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Sildenafil Citrate For Treatment Of Erectile Dysfunction In Men With Type 1 Diabetes

Sildenafil Citrate For Treatment Of Erectile Dysfunction In Men With Type 1 Diabetes

Results of a randomized controlled trial Abstract OBJECTIVE—In the 5–10% of diabetic men with type 1 diabetes, erectile dysfunction (ED) may be a particularly common and unwanted complication. This is the first study focusing exclusively on the effects of sildenafil in men with type 1 diabetes and ED. RESEARCH DESIGN AND METHODS—A total of 188 patients were entered into a double-blind, placebo-controlled, parallel-group, flexible-dose study and were randomized to receive sildenafil (25–100 mg; n = 95) or placebo (n = 93) for 12 weeks. Efficacy was evaluated using questions three (Q3; achieving an erection) and four (Q4; maintaining an erection) from the International Index of Erectile Function (IIEF), a global efficacy question (GEQ; “Did treatment improve your erections?”), and a patient event log of sexual activity. RESULTS—Improvements in mean scores from baseline to end-of-treatment for IIEF Q3 (35.7 vs. 19.9%) and Q4 (68.4 vs. 26.5%) were significant in patients receiving sildenafil compared with those receiving placebo (P = 0.0001). Moreover, the percent of improved erections (GEQ, 66.6 vs. 28.6%) and successful intercourse attempts (63 vs. 33%) was significantly increased with sildenafil compared with placebo. Improvements in sexual function were seen irrespective of the degree of ED severity. Adverse events were generally mild to moderate in severity, with headache (20 vs. 8%), flushing (18 vs. 3%), and dyspepsia (8 vs. 1%) reported more often in the sildenafil than in placebo-treated patients. CONCLUSIONS—Treatment with sildenafil for ED was effective, resulting in an increased percentage of successful attempts at intercourse, and was well tolerated among men with type 1 diabetes. According to the World Health Organization, the number of adults Continue reading >>

How Sildenafil Citrate (viagra) Treats Sexual Impotence In Diabetes Patients

How Sildenafil Citrate (viagra) Treats Sexual Impotence In Diabetes Patients

Sexual impotence is just one of the many symptoms that a person can experience with diabetes. According to the National Institutes of Health, approximately 10 percent of men with type 1 diabetes have erectile dysfunction as a common complication. A study was done with 188 patients to see if sildenafil citrate, the drug that is marketed as Viagra, was able to improve the overall quality of erections. The results were significant in comparison to the patients who were given the placebo. Sexual function was drastically improved. Headaches, flushing, and dyspepsia were seen as adverse effects, though these were in low numbers. The conclusion of the study showed that sildenafil citrate was in fact effective for erectile dysfunction. Sildenafil citrate helps to reduce the blood pressure in diabetic patients. When this occurs, it allows for hypertension to be controlled. This in turn helps with the atherosclerosis of the penile artery so that an erection can take place with greater frequency. Atherosclerosis is a buildup of fat, cholesterol and other substances that can lead to problems within the body. Just as it would be bad for it to build up in the arteries of the heart, it is bad when it builds up within the penile artery because it makes it harder for blood to flow to the penis for an erection. When the plaque is removed within the arteries, there is a greater amount of blood flow. This allows men with diabetes to experience an erection, thereby improving their overall sexual function. Approximately 135 million adults had diabetes in 1995 according to the World Health Organization and that number has only grown. In the past 10 to 15 years treatment options for erectile dysfunction have improved dramatically. The study that was conducted with sildenafil citrate focused on Continue reading >>

Don’t Ignore Erectile Dysfuntion: It’s Treatable!

Don’t Ignore Erectile Dysfuntion: It’s Treatable!

If you are a man with diabetes, we’ve got good news and bad news about your sex life. The bad news: Men with diabetes are three times more likely to report having problems with sex than non-diabetic men. The most common sexual problem is Erectile Dysfunction, or ED, sometimes called impotence. Even worse, because ED is such a private issue, many men feel embarrassed to discuss the problem with their doctor, or even their partner, so the problem is never addressed. The good news: ED is one of the most treatable complications of diabetes. In fact, over 95 percent of cases can be successfully treated. With proven treatments available, diabetic men with ED have options. It isn’t something you—or your partner—should have to live with. What ED Is—and What It Isn’t ED means the repeated inability to achieve or sustain an erection sufficient for sexual intercourse. Although sexual vigor generally declines with age, a man who is healthy, physically and emotionally, should be able to produce erections, and enjoy sexual intercourse, regardless of his age. ED is not an inevitable part of the aging process. ED does not mean: • An occasional failure to achieve an erection. The adage is true: It really does happen to everyone. All men experience occasional difficulties with erection, usually related to fatigue, illness, alcohol or drug use, or stress. It isn’t fun, but it is totally normal. • Diminished interest in sex. ED occurs when a man is interested in sex, but still cannot achieve or maintain an erection. Many men with diabetes also experience a decreased sex drive, often as a result of hormone imbalances or depression. Decreased sex drive is quite treatable, but it is treated differently from ED. • Problems with ejaculation. Such problems often indicate a st Continue reading >>

Viagra Side Effects

Viagra Side Effects

What Is Viagra? Viagra is the brand name of the prescription medicine sildenafil citrate. It’s used to treat erectile dysfunction (ED) in men. ED means you can’t get or keep an erection. This medicine is also sold under the name Revatio to treat adults with pulmonary arterial hypertension (high blood pressure in the lungs). Revatio is given to improve exercise ability and slow down worsening changes in people with this condition. Additionally, Viagra has been used “off-label” for other medical conditions, such as Raynaud’s disease (a condition that causes fingers and toes to become cold and numb) and prostate cancer. Viagra is in a class of medicines known as phosphodiesterase (PDE) inhibitors. It works by increasing blood flow to the penis. The Food and Drug Administration (FDA) approved Viagra in 1998. It’s marketed by Pfizer, Inc. Viagra Warnings Some medicines are not safe to take with Viagra. Specifically, Viagra shouldn’t be used in combination with a nitrate drug for treating chest pain or heart problems. This includes nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, amyl nitrate, or nitrite "poppers". Taking Viagra with a nitrate drug can cause a sudden and dangerous drop in blood pressure. Also, you shouldn’t use the medicine for pulmonary hypertension Adempas (riociguat) if you’re taking Viagra. Before you start on Viagra, tell your doctor if you have or have ever had: Heart disease, a heart attack, heart failure, or heart rhythm problems High or low blood pressure High cholesterol Kidney or liver disease Diabetes A blood disorder, such as multiple myeloma, leukemia, or sickle cell anemia A bleeding disorder, such as hemophilia Blood circulation problems Blockages in the veins of the lungs Retinitis pigmentosa (an inherited eye co Continue reading >>

Why Erectile Dysfunction Is So Common In Men With Diabetes

Why Erectile Dysfunction Is So Common In Men With Diabetes

In one study, nearly 40% of men with diabetes had erectile dysfunction.(ISTOCKPHOTO)Erectile dysfunction is a common problem in diabetes. Diabetic nerve damage and blood vessel disease are usually the culprits, although blood-pressure-lowering medication, stress, and depression can also play a role. A study of nearly 28,000 men in Europe, North America and South America found that 16% of the men reported erectile dysfunction, but nearly 40% of those with diabetes had problems with erections. Many men with diabetes can benefit from prescription medications, such as Viagra, Cialis, and Levitra, says Thomas Blevins, MD, an Austin, Texas–based endocrinologist. But in the study, called "Men's Attitudes to Life Events and Sexuality," or "MALES," men with diabetes were more likely than other men to consider their erection problems "severe" and "permanent." Men with diabetes were also more likely to stop taking such drugs because they didn't solve their erection problems. It important not to assume that erectile dysfunction is caused by diabetes itself, or to give up if Viagra or a similar drug doesn't workthere are other options. If Viagra doesn't help, there are alternatives Dick Robbins, 72, of Hot Springs Village, Ark., was diagnosed with type 2 diabetes in 2001. He experienced erectile dysfunction and saw a urologist for help. He tried Viagra with little success as well as another drug, alprostadil. Alprostadil is delivered via injection into the shaft of the penis or by suppositories inserted into the tip of the penis. One of the important messages is, if you are having a problem, be sure and tell your doctor.—William Bornstein, MD, EndocrinologistAlthough injecting a drug into the penis "sounds horrible," many men tolerate the injections well and find they are helpfu Continue reading >>

Viagra Improves Insulin Sensitivity In Those With Prediabetes

Viagra Improves Insulin Sensitivity In Those With Prediabetes

With commentary by study lead author Nancy J. Brown, MD, professor of medicine and pharmacology at Vanderbilt University School of Medicine. Viagra, a drug better known for its ability to improve men's erections, can also help improve insulin sensitivity in those who have prediabetes, potentially helping to delay or avoid the onset of type 2 diabetes, according to new research. Researchers at Vanderbilt University School of Medicine looked at how sildenafil (Viagra) affected insulin sensitivity compared with placebo, says study leader Nancy J. Brown, MD, professor of medicine and pharmacology. Her team randomly assigned 21 men and women to take sildenafil, 25 milligrams three times a day, and 21 others to take a placebo pill. Neither group knew which they were taking during the three-month regimen. The average age in both groups was about 50. The average body mass index (BMI) was about 36, considered obese. Those who took the sildenafil ''had a 20% improvement in insulin sensitivity compared to placebo," Dr. Brown says. The more insulin sensitivity a person has, the less insulin is needed to lower blood sugar levels. If a person has insulin resistance, their body can't make enough insulin to clear blood sugar, or it doesn't work well enough to lower the sugar. The research is published online Nov. 18 in The Journal of Clinical Endocrinology & Metabolism. In the U.S., 29 million people have type 2 diabetes, according to the Endocrine Society. About 3 in 10 people have prediabetes, in which the blood sugar levels are high but not high enough to be diagnosed as diabetes. "We know a percentage [with prediabetes] go on to develop diabetes," Dr. Brown says. "The gold standard to preventing that is diet and exercise," Dr. Brown says. Yet, many patients find it difficult to kee Continue reading >>

Choosing The Right Pill To Treat Ed

Choosing The Right Pill To Treat Ed

The most common sexual dysfunctions in men include lack of interest, premature ejaculation and erectile dysfunction. The latter affects 52% of men between the ages of 40 and 70, including mild, moderate and complete forms of ED. Organic or physical causes for sexual dysfunction in men include vascular, hormonal and neurologic factors. Concerning vascular causes, the risk factors for atherosclerosis (including smoking, high blood pressure, diabetes (diabetics do not respond well to pills like sildenafil (Viagra)) and high cholesterol are ALSO risk factors for erectile dysfunction. Since a straddle injury or use of a narrow saddle can obstruct and impair arteries to the penis, bicycle riding is also considered a risk factor for erectile dysfunction. Little attention has been paid to endocrine factors. Testosterone modulates desire, arousal and orgasmic function. Concerning the orgasmic response, testosterone modulates the integrity of genital sensory receptors. Concerning the arousal response, decreased testosterone blood levels can influence the efficacy of sildenafil (Viagra). If the sildenafil response is not reliably improving erection, the physician should first check if the patient is taking the pill correctly. The physician should also check the patient’s testosterone level. One investigator in Italy gave testosterone to patients with low testosterone who did not respond to sildenafil (Viagra). When daily testosterone was given, subsequent sildenafil (Viagra) use resulted in IIEF (the International Index of Erectile Function questionnaire used to determine erectile function) scores improving significantly. Other risk factors for erectile dysfunction include neurologic problems (multiple sclerosis, stroke), depression and medications for treating diabetes, hyperte Continue reading >>

Sexual Health

Sexual Health

A healthy sexual relationship can be an important part of someone's life. When things go wrong, whether or not we have diabetes, many of us find it hard to accept that there might be a problem. It’s important to know support available. While most people with diabetes, both male and female, are able to lead completely normal sex lives, diabetes may contribute to sexual problems for some people The most common problem is erectile dysfunction in men (also known as impotence) which results in the inability to get or keep an erection long enough for intercourse. Ejaculation may or may not be affected. Fertility remains normal Both men and women with diabetes may also lose their sexual desire when their blood glucose levels are high Most men have an occasional problem with erectile dysfunction at some time in their life. This can be caused by many factors including being tired, stressed, and depressed or drinking too much alcohol. Some medications may also cause erectile dysfunction. This can include medications taken for high blood pressure, depression or stomach ulcers. It’s important to always tell your doctor about any medications you may be taking for other conditions. Reduced blood flow and nerve damage to the penis are generally the underlying reasons for erectile dysfunction for men with diabetes. Often men with diabetes who have the condition also have other complications related to nerve damage or blood circulation problems, such as high blood pressure, high cholesterol or heart disease. Erectile dysfunction can be treated in a number of ways including: Tablets (e.g. Viagra, Cialis and Levitra) Prostaglandin injection into the side of the penis (e.g. Caverject) Devices such as the vacuum pump Surgery such as penile implants While tablets are easy to take, they m Continue reading >>

Viagra: Unexpected Benefits For Men With Diabetes

Viagra: Unexpected Benefits For Men With Diabetes

A study found that men with type 2 diabetes taking medication for erectile dysfunction had an overall lower risk of death and that those who had experienced a heart attack and were taking viagra also had a lowered risk of death. Erectile dysfunction treatments like viagra blog the enzyme PDE5 which reduces the risk of death in men with type 2 diabetes. The retrospective cohort study at the University of Manchester involved about 6,000 men with type 2 diabetes who had high-attendant cardiovascular risk taking data from electronic health records of 42 general practice in Cheshire, UK. The men were between 40 and 89, diagnosed with type 2 diabetes before 2007 and were followed for 6.9 years. Study Results and Why They Matter The study was funded by the British Heart Foundation and the National Institute of Health Research. Study results according to a press release by Medical Xpress states, “Compared with [non-viagra users], the 1,359 men who were prescribed PDE5 inhibiting drugs experienced lower percentage of deaths during follow-up (19.1 per cent vs. 23.8 per cent) and lower risk of death (31 per cent) by any cause. Risk of death was still reduced after adjusting for age and other factors that affect heart disease risk. They also found that there were significantly fewer heart attacks in people taking erectile dysfunction treatment over the study period. And in a subgroup of patients who had a history of heart attack or had one during the study period, the drugs were associated with significantly lower risk of death.” According to the American Heart Association, heart disease is a real problem in the United States, particularly among those living with diabetes: At least 68 percent of people age 65 or older with diabetes die from some form of heart disease and 16% di Continue reading >>

Medication Information : Viagra And Diabetes Cefixime Online Overnight!

Medication Information : Viagra And Diabetes Cefixime Online Overnight!

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Viagra And Diabetes » Canadian Pharmacy - Hot Offers

Viagra And Diabetes » Canadian Pharmacy - Hot Offers

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Viagra May Reduce Type 2 Diabetes Risk

Viagra May Reduce Type 2 Diabetes Risk

The impotence drug Viagra may help ward off type 2 diabetes in people already at risk for the illness, a small new trial suggests. The study, funded by the U.S. National Institutes of Health, found that Viagra (sildenafil) improved "insulin sensitivity" in overweight, pre-diabetic people. Insulin sensitivity involves the body's ability to efficiently use the hormone. Small trial The erectile dysfunction drug was also tied to a lowering of levels of a marker associated with a raised risk of heart and kidney disease, the researchers reported in the Journal of Clinical Endocrinology & Metabolism. However, the trial was small with just 42 patients and "further studies will be needed to determine whether long-term treatment with drugs like sildenafil can prevent the onset of diabetes in high-risk patients", study lead author Dr Nancy Brown said in a journal news release. Brown and her colleagues at Vanderbilt University School of Medicine in Nashville tracked outcomes for 42 overweight men and women with pre-diabetes. All of the patients were randomly assigned to take Viagra (25 milligrams, three times per day) or an inactive placebo for three months. By the end of that time, those in the Viagra group were more sensitive to insulin and also had lower levels of albumin in their urine (a marker of heart and kidney disease risk) than those in the placebo group, the researchers found. Without treatment, as many as 30 percent of people with pre-diabetes go on to develop type 2 diabetes within five years, Brown's team pointed out. Read: Who gets type 2 diabetes? "Because existing drug therapies to prevent type 2 diabetes can have negative effects on the heart or be of limited use in patients with kidney disease, strategies to prevent diabetes without adversely affecting the risk o Continue reading >>

Repurposing Viagra Reverses Peripheral Neuropathy

Repurposing Viagra Reverses Peripheral Neuropathy

Drug development can be costly and time consuming, and repurposing already approved therapeutics is a growing industry. A new report in PLoS One (Wang et al. 2015) demonstrates that sildenafil (aka Viagra®, Revatio®), a well-known drug that increases blood flow and is used to treat erectile dysfunction and pulmonary hypertension, improves neurovascular functions and ameliorates long-term peripheral neuropathy in middle-aged diabetic mice. This report echoes the findings of a case report study from 2006 indicating that diabetic patients treated for erectile dysfunction with a phosphodiesterase type 5 inhibitor reported improvement in their symptoms relating to peripheral neuropathy and peripheral vascular disease. Diabetic peripheral neuropathy is the most common complication of diabetes, affecting ~60% of patients, and is the primary cause of diabetes-related non-traumatic amputations. This condition is the result of microvascular injury of the blood vessels that feed peripheral nerves and is characterized by reductions in nerve conduction velocity, distal motor latency, and reduced nerve fiber density. This report could mean good news for diabetics because current treatment options are mainly limited to pain management. Sildenafil improves neuropathy in long-term diabetic mice BKS.Cg-Dock7m +/+ Leprdb/J (000642) mice are frequently used to study diabetes and diabetes-related complications. Leprdb homozygotes (db) display glucose intolerance with chronic hyperglycemia by 8 weeks of age. As the homozygotes age, they develop slowed sensory and motor nerve conduction velocity (SCV and MCV), increased motor latency, and decreased intraepidermal nerve fiber density as compared to non-diabetic control mice. Daily treatment with sildenafil for 8 weeks dramatically improved p Continue reading >>

Ed And Diabetes

Ed And Diabetes

Erectile dysfunction, which is also called ED or impotence, can be caused by many factors. One common cause of erectile dysfunction is diabetes. In fact ED may be the first symptom of diabetes in some men. Studies show that as many as 75 per cent of men with diabetes will go on to develop erectile dysfunction. Depending on what’s causing your ED, lifestyle changes and medication may help. Why can diabetes cause erectile dysfunction in men? The causes of ED are complex, and so is the link between diabetes and ED. ED is commonly caused by changes to nerve, muscle and blood vessel functions. It’s thought that men with diabetes will tend to develop ED between 10 and 15 years earlier than other men. There are several reasons for this. A chemical called nitric oxide goes into the bloodstream when a man gets sexually aroused. It acts as a chemical message to tell the arteries and muscles in the penis to relax. This allows more blood flow into the penis, resulting in an erection. If your blood sugar level is too high, for example as a result of poorly managed diabetes, it can affect your nerves and blood vessels and stop the release of nitric oxide. This can mean there’s not enough blood flowing into the penis to get or keep an erection. If you have diabetes, it’s quite common to also have high cholesterol. High levels of LDL (bad) cholesterol can cause fatty deposits to build up in your artery walls. This can also reduce the blood flow to your penis. Lifestyle can play a part in ED, particularly smoking. Smoking can reduce the blood flow all around your body, including to your penis. Sometimes, the medication you’re taking to manage diabetes, or other conditions that go with it, can cause you to experience ED. If this is the case, ask your doctor if you can try anoth Continue reading >>

Diabetes And Erectile Dysfunction

Diabetes And Erectile Dysfunction

Diabetes, high blood pressure (hypertension), elevations in blood lipids or cholesterol are considered blood vessel problems and have all been associated with Erectile Dysfunction. The blood vessel abnormalities caused by these diseases affect vessels throughout the body and often produce other symptoms of vascular diseases. Diabetics and patients with hypertension frequently have heart disease. These conditions typically interfere with the ability of the penile vessels to work properly and ultimately cause ED. ED & Diabetes Dr. J. Francois Eid discusses the relationship between ED and Diabetes. Diabetes is one of the most common causes of ED. Men who have Diabetes are three times more likely to have Erectile Dysfunction than men who do not have Diabetes. Among men with ED, those with Diabetes are likely to have experienced the problem as much as 10 to 15 years earlier than men without Diabetes. A recent study of a clinic population revealed that 5% of the men with ED also had undiagnosed Diabetes. The risk of ED increases with the number of years you have Diabetes and the severity of your Diabetes. Even though 20% to 75% of men with Diabetes have ED, it can be successfully managed in almost all men. In regards to high blood pressure, this makes the heart work harder to pump blood which can prevent blood flow from reaching the penis and in turn prevent an erection. Recent reports say that close to 2 out of 3 men report a change in the quality of their erections if they have high blood pressure. It is established that Diabetes affects not only peripheral nerve function but peripheral blood flow as well. The association between Diabetes and ED was first documented in 1978. Men with Diabetes have four main risk factors for ED. First, diabetes can cause damage to nerves (ne Continue reading >>

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