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Diabetic Neuropathy

What is Diabetic Neuropathy Diabetic neuropathy is a type of nerve damage that happens in people who have diabetes mellitus. It affects mainly the peripheral nerves. There are three types of peripheral nerve affected: motor, sensory, and autonomic. Motor nerve fibres carry signals to muscles to allow motions like walking and fine finger movements. Sensory nerves take messages in the opposite direction. They carry information to the brain about shape, movement, texture, warmth, coolness, or pain from special sensors in the skin and from deep in the body. Autonomic nerves are nerves that are not consciously controlled. These nerves have functions such as controlling the heart rate, maintaining blood pressure, and controlling sweating. Damage to these nerves makes it hard for the nerves to carry messages to the brain and other parts of the body. This can result in numbness (loss of feeling) or painful tingling in parts of the body. Diabetic neuropathy can also affect the following: Strength and feeling in different body parts. Ability of the heart to keep up with the body’s needs. Ability of the intestines to digest food. Ability to achieve an erection (in men). Statistics on Diabet Continue reading >>

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Popular Questions

  1. joralo

    Lab results are back - no antibodies - but low C-peptide and insulin

    Hello,
    I am the one from this thread: High postprandials, beta blockers and LADA possibility
    (Summary: 33 years old. BMI 21. No diabetes in my family, not even distant relatives. "Normal" fasting glucose and hba1c, yet HIGH postprandials > 200 occasionally, depending on what I eat.)
    I checked for LADA since I read that that is most likely with my stats ("young age", normal weight, and no diabetes in the family).
    Ordered a whole range of blood panels (I didn't eat 12 hours before they took my blood and had no coffee or anything at all in the morning either, so these are completely fasting numbers) and here are the results (lab reference in brackets):
    Glucose: 92 mg/dl (< 100)
    Hba1c: 5.2 % (< 6.2 %)
    (I know, I know. Both bad according to Doc Bernstein. Hba1c used to be 5.1% in February, so it climbed up a bit here.)
    MBG: 103 mg/dl (<120)
    Hemoglobine 13.9 g/dl (12.0 - 16.0)
    Hematocrit: 41.1 % (36 - 47)
    (so no "false low" hba1c due to anemia or something)
    ICA: negative (< 3.125 JDF-Units)
    GAD-65: < 0.3 U/ml (<1.0)
    IA-2: < 0.8 U/ml (<1.0)
    IAA: <0.4 U/ml (<0.4)
    (so far, so good. Now for the bad stuff):
    C-Peptide basal: 1.3 ng/l (1.4 - 5.4)
    Insulin basal: 1.9 mU/l (5.0 - 30.0)
    HOMA-IR: 0.4 (< 2.5)
    I have tons of other values too but I don't think they would be too interesting or matter much here. Lipids are all perfect. Kidney and liver too.
    Summary: no Insulin resistance (no Type 2?). No antibodies (no Type 1?). But low C-Peptide and Insulin - wth is wrong with me?
    Am I such an early LADA case that my endogenous Insulin production is failing despite lack of antibodies? Am I one of those supposed 30% who don't show antibodies despite being LADA?
    What else can I do or should I test for in order to find out what's wrong with me? Can any one of you make sense of these results?

  2. Roxanne0312

    What did your doctor say? Some LADA's don't show antibodies. Diabetes is intriguing some time. We can't diagnose you we are not doctor's, but we have opinions. I would like to hear what the doctor says.

  3. VeeJay

    Are those results showing that your pancreas isn't producing the normal amount of insulin? I don't know what the Insulin Basal test is for, but you show low on that one also.
    I know what I would do just with those two test results - I'd be asking my doctor for at least basal insulin to make up for my low production. Obviously, since your A1C is rising, and you don't have insulin resistance, then you need some help. And if basal doesn't do the trick, I'd be asking for bolus for meals.
    Diabetes is a complicated condition. Trying to find out exactly what's going on may not be as important as getting the right insulin regimen in place.
    Let us know what your doctor says and how he suggest you manage your diabetes according to these test results.

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