Diabetes Cure: A Researcher With Type 1 Works To Understand The Cause Of The Disease As A Way To Cure It
Diabetes Cure: A Researcher with Type 1 Works to Understand the Cause of the Disease As a Way to Cure It Diabetes Cure: A Researcher with Type 1 Works to Understand the Cause of the Disease As a Way to Cure It Thomas Delong's work investigating the mysteries of the immune system may eventually stop the misguided attack that causes diabetes. Diabetes researcher Thomas Delong lives with type 1 diabetes. His work to understand what triggers the disease may pave the way to preventing type 1 diabetes to develop in the first place. Thomas Delong was just 12 years old when he was diagnosed with type 1 diabetes more than 30 years ago. And while he learned to accept the many life challenges that come with this diagnosis, he never completely accepted that his disease was incurable. As a young teenager, he was driven to work in the field of diabetes research. Mostly, he wanted to pursue what he saw as his mission in lifeto find a cure for type 1 diabetes. When the father of a friend told him that he needed to do well in chemistry if he wanted to pursue life sciences, he made studying for chemistry his priority. Born in Germany, he was diagnosed with type 1 diabetes in 1986, when he fell ill while away at a youth camp. Originally from Bavaria, in Southern Germany, he worked hard to get his PhD in chemistry and biochemistry. After getting in touch with labs all over the world, he landed a position in Denver, at the University of Colorado for his post-doc work. That was more than a decade ago, and just last year, Dr. Delong was hired to a tenure-track position. In the more than three decades since his diagnosis, his hard work has paid off: Dr. Delong, now a dad of two who lives with his family in Denver recently discovered a new type of hybrid-protein in the body that the immune sys Continue reading >>
Is There A Diabetes Cure?
Everyone at Diabetes Daily is extremely excited for the day when diabetes is cured. We interview the greatest researchers in the world and are amazing by the continuous advances in understanding diabetes. In this section, we will look at our progress in curing type 1 and type 2 diabetes. You can also check out the many posts in our blog about the hunt for a diabetes cure. Is There a Type 2 Diabetes Cure? The short answer is: No. In reality, the answer is a little more complicated and depends upon how you define the word cure. There is currently no known treatment that will permanently eliminate type 2 diabetes. However, there are treatments that can cause diabetes to go into remission, often for very long periods of time. Those treatments include weight loss surgery and, in some circumstances, aggressive treatment with either diet, exercise and weight loss. At Diabetes Daily, we prefer using the word remission over cure because far too often the state of diabetes returns even with people’s best efforts. Regardless of the definition of a cure, finding a way to live with little to know highs or lows is a worthwhile endeavor. Long-term studies show that even a few years of great blood sugars significantly reduces your long-term risk of complications. A majority of people who undergo weight loss surgery experience diabetes remission. As the first major long-term studies are completed, we are discovering that many people do eventually relapse and the benefits are not permanent. In an interview with diaTribe, Dr. David Cummings shares the current state of research: A substantial proportion of people who experience type 2 diabetes remission after gastric bypass eventually have relapse of the disease down the road. I feel the best study of this was done by my co-author on CRO Continue reading >>
Tweet Cures for both type 1 diabetes and type 2 diabetes have not yet been discovered, but progress is being made to prospectively cure type 1 diabetes in this generation. As studies continue, the root causes and mechanism behind both forms of the disease are becoming more clearly understood all the time. People with type 2 diabetes can go into remission, but while a cure is still elusive for type 1 diabetes, research from major angles is contributing towards a potential cure. Type 1 diabetes cure Researchers are beginning to get excited again that a cure or near-cure treatment could come as early as within the next decade or two. A diabetes vaccine diabetes vaccine is consistently being investigated to provide a true biological cure for type 1 diabetes. The aim is for a vaccine to be created that stops the immune system from attacking the body's insulin-producing beta cells. Another cure prospect gaining momentum is islet cell encapsulation, with stem cells used to create insulin-producing cells that can work without immune system interference. Type 1 diabetes vaccine Research into a diabetes vaccine is being made on several fronts, with Selecta Bioscience, a clinical bioscience company, developing a Synthetic Vaccine Particle (SVP) as an immunotherapy for type 1 diabetes. The vaccine is expected to reprogram the immune system to prevent inflammatory responses to insulin cells, with Selecta currently trialling SVP on mice courtesy of funding from JRDF, a leading global organisation funding type 1 diabetes research. Elsewhere, the Faustman Lab at Massachusetts General Hospital is currently leading a human clinical trial program to test the efficiency of their Bacillus-Calmette-Guerin (BCG) vaccine. Positive results have already been reported from their Phase I study. An Continue reading >>
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Diabetes Cured In Mice. Are We Next?
2 pictures According to the Center for Disease Control, 1.25 million people suffer from type 1 diabetes in the US alone. So far, it can only be managed with diet and regular doses of insulin, but scientists at UT Health San Antonio have invented a way of curing the disease in mice that may one day do the same for humans even with type 2 diabetes. Type 1 diabetes is a particularly unpleasant condition. It occurs when the pancreas ceases to produce the insulin needed by the body to metabolize sugar and, until the invention of artificial insulin injections, it was as deadly as cancer. Type 2 is the less severe form of the disease, where the body produces insufficient insulin; it can often be managed through diet alone. Add some color to your diet with this recipe for rainbow sheet pan veggies, using Eggland’s Bes... Surprisingly, diabetes is an autoimmune disease. Insulin is made by specialized cells in the pancreas, called beta cells, and sometimes the body's immune system turns against itself and attacks these beta cells, destroying them. Diabetes results when this destruction is over 80 percent. Invented by Bruno Doiron and Ralph DeFronzo, the UT Health technique uses gene transfer to alter cells in the pancreases of mice to make them think they're beta cells and start making insulin. This involves taking selected genes from external beta cells and using viruses as carriers to move them into the new host cells, in the diabetic pancreas. According to DeFronzo, the altered cells then produce insulin, but only in the presence of sugar, which is how a functioning beta cell is supposed to work. Otherwise, the cells would just keep cranking out the hormone, metabolizing all the sugar in the bloodstream and causing hypoglycemia. Only about 20 percent of the lost cells need t Continue reading >>
At the Diabetes Research Institute,the vision is a world without diabetes. To make that vision a reality,we arelaser focused on one goal:to discover a biological cure.For millions of children and adults living with diabetes today, a cure would mean: The ability to restore natural insulin production and normalize blood sugar levels without imposing other risks. Over the last century, advancements in new treatments aided by the remarkable developments in computer technology have helped many people better manage the disease, but achieving optimal glucose control remains an unattainable goal for the vast majority of those with diabetes, and particularly among young people . Despite patients' best attempts, managing diabetes remains a challenging, daily balancing act that requires constant vigilance. That'sbecause insulin therapy cannot ideally mimic the exquisite biological function of a healthy pancreas. And that's why the Diabetes Research Institute and Foundation remain passionately committed to achieving this singular goal. Learn more about our progress towarda cure and the steps we are taking to turnour visioninto reality. The BioHub strategyis built onthree pillars of research - the Site , Sustainability , and Supply , whichare essential for restoring insulin production in those livingwith diabetes. Continue reading >>
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Could Fasting Cure Diabetes? Evidence On Not Eating For Long Stretches Is Compellingand Controversial
Could Fasting Cure Diabetes? Evidence on Not Eating for Long Stretches Is Compellingand Controversial Slice of pound cake with lock and chain Tooga/Getty Health type 2 diabetes diabetes Fasting intermittent fasting Weight Loss Weight gain may be driven not only by what we eat but also by our tendency to eat all day long. In the past few years, intermittent fasting has emerged as a popular trend in weight loss. A growing number of health professionals are also prescribing fasting to people with type 2 diabetes, which currently afflicts more than 29 million people in the U.S. Yet a recent study warns that going for long stretches without eating could cause the very damage its supposed to prevent. Slice of pound cake with lock and chain Tooga/Getty Type 2 diabetes is triggered in part by unhealthy eating, which renders the body resistant to insulin, a hormone produced by the pancreas. Without insulin, sugar from food cant enter our cells, leaving the blood with an excess amount of it. At first, the pancreas compensates by making more insulin, but eventually the demand wears out the digestive organ. Diabetics then become dependent on insulin injections to control their blood sugar. 50 Facts About the Human Body You Probably Didn't Know Dr. Jason Fung, a kidney specialist, is convinced that fasting undoes that cycle: Not eating reduces blood sugar. As he points out, fasting is simply extending what we already do at night when we sleep. Its supposed to be part of everyday life, says Fung, who co-founded the Toronto-based Intensive Dietary Management Program and wrote The Obesity Code and The Complete Guide to Fasting . Fasting can also send the body into ketosis, in which it burns fat rather than sugar. That helps with losing weight, which also helps slow diabetes. Several r Continue reading >>
Massachusetts General Hospital Researchers Diabetes Vaccine Appears To Present Cure 8 Years Later
Massachusetts General Hospital Researchers Diabetes Vaccine Appears to Present Cure 8 Years Later Researchers at Massachusetts General Hospital in Boston published results from a long-term clinical trial of a tuberculosis vaccine in type 1 diabetes patients that in a long-term follow-up appears to have cured the disease. Denise Faustman, director of the MGH Immunobiology Laboratory, has been conducting work on the bacillus Calmette-Guerin (BCG) vaccine and its ability to restore near-normal blood sugar levels. In follow-up studies to a Phase I clinical trial, three years after patients received two doses of the BCG vaccine four weeks apart, all the adults with longstanding type 1 diabetes had an improvement of HbA1c levels that were close to normal, and that improvement lasted for the next five years. The work was published in npj Vaccines. Faustman will also be presenting results from a separate group of BCG clinical trial patients on Saturday, June 23, at the 78th Scientific Sessions of the American Diabetes Association in Orlando. This is clinical validation of the potential to stably lower blood sugars to near normal levels with a safe vaccine, even in patients with longstanding diseases, Faustman said in a statement. In addition to the clinical outcomes, we now have a clear understanding of the mechanisms through which limited BCG vaccine doses can make permanent, beneficial changes to the immune system and lower blood sugars in type 1 diabetes. The BCG vaccine has been in use for almost 100 years to prevent tuberculosis. For the last 30 years, it was recognized as increasing production of tumor necrosis factor (TNF), a cytokine that seems to help in autoimmune diseases by eliminating the autoreactive T cells that attack the patients tissues. In the case of type 1 Continue reading >>
The Diabetes Cure That Most Insurance Companies Won't Pay For
The Diabetes Cure That Most Insurance Companies Won't Pay for For 15 years, Erez Benaris struggle with his type 2 diabetes had been a losing one. A software engineer at Microsoft in Seattle, Washington, Benari had stuck to a restrictive diet that kept him off most carbs, along with regular insulin shots. But still, his high blood sugar levels never dropped, while his health continued to decline. In 2013, the then 39-year-old Benari suffered a heart attack. In May 2016, however, Benari received a procedure known as a gastric bypass, a laparoscopic surgery that gave him something few of the 30 million diabetic Americans ever havea life free of insulin therapy and other medications. My diabetes went into remission basically immediately, almost that same day. And Ive been off insulin for about 8 months now, Benari told Gizmodo in February. Its not only improved my health, but my mental state, because I dont have to fear death all the time. At first glance, Benaris decision to get a bypass isnt that strange. The American Society for Metabolic & Bariatric Surgery estimates that nearly 200,000 Americans annually get a form of whats referred to as either weight loss or bariatric surgery. But Benari, now 44, was a very unusual patient in one clear way: He wasnt obese. Benari doesnt want to remain an outlier, though. And perhaps surprisingly, many doctors and surgeons are starting to agree that surgery should be considered more than a last-resort remedy for weight loss. Instead, it should be seen as a crucial aspect of diabetes care, and quite possibly the best tool we have against the chronic, often worsening condition. People dont realize theres a cure for diabetes out there, Vivek Kumbhari, director of bariatric endoscopy at Johns Hopkins Medicine, told Gizmodo. Were just not Continue reading >>
What If There Was A Cure For Diabetes
Dreaming of a cure for diabetes: Fact or Fiction? With tears in her eyes but a faint smile, Camp Director Maura Prescott, approached the podium. I would like to say that I am overjoyed that we are closing our Diabetes Camp with the announcement from the CDC that Type 1 Diabetes has now been eradicated, and that the services of our camp are no longer needed. I look forward to continuing to work in the diabetes world, but with the older Type 2 population, helping to fine tune their diabetes control with the Bionic Pancreas and increase their quality of life and time on this earth. I have given my life to working with and improving the lives of those with diabetes, and I will continue to do so. By the end of my life, I hope to see that there is not one single person with diabetes on this planet, and that our children and grandchildren are taught about this debilitating chronic illness in history class. We have come so far since the 1920’s, where we saw the discovery of insulin. We have come to the point of cure. Here, in 2056, we can say that on the horizon, we can see a world without diabetes. I stand before you today in awe at the shear genius of scientists who have worked tirelessly in efforts to make this day come. From the introduction of the vaccine for Type 1 diabetes in 2032, we have seen worldwide eradication similar to that seen many years ago with polio. The camp closes because there are no more children with diabetes to attend it, and is that not what we have all been working for? Honestly, I never expected to be able to say those words in my lifetime. But here we are. Tania Prescott read the scribbled notes from her mother’s speech some 25 years before. She had just read a news article online explaining how there are now only a few people left on the earth Continue reading >>
Here's Exactly What I Ate To Cure My Type 2 Diabetes & High Cholesterol
Here's Exactly What I Ate To Cure My Type 2 Diabetes & High Cholesterol Mary Jenkins is 51 and lives in Kanab, Utah. Last December, before starting her new diet, she weighed 225 pounds. She has since lost 50 poundsand the weight is still coming off. This is her story. I was born in Charlotte, North Carolina, so I lived off a Southern-fried diet for most of my life. As a result, I had extremely high blood pressure for over 30 years. I tried every eating plan out there to get it under control: low-carb diets, high-protein dietsall that stuff. None of it worked for me. I was still obese, and my cholesterol levels didnt improve. (Discover the ONE simple, natural solution that can help you reverse chronic inflammation and heal more than 45 diseases. Try The Whole Body Cure today !) Then two years ago, my doctor ordered an A1C test. He had a hunch I may have type 2 diabetes as a result of my weight. My score was a seven, which meant his suspicions were correct. (A normal A1C level is below 5.7. ) It got worse: Because Ive had high blood pressure for so long, he said I could have long-term organ damage now that I also had diabetes. Youd think at that point, he would have sat me down and talked to me about how I could improve my diet, but he didnt. He just said something like, Watch your carbs and exercise. That was it. So I basically kept living as I had before. MORE: 15 Common Risk Factors Of Type 2 Diabetes Then my doctor moved away, and I found another doctor in a larger town nearby. My new physician told me that I needed to go on metformin (the generic name for a drug used to treat high blood sugar levels) immediately. He also told me that I should ramp up my exercise routine. So last year, I started hiking and rock climbing with my neighbor, who happens to be a yoga inst Continue reading >>
Can Diabetes Be Cured? A Review Of Therapies And Lifestyle Changes
Diabetes is a condition that affects blood sugar levels and causes many serious health problems if not managed well. The health impacts of diabetes can be limited, but can it ever be "cured"? Type 1 diabetes is an autoimmune disease that develops when the body destroys the cells in the pancreas that produce insulin. This means people with type 1 diabetes do not make insulin. In those with type 2 diabetes, there is a decreased sensitivity to insulin and the body does not make or use as much insulin as it needs. Type 2 diabetes is much more common than type 1 diabetes. This article reviews therapies and lifestyle changes that can help reduce the effects of diabetes on a person's health. It also explores whether these treatments can help "cure" diabetes, or if they are simply helpful ways to manage the condition. Contents of this article: Is diabetes curable? Medically speaking, there is no cure for diabetes but it can go into "remission." Diabetes in remission simply means the body does not show any signs of diabetes. However, the disease is technically still there. According to Diabetes Care, remission can take different forms: Partial remission: When a person has had a blood glucose level lower than that of a person with diabetes for at least 1 year without any diabetes medication. Complete remission: When the blood glucose level returns to normal, not simply pre-diabetic levels, for at least 1 year without any medications. Prolonged remission: When complete remission lasts for at least 5 years. Even if a person has had normal blood sugar levels for 20 years, their diabetes is still considered to be in remission rather than "cured." There is no known cure for diabetes. The good news is that remission is possible in many cases and can be as simple as making some lifestyl Continue reading >>
How To Reverse Diabetes Naturally
According to the 2017 National Diabetes Statistics Report, over 30 million people living in the United States have diabetes. That’s almost 10 percent of the U.S. population. And diabetes is the seventh leading cause of death in the United States, causing, at least in part, over 250,000 deaths in 2015. That’s why it’s so important to take steps to reverse diabetes and the diabetes epidemic in America. Type 2 diabetes is a dangerous disease that can lead to many other health conditions when it’s not managed properly, including kidney disease, blindness, leg and food amputations, nerve damage, and even death. (1) Type 2 diabetes is a completely preventable and reversible condition, and with diet and lifestyle changes, you can greatly reduce your chances of getting the disease or reverse the condition if you’ve already been diagnosed. If you are one of the millions of Americans struggling with diabetes symptoms, begin the steps to reverse diabetes naturally today. With my diabetic diet plan, suggested supplements and increased physical activity, you can quickly regain your health and reverse diabetes the natural way. The Diabetes Epidemic Diabetes has grown to “epidemic” proportions, and the latest statistics revealed by the U.S. Centers for Disease Control and Prevention state that 30.3 million Americans have diabetes, including the 7.2 million people who weren’t even aware of it. Diabetes is affecting people of all ages, including 132,000 children and adolescents younger than 18 years old. (2) The prevalence of prediabetes is also on the rise, as it’s estimated that almost 34 million U.S. adults were prediabetic in 2015. People with prediabetes have blood glucose levels that are above normal but below the defined threshold of diabetes. Without proper int Continue reading >>
Can A Cheap And Widely Available Tb Vaccine Help Diabetics?
Can a cheap and widely available TB vaccine help diabetics? Can a cheap and widely available TB vaccine help diabetics? BCG vaccine may change the way the body handles sugar, study finds Get breaking news alerts and special reports. The news and stories that matter, delivered weekday mornings. Theres more evidence that a vaccine used to fight tuberculosis for 100 years might help people with diabetes. Researchers said Monday that a few diabetics who got the vaccine had much better control of their blood sugar after eight years than people who did not get it. Its a small study and many experts are skeptical about it. But if the results hold up in more people over time, it could point to a cheap and easy way to help keep people with type-1 diabetes healthy. The team at Massachusetts General Hospital has been testing the bacillus Calmette-Gurin (BCG) vaccine, used to prevent tuberculosis and to treat some forms of bladder cancer. Tests in animals had indicated that it might help fight the immune system mistakes that cause type-1 diabetes, also known as juvenile diabetes. Its caused when the body mistakenly destroys the cells in the pancreas that make insulin, forcing patients to carefully monitor their blood sugar for life and to inject insulin as needed. This team in the lab of Dr. Denise Faustman has been following 282 people, including 52 diabetics who got the vaccine. FDA approves the first artificial pancreas Three years after they got two doses of BCG, six of the diabetes patients had near-normal levels of blood sugar and had lower average blood sugar levels than those who got placebo shots, the team reported in the journal npj Vaccines . These effects have lasted, so far, for five years. We still have to use insulin, but were finally able to get to the nearly norma Continue reading >>
Is There A Diabetes Cure?
With all the research on diabetes and advances in diabetes treatments, it's tempting to think someone has surely found a diabetes cure by now. But the reality is that there is no cure for diabetes -- neither type 1 diabetes nor type 2 diabetes. (Although lifestyle changes can achieve remission in type 2 diabetes in some cases.) However, there are treatments, including simple things you can do daily, that make a big difference. No. Natural therapies such as deep abdominal breathing, progressive muscle relaxation, guided imagery, and biofeedback can help relieve stress. And emotional stress affects your blood sugar levels. So learning to relax is important in managing your diabetes. Supplements don't cure diabetes, either. Some natural supplements may interact dangerously with your diabetes medication. Others have been shown to help improve your diabetes, but always check with your doctor before taking any supplement. Be skeptical about claims of a diabetes cure. A genuine cure will have been tested repeatedly in clinical trials with clear success. Even though there's no diabetes cure, diabetes can be treated and controlled, and some people may go into remission. To manage diabetes effectively, you need to do the following: Manage your blood sugar levels. Know what to do to help keep them as near to normal as possible every day: Check your glucose levels frequently. Take your diabetes medicine regularly. And balance your food intake with medication, exercise, stress management, and good sleep habits. Plan what you eat at each meal. Stick to your diabetes eating plan as often as possible. Bring healthy snacks with you. You’ll be less likely to snack on empty calories. Exercise regularly. Exercise helps you keep you fit, burns calories, and helps normalize your blood gluc Continue reading >>
Has Dr. Denise Faustman Found A Cure For Type 1 Diabetes?
Has Dr. Denise Faustman Found a Cure for Type 1 Diabetes? Has Dr. Denise Faustman Found a Cure for Type 1 Diabetes? A new study from the Faustman Lab at Massachusetts General Hospital suggests that a nearly 100 year old tuberculosis vaccine called BCG may hold cure-like promise for people with Type 1 diabetes.The bacillus Calmette-Gurin (BCG) vaccine, one of the oldest vaccines in the world, was developed for tuberculosis protection and for early stage bladder cancer therapy. In Dr. Faustmans small, ongoing trial, patients lowered their blood sugar levels to near normal, and blood sugar levels in the patients have remained near normal for five to eight years. (See StatNews for more.) Three years after receiving two administrations of the bacillus Calmette-Gurin (BCG) vaccine four weeks apart, all members of a group of adults with longstanding type 1 diabetes showed an improvement in HbA1c to near normal levels improvement that persisted for the following five years. The study from a Massachusetts General Hospital (MGH) research team published in npj Vaccines also reports that the effects of BCG vaccine on blood sugar control appear to depend on a totally novel metabolic mechanism that increases cellular consumption of glucose. BCG has been known for more than 30 years to boost production of a cytokine called tumor necrosis factor (TNF), which may be beneficial in autoimmune diseases both by eliminating the autoreactive T cells that attack an individuals tissues in the case of type 1 diabetes, pancreatic islets and by inducing production of regulatory T cells (Tregs) that could prevent an autoimmune reaction. Faustmans team first reported in 2001 that inducing TNF production could cure type 1 diabetes in mice, but since TNF dosing is toxic in humans, clinical trials hav Continue reading >>
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