Genetics And Type 1 Diabetes
If you have type 1 diabetes, you might wonder if your child would get it, too. Or if one of your parents has it, what it means for you. Your genes definitely play a role in type 1, a less common form of diabetes that’s often diagnosed in children and young adults. But they’re not the whole story. Like much in life, it’s a mix of nature and nurture. Your environment, from where you grow up to the foods you eat, also matters. Researchers don’t know exactly how -- and how much -- all those things affect your chances of getting the disease. Your genes set the stage, but you can’t be certain how it'll all play out. There’s no diabetes gene that gets turned on or off to give you type 1. Instead, a bunch of them play a role, including a dozen or so that have the biggest say: the HLA genes. They make proteins your immune system uses to keep you healthy. Since type 1 diabetes is an autoimmune disease -- your body destroys the cells that make insulin -- it makes sense that HLA genes are front and center. There are thousands of versions of them in the human gene pool. Which ones you get from your parents affect your chances of diabetes in a big way. Some make you more likely to get it, while others can help protect you from it. You have type 1 if your body makes little or no insulin, a hormone that helps your body turn sugar into energy. Certain genes are more common in one group of people than in another. That’s why race and ethnicity affect things, too. For example, white people are more likely to have type 1 diabetes than others. But even if you have genes that make you more likely to get type 1, that doesn’t mean you definitely will. Even with identical twins -- who have the same exact genes -- sometimes one gets it and the other doesn’t. That’s where the e Continue reading >>
Is Type 2 Diabetes Caused By Genetics?
Diabetes is a complex condition. Several factors must come together for you to develop type 2 diabetes. For example, obesity and a sedentary lifestyle play a role. Genetics can also influence whether you’ll get this disease. If you’ve been diagnosed with type 2 diabetes, there’s a good chance that you’re not the first person with diabetes in your family. According to the American Diabetes Association, your risk of developing type 2 diabetes is: 1 in 7 if one of your parents was diagnosed before the age of 50 1 in 13 if one of your parents was diagnosed after the age of 50 1 in 2, or 50 percent, if both your parents have diabetes Several gene mutations have been linked to the development of type 2 diabetes. These gene mutations can interact with the environment and each other to further increase your risk. Type 2 diabetes is caused by both genetic and environmental factors. Scientists have linked several gene mutations to a higher diabetes risk. Not everyone who carries a mutation will get diabetes. But many people with diabetes do have one or more of these mutations. It can be difficult to separate genetic risk from environmental risk. The latter is often influenced by your family members. For example, parents with healthy eating habits are likely to pass them on to the next generation. On the other hand, genetics plays a big part in determining weight. Sometimes behaviors can’t take all the blame. Studies of twins suggest that type 2 diabetes might be linked to genetics. These studies were complicated by the environmental influences that also affect type 2 diabetes risk. To date, numerous mutations have been shown to affect type 2 diabetes risk. The contribution of each gene is generally small. However, each additional mutation you have seems to increase your Continue reading >>
Is Diabetes A Hereditary Disease?
The entire approach and foundation of Orthodox Medicine is based on Luis Pasteur's Germ Theory, a flawed concept. A disease condition is viewed by the orthodoxy as an isolated event, confined to the area in which it manifests itself (E.g. an ear infection, eye infection, gum infection, lung cancer, skin cancer, diabetes, heart disease, etc. ). Under this theory, for unknown reasons, microbes or tumors indiscriminately grow in the patient and must be cut (surgery), burned (radiation), or poisoned (drugs) out of the body. In the orthodox model, the solution is sought through mechanical and chemical means. Seeking to understand WHY the infection or disease condition appeared in the first place, is not explored. The quick fix with a prescription for drugs to smother the symptoms is the typical orthodox 'answer'. A contemporary of Pasteur, Antoine Bechamp, had a different opinion as to why disease conditions 'took hold'. Bechamp felt that the ENVIRONMENT, or the ECOLOGY of the blood played the critical role in deciding whether disease conditions would manifest or not. It is important to discover the stressors (environmental, biological, chemical, psychological, and emotional) in a patient's life that cause a weakening of a particular bodily system; which in turn allows the manifestation of a disease condition in a weakened area. In order to maintain a state of health, all systems within the body need to exist in a state of balance or equilibrium. Imbalance leads to conditions of discomfort (dis-ease) which eventually spirals into ill health if not corrected. The Chinese and Indians (Ayurvedic medicine) had worked all of this out thousands of years ago. Doctors at the International Council for Truth in Medicine are revealing the truth about diabetes that has been suppressed f Continue reading >>
Diabetes Mellitus Type 1 Inheritance
Type 1 diabetes is an inherited condition and individuals with a first degree relative who has the condition are at an increased risk of developing the condition. Details regarding the risk of inheriting type 1 diabetes are given below: In men with type 1 diabetes, the risk of their child also developing the condition is one in 17. In women with type 1 diabetes who have their baby before the age of 25, the risk of the child developing the condition is one in 25. If she has her baby after the age of 25, the risk falls to 1 in 100. If both parents have type 1 diabetes, the risk of the condition developing in offspring varies between 1 in 4 and 1 in 10. The risks are somewhat increased if one of the parents developed type 1 diabetes before the age of 11. Around 1 in 7 people with type 1 diabetes suffer from a condition called type 2 polyglandular autoimmune syndrome and these individuals have parathyroid and adrenal gland disorders in addition to type 1 diabetes. If one of the parents has type 2 polyglandular autoimmune syndrome, the risk that the child will inherit the condition, including type 1 diabetes, is 50%. Genes associated with type 1 diabetes Some genes have repeatedly been identified in people with type 1 diabetes. Among white individuals, examples of such genes include the HLA-DR3 or HLA-DR4 genes. Carrying these genes raises the risk that offspring will inherit type 1 diabetes. Children born with the HLADR3/4-DQ8 genotype make up nearly 50% of all children who develop type 1 diabetes before they are 5 years of age. Some studies on other ethnic groups have shown that similar risks are associated with the HLA-DR7 genotype among African Americans and with the HLA-DR9 gene among Japanese individuals. Genetic studies have also located HLA class II genes at 6p21 and Continue reading >>
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Is Diabetes Genetic?
Diabetes is a complex disease. Several factors must come together for a person to develop Type 2 Diabetes. While genetics may influence whether you’ll get this disease or not, other factors like environmental risk factors and a sedentary lifestyle also play a huge role. So, is type 2 diabetes genetic? And if not, which type of diabetes is genetic? Those are the questions we are faced with today. And unfortunately, the answer is not that simple. Yes, genetics can play a role in increasing the risk for both Diabetes Type 1 as well as Diabetes Type 2, but genes alone will not determine whether you will develop diabetes or not. Will You Get Diabetes If It Runs In Your Family? If you’ve just been diagnosed with diabetes, chances are that you’re not the first person in your family who has diabetes. The details of whether diabetes can be inherited, and how this occurs, are not clear yet. About 10% of patients diagnosed with insulin-dependent Type 1 diabetes have a first degree relative with this type of diabetes. By first degree relative, we mean father, mother, sibling, twin and child. However, when it comes to the more common type of diabetes, which is Diabetes Type 2, it has a tendency to occur in families, but this is also not very strong and not predictable. A Swedish study on Metabolic Consequences of a Family History of Non-Insulin Dependent Diabetes Mellitus concluded that abdominal obesity, insulin resistance, and decreased resting metabolic rate are characteristic features of first-degree relatives of patients with non-insulin dependent diabetes mellitus (in other words, Diabetes Type 2). And that the decrease in resting metabolic rate is partially related to the degree of abdominal obesity. Many doctors with clinical practice treating diabetes believe that thi Continue reading >>
Inherited Diabetes Test By Admera Health
Type 1 and Type 2 Diabetes are known to be caused by a complex combination of environmental, lifestyle and genetic factors, where many genetic variations add up to play a small role in developing the disease. One form of inherited diabetes, also known as Maturity Onset Diabetes of the Young (MODY), is different. With MODY, a single genetic variation can cause the disease. While MODY is often diagnosed in childhood or adolescence, despite the name, it can be diagnosed at any age. People with MODY may respond best to different therapies than people with other types of diabetes. Type 1 Diabetes is treated with insulin, and Type 2 Diabetes is treated with lifestyle modifications, oral medications, and sometimes insulin. For some people with MODY, insulin may not be an effective treatment. By knowing if you have MODY, you and your doctor can make sure you’re managing your diabetes most effectively. Because this type of diabetes is inherited, it can also be important information for relatives who may have or might be at risk for MODY. If your diabetes was diagnosed at a young age (often under age 25), you are not overweight, and you have a first degree relative with diabetes (such as a parent, sibling, or child), you may want to learn if you have MODY. While most people diagnosed with MODY are young, it can be diagnosed at any age. If someone is found to have a genetic variation that causes inherited diabetes, there is a 50% (or a 1 out of 2) chance that their first degree relatives will have it too. This means that their parents, siblings, and children all have a 1 in 2 chance of inheriting the same variation and at some point developing MODY. Up to 500,000 people in the United States are estimated to have MODY2, but because genetic testing for inherited diabetes is relati Continue reading >>
Type 2 Diabetes Causes
Type 2 diabetes has several causes: genetics and lifestyle are the most important ones. A combination of these factors can cause insulin resistance, when your body doesn’t use insulin as well as it should. Insulin resistance is the most common cause of type 2 diabetes. Genetics Play a Role in Type 2 Diabetes Type 2 diabetes can be hereditary. That doesn’t mean that if your mother or father has (or had) type 2 diabetes, you’re guaranteed to develop it; instead, it means that you have a greater chance of developing type 2. Researchers know that you can inherit a risk for type 2 diabetes, but it’s difficult to pinpoint which genes carry the risk. The medical community is hard at work trying to figure out the certain genetic mutations that lead to a risk of type 2. Lifestyle Is Very Important, Too Genes do play a role in type 2 diabetes, but lifestyle choices are also important. You can, for example, have a genetic mutation that may make you susceptible to type 2, but if you take good care of your body, you may not develop diabetes. Say that two people have the same genetic mutation. One of them eats well, watches their cholesterol, and stays physically fit, and the other is overweight (BMI greater than 25) and inactive. The person who is overweight and inactive is much more likely to develop type 2 diabetes because certain lifestyle choices greatly influence how well your body uses insulin. Lack of exercise: Physical activity has many benefits—one of them being that it can help you avoid type 2 diabetes, if you’re susceptible. Unhealthy meal planning choices: A meal plan filled with high-fat foods and lacking in fiber (which you can get from grains, vegetables, and fruits) increases the likelihood of type 2. Overweight/Obesity: Lack of exercise and unhealthy me Continue reading >>
Is Diabetes Genetic? Facts About Hereditary Risk
Diabetes is a complex set of diseases with no single cause. Genetic factors make some people more vulnerable to diabetes, particularly with the right environment. In addition, certain lifestyle factors can cause type 2 diabetes in individuals with no known family history. This complex interaction between genes, lifestyle, and environment points to the importance of taking steps to minimize individual diabetes risk. Is type 1 diabetes hereditary? Type 1 diabetes is an autoimmune disease, which means that it causes the body's immune system to attack healthy cells. It is often called juvenile diabetes because most people are diagnosed in childhood, and the condition then lasts their lifetime. Doctors used to think type 1 diabetes was wholly genetic. Newer studies have shown, however, that children develop type 1 diabetes 3 percent of the time if their mother has the condition, 5 percent of the time if their father has it, or 8 percent if a sibling has type 1 diabetes. Consequently, researchers now believe that something in the environment has to trigger type 1 diabetes. Some risk factors include: Cold weather. People develop type 1 diabetes in winter more frequently than summer. It is also more common in places with cool climates. Viruses. Researchers think some viruses might activate type 1 diabetes in people who are otherwise vulnerable. Measles, mumps, coxsackie B virus, and rotavirus have been linked to type 1 diabetes. Research suggests that people who develop type 1 diabetes may have autoimmune antibodies in their blood for many years before showing symptoms. As a result, the disease may develop over time, or something may have to activate the autoimmune antibodies for symptoms to appear. Is type 2 diabetes hereditary? Type 2 diabetes is the more common form of the d Continue reading >>
Diabetes And Genetics
Tweet Genetics play a strong role in the chances of developing both type 1 and type 2 diabetes. Other factors include environment and lifestyle. Diabetes is an increasingly common chronic condition affecting millions of people in the UK alone. Diabetes and genetic risk The risk of developing diabetes is affected by whether your parents or siblings have diabetes. The likelihood of developing type 1 diabetes or type 2 diabetes differ, as you can see below. Type 1 diabetes and genetics - average risks Mother with diabetes increases risk of diabetes by 2% Father with diabetes increases risk of diabetes by 8% Both parents with diabetes increases risk by 30% Brother or sister with diabetes increases risk by 10% Non-identical twin with diabetes increases risk by 15% Identical twin with diabetes increases risk by 40% Type 2 diabetes and genetics - average risks If either mother of father has diabetes increases risk of diabetes by 15% If both mother and father have diabetes increases risk by 75% If non-identical twin has diabetes increases risk by 10% If identical twin has diabetes increases risk by 90% Some other forms of diabetes may be directly inherited, including maturity onset diabetes in the young (MODY) and diabetes due to mitochondrial DNA mutation. However, neither type 1 or type 2 diabetes may be entirely genetically determined. Experts believe that environmental factors act as either ‘initators’ or ‘accelerators.’ Several genes are known as susceptibility genes, meaning that if an individual is carrying this gene they face greater risk of developing diabetes. Similarly, other genes provide greater immune tolerance for non-diabetics. My family have type 2 diabetes, will I get it? Type 2 diabetes is, in part, inherited. First degree relatives of individuals wit Continue reading >>
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11111 Fact Sheet 48|diabetes Types 1 And 2 And Inherited Predisposition
ï‚· WHAT IS DIABETES? Diabetes mellitus (commonly known as diabetes) refers to a group of conditions which cause high levels of glucose (a form of sugar) in the blood. Glucose provides the energy that cells need to function. The level of glucose in an individualâ€™s blood is carefully regulated by the hormone insulin. Insulin is produced in the pancreas and its role is to keep the levels of glucose balanced - not too high and not too low - as both extremes are dangerous and can disrupt the bodyâ€™s chemical processes. There are two major forms of diabetes: ï‚· Type 1 (insulin dependent diabetes mellitus: IDDM) ï‚· Type 2 (non-insulin dependent diabetes mellitus: NIDDM). There is also another rarer type of diabetes called mature onset diabetes of the young (MODY). All of these forms of diabetes have different symptoms and a different genetic basis. Type 1 diabetes (IDDM) Type 1 diabetes is a chronic autoimmune disease, where the immune system destroys the insulin- producing cells of the pancreas. About 10% to 15% of people with diabetes in Australia have type 1 diabetes. The general population risk for developing type 1 diabetes is around 1 in 1000. The condition is usually first seen in childhood or adolescence and so is sometimes called juvenile diabetes. The risk of type 1 diabetes in 0-14 year olds around 1 in 750. It can, however, occur at any age and onset after the age of 20 years occurs in 50% of cases. Symptoms include: ï‚· thirst ï‚· frequent urination ï‚· weight loss ï‚· fatigue ï‚· blurred vision ï‚· sugar in the urine Insulin medication (usually by injection) is necessary to provide the body with insulin, and thus type 1 diabetes is described as insulin- dependent diabetes (IDDM). In about 90% of cases, individua Continue reading >>
Diabetes In The Family: Is It Inherited?
Weve updated our Privacy Notice. Take a moment to review it here. Im asking this on behalf of a friend whose grandfather and father have diabetes. Is it more likely that my friend will get it too? Is diabetes... Im asking this on behalf of a friend whose grandfather and father have diabetes . Is it more likely that my friend will get it too? Is diabetes fatal? type 1 diabetes (insulin-dependent diabetes), which occurs in young people and is the more severe form, requiring insulin injections type 2 diabetes (non-insulin dependent diabetes), which is milder and occurs in older people and is usually controlled with diet and tablets. The details of whether diabetes can be inherited, and how this occurs, are not clear. About 10 per cent of people getting the more severe Type 1 diabetes have a close relative with this type of diabetes. That is not the same as saying that 10 per cent of people with affected relatives will get diabetes, but there is an unpredictable association. Type 2 diabetes also has a tendency to occur in families, but this is also not very strong and not predictable. In your friends case, if grandfather and father are affected, they probably have the milder Type 2 form of diabetes, so your friend has little risk of developing diabetes at a young age. It may be there is an increased risk of him developing diabetes in later life, but it would be the milder Type 2 form. I am a little confused that you say, he takes pills and does a blood sugar tes t. If you are referring to your friend then this probably means he has the mild form of diabetes already, and is probably an older person. You ask if you can get very ill with diabetes and die. Diabetes is a serious condition, but these days if patients follow their diet and take their pills or insulin treatment re Continue reading >>
Type 2 Diabetes
Type 2 diabetes is a disorder characterized by abnormally high blood sugar levels. In this form of diabetes, the body stops using and making insulin properly. Insulin is a hormone produced in the pancreas that helps regulate blood sugar levels. Specifically, insulin controls how much glucose (a type of sugar) is passed from the blood into cells, where it is used as an energy source. When blood sugar levels are high (such as after a meal), the pancreas releases insulin to move the excess glucose into cells, which reduces the amount of glucose in the blood. Most people who develop type 2 diabetes first have insulin resistance, a condition in which the body's cells use insulin less efficiently than normal. As insulin resistance develops, more and more insulin is needed to keep blood sugar levels in the normal range. To keep up with the increasing need, insulin-producing cells in the pancreas (called beta cells) make larger amounts of insulin. Over time, the beta cells become less able to respond to blood sugar changes, leading to an insulin shortage that prevents the body from reducing blood sugar levels effectively. Most people have some insulin resistance as they age, but inadequate exercise and excessive weight gain make it worse, greatly increasing the likelihood of developing type 2 diabetes. Type 2 diabetes can occur at any age, but it most commonly begins in middle age or later. Signs and symptoms develop slowly over years. They include frequent urination (polyuria), excessive thirst (polydipsia), fatigue, blurred vision, tingling or loss of feeling in the hands and feet (diabetic neuropathy), sores that do not heal well, and weight loss. If blood sugar levels are not controlled through medication or diet, type 2 diabetes can cause long-lasting (chronic) health prob Continue reading >>
Type 1 Diabetes Risk Factors
There are several risk factors that may make it more likely that you’ll develop type 1 diabetes—if you have the genetic marker that makes you susceptible to diabetes. That genetic marker is located on chromosome 6, and it’s an HLA (human leukocyte antigen) complex. Several HLA complexes have been connected to type 1 diabetes, and if you have one or more of those, you may develop type 1. (However, having the necessary HLA complex is not a guarantee that you will develop diabetes; in fact, less than 10% of people with the “right” complex(es) actually develop type 1.) Other risk factors for type 1 diabetes include: Viral infections: Researchers have found that certain viruses may trigger the development of type 1 diabetes by causing the immune system to turn against the body—instead of helping it fight infection and sickness. Viruses that are believed to trigger type 1 include: German measles, coxsackie, and mumps. Race/ethnicity: Certain ethnicities have a higher rate of type 1 diabetes. In the United States, Caucasians seem to be more susceptible to type 1 than African-Americans and Hispanic-Americans. Chinese people have a lower risk of developing type 1, as do people in South America. Geography: It seems that people who live in northern climates are at a higher risk for developing type 1 diabetes. It’s been suggested that people who live in northern countries are indoors more (especially in the winter), and that means that they’re in closer proximity to each other—potentially leading to more viral infections. Conversely, people who live in southern climates—such as South America—are less likely to develop type 1. And along the same lines, researchers have noticed that more cases are diagnosed in the winter in northern countries; the diagnosis rate Continue reading >>
Type 1 Diabetes
Type 1 diabetes is a disorder characterized by abnormally high blood sugar levels. In this form of diabetes, specialized cells in the pancreas called beta cells stop producing insulin. Insulin controls how much glucose (a type of sugar) is passed from the blood into cells for conversion to energy. Lack of insulin results in the inability to use glucose for energy or to control the amount of sugar in the blood. Type 1 diabetes can occur at any age; however, it usually develops by early adulthood, most often starting in adolescence. The first signs and symptoms of the disorder are caused by high blood sugar and may include frequent urination (polyuria), excessive thirst (polydipsia), fatigue, blurred vision, tingling or loss of feeling in the hands and feet, and weight loss. These symptoms may recur during the course of the disorder if blood sugar is not well controlled by insulin replacement therapy. Improper control can also cause blood sugar levels to become too low (hypoglycemia). This may occur when the body's needs change, such as during exercise or if eating is delayed. Hypoglycemia can cause headache, dizziness, hunger, shaking, sweating, weakness, and agitation. Uncontrolled type 1 diabetes can lead to a life-threatening complication called diabetic ketoacidosis. Without insulin, cells cannot take in glucose. A lack of glucose in cells prompts the liver to try to compensate by releasing more glucose into the blood, and blood sugar can become extremely high. The cells, unable to use the glucose in the blood for energy, respond by using fats instead. Breaking down fats to obtain energy produces waste products called ketones, which can build up to toxic levels in people with type 1 diabetes, resulting in diabetic ketoacidosis. Affected individuals may begin breathin Continue reading >>
Genetics & Diabetes : What's Your Risk?
A school nurse anxiously wants to know if there is a reason why several children from her small grade school have been diagnosed with type 1 (juvenile onset) diabetes. Is it an epidemic? Will there be more cases? Is a recent chicken pox outbreak to blame? A man in his 50s develops type 2 diabetes. His mother developed diabetes in her 60s. Should this man's brother and sister be concerned, too? What about his children's chances of developing diabetes? A married couple wants to have children, but they are concerned because the husband has type 1 diabetes. They wonder what the risk is that their child would have diabetes. A couple has three young children. One of the children develops type 1 diabetes. There's no history of diabetes anywhere in either parent's families. Is this just a fluke? What are the chances the other children will develop diabetes? Chances are if you or a loved one have diabetes, you may wonder if you inherited it from a family member or you may be concerned that you will pass the disease on to your children. Researchers at Joslin Diabetes Center report that, while much has been learned about what genetic factors make one more susceptible to developing diabetes than another, many questions remain to be answered. While some people are more likely to get diabetes than others, and in some ways type 2 (adult onset diabetes) is simpler to track than type 1 (juvenile onset) diabetes, the pattern is not always clear. For more than 20 years researchers in the Epidemiology and Genetics Section at Joslin in Boston (Section Head Andrzej S. Krolewski, M.D., Ph.D., Senior Investigator James H. Warram, M.D., Sc.D., and colleagues) have been studying diabetes incidence and hereditary factors. They are continuing a scientific journey begun by Elliott P. Joslin, M.D., Continue reading >>