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Diabetes And C4

Is It Safe To Take Supplements If You Have Diabetes?

Is It Safe To Take Supplements If You Have Diabetes?

You will find supplements for anything and everything these days. Even when you do not suffer from an ailment, supplements are suggested to keep you healthy and ailment-free. According to CDC, use of supplements is common among US adult population – over 50% adults used supplements during 2003-2006, with multivitamins/multiminerals being the most commonly used. So when you are a diabetic, especially if you have prediabetes and type-2 diabetes, you may find yourself confronting a large number of options for supplements that claim to support, reduce and even cure your diabetes. Diabetes is quite a frustrating disorder and you may find yourself tempted to try out these supplements one after another. But is it really safe to take supplements when you are a diabetic? Let us find out. But before that you need to understand what exactly supplements are. Defining Supplements As the name suggests, a supplement is anything that adds on to something. A dietary supplement is therefore something that one takes in addition to one’s diet to get proper nutrition. US Congress in the Dietary Supplement Health and Education Act defines dietary supplements as having the following characteristics: It is a product that is intended to supplement the diet; It contains one or more dietary ingredients (including vitamins, minerals, herbs and other botanicals, amino acids, and other substances) or their constituents; It is intended to be taken by mouth as a pill, capsule, tablet, or liquid; It is not represented for use as a conventional food or as sole item of a mean or a diet; and, It is labeled on the front panel as being a dietary supplement. Now let us look at some general benefits and risks of taking supplements. We will discuss these in context of diabetes later in the article. Benefit Continue reading >>

Recommended Weight Lifting Supplements For Diabetics

Recommended Weight Lifting Supplements For Diabetics

Diabetes is a medical condition in which you experience abnormally high blood glucose levels because your body has trouble producing or using insulin. The American Diabetes Association explains that you should limit saturated fat intake and keep sugar intake low, as that can rapidly increase your blood sugar levels. Because many weight lifting supplements contain both of these nutrients, you need to choose supplements carefully and consult a doctor before using any. Many protein bars are high in saturated fat and sugar to overcome the taste of healthy ingredients. However, there are some low-fat, low-sugar protein bars available that may not significantly impact your blood glucose levels. Protein bars such as Doctor's CarbRite Diet bars and Allmax Isofemme bars, which have 6 g or less of fat and 1 g or less of sugar per bar, may support weight lifting because they are high in protein. Both bars use sugar alcohols, which provide fewer calories than sugar and don't cause quick increases in your blood sugar levels. Weight gainers are high-calorie, high-protein supplements that come in powdered form. Unfortunately, many of these weight gainers use sugar and fat to increase the calorie content. Try to find weight gainers that provide fiber and have low sugar and low fat content, such as Cytosport Cytogainer. This supplement contains only 7 g of sugar, 6 g of fat and 4 g of fiber in each 570-calorie serving. Protein powders tend to contain between 100 and 200 calories per serving, and offer primarily protein and much fewer grams of fat and carbohydrates than weight gainers. However, these powder still may contain added sugars and saturated fat. For this reason, you may want to choose a whey protein isolate, a type of protein powder with very little fat and at least 90 percent Continue reading >>

Complement Factors C4 And C3 Are Down Regulated In Response To Short Term Overfeeding In Healthy Young Men

Complement Factors C4 And C3 Are Down Regulated In Response To Short Term Overfeeding In Healthy Young Men

Complement factors C4 and C3 are down regulated in response to short term overfeeding in healthy young men Scientific Reportsvolume7, Articlenumber:1235 (2017) | Download Citation Insulin resistance is associated with high circulating level of complement factor C3. Animal studies suggest that improper complement activation mediates high-fat-diet-induced insulin resistance. Individuals born with low birth weight (LBW) are at increased risk of developing insulin resistance. We hypothesized that high-fat overfeeding (HFO) increase circulating C3 and induce complement activation in a birth weight differential manner. Twenty LBW and 26 normal birth weight (NBW) young men were studied using a randomised crossover design. Insulin resistance was measured after a control-diet and after 5-days HFO by a hyperinsulinemic-euglycemic-clamp. Circulating C4, C3, ficolins, mannose-binding-lectin, complement activation products C3bc, terminal complement complex (TCC) and complement activation capacity were determined using turbidimetry and ELISA. HFO induced peripheral insulin resistance in LBW individuals only, while both groups had the same degree of hepatic insulin resistance after HFO. Viewing all individuals circulating levels of C4, C3, C3bc, TCC and complement activation capacity decreased paradoxically along the development of insulin resistance after HFO (P = 0.0015, P < 0.0001, P = 0.01, P < 0.0001, P = 0.0002, P < 0.0001, P = 0.0006). Birth weight did not influence these results. This might reflect a hitherto unrecognized down-regulatory mechanism of the complement system. More human studies are needed to understand the underlying physiology and the potential consequences of these findings. Affecting more than 170 million people worldwide, diabetes constitutes a major threat Continue reading >>

C4 Polymorphism In Multiplex Families With Insulin Dependent Diabetes In The Tunisian Population: Standard C4 Typing Methods And Rflp Analysis

C4 Polymorphism In Multiplex Families With Insulin Dependent Diabetes In The Tunisian Population: Standard C4 Typing Methods And Rflp Analysis

Volume 5, Issue 2 , April 1992, Pages 149-160 C4 polymorphism in multiplex families with insulin dependent diabetes in the Tunisian population: Standard C4 typing methods and RFLP analysis Author links open overlay panel F.Jenhani Get rights and content The polymorphism of C4A and C4B genes was investigated in Tunisian patients with insulin dependent diabetes (IDDM) and compared to family members (sibs) and to healthy controls. Multiplex families were analysed. A significant increase in C4AQO (26.86% vs 6.90%) and C4BQO (40.29% vs 8.28%) phenotypes was noted in IDDM patients compared with controls. Using RFLP analysis, we confirmed the high frequency of C4 null alleles. We also observed that most of these alleles were genes deleted in IDDM patients (72.23% vs 20% for CA4QO and 74.07% vs 16.70% for C4BQO). A significant decrease in the C4B long (14.92% vs 67.12%) form of the gene was also demonstrated by RFLP analysis compared with controls. Two haplotypes were frequently associated with IDDM patients in whom the C4A and C4B were deleted genes. Continue reading >>

Supplements For Diabetics

Supplements For Diabetics

Diabetes is a condition people face when the body goes throughan abnormally high blood glucose levels. This is caused by a person having a difficult time producing or making use of insulin. The American Diabetes Association shows that you should keep the amount of sugar and saturated fat rather low in you diet. If you are diabetic and also weight lifting, you need to choose the right supplements that fit your dietary needs. Many people take pre-workouts before a workout in order toincreaseenergy and strength. For diabetics, you should choose a pre-workout that is caffeine free. Caffeine may interfere with glucose levels in the body and makes it hard for people to control their blood sugar.You can Build Your Own Stim-Free Pre-Workout on Campusprotein.com to take your workouts to the next level, minusthe added caffeine and stimulants. There are many more benefits for diabetics when it comes to adding protein powder to your diet. Although protein is a great wayto build and maintain muscle, it can also help lower blood glucose levels.Choosing the right protein powder is very important, you want to stay away from oneswith added sugars or fat. Whey isolates will be your best choice, they contain minimal fats and easily digestible protein.Wheyhas theability to boost metabolic rate, improve insulin and blood sugar metabolism, and help maintain appetite that maybenefit many people. Here are some of the best protein options: Continue reading >>

"c4 Supplement": Diabetes Community - Support Group

These message boards are closed to posting. Please head onover to our new WebMD Message Boards to check out and participate in the greatconversations taking place: Your new WebMD Message Boards are now open! 1. Head over to this page: 2. Choose the tag from the drop-down menu thatclicks most with you (and add it to any posts you create so others can easilyfind and sort through posts) I am a type one diabetic. I'm looking to gain weight and muscle. Is the C4 Ssupplement safe? I am a type one diabetic. I'm looking to gain weight and muscle. Is the C4 Ssupplement safe? Your reply violates WebMD's rules. The issue ishighlighted in red. Please correct the issue, then click Submit. Post my content anonymously (without my username) Put this on my watchlist and alert me by email to new posts always check with a doctor before taking any kind of supplement. I don't know what C4 is so I goggled it, probably not good for diabetic kidneys... I have read and agree to WebMD's Privacy Policy . does anyone have tips to bring down diabetes More Dr. Michael Dansinger provides thoughtful tips for those with type 2 diabetes or pre-diabetes who want to reclaim their health... Read More Report Problems With Your Medications to the FDA You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088. The opinions expressed in WebMD Communities are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. Communities are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Some of these opinions may contain infor Continue reading >>

Involvement Of C4 Allotypes In The Pathogenesis Of Human Diseases

Involvement Of C4 Allotypes In The Pathogenesis Of Human Diseases

Involvement of C4 allotypes in the pathogenesis of human diseases O envolvimento dos altipos de C4 na patognese das doenas humanas Eliana Sueco Tibana Samano; Lia de Melo Ribeiro; Rosa G. Gorescu; Katya Cristina Rocha; Anete S. Grumach From the Laboratory of Medical Investigation in Clinical Allergy and Immunology, Hospital das Clnicas, Faculty of Medicine, University of So Paulo - So Paulo/SP, Brazil. E-mail: [email protected] The complement system is an important humoral defense mechanism that plays a relevant role against microbial agents, inflammatory response control, and immunocomplex clearance. Classical complement pathway activation is antibody-dependent. The C4 component participates in the initial step of activation, and C4 expression is determined by 2 pairs of allotypes: C4A and C4B. Deficiencies in C4 allotypes have been associated with several diseases. The aim of the present review is evaluate the reported data in the literature regarding specific C4A and C4B deficiencies and characterize their clinical relevance. We searched the MEDLINE and LILACS databases. Papers referring to total C4 deficiency without allotype evaluation and case reports of primary C4 deficiency were not included. Deficiencies in C4 allotypes have been associated with Mycobacterium leprae infection, erythema nodosum, systemic sclerosis with anti-topoisomerase I antibodies, intermediate congenital adrenal hyperplasia with DR5 genotype, diabetes mellitus type 1 with DR3,4 genotype, and diabetes mellitus with antibodies against islet cells. C4 allotype deficiency is also related to C4B deficiency and autoimmune-associated diseases, such as systemic lupus erythematosus, or diseases with an autoimmune component, such as autism. Some reports associate C4A with thyroiditis after delivery as w Continue reading >>

Diabetes Mellitus And Increased Tuberculosis Susceptibility: The Role Of Short-chain Fatty Acids

Diabetes Mellitus And Increased Tuberculosis Susceptibility: The Role Of Short-chain Fatty Acids

Copyright © 2016 Ekta Lachmandas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Type 2 diabetes mellitus confers a threefold increased risk for tuberculosis, but the underlying immunological mechanisms are still largely unknown. Possible mediators of this increased susceptibility are short-chain fatty acids, levels of which have been shown to be altered in individuals with diabetes. We examined the influence of physiological concentrations of butyrate on cytokine responses to Mycobacterium tuberculosis (Mtb) in human peripheral blood mononuclear cells (PBMCs). Butyrate decreased Mtb-induced proinflammatory cytokine responses, while it increased production of IL-10. This anti-inflammatory effect was independent of butyrate’s well-characterised inhibition of HDAC activity and was not accompanied by changes in Toll-like receptor signalling pathways, the eicosanoid pathway, or cellular metabolism. In contrast blocking IL-10 activity reversed the effects of butyrate on Mtb-induced inflammation. Alteration of the gut microbiota, thereby increasing butyrate concentrations, can reduce insulin resistance and obesity, but further studies are needed to determine how this affects susceptibility to tuberculosis. 1. Introduction Tuberculosis (TB) is the second leading cause of death from an infectious disease worldwide [1]. Susceptibility to TB can be increased by several comorbidities, one of which is type 2 diabetes mellitus (DM) [2]. DM patients present with an overall threefold increased risk of developing active TB [3]. Globally, 15% of TB cases are estimated to be attributable to DM [4] and thus with a Continue reading >>

Pre Workouts With Diabetes

Pre Workouts With Diabetes

Ok I'm kinda new to this whole pre workout stuff so I've been doing some research on them and I'm not really sure what is the best bang for my buck but also healthier.. I've also got diabetes too so that's a problem I have with finding a good pre workout that will work with my diabetes.. Anyone got any good ideas for a pre workout to fit my life style?? what ingredients dont work with your diabetes? some of my favorites are: AMPLIFY-awesome pump/fullness that users report lasts all day, good energy and a good focus blend. sma5h- another great pump product, good smooth energy D-stunner- great energy and focus, decently good pump as well Disclaimer: The statement above reflects that of my own opinion and in no way that of MAN Sports. Our products are not intended to diagnose, treat, cure, or prevent any disease. what ingredients dont work with your diabetes? some of my favorites are: AMPLIFY-awesome pump/fullness that users report lasts all day, good energy and a good focus blend. sma5h- another great pump product, good smooth energy D-stunner- great energy and focus, decently good pump as well Like I said I'm a little new to pre workouts but I really don't know what the single ingredient is that effects me. the sumplement i got recently was this stuff called Krank, haven't taken any yet but it says on the caution label tht ppl with diabetes need to consult your physician before use an I already know what mine will say. Thank you ill have to look into those. Disclaimer: The statement above reflects that of my own opinion and in no way that of MAN Sports. Our products are not intended to diagnose, treat, cure, or prevent any disease. Last edited by IowaGuy515; 12-24-2013 at 04:16 PM. Reason: For got a couple wirds Disclaimer: The statement above reflects that of my own op Continue reading >>

Higher Complement C4 And C4a Are Genetic Modifiers Of [beta]-cell Preservation In New Onset Type 1 Diabetes Mellitus

Higher Complement C4 And C4a Are Genetic Modifiers Of [beta]-cell Preservation In New Onset Type 1 Diabetes Mellitus

Higher Complement C4 and C4A Are Genetic Modifiers of [beta]-Cell Preservation in New Onset Type 1 Diabetes Mellitus Type 1 diabetes (T1D) has been Type 1 diabetes (T1D) has been extensively characterized as a T-cell mediated autoimmune disease caused by multiple genetic and environmental factors. Complement C4 gene, which plays an important role in immunotolerance and autoimmunity, is 544kb telomeric from HLA-DRB1, one of the strongest genetic risk loci in the MHC for T1D. The potential role for complement C4 in organ-specific autoimmunity is unclear and under-studied.[br]We investigated whether complement C4 is engaged in protection or destruction of the pancreatic [beta]-cells at T1D disease onset and during the partial remission period. We studied 33 patients of European ancestry, ages 4 to 16 years (10.77 [plusmn] 3.40, mean [plusmn] SD) with recently diagnosed T1D at Nationwide Children[apos]s Hospital in Columbus, Ohio. Gene copy number and size variations of complement C4 and RCCX modules were characterized by genomic Southern blot analyses. C4 protein phenotypes were elucidated by immunofixation and immunodiffusion using EDTA-plasma. At 1 month and 9 months post type 1 diabetes diagnosis, stimulated C-peptide levels were measured during a standardized mixed meal tolerance test.[br]Patients with lower total C4 copy number variation (CNV) and C4A CNV had lower stimulated C-peptide at 1 month post T1D diagnosis (p=0.054, p=0.008). Patients with lower total C4 protein concentration and lower C4A protein concentration also had lower stimulated C-peptide at 1 month post T1D diagnosis (p=0.058, p=0.008). Patients who had higher total C4 protein concentration had a smaller change in C-peptide at 9 months post T1D diagnosis (p=0.024). In a regression analysis with both Continue reading >>

4.4.4 C4.4 Treatment Of Hypoglycaemia - Diabetes Guidelines

4.4.4 C4.4 Treatment Of Hypoglycaemia - Diabetes Guidelines

Half of a small bottle(150ml) of sugary drink e.g cola, lemonade, or similar (not diet or litevarieties) If the patients medication includesacarbose (Glucobay), then glucose e.g. Dextrosol must be used for treatment ofhypoglycaemia (not a disaccharide such as sucrose (table sugar) or lactose(milk sugar)). If symptoms and / or meteredglucose are not improving after 10 minutes this should be repeated. Ifthe patient is too drowsy to cooperate, Glucogel (formerly known asHypostop) may be applied to the inside of the cheekand massaged from the outside. It may be advisable for patients to keepGlucogel at home/work and instruct family members/ friends/colleagues how touse it. If the patient is unresponsive, 1 mg of glucagon (Glucogen) should be given subcutaneously orintramuscularly (once only per episode).It may be also appropriate to instruct partners, close relatives, friendsor colleagues of susceptible insulin-treated people in the use of glucagon andto ensure that they keep a kit available. Alternatively 25g(50ml) of 50% dextrose can be givenintravenously by professional help. During the initialtreatment of hypoglycaemia, high fat foods (eg chocolate) or long actingcarbohydrates (bread, plain biscuits) are not the best choice as these willtreat be slow to raise the blood glucose and may impair absorption of ingestedfast acting carbohydrate. After the initial treatment (once meteredglucose is >4mmol/l), it is essential for the patient to take long acting carbohydrate such asbiscuits and milk or a sandwich to prevent the hypoglycaemia from recurring. Continue reading >>

Low Serum C4 Concentrations In Type-1 Diabetes Mellitus

Low Serum C4 Concentrations In Type-1 Diabetes Mellitus

, Volume 147, Issue2 , pp 197198 | Cite as Low serum C4 concentrations in type-1 diabetes mellitus Serum levels of complement factors C3 and C4 were investigated in 64 insulin-dependent diabetic children and 52 healthy controls. The mean value of C4 was significantly lower in diabetic than in control subjects (27.998.01 vs 32.038.91 mg/dl; P<0.01). Sixteen out of 64 children had serum C4 levels below the normal range; 6 out of these 11 patients had microalbuminuria. This study demonstrates low serum levels of C4 in insulin-dependent diabetes; this reduction is not related to the duration nor to the degree of metabolic control. There is a high prevalence of microalbuminuria in patients with a low C4 concentration. Insulin-dependent diabetes mellitusComplementDiabetic nephropathy This is a preview of subscription content, log in to check access. Barnett AH, Mijovic C, Fletcher J, Chesner I, Kulkuska-Langlands BM, Holder R, Bradwell AR (1984) Low plasma C4 concentrations: association with microangiopathy in insulin-dependent diabetes. Br Med J 289:943945 Google Scholar Bertrams J, Hintzen U, Schlicht V, Schoeps S (1982) C4: another marker for type I diabetes. Lancet I:41 Google Scholar Cooper ME, Duff R, Buchanan R, McPherson J, Jerums G (1986) Low serum C4 concentrations and microangiopathy in type I and type II diabetes. Br Med J 292:801 Google Scholar Kurtz F, Juif JG, Hauptmann GR, Goetz J (1983) Insulin-dependent diabetes in children and fourth component of complement (C4). In: Chiumello G, Sperling M (eds) Recent progress in pediatric endocrinology. Raven Press, New York, pp 351358 Google Scholar Leslie RD, Pyke DA (1982) Diabetic retinopathy in identical twins. Diabetes 31:1921 Google Scholar Mogensen CE, Christensen CK (1984) Predicting diabetic nephropathy in ins Continue reading >>

Diabetes In Scotland: Groups

Diabetes In Scotland: Groups

Health-care professionals and service users who are dedicated to improving foot care for patients with diabetes across Scotland. It is chaired by a consultant in Diabetes (Graham Leese), and there is a seconded National Co-ordinator (Duncan Stang) who is a specialist podiatrist as well a part-time administrator. Identify Specialist Foot Services Available in Scotland Support development of Local Foot Networks Record Foot Screening: 75% of all patients in Scotland by 2009 Develop consistent patient information nationally Accredit training programmes to recognise specialist skills Other adopted targets include; Improving the provision orthotic services for people with diabetes throughout the country The Scottish Diabetes Foot Action Group (SDFAG) is currently working on a National initiative called CPR for Diabetic feet. This initiative is to try and make sure all patients with Diabetes who are admitted to hospital have their feet Checked on admission, if they are at risk of developing a foot ulcer their feet are Protected and if they have a current foot ulcer they are Referred appropriately. This is a simple concept to try and address a problem which was highlighted following an audit of 1,048 in-patients with diabetes which showed that: 2.4% of in patients with diabetes developed a new foot lesion whilst in hospital 57% of in patients had not had their feet checked 60% who were discovered to be at risk of developing a foot ulcer did not have any pressure relief in place (Scottish Diabetes Foot Action Group 2013) A LearnPro module is available to support this initiative and can be found at nhs.learnprouk.com and is under the CPD section. We are currently trying to define a framework for optimal service provision and map how each MCN area around the country is managing t Continue reading >>

Food Hospital (c4) Is Talking About Ketogenic..

Food Hospital (c4) Is Talking About Ketogenic..

Diabetes Forum The Global Diabetes Community This site uses cookies. By continuing to use this site, you are agreeing to our use of cookies. Learn More. Get the Diabetes Forum App for your phone - available on iOS and Android . Find support, ask questions and share your experiences. Join the community Food Hospital (C4) is talking about Ketogenic.. .. diets as a treatment for Epilepsy - on at the moment no seizures in 2 months since going on ketogenic diet I'm crying my eyes out at little Charlie, who's now free from seizures due to his ketogenic diet. What a wonderful outcome for the little fella and his parents! My older sister who's now in her 60s was diagnosed with grand mall epilepsy when she was 16 but petit mal was suspected prior to that and interestingly, my mother told me that when she was born she took ages to finish a feed and would fall asleep and have to be tickled to wake her up. It was also recommended that she be put on a full cream feed so I'm pretty sure the medics even all those years ago had an idea about diet and neurology although nothing was ever explained to my mother. My sister was also known to be a 'naughty' child and often punished for it. Today we'd probably call her 'hyperactive'. I discovered the ketogenic diet about 15 years ago and read up on it and found a video about a true life family with a young child with epilepsy, called 'First Do No Harm' which I think Meryl Streep starred in and I gave it to my sister to watch. She'd been on meds for so long though that she didn't trust that the diet would work for her so I don't think she ever tried it. But for young children I'd say it has to be worth a try. Before any diet is dismissed as a 'fad' we really need to stop and think about what it might just be correcting in the body of someone Continue reading >>

Studies Of Hla, Factor B (bf), Complement C2 And C4 Haplotypes In Type 1 Diabetic And Control Families From Northern Sweden

Studies Of Hla, Factor B (bf), Complement C2 And C4 Haplotypes In Type 1 Diabetic And Control Families From Northern Sweden

Studies of HLA, Factor B (Bf), Complement C2 and C4 Haplotypes in Type 1 Diabetic and Control Families from Northern Sweden Hgglf B.a Holmgren G.a,b Holmlund G.c Lindblom B.c Olaisen B.d Teisberg P.e I have read the Karger Terms and Conditions and agree. I have read the Karger Terms and Conditions and agree. Buy a Karger Article Bundle (KAB) and profit from a discount! If you would like to redeem your KAB credit, please log in . Save over 20% compared to the individual article price. Buy Cloud Access for unlimited viewing via different devices Access to all articles of the subscribed year(s) guaranteed for 5 years Unlimited re-access via Subscriber Login or MyKarger Unrestricted printing, no saving restrictions for personal use * The final prices may differ from the prices shown due to specifics of VAT rules. For additional information: The HLA-A-B-C-DR antigens and the complement factors C2, C4 and Bf were determined in 30 insulin-dependent diabetes mellitus (IDDM) patients and 30 healthy controls from northern Sweden. Family studies allowed the deduction of extended haplotypes in the HLA and complement systems. Phenotype studies revealed significant associations between IDDM and HLA-DR4 (p < 0.001), HLA-DR3 (p < 0.05), HLA-DR3/4 (p < 0.025), C4-B3 (p < 0.001) and Bf-S (p < 0.025). Haplotype studies showed that the extended haplotype [HLA-B15, C21, C4-A3B3, Bf-S, HLA-DR4] had a particularly strong association to IDDM. This haplotype was found in 10 out of 30 IDDM probands but in none of 30 control children and accounts for practically all the C4-B3 allotypes among the 30 IDDM probands. The C4-B3 gene therefore seems to be a valuable marker for IDDM. No haplotype containing HLA-DR3 was increased in frequency among the IDDM probands. The extended haplotype [HLA-B7, C21, Continue reading >>

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