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Type 2 Oral Diabetes Medications Side Effects, Differences, And Effectiveness

What are the types of oral diabetes medications? Currently, there are nine drug classes of oral diabetes medications approved for the treatment of type 2 diabetes. α-glucosidase inhibitors Biguanides Sulfonylureas Meglitinides Thiazolidinediones DPP-4 inhibitors Sodium-glucose cotransporter (SGLT)-2 inhibitors These medications differ in the way they function in the body to reduce blood glucose. Metformin (Glucophage) is the only biguanide available in the United States and is generally the first choice for oral treatment of type 2 diabetes mellitus. Metformin improves Sulfonylureas are the oldest classes of oral diabetes medications. Sulfonylureas work primarily by stimulating the release of insulin. Insulin is the hormone responsible for regulating blood glucose by increasing the uptake of blood glucose by tissues and increasing storage of glucose in the liver. Meglitinides and sulfonylureas have a similar mechanism of action. Meglitinides are short acting glucose lowering medications. They stimulate the secretion of insulin from the pancreas. Thiazolidinediones enhance insulin sensitivity meaning that the effect of a given amount of insulin is greater. Thiazolidinediones also a Continue reading >>

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  1. matrix123

    Pre-diabetic neuropathy?

    I've posted a few times here before because I was very worried about diabetes (I have Health Anxiety). After starting anxiety meds I'm feeling much better in general. However my left leg (and to a less degree arm also) feels weak. After reading around (maybe too much) weakness (especially in one side) is associated with neuro diseases such as MS, ALS, etc or with Brain Tumor. So now the diabetes seems like a walk in the park compared the above stuff.
    But today, I remembered that diabetes can also cause neuropathy, but I'm don't know much about it. My last fasting glucose test was 104 (here the limit is 106) so the doc said nothing about it. Also I was pretty anxious when I did the test so that may have contributed to the high value. The questions I have are:
    Most importantly? Does diabetic neuropathy causes leg/arm weakness?
    Can neuropathy develop with a glucose value lower than pre-diabetic or in the pre-diabetic range?
    From what I have read it seems the feet or hands are affected first. Is it possible to affect some other parts first? In my case the weakness is more severe behind the knees...as if they would not hold me (I was worse before I started meds...now it's better....but still there).
    Can it affect only one side of the body...or typically affect both sides?

    I don't have any great pain...but sometimes my tendons would ache...sometimes the knee..and sometimes the calf feels sore/stiff. Is it possible to have diabetic neuropathy without pain?Thanx a lot

  2. jwags

    If I were you I would get a BG meter and start testing at 1 hour , 2 hours and even 3 hours after meals. Many times pre diabetics will have an OK fasting but they will spike quite high after meals. It is this spike after meals that may be responsible for neuropathy symptoms. I had those symptoms several years before diabetes, of course since I didn't know I was diabetic or Pre D I thought they were from exercising too much. I would get the pins and needles during exercise or the sharp pains in my thighs, calves or quads. Once I got my bgs under 120 it seems to lessen. But anytime I slip up in my diet and let my bgs climb the neuropathy seems to return. I would work on bgs first. If you are concerned about other diseases there are tests your doctor can run.

  3. matrix123

    Thanx for you reply. I have already bought a BG meter...but haven't used it yet. If you can give me some more specific answers for the questions I posted, it would be very helpful.

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