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Lipid Profile Of Type 2 Diabetic Patients At A Tertiaryhospital In Tanzania: Cross Sectional Study

Lipid Profile Of Type 2 Diabetic Patients At A Tertiaryhospital In Tanzania: Cross Sectional Study

Lipid Profile of Type 2 Diabetic Patients at a TertiaryHospital in Tanzania: Cross Sectional Study Nyasatu G. Chamba1,2,Elichilia R Shao1,2,3,4,5*,Tolbert Sonda1,3and Isaack A. Lyarru1,2 1Department of Internal medicine Kilimanjaro Christian Medical University College, TumainiUniversity, Makumira PO BOX 2240, Moshi Tanzania 2Department of Internal Medicine Kilimanjaro Christian Medical Centre, PO BOX 3010Moshi Tanzania 3Kilimanjaro Clinical Research Institute, PO BOX 2236, Moshi Tanzania 4Better Human Health Foundation, PO BOX 1348, Moshi Tanzania 5Imagedoctors Organization, PO BOX 16341, Arusha Tanzania *Corresponding author: Elichilia R Shao, Department of Internal Medicine Kilimanjaro ChristianMedical University College, Tumaini University Makumira, Moshi, Tanzania. Tel: 255784491622; E-mail: Received:December 02, 2016; Accepted:December 08, 2016; Published:February 02, 2017 Citation: Nyasatu G. Chamba, Elichilia R Shao, Tolbert Sonda,Isaack A. Lyaruu(2017) Lipid Profile of Type 2 Diabetic Patients at a Tertiary Hospital inTanzania: Cross Sectional Study. J Endocrinol Diab 4(1): 1-6 DOI: Background:Patients with diabetes mellitus are at high risk of cardiovascularevents because of abnormal lipid status. Dyslipidemiais common in diabetes mellitus and is associatedwith cardiovascular complications. Early diagnosisand treatment is the main cornerstone in the preventionof its multiple complications. There is scarcity of dataon the magnitude and risk factors associated with dyslipidemiaamong diabetic patients in the Northern zoneof Tanzania. Objective:The aim of the study was to determine the prevalenceof abnormal lipid profile levels among patients attendingthe diabetes clinic at Kilimanjaro Christian MedicalCentre, Moshi Tanzania. Methodology:A cross-sectional study wa Continue reading >>

Characteristics Of The Lipid Profile In Patients With Diabetes Mellitus And Chronic Kidney Disease

Characteristics Of The Lipid Profile In Patients With Diabetes Mellitus And Chronic Kidney Disease

1. Ogurtsova K, da Rocha Fernandes JD et al. IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res Clin Pract 128: 40-50, 2017. 2. Kannel WB, McGee DL. Diabetes and cardiovascular disease. The Framingham study. JAMA 241: 20352038, 1979. 3. Ginsberg HN. Insulin resistance and cardiovascular disease. J Clin Invest 106: 453458, 2000. 4. Battisti WP, Palmisano J, Keane WE. Dyslipidemia in patients with type 2 diabetes. relationships between lipids, kidney disease and cardiovascular disease. Clin Chem Lab Med 41: 11741181, 2003. 5. Tai TY, Tseng CH, Sung SM, Huang RF, Chen CZ, Tsai SH. Retinopathy, neuropathy and nephropathy in non-insulin-dependent diabetic patients. J Formos Med Assoc 90: 936940. 1991. 6. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 414(6865): 813820, 2001. 7. Wassef L, Langham RG, Kelly DJ. Vasoactive renal factors and the progression of diabetic nephropathy. Curr Pharm Des 10: 33733384. 2004. 8. de Boer IH, Rue TC, Hall YN, Heagerty PJ, Weiss NS, Himmelfarb J. Temporal trends in the prevalence of diabetic kidney disease in the United States. JAMA 305: 25322539, 2011. 9. Collins AJ, Foley RN, Chavers B et al. United States Renal Data System 2011 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States. Am J Kidney Dis 59(1 Suppl 1): A7, 2012. 10. Parving HH, Lewis JB, Ravid M, Remuzzi G, Hunsicker LG. Prevalence and risk factors for microalbuminuria in a referred cohort of type II diabetic patients: a global perspective. Kidney Int 69: 20572063, 2006. 11. Barkoudah E, Skali H, Uno H, Solomon SD, Pfeffer MA. Mortality rates in trials of subjects with type 2 diabetes. J Am Heart Assoc 1: 815, 2012. 12. Chahil TJ, Ginsberg HN. D Continue reading >>

Cholesterol Abnormalities & Diabetes

Cholesterol Abnormalities & Diabetes

Cholesterol is a waxy substance that is made by the body and found in some animal-based foods. Blood cholesterol levels describe a group of fats also known as lipoproteins which includes HDL-C, or "good" cholesterol and LDL-C or "bad" cholesterol. Cholesterol is important to overall health, but when levels are too high, cholesterol can be harmful by contributing to narrowed or blocked arteries. Unfortunately, people with diabetes are more prone to having unhealthy high cholesterol levels, which contributes to cardiovascular disease (CVD). By taking steps to manage cholesterol, individuals can reduce their chance of cardiovascular disease and premature death. Using a blood sample taken after a brief period of fasting by the patient, a lipoprotein profile reveals the following lipid measures: Low-density-lipoprotein (LDL) cholesterol = "bad" cholesterol A high LDL-C level is associated with a higher risk for CVD. However, your LDL number should no longer be the main factor in guiding treatment to prevent heart attack and stroke, according to the latest guidelines from the American Heart Association. For patients taking statins, it’s important to work with your doctor to manage your LDL appropriately. A diet high in saturated and trans fats can raise your LDL cholesterol. High-density-lipoprotein (HDL) cholesterol = "good" cholesterol With HDL-C, higher levels are associated with a lower risk for CVD. Low HDL cholesterol puts you at higher risk for heart disease. People with high blood triglycerides usually also have lower HDL cholesterol. Genetic factors, type 2 diabetes, and certain drugs, such as beta-blockers and anabolic steroids, also lower HDL cholesterol levels. Smoking, being overweight and being sedentary can all contribute to lower HDL cholesterol. Triglycerid Continue reading >>

Comparison Of Lipid Profile Between Controlled And Uncontrolled Type - 2 Diabetic Subjects.

Comparison Of Lipid Profile Between Controlled And Uncontrolled Type - 2 Diabetic Subjects.

Department of Biochemistry, Shri Sathya Sai Medical College and Research Institute, Ammapettai, Nellikuppam, Kancheepuram (Dist), Tamil Nadu - 603108, India. Visit for more related articles at Research & Reviews: Journal of Medical and Health Sciences Abstract Diabetic patients with accompanied (but often unnoticed) dyslipidemia are soft targets of cardiovascular deaths. An early intervention to normalize circulating lipids shown to reduce cardiovascular complications and mortality. Glycated hemoglobin (HbA1c) is a routinely used marker for long term glycemic control. In the present study we have compared the lipid profiles between controlled diabetic subjects (HbA1c < 7%), moderately controlled (HbA1c > 7% and ≤ 9%) and Uncontrolled diabetic subjects (HbA1c >9%). We found that blood glucose levels and lipid profile parameters (except HDL) were increased significantly in uncontrolled diabetics and moderately controlled diabetics when compared to controlled diabetics. Keywords Diabetes, Glycated haemoglobin, blood glucose levels. Introduction Diabetes mellitus is a group of metabolic disease characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Diabetes causes about 5% of all deaths globally each year. The chronic hyperglycemia of diabetes is associated with long term damage, dysfunction, and failure of various organs, especially the eyes, kidneys, nerves, heart, and blood vessels. 50% of people with diabetes die of cardiovascular disease (CVD) (primarily heart disease and stroke) [1,2]. Low density Lipoprotein (LDL) is considered as an independent risk factor for the development of CVD [3]. The risk for CVD is higher in Diabetic subjects than non-diabetic subjects [4]. Glycated hemoglobin (HbA1c) is a routinely used marke Continue reading >>

Lipid Profile In Women With Gestational Diabetes Mellitus

Lipid Profile In Women With Gestational Diabetes Mellitus

Lipid profile in women with gestational diabetes mellitus Anargyros Kourtis, Kali Makedou, Athina Giomisi, Maria Mouzaki, Sofia Masoura, Antonios Goutzioulis, Nikolaos Prapas & Theodoros Agorastos Aristotle University of Thessaloniki, Thessaloniki, Greece. Background-aim: Increased serum cholesterol and triglycerides levels may have a role in the development of gestational diabetes mellitus (GDM) and its complications. This study was designed in order to provide a description of lipids profile by gestational age during pregnancy. Subjects and methods: We studied 211 women from the outpatient clinic of metabolic disorders in pregnancy. These women were ordered to perform the oral glucose tolerance test (OGTT) with 75 g of glucose, between 26th and 28th weeks of pregnancy. In 14 (6.64%) women, GDM (two or three values above normal) was diagnosed, in 28 (13.27%) impaired glucose tolerance (IGT) (only one abnormal glucose value) was the diagnosis and 169 (80.1%) women had normal OGTT results (controls). All women had lipid profile assessment, which included determination of total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides (TGs). An additional lipids test was obtained within 32nd and 33rd gestational weeks. of lipids are presented in the following table: There was no statistical difference (P<0.05) in TC, HDL and LDL values of the women of three groups in the second trimester, while significant difference was observed in TGs values between controls and the other two groups (P<0.001). Comparison of values between second and third trimester showed significant increase in TC and TG in control group, whereas pregnant women with GDM presented only significant increase in serum levels of TG, greater than that of controls. Co Continue reading >>

Lipid Profile Abnormalities Seen In T2dm Patients In Primary Healthcare In Turkey: A Cross-sectional Study

Lipid Profile Abnormalities Seen In T2dm Patients In Primary Healthcare In Turkey: A Cross-sectional Study

Lipid profile abnormalities seen in T2DM patients in primary healthcare in Turkey: a cross-sectional study Medical Faculty, Department of Family Medicine, Bezmialem Vakif University, Adnan Menderes Boulevard, 34093 Fatih, Istanbul, Turkey Aclan Ozder, Email: [email protected] . Received 2014 Aug 28; Accepted 2014 Nov 29. Copyright Ozder; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( ) applies to the data made available in this article, unless otherwise stated. This article has been cited by other articles in PMC. Diabetes is characterized by chronic hyperglycemia and disturbances of carbohydrate, lipid and protein metabolism. We aimed to research association between serum lipid profile and blood glucose, hypothesizing that early detection and treatment of lipid abnormalities can minimize the risk for atherogenic cardiovascular disorder and cerebrovascular accident in patients with type 2 diabetes mellitus. Fasting blood glucose (FBG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), triglyceride (TG) and glycated haemoglobin (HbA1c) levels were evaluated. A hepatic ultrasound was performed for every diabetic to evaluate hepatosteatosis. The study was done from January 2014 to June 2014 among 132 patients with T2DM who were admitted to outpatient clinic of Family Medicine department in a university hospital. The patients whose taking multi-vitamin supplementation or having hepatic, renal or metab Continue reading >>

What Is A Lipid Profile? - Diabetes Nsw & Act - Live Your Life

What Is A Lipid Profile? - Diabetes Nsw & Act - Live Your Life

What is a lipid profile? Mel W 2016-04-28T15:29:04+00:00 by Credentialled Diabetes Educator, Kristine Bell A lipid profile consists of a series of tests that measure the different types of fats, called cholesterol and triglycerides, in the blood. People with diabetes are at a higher risk of heart disease and so this test can help determine your risk of heart attack and stroke. What is cholesterol and why is it so bad? Cholesterol isnt all bad. In fact it is an essential part of all the cells around your body, making up about half of the cell wall and helping the cell communicate with the other cells around it. Cholesterol is carried around the body by two different types of transporters called lipoproteins. The LDL (Low Density Lipoprotein) cholesterol is the lousy type. It can damage the cell wall and leaves cholesterol lying around the blood stream, where it can clog the arteries and cause a heart attacks or stroke. The other type is the HDL (High Density Lipoprotein) cholesterol. This is the healthy type of cholesterol. It works as a cleaner scrubbing the cell walls clean and picking up all the excess cholesterol and taking it back to the liver to be processed. Having a high HDL-cholesterol level is protective against heart disease. Your doctor can check your cholesterol and triglyceride levels through a blood test. We recommend getting your lipids checked once a year. Your doctor may recommend getting it tested more frequently if your levels are above your target range or if you have started or changed a medication to help lower your cholesterol levels. I have diabetes, what levels should I be aiming for? Your doctor will recommend the cholesterol and triglyceride targets that are most appropriate for you. Because people with diabetes are at a higher risk of heart Continue reading >>

Lipids | Joslin Diabetes Center

Lipids | Joslin Diabetes Center

Heart attacks and strokes are the leading causes of death for people with diabetes. Research indicates that high levels of lipids,also known asblood fats (including cholesterol), increase the risk of heart disease. The Joslin Guidelinesrecommend that you have a lipid profile screening at least once a year.A lipid profile screening measures your LDL and HDL cholesterol as well as your triglycerides. The most important factor is LDL, or bad cholesterol.You need to get this number as low as possible because it is the most important factor for causing cardiovascular disease. If you dont have a history of heart problems, you should aim for an LDL level of less than 100. If you already have a history of heart disease, stroke or vascular disease, you should aim even lower70 or below. The greater the risk factors, the lower the LDL should be. Every 40 mg decrease in LDL cholesterol reduces the risk of cardiovascular complications by 20 to 30 percent. After achieving your LDL goals, you should work with your doctor to raise your HDLalso called good cholesterolto more than 40 for men, and more than 50 for women. At the same time, you should aim to lower triglyceridesanother bad fatto under 150. Lipid abnormalities can be modified througha nutrition planand weight loss, physical activity, good blood glucose control and a range of medications available today. Although theres no guaranteed way to avoid heart disease, here at Joslin our ongoing research takes place at multiple levels concerning the treatment and management of diabetes.You can cut your risk of heart disease through lower LDL levels and by keeping your A1C, blood pressure and other factors within the recommended ranges. Would you like a summary of the"Sixtests for Staying Healthy with Diabetes," featured in this serie Continue reading >>

Diabetic Dyslipidemia: Causes And Consequences

Diabetic Dyslipidemia: Causes And Consequences

Diabetic Dyslipidemia: Causes and Consequences Division of Preventive Medicine and Nutrition, Columbia University College of Physicians and Surgeons, New York, New York 10032 Search for other works by this author on: The Journal of Clinical Endocrinology & Metabolism, Volume 86, Issue 3, 1 March 2001, Pages 965971, Ira J. Goldberg; Diabetic Dyslipidemia: Causes and Consequences, The Journal of Clinical Endocrinology & Metabolism, Volume 86, Issue 3, 1 March 2001, Pages 965971, More cardiovascular disease occurs in patients with either type 1 or 2 diabetes. The link between diabetes and atherosclerosis is, however, not completely understood. Among the metabolic abnormalities that commonly accompany diabetes are disturbances in the production and clearance of plasma lipoproteins. Moreover, development of dyslipidemia may be a harbinger of future diabetes. A characteristic pattern, termed diabetic dyslipidemia, consists of low high density lipoprotein (HDL), increased triglycerides, and postprandial lipemia. This pattern is most frequently seen in type 2 diabetes and may be a treatable risk factor for subsequent cardiovascular disease. The pathophysiological alterations in diabetes that lead to this dyslipidemia will be reviewed in this article. Causes of lipoprotein abnormalities in diabetes Defects in insulin action and hyperglycemia could lead to changes in plasma lipoproteins in patients with diabetes. Alternatively, especially in the case of type 2 diabetes, the obesity/insulin-resistant metabolic disarray that is at the root of this form of diabetes could, itself, lead to lipid abnormalities exclusive of hyperglycemia. Type 1 diabetes, previously termed insulin-dependent diabetes mellitus, provides a much clearer understanding of the relationship among diabetes, ins Continue reading >>

Lipid Profile And Persistent Lipid Abnormalities In Diabetic Patients – A Retrospective Study

Lipid Profile And Persistent Lipid Abnormalities In Diabetic Patients – A Retrospective Study

Abstract The purposes of this study are the characterization the lipid profile and the suitability of the statins treatment according to the cardiovascular profile. Also, in statin-treated patients, we aim to determine the prevalence of persistent lipid abnormalities. Observational and retrospective study of outpatient diabetic patients of a hospital consultation, between Jun/2014 and Jun/2015. Of the 199 diabetic patients included, 58.6% were treated with statins and only 13.9% were treated with statin dose adequate for its cardiovascular profile. The patients without overt cardiovascular disease had higher total cholesterol (178.0 vs 157.5 mg/dl; p = 0.003), HDL-C (51.0 vs 43.0 mg/dl; p = 0.005), LDL-C (97.0 vs 79.0 mg/dl; p = 0.004) and non-HDL-C (127.0 vs 112.5 mg/dl; p = 0.04) and higher prevalence of patients who achieved HDL-C goals (64.3 vs 33.3%; p < 0.0001). Almost half of statin-treated patients (46.8%) failed to achieve the LDL-C goals, 35.8% and 51.6% failed the triglycerides and HDL-C goals, respectively. Only 11.7% achieved all three goals. In statin-treated patients, we found a statistically significant difference between patients with and without cardiovascular disease on the prevalence of patients reaching the target HDL-C (68.1 vs 35.4%; p = 0.001). There were no differences in the prevalence of patients who achieved LDL-C and triglyceride goals. There is a suboptimal utilization of statins and a substantial percentage of diabetic patients that do not achieve the therapeutic goals. We emphasize the need for an effort to optimize the lipid profile of diabetics in order to contribute to reducing the prevalence of cardiovascular diseases in this population. Resumo Os objetivos são a caracterização do perfil lipídico e a avaliação do tratamento com Continue reading >>

Correlation Of Lipid Profile And Risk Of Developing Type 2 Diabetes Mellitus In 10-14 Year Old Children

Correlation Of Lipid Profile And Risk Of Developing Type 2 Diabetes Mellitus In 10-14 Year Old Children

Correlation of Lipid Profile and Risk of Developing Type 2 Diabetes Mellitus in 10-14 Year Old Children Habiba N.M.a Fulda K.G.b Basha R.a Shah D.a Fernando S.a Nguyen B.c Xiong Y.c Franks S.F.b Matches S.J.a Magie R.D.a Bowman W.P.a Nusrath M. Habiba, MD, FAAP Associate Professor and Assistant Clerkship Director Department of Pediatrics, University of North Texas Health Science Center Fort Worth, Texas (USA) Tel. +1-817-735-2363, Fax +1-817-735-2653, E Mail [email protected] Background/Aims: The role of lipid profile in predicting the risk of Type 2 diabetes mellitus (T2DM) in children is not clearly established. Our aim is to screen non-diabetic children aged 10-14 years for risk of developing T2DM and evaluate the association of abnormal lipids and socioeconomic status (SES). Methods: Data on race/ethnicity, family history, body mass index percentile, blood pressure and presence of neck pigmentation (acanthosis nigricans) were collected from 149 non-diabetic children. Using these factors, children were classified into low risk (<3 risk factors) and high risk (>3 risk factors) groups. Logistic regression model and chi-square tests were used to evaluate the association of blood lipid profile and demographic variables. Independent t-test was used to compare the ratio of Total Cholesterol (TC) and High Density Lipids (HDL) with T2DM risk. Results: 60% of children were at high risk for developing T2DM. HDL (p<0.001), triglycerides (p=0.02) and TC/HDL ratio (p<.001) were significantly abnormal in high risk group. Low SES showed a marginal association with high risk group. There were no gender or age differences between high and low risk groups. Conclusions: The significant determinants associated with high risk group were modifiable factors providing an opportunit Continue reading >>

Effect Of Diabetes Mellitus Type 2 On Lipid Profile; Age Duration | 55506

Effect Of Diabetes Mellitus Type 2 On Lipid Profile; Age Duration | 55506

Diabetes mellitus is a group of metabolic disorder caused by increase in blood glucose level and defects in insulin resistance,insulin action. Certain ethnic and racial group of Asia and Africa has greater risk of diabetes. Insulin deficiency causeshigher metabolization of free fatty acid and can cause disorder in lipid metabolism. As compared to non-diabetic controlgroup, type 2 diabetes mellitus have high triglycerides and low HDL-c levels. Type 2 diabetes is associated with increasedrisk of cardiovascular disease. In the female category, diabetic female showed a significant increase in the level of these lipidparameters compared to male diabetic subjects had higher HDL, LDL and TC. There was a sharp and definite increase in thenumber of patients having >200 mg/dl total cholesterol after 35 years of diabetes mellitus. There was a sharp increase in thenumber of patients having >160mg/dl of triglycerides after 35 years of diabetes mellitus. After the age of 30 years, there was alsoincrease in LDL and TG in female and in males and there was slight change in HDL-c level in both the sexes. Diabetic males hadsignificantly higher level of cholesterol triglycerides, LDL and significantly lower level of HDL cholesterol as compared to thatof female diabetics and also the diabetic subjects were on medications (oral hypoglycemic). Such treatment decreases the bloodglucose level and most possibly changes the overall pathophysiology, including the lipidemia of the condition. Many factorsaffect lipid levels in diabetes because carbohydrate metabolism affect lipid metabolism. The study showed that dyslipidemiawas observed in the diabetic population but HDL-c was not significantly decreased. In our study, diabetic women were foundto have more elevation of LDL as compared to men but t Continue reading >>

Study Of Serum Lipid Profile In Type 2 Diabetes Mellitus Patients And Its Association With Diabetic Nephropathy | Kolhar | International Journal Of Advances In Medicine

Study Of Serum Lipid Profile In Type 2 Diabetes Mellitus Patients And Its Association With Diabetic Nephropathy | Kolhar | International Journal Of Advances In Medicine

DOI: Study of serum lipid profile in type 2 diabetes mellitus patients and its association with diabetic nephropathy Background:Dyslipidaemia is highly prevalent in type 2 Diabetes mellitus patients. The role of dyslipidaemia in macrovascular complications of Diabetes have been extensively studied but its role in microvascular complications namely nephropathy is still unclear. The present study was undertaken to study the prevalence and pattern of dyslipidaemia and its association with Diabetic nephropathy (DN) in patients with type 2 DM. Methods: 100 patients with type 2 DM attending OPD or admitted, over a period of 1 year were studied. Detailed history was taken and clinical examination was done. Serum lipid profile was studied in all patients and its association with DN was assessed. Results:The prevalence of dyslipidaemia in DM patients in our study was 90% and there was no statistically significant difference in the prevalence among males and females. Poorly controlled diabetics had high prevalence of dyslipidaemia as compared to well controlled diabetics. The prevalence of Diabetic nephropathy in our study was 41%. There was significant association of DN with high Total Cholesterol, high Low-density lipoprotein (LDL-C) and high Triglycerides. There was no significant association of DN with High density lipoprotein (HDL-C). Conclusions:Present study highlights the magnitude of dyslipidaemia in type2 DM patients and that there is a significant association of DN with lipid parameters. Hence patients should be managed with life style modifications with or without lipid lowering agents to achieve target lipid values along with adequate glycemic control to prevent or delay the appearance and progression of DN. Diabetes mellitus, Diabetic nephropathy, Lipid profile Sha Continue reading >>

Lipid Profile In Adolescent Girls With Type 1 Diabetes Mellitus And Hyperandrogenemia

Lipid Profile In Adolescent Girls With Type 1 Diabetes Mellitus And Hyperandrogenemia

Lipid Profile in Adolescent Girls with Type 1 Diabetes Mellitus and Hyperandrogenemia Agnieszka Zachurzok ,1 Grazyna Deja ,2 Aneta Gawlik ,1 Agnieszka Drosdzol-Cop ,3 Katarzyna Klimek ,4and Ewa Malecka-Tendera 1 1Department of Pediatrics and Pediatric Endocrinology, School of Medicine in Katowice, Medical University of Silesia, Medykow Street 16, 40-752 Katowice, Poland 2Department of Pediatric Diabetes, School of Medicine in Katowice, Medical University of Silesia, Medykow Street 16, 40-752 Katowice, Poland 3Department of Womans Health, School of Medicine in Katowice, Medical University of Silesia, Medykow Street 12, 40-752 Katowice, Poland 4Department of Instrumental Analysis, School of Pharmacy in Sosnowiec, Medical University of Silesia, Jednosci Street 8, 41-200 Sosnowiec, Poland Received 17 January 2016; Revised 30 March 2016; Accepted 6 April 2016 Copyright 2016 Agnieszka Zachurzok et al. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Study Objectives. The study aim was to evaluate whether hyperandrogenemia in adolescent girls with type 1 diabetes mellitus (T1DM) may adversely influence lipid profile. Design and Participants. Lipid levels in 16 diabetic girls with biochemical hyperandrogenemia (T1DM-H) aged 16.3 1.2 years were compared to 38 diabetic girls with normal androgen levels (T1DM-N) aged 15.8 1.2 years. 15 healthy girls served as controls (CG). In all patients, anthropometric measurements were done, and androgens and SHBG were assessed. Results. In T1DM-H, total cholesterol (TC) and low density cholesterol (LDL-ch) were significantly higher than in CG (196.1 41.2 versus 162.7 31.7 mg/dL Continue reading >>

[ps 01-30] Evaluation Of Serum Lipid Profile Among Hypertensive And Type 2 Diabetes Mellitus Patients In Sudan

[ps 01-30] Evaluation Of Serum Lipid Profile Among Hypertensive And Type 2 Diabetes Mellitus Patients In Sudan

The aim of the current study is to assess the impact of hyperglycemia and elevated blood pressure on serum lipid profile in Sudanese patients. The results will influence the monitoring and management policies so as to avoid complications related to hypertension and diabetes mellitus. This is a cross sectional case control study conducted in Khartoum state, Sudan at 2015. A total of 228 participants we enrolled in this study. Out of them 68 were known hypertensive, 42 were known diabetics, 24 were both hypertensive and diabetic and 94 were sex and age matched controls. Fasting blood glucose was measured by calibrated glucometer. Parameters of lipid profile were determined by using clinical chemistry analyser (Echo, Italy) and commercial kits (Biosystem, Spain). Mean triacylglycerol level among hypertensive and hypertensive patients combined with diabetes was significantly higher than that of controls (p < 0.023, p < 0.007) respectively. Hypertensive patients combined with diabetes also showed significantly higher triacylglycerols level than the diabetic group (p < 0.019). Apart from fasting blood glucose, No significant difference was observed between diabetics and controls in all study parameters. In contrast to the reported data, our results clearly demonstrate that lipid profile is not influenced by type 2 diabetes mellitus. However, hypertension increases the level of triacylglycerols significantly. This increase is even worse when hypertension is combined with diabetes. Interestingly, neither diabetes nor hypertension alters the levels of cholesterol, LDL-C and HDL-C. Further studies are therefore recommended, probably at DNA level, to reveal the causes of low cholesterol level among Sudanese hypertensive and diabetic patients compared to other populations. Copyrig Continue reading >>

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