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Dawn Phenomenon Prediabetes

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Demonstration Of A Dawn Phenomenon In Normal Human Volunteers.

Abstract To ascertain whether the dawn phenomenon occurs in nondiabetic individuals and, if so, whether it is due to an increase in glucose production or a decrease in glucose utilization, we determined plasma concentrations of glucose, insulin, C-peptide, and counterregulatory hormones, as well as rates of glucose production, glucose utilization, and insulin secretion at one-half-hourly intervals between 1:00 and 9:00 a.m. in eight normal volunteers. After 5:30 a.m., plasma glucose, insulin, and C-peptide concentrations all increased significantly; rates of glucose production, glucose utilization, and insulin secretion also increased (all P less than 0.05). Plasma cortisol, epinephrine, and norepinephrine increased significantly from nocturnal nadirs between 4:00 and 6:30 a.m. Plasma growth hormone, which had increased episodically between 1:00 and 4:30 a.m., decreased thereafter nearly 50% (P less than 0.05). Plasma glucagon did not change significantly throughout the period of observation. These results indicate that a dawn-like phenomenon, initiated by an increase in glucose production, occurs in nondiabetic individuals. Thus, early morning increases in plasma glucose concentra Continue reading >>

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Popular Questions

  1. grandmagirl

    Hi ! (New member here...) I was diagnosed with prediabetes a month ago, having been on insulin six years ago with gestational diabetes. My basal (c. 7:00) readings have been 96-126, usually near 100. I've noticed that if I eat a HUGE (3-4) carb and protein snack before bed (about midnight/ 1:00) my sugars are generally better. Last night, I was 106 at 12:30. I had 1 1/2 carbs and a fat, and went to bed. My reading this morning was 141, which I never had, even on insulin. An hour later, still fasting, it was 133. I started to get shaky after that, and decided to eat breakfast . Also, I have been going low near noon ( 54-67 and very shaky). Advice, please? Thanks !

  2. richard157

    Hi grandmagirl, welcome to a great website. We are small but very supportive. We also get kinda silly at times. Humor can help too!
    I don't understand why you would eat so many carbs at bedtime. I eat 15 grams of carbs at bedtime. It carries me through the night if I include some fat, like peanutbutter. I do not have morning highs. You might try an Extend Bar. It digests slowly and lasts all night. It keeps your liver from producing glucose in the middle of the night. That is what causes morning highs. The following site helps with the Dawn Phenomenon (morning highs):
    http://www.diabetic-talk.org/dp.htm
    You might also be interesred in the following for planning meal portions:
    http://www.platemethod.com
    If you get the shakes at 133 then you must run a lot of highs when you test. If you get good control and have very few tests above 150 then you would not feel low above 100. I do not feel low unless I am 75 or less. Your doctor should help you with your control. Maybe a dietitian might help you too.
    Good luck to you! Visit often and as all the questions you want. The more information you give us about your diabetes, the more we can help.
    Richard

  3. grandmagirl

    Thanks, Richard, for your reply. My total averages are in the low 100's; the highest I've gone since I began checking again has been 156 after a big meal. I don't normally get shaky unless I'm nearing 70; perhaps today was an anomaly? I just think it odd that if I carboload with protein or fat at bedtime my results are better than a small carb/protein/fat snack. ( I also get an average of six hrs. or less of sleep, which may mess up my hormones.) I have cleared my meal plan with a dietician (except for the extra bedtime carbs). It is possible that I am a lean type 2; I put myself on a diet last fall and lost nearly 20 lbs. My IFG's weren't until mid-June, and they came in at 114 and 124. Thanks again for the ideas !

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