.youtube.com/channel/UC6Uu... Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of diabetes mellitus. Signs and symptoms may include vomiting, abdominal pain, deep gasping breathing, increased urination, weakness, confusion, and occasionally loss of consciousness. A person's breath may develop a specific smell. Onset of symptoms is usually rapid. In some cases people may not realize they previously had diabetes. DKA happens most often in those with type 1 diabetes, but can also occur in those with other types of diabetes under certain circumstances. Triggers may include infection, not taking insulin correctly, stroke, and certain medications such as steroids. DKA results from a shortage of insulin; in response the body switches to burning fatty acids which produces acidic ketone bodies. DKA is typically diagnosed when testing finds high b

Diabetic Ketoacidosis

Author: Osama Hamdy, MD, PhD; Chief Editor: Romesh Khardori, MD, PhD, FACP more... Diabetic ketoacidosis (DKA) is an acute, major, life-threatening complication of diabetes that mainly occurs in patients with type 1 diabetes, but it is not uncommon in some patients with type 2 diabetes. This condition is a complex disordered metabolic state characterized by hyperglycemia, ketoacidosis, and ketonuria. The most common early symptoms of DKA are the insidious increase in polydipsia and polyuria. The following are other signs and symptoms of DKA: Malaise, generalized weakness, and fatigability Nausea and vomiting; may be associated with diffuse abdominal pain, decreased appetite, and anorexia Rapid weight loss in patients newly diagnosed with type 1 diabetes History of failure to comply with insulin therapy or missed insulin injections due to vomiting or psychological reasons or history of mechanical failure of insulin infusion pump Altered consciousness (eg, mild disorientation, confusion); frank coma is uncommon but may occur when the condition is neglected or with severe dehydration/acidosis Signs and symptoms of DKA associated with possible intercurrent infection are as follows: Gl Continue reading >>

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  1. coastman

    Bayer A1CNow (SELFCHECK) - not now, not ever again

    A few weeks ago, when I was at my local pharmacy purchasing test strips, I noticed a new device on the shelf by Bayer called the A1CNow. This is a kit for self-testing your A1C. I normally get mine done every 6 months as part of my diabetic blood work. But I was curious as to how well the self-test compared to the lab test (Very well I found out. But that was the good news.)
    In Canada, the kit cost about $40 plus tax. It is good for 2 A1C tests. So the cost is approximately $20 per test. What I didn't find out until after I bought the kit is that the device that measures the blood sample is disposable after the 2 tests are done. I was told there are no refills. You have to buy another whole kit.
    I read the instructions very carefully several times. Then I tried my first test. Remember, this is a brand new product. So I was something of a volunteer Guinea Pig.
    Everything went well until I plugged in the container with my blood sample at which point I got an error message. I waited about 10 minutes. But the message never cleared. So I called Bayer. The representative on the other end of the phone helpfully suggested that I run another test without first obtaining a blood sample. Since I had already wasted one test I wasn't about to go there. So I had her wait while I obtained a blood sample. This time when I ran the test everything went off without a hitch.
    After about 5 minutes a reading of 6.2 popped up which was exactly the reading my next lab work got. So while I was impressed, it cost me over $40 to satisfy my curiosity. I had carefully followed the instructions and done both tests exactly the same way each time. But the Bayer representative never suggested a replacement kit or even materials to perform another test. Customer service? Not in my books.
    This experience and the inconsistent results I was getting with my Bayer Contour meter have caused me to cross Bayer off my list. A1CNow? No thanks. Not now, not ever again.

  2. jwags

    Why didn't you ask the rep to send you a coupon for a free kit? Usually when a meter goes bad they are more than helpful about keeping you a customer. I usually wait until they are on sale for $19.99 and then I download a coupon off the Bayer site, so it costs about $15. My kit was pretty self explanatory and I didn't have any problems. One thing though is to always check the exp date on the box before buying. I have to pay for my own HbA1c tests once a year which can run me hundreds of dollars, so this product is great for me.

  3. coastman

    Originally Posted by jeanne wagner
    Why didn't you ask the rep to send you a coupon for a free kit? Usually when a meter goes bad they are more than helpful about keeping you a customer. I shouldn't have to ask for anything. I am a customer. The representative was supposed to be serving me. Since she is Bayer to me Bayer earned a failing grade. Do you live in Canada or the US? It can make a big difference. As a proud Canadian I am ashamed to admit that, with few exceptions, our American counterparts run rings around Canadians when it comes to giving service. My wife and I cheered when we heard that Nordstrom's was coming to Vancouver. YES!!
    Good to see you are keeping your carbs low. Good on you.

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What is KETOACIDOSIS? What does KETOACIDOSIS mean? KETOACIDOSIS meaning - KETOACIDOSIS definition - KETOACIDOSIS explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/... license. SUBSCRIBE to our Google Earth flights channel - https://www.youtube.com/channel/UC6Uu... Ketoacidosis is a metabolic state associated with high concentrations of ketone bodies, formed by the breakdown of fatty acids and the deamination of amino acids. The two common ketones produced in humans are acetoacetic acid and ß-hydroxybutyrate. Ketoacidosis is a pathological metabolic state marked by extreme and uncontrolled ketosis. In ketoacidosis, the body fails to adequately regulate ketone production causing such a severe accumulation of keto acids that the pH of the blood is substantially decreased. In extreme cases ketoacidosis can be fatal. Ketoacidosis is most common in untreated type 1 diabetes mellitus, when the liver breaks down fat and proteins in response to a perceived need for respiratory substrate. Prolonged alcoholism may lead to alcoholic ketoacidosis. Ketoacidosis can be smelled on a person's breath. This is due to acetone, a direct by-product of the sp

Euglycemic Diabetic Ketoacidosis: A Review

Euglycemic Diabetic Ketoacidosis: A Review Author(s): Anar Modi , Department of Endocrinology, Diabetes & Metabolism, Cooper University Hospital, Camden, New Jersey, United States Abhinav Agrawal* , Department of Medicine, Monmouth Medical Center, 300 Second Avenue, Long Branch, New Jersey, United States Farah Morgan . Department of Endocrinology, Diabetes & Metabolism, Cooper University Hospital, Camden, New Jersey, United States Introduction: Diabetic ketoacidosis (DKA) is one of the most serious complications of diabetes.It is characterised by the triad of hyperglycemia (blood sugar >250 mg/dl), metabolic acidosis(arterial pH <7.3 and serum bicarbonate <18 mEq/L) and ketosis. Rarely these patients can present withblood glucose (BG) levels of less than 200 mg/dl, which is defined as euglycemic DKA. The possibleetiology of euglycemic DKA includes the recent use of insulin, decreased caloric intake, heavy alcoholconsumption, chronic liver disease and glycogen storage disorders. DKA in pregnancy has also beenreported to present with euglycemia. The recent use of sodium glucose cotransporter 2 (SGLT2) inhibitorshas shed light on another possible mechanism of euglycemic DKA. Clinicia Continue reading >>

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  1. MAYABLUE

    You'd be okay to double the dose if you didn't have the GI side effects. If your body can tolerate it, you can actually take 4 pills at once.

  2. LUVINPURPLE

    On missing a dose, the doctor I used to work for told to take the missed dose when I remembered UNLESS it was close to the next dose and then just skip it. You should probably discuss this with your doctor, though.
    Dee
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  3. NYXWOLFWALKER

    First it would be best to talk to your doc about it, but in general doubling up on a dose wont hurt just remember that any side effects you have with a single dose might be amplified by taking double.
    I'll say this, for me I do not take it with food and when I don't I find I do not have the side effects, or what side effects I do have are lessoned a great deal, so for me taking it with food is the worse thing (my endro knows this, doesn't like it, but as long as I take it and he see's results he's alright with me taking it without food).
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Demystifying Medicine 2014 - Obesity: Etiology, Pathogenesis and Why Weight Loss is Difficult Air date: Tuesday, February 04, 2014, 4:00:00 PM Runtime: 01:51:29 The 2014 Demystifying Medicine Series, which is jointly sponsored by FAES and NIH, will begin January 7th and includes the presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, clinicians and program managers, the course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components presented by NIH staff and invitees. All students, fellows and staff are welcome, as well. For more information go to http://demystifyingmedicine.od.nih.gov Author: Jack Yanovski, MD, PhD (NICHD) Kevin Hall, PhD (NIDDK) Permanent link: http://videocast.nih.gov/launch.asp?1...

The Evolution Of Diabetic Ketoacidosis: An Update Of Its Etiology, Pathogenesis And Management - Sciencedirect

Volume 65, Issue 4 , April 2016, Pages 507-521 The evolution of diabetic ketoacidosis: An update of its etiology, pathogenesis and management Author links open overlay panel Ebenezer A.Nyenwe Get rights and content The prognosis of diabetic ketoacidosis has undergone incredibly remarkable evolution since the discovery of insulin nearly a century ago. The incidence and economic burden of diabetic ketoacidosis have continued to rise but its mortality has decreased to less than 1% in good centers. Improved outcome is attributable to a better understanding of the pathophysiology of the disease and widespread application of treatment guidelines. In this review, we present the changes that have occurred over the years, highlighting the evidence behind the recommendations that have improved outcome. We begin with a discussion of the precipitants and pathogenesis of DKA as a prelude to understanding the rationale for the recommendations. A brief review of ketosis-prone type 2 diabetes, an update relating to the diagnosis of DKA and a future perspective are also provided. Continue reading >>

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  1. RAYT721

    Any Coke Addicts Here???

    I have pretty much been staying away from soda/pop and doing more water but there are times when I really crave the Diet Coke with Lime or the Cherry Diet Coke. I don't care much for the regular high octane Diet Coke so for me, it's Diet Pepsi when I don't have a flavoring. Do you know what annoys me? (well, several things but I'll get to the point) … I hate when you go to a pop machine and you have a choice of Diet Pepsi or Diet Pepsi. Come on, vending machine Gods… you can do better for the millions of diabetics out there! I am ready to write my congressman, senator or President to change the rules for vending machines. And it's really not just beverages that are unfriendly to diabetics. We should have saner choices available in our vending machines. It is always a surprise (shock) to get something from a vending machine and then get to look at the nutritional labels. There have been many "how bad can it be?" products that I have selected in a pinch only to wonder if Sara Lee had her hands in the recipe. I try to avoid vending machines by keeping healthier snacks at the office, in the car and around the house. So, tell me, are you a Coke or Pepsi addict???

  2. FISHINBOB

    I am not a Coke Addict. I am I Mountain Dew Addict. I first discovered it in the 60's when I was working in a Bakery at Night.During the Summer the Temperature would reach 120 Degraese and Coke wold only make us Thirstier.

  3. pjd67

    I do not like Diet Pepsi..too sweet tasting. I drink Coke Zero and lots of ice tea…no sweetener,just black like my coffee. I could say that I'm a tea addict. w/lemon. .That's my fruit.

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