D-ribose And Metformin

D-ribose And Metformin Interaction | Treato

Metformin and PCOS D-ribose and Tiredness Metformin and Diabetes D-ribose and Coenzyme Q10 Metformin and Clomid D-ribose and Pain Metformin and Weight Loss D-ribose and Magnesium Metformin and Pregnancy D-ribose and Fibromyalgia Treato does not review third-party posts for accuracy of any kind, including for medical diagnosis or treatments, or events in general. Treato does not provide medical advice, diagnosis or treatment. Usage of the website does not substitute professional medical advice. The side effects featured here are based on those most frequently appearing in user posts on the Internet. The manufacturer's product labeling should always be consulted for a list of side effects most frequently appearing in patients during clinical studies. Talk to your doctor about which medications may be most appropriate for you. The information reflected here is dependent upon the correct functioning of our algorithm. From time-to-time, our system might experience bugs or glitches that affect the accuracy or correct application of mathematical algorithms. We will do our best to update the site if we are made aware of any malfunctioning or misapplication of these algorithms. We cannot guarantee results and occasional interruptions in updating may occur. Please continue to check the site for updated information. Continue reading >>

Metformin Induces Both Caspase-dependent And Poly(adp-ribose) Polymerase-dependent Cell Death In Breast Cancer Cells

Metformin Induces Both Caspase-Dependent and Poly(ADP-ribose) Polymerase-Dependent Cell Death in Breast Cancer Cells 1Cancer Biology Research Center, Sanford Research/USD, Sioux Falls, South Dakota 2Department of Obstetrics and Gynecology and Division of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, Sioux Falls, South Dakota 1Cancer Biology Research Center, Sanford Research/USD, Sioux Falls, South Dakota 2Department of Obstetrics and Gynecology and Division of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, Sioux Falls, South Dakota *Corresponding author, Address: Cancer Biology Research Center, Sanford Research/USD, 2301 East 60th Street-North, Sioux Falls, SD 57104, USA, [email protected] , Telephone: 605-328-0464 The publisher's final edited version of this article is available free at Mol Cancer Res See other articles in PMC that cite the published article. There is substantial evidence that metformin, a drug used to treat type 2 diabetics, is potentially useful as a therapeutic agent for cancer. However, a better understanding of the molecular mechanisms through which metformin promotes cell cycle arrest and cell death of cancer cells is necessary. It will also be important to understand how the response of tumor cells differs from normal cells and why some tumor cells are resistant to the effects of metformin. We have found that exposure to metformin induces cell death in all but one line, MDA-MB-231, in a panel of breast cancer cell lines. MCF10A non-transformed breast epithelial cells were resistant to the cytotoxic effects of metformin, even after extended exposure to the drug. In sensitive lines, cell death was mediated by both apoptosis and a caspase-independent mechani Continue reading >>

Side Effects Of The D-ribose Supplement | Diabetes

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Overwhelmed By Which Supplements/brands/tests To Take And How Much

Overwhelmed by which Supplements/Brands/Tests to take and how much Hi, I've divided this post into "General" and "Specific to myself" in case it's only appropriate to respond to general questions in the forum. Sorry if I cannot post specific questions about myself! In that case, I've divided out the specifics part so you don't have to respond to that. Now, I appreciate and fully understand that I should not take any advice in this forum as "professional medical advice" and so will not take any responses in place of a medical professional. But I would appreciate advice to help me navigate through all of the information out there. I am not sure if posting specifics about myself is okay, but I have heard and read a lot about supplementation, particularly Mg, K, and Taurine. I REALLY want to try them, but I feel *very overwhelmed* with the decision of which brand to use and how much I should take--because I know that everyone is different and that even: 3) but with the wrong dose (too little/too much - ref. "Food Matters" DVD) My medical doctor is open to alternative therapies and has a whole slew of supplements in his office (Metagenics, Designs for Health, NOW, Physiologics, Pure, etc.) and has recommended some to me based on my blood work/report below. But he is not an Afib expert, and I fear that the "normal" suggested daily dosages won't do me any good. I have taken supplements for years (which has resulted in limited results and very expensive urine as they say ), particularly by working through a Nutrition Response Testing doctor who uses Standard Process and Nature's Sunshine. I have had some success, but nothing major or long term. But she doesn't test for most of this stuff, and is not an expert on Afib, either. I have an ablation scheduled in May, and could real Continue reading >>

Enhancing Cardiac Energy With Ribose

By Stephen T. Sinatra, MD, and James C. Roberts, MD Until 1944, D-ribose was thought to be primarily a structural component of DNA and RNA with little physiological significance. But a series of studies, culminating in 1957, revealed that this sugar molecule played an intermediate role in an important metabolic reaction called the pentose phosphate pathway. This reaction is central to energy synthesis, the production of genetic material, and for providing substances used by certain tissues to make fatty acids and hormones. The D-ribose connection to cardiac function was made by the physiologist Heinz-Gerd Zimmer at the University of Munich. In 1973, he reported that energy-starved hearts could recover faster if D-ribose was given prior to, or immediately following, ischemia (oxygen deprivation). Five years later, he reported the same effect in skeletal muscle and also showed for the first time that the energy-draining effects of drugs that make the heart beat more strongly (inotropic agents) could be lessened if D-ribose was given along with the drug. Zimmer and his research colleagues later proved that D-ribose was the limiting element in energy recovery in ischemic tissue and that energy synthesis could not occur without it. Zimmers research sparked a flurry of research on humans, rats, rabbits, guinea pigs, dogs, and even turkeys, all with similar results. D-ribose administration significantly improved energy recovery in ischemic, hypoxic, or cardiomyopathic hearts and skeletal muscle, and it improved functional performance of the tissue. In addition, studies with several common heart drugsthose used even todayshowed that D-ribose administration did not negatively affect (and in many cases helped) the action of the drug on the heart. The most significant findings of Continue reading >>

Metformin Suppresses High Glucose-induced Poly(adenosine Diphosphate-ribose)polymerase Overactivation In Aortic Endothelial Cells.

1. Metabolism. 2009 Apr;58(4):525-33. doi: 10.1016/j.metabol.2008.11.012. Metformin suppresses high glucose-induced poly(adenosine diphosphate-ribose)polymerase overactivation in aortic endothelial cells. Mahrouf-Yorgov M(1), Marie N, Borderie D, Djelidi R, Bonnefont-Rousselot D,Legrand A, Beaudeux JL, Peynet J. (1)EA 3617 Biochimie radicalaire et atteintes vasculaires, Universit Paris Descartes, UFR des Sciences Pharmaceutiques et Biologiques, 4, avenue de l'Observatoire, F75006 Paris, France. Overactivation of poly(adenosine diphosphate-ribose) polymerase (PARP), an enzymeinvolved in cellular response to DNA injury resulting from oxidative andnitrosative stress, is considered to play a key role in the pathogenesis ofdiabetes complications by promoting numerous vascular dysfunctions. In thisstudy, we examined the ability of metformin, which was reported to possessintrinsic vasculoprotective properties independently of its antihyperglycemiceffects, to inhibit PARP activation induced by high glucose concentrations inbovine aortic endothelial cells; and we investigated the potential mechanismsinvolved in this inhibition. The PARP activity was measured by cellularenzyme-linked immuno-specific assay (CELISA) method; cell poly(ribosyl)atedprotein polymer accumulation was evaluated by immunofluorescence. Peroxynitriteanion productions were determined using dihydrorhodamine 123 fluoroprobe; andexpression of p47phox subunit of nicotinamide adenine dinucleotide phosphate(NAD(P)H) oxidase was analyzed by Western blot in the absence and presence ofprotein kinase C and NAD(P)H oxidase inhibitors (calphostin anddiphenyleneiodonium chloride, respectively). Our data showed that atherapeutically relevant concentration of metformin (5.10(-5) mol/L) was able to abolish PARP activation, Continue reading >>

The Life Changing Power Of D-ribose

For us to stay healthy and active our bodies need energylots of energy. The energy produced by each of the trillions of cells in our bodies keeps our hearts beating, our muscles contracting, our brains functioning to send signals to the far reaches of our bodies, and our nerves carrying those signals to each of our organs to sustain life. Each day, our bodies produce and consume extraordinary amounts of energy. Lets take the heart for example. At any given moment an average heart contains less than one gram of stored energy, about 0.7-grams to be exact. But every day our hearts consume almost 6,000-grams of energy in performing its ceaseless work of pumping blood and delivering life-giving oxygen to tissues throughout our bodies. Think about the magnitude of this feat! Six-thousand grams is more than 10 times the average weight of a heart and almost 10,000 times the amount of energy that is normally found in the heart at any one time. Ask yourself, Where does this energy come from? and How can the heart produce such an extraordinary volume of energy? In large part, the answers to these questions are found with D-ribose, as you will see. The energy that fuels our bodies is held in a small molecule with a large name. Adenosine triphosphate, or simply ATP, is the compound found in every cell in our bodies that gives us energy. In fact, virtually all the energy used by our bodies comes from ATP. Because of its universal importance in the body, ATP is commonly referred to as the energy currency of the cell. In each cell, ATP is made, consumed, and re-processed in a cycle that keeps a continual supply of energy flowing. And our bodies have developed very elaborate metabolic processes to make sure we dont run out. These processes efficiently recycle energy as it is used, maki Continue reading >>

Metformin Increases Vascular Stem Cells.

Health Rising's Chronic Fatigue Syndrome (ME/CFS) and Fibromyalgia Forums Considering how many of us have weird heart things going on, the ability of a cheap drug like metformin to increase vascular stem cells seems to have a lot of relevance. I still do wonder about the effect of metformin on the mitochondria, but until I understand the mechanism, I'm not going to worry about it too much. Study after study has shown metformin is a useful drug in a variety of ways that promote longevity. Metformin is an inexpensive treatment that is often used for Type 2 diabetes to lower blood sugar levels by reducing glucose production in the liver. The drug is not regularly given to patients with Type 1 diabetes. However, for the first time, a clinical trial has revealed metformin can promote a patient's ability to repair their own damaged blood vessels by increasing vascular stem cells. Heart disease is the leading cause of illness in diabetic patients, accounting for more than half of all fatalities. Metformin may be used to lower Type 1 diabetic patients' risk of developing this complication. Findings of the clinical trial are published today in the journal, Cardiovascular Diabetology. This follows previous laboratory work at Newcastle University which explored the mechanism behind metformin. Dr Jolanta Weaver, Senior Lecturer in Diabetes Medicine at Newcastle University and Honorary Consultant Diabetologist at Queen Elizabeth Hospital, Gateshead, led both studies. She believes this new research is a major development in understanding the best ways to further improve treatment in Type 1 diabetes. Dr Weaver said: "As the outcomes of heart disease is worse in diabetic versus non-diabetic patients, there is a need to identify additional treatment options. "Metformin could routinely Continue reading >>

Gliclazide Does Not Fully Prevent 2-deoxy-d-ribose-induced Oxidative Damage Because It Does Not Restore Glutathione Content In A Pancreatic -cell Line

Gliclazide, NAC, dihydrorhodamine 123 (DHR 123), dimethylsulfoxide (DMSO), 5, 5-dimethyl-1-pyrroline-N -oxide (DMPO), FeSO4, and H2O2 were purchased from Sigma-Aldrich (St. Louis, MO, USA). dRib, trypan blue, and monochlorobimane (mBCl) were obtained from Amresco (Solon, OH, USA). Hydrochloric acid and ethanol were from Merck (Darmstadt, Germany). RPMI-1640, phenol red-free RPMI-1640, Dulbeccos phosphate-buffered saline (DPBS), trypsin, penicillin, and streptomycin were from Gibco Invitrogen (Grand Island, NY, USA). Fetal bovine serum (FBS) was from HyClone (Logan, UT, USA). All culture dishes were from BD Falcon (Franklin Lakes, NJ, USA). Insulin-secreting HIT-T15 cells were provided by the Korean Cell Line Bank (Seoul, Korea). Cells were cultured in RPMI-1640 medium supplemented with 10% FBS, 100 mU/mL penicillin, and 100 mg/mL streptomycin. The cultures were maintained at 37C in a humidified 5% CO2 atmosphere and subcultured by trypsinization with 0.05% trypsin0.02% EDTA in Ca2+- and Mg2+-free DPBS when they reached about 70% confluence. Two days after subculture, the culture medium was replaced with fresh RPMI-1640 containing 10% FBS, and 35 or 50 mM dRib was added to the medium after pretreatment with various concentrations of gliclazide or 1 mM NAC for 30 min. The cultures were then incubated for 6 or 24 h. Cells were cultured in 24-well plates at a density of 1 105 per well. They were incubated with 35 mM dRib for 24 h, with or without gliclazide or NAC. Then, cells were harvested and stained vitally with 0.4% trypan blue for 5 min. In the sample transferred to a hemocytometer, dead cells that did not exclude the dye and viable cells that excluded it were counted. The results were expressed as the percentage of viable cells in the whole population. 2.4. Flow Cyt Continue reading >>

11 Incredible Health Benefits Of D-ribose With Side Effects

D-ribose is a naturally occurring sugar present in all living cells. It is a key component in many biological pathways, but is most active in glycation (bonding between a sugar and a protein or fat molecule) [ R ]. D-ribose, together with adenine, make the adenosine molecule of adenosine triphosphate ( ATP ), the main storage and transportation unit of energy [ R ]. D-ribose is also used to make nicotinamide adenine dinucleotide ( NAD ) and flavin adenine dinucleotide (FAD), two important molecules involved in cellular respiration. D-Ribose is also the key structural basis of RNA and DNA [ R , R , R ]. Health Benefits of D-Ribose Supplementation 1) D-Ribose May Treat Heart Disease and Improve Heart Health D-ribose increases ATP levels in heart cells and improves heart function [ R , R , R ]. Congestive heart failure is a condition in which heart muscles dont pump blood as well as they should. In a study of 15 congestive heart failure patients (DB-RCT), D-ribose improved heart function [ R ]. D-ribose helped patients with stable heart disease to exercise longer without developing chest pains (angina) or ECG changes [ R ]. D-ribose and L- cysteine supplementation also lowered LDL and other oxidized fat and reduced oxidative stress in the aorta, the main artery that carries blood from the heart [ R ]. However, D-ribose showed no benefits in treating chronic heart failure in healthy mice or in mice with elevated myocardial creatine [ R ]. 2) D-Ribose Helps with Fibromyalgia and Chronic Fatigue Syndrome A case study found that 5 grams of D-ribose taken twice daily with other medications reduced fibromyalgia symptoms, which returned after one week of stopping D-ribose supplementation [ R ]. A pilot study of 41 patients with fibromyalgia or chronic fatigue syndrome found that Continue reading >>

D-ribose & Blood Sugar

Angela Ogunjimi has been a prize-winning writer and editor since 1994. She was a general assignment reporter at two newspapers and a business writer at two magazines. She writes on nutrition, obesity, diabetes and weight control for a project of the National Institutes of Health. Ogunjimi holds a master's degree in sociology from George Washington University and a bachelor's in journalism from New York University. Someone is testing their blood sugar.Photo Credit: BernardaSv/iStock/Getty Images D-Ribose is a special sugar made in your body, but it also comes as a supplement. D-ribose's main claim to fame is that it delivers energy rapidly and helps athletes and strenuous exercisers recover from their workouts faster. D-ribose behaves in a similar fashion in diabetics and non-diabetics. However, the sugar also increases insulin releases, and it can dramatically lower blood sugar. Although D-ribose is well tolerated, you should talk to your doctor before taking it. D-ribose, more often referred to as simply ribose, is a simple carbohydrate with five carbon molecules. Athletes take it in supplement form to shorten their recovery time. Ribose sparks the synthesis of a molecule called ATP, or adenosine triphosphate, which is the chemical form of the energy that goes to your cells and powers all the activities of life. Writing on the ShareCare website, Dr. Mehmet Oz states, "Of all the things you can do to combat the effects of knee-dragging fatigue, taking daily a ribose supplement is the one that seems to really turbo-charge some people who have diseases with low energy associated with them." Scientists have studies the effects of ribose since the late 1950s. When injected into diabetics and non-diabetics, ribose causes a swift release of insulin and a dramatic reduction i Continue reading >>

What The Heck Is Wrong With Me?

I've been taking Metformin for over 5 weeks (6 weeks this coming Saturday), building up to 2000mg/day; I've been on 2000mg/day for the past 2 weeks. Early on there was a little drop in my BG, but now everything is right back where it started. Fastings are in the 150-170 range (sometimes in the 180s), and after meal readings go up 20-40 points from there. That's the story with almost everything I've tried; it works (sort of) for a couple of weeks, then my BG drifts right back where it was. That's about the end of my options, treatment-wise. I don't have health insurance, so can't afford Byetta or Victoza. I tried Glipizide (on it for 10 months; didn't do much for my BG), Janumet (didn't do much, but stopped it after 2 weeks), Metformin twice (on it for 4 months the first time caused total exhaustion AND didn't bring BG down, this time isn't doing anything), and insulin twice (first time about a month on Levemir, but I had bad edema and other reactions, this time 3 months on NPH, about 28-32units/day brought my BG down, but caused massive weight gain that hasn't gone away since I stopped). I don't want to take sulfonylureas, and Glipizide didn't do much for me, anyway. I loosely follow Bernstein's 6-12-12 diet (rarely more than 30g of carbs/day, usually less); I've been eating more or less this way (following various low card diets) for 2.5 years. Now, thanks to the slight queasiness from Metformin, I'm eating less than ever. I force myself to have a big breakfast (whey shake with a little heavy cream and 2 eggs), often skip lunch, or have a handful of nuts or some cheese, then a small dinner (usually meat and salad or veg, last night shiritaki noodles with a little tomato sauce and lots of cheese). No grains (except 1-2 slices of sprouted grain Ezekiel bread/week), litt Continue reading >>

Ribose Supplement For Heart Failure, Fibromyalgia And Chronic Fatidue

Ribose supplement for fibromyalgia, heart failure, exercise, and fatigue, how effective is this pill? What is the right dosage? by Ray Sahelian, M.D. Ribose is a carbohydrate, or sugar, used by all living cells and is an essentialcomponent in our bodys energy production.It has many important roles in physiology. Among them, it is anecessary substrate for synthesis of nucleotides, and it is part of the building blocksthat form DNA and RNA molecules. The claim made is that ribose enhances athleticperformance. If you would like to take a pill for more energy, consider MultiVit Rx. As of 2018, I have not come across reliabledata to support the claims that ribose, by itself, is a helpful nutrient in athletes in terms of athletic performance enhancement but it may reduce oxidative stress. It appears that it may be beneficial to individuals with congestive heart failure and perhaps may offer some relief in those with chronic fatigue syndrome or fibromyalgia. J Am Coll Nutr. 2015. (D)-Ribose supplementation in the equine: lack of effect on glycated plasma proteins suggesting safety in humans. d-Ribose is a popular dietary supplement for humans and the equine because of its crucial role in cellular bioenergetics. However, as a reducing sugar, it has been suggested that ingestion of d-ribose might promote the formation of glycated proteins in vivo with potential adverse consequences. Ribose supplementation is safe and does not cause glycation in vivo. This investigation also establishes safety of d-Ribose in thoroughbred racehorses, suggesting similar implications in humans as well. The role of ribose on oxidative stress during hypoxic exercise: a pilot study. J Med Food. 2009. Department of Health and Human Development, Montana State University, Bozeman, USA. We tested the effe Continue reading >>

Instant Energy With D-ribose

Energetics , Fitness , Recent Posts , TianChi When you think of instant energy, youll often just think of coffee or caffeine. That may be one way of getting a boost, but if you rely on that alone you will eventually burn out because it doesnt supply your cells with the material needed to make real energy. Your cells have to be able to make ATP or adenosine triphosphate the source of all cellular energy. Ribose forms the backbone of ATP and without a constant source, your body will fall short. This is especially important for athletes. Energy recovery and tissue repair are much slower in the heart and major muscle groups, the exact places athletes are continuously stressing. Ribose fuels the process that replenishes ATP and other energy essentials in your cells. Now for the average person this might not mean much. As a former triathlete Im always tinkering with my own program and trying to put high quality substances into my own body. I might not be running like a well-kept Mercedes anymore but that doesnt mean I cant treat myself like one. I love ribose and the simplicity of it. Its pretty basic and yet profound. I love it enough that we changed our proprietary formula of TianChi to add a good dose of D-Ribose . Its part of why we say it creates real energy. (Im sure you thought we just made that up.) Its always great to see your theories play out in real life and I just had the opportunity to experience that. We have a lot of athletes on our product from weekend warriors to Olympic hopefuls, and so we get a lot of feedback on the product. One of our runners had hit the wall two weeks before the state finals. I got a frantic call for help and simply adjusted her diet and had her add ten grams of D-Ribose powder to her program. This athlete was already on TianChi , whic Continue reading >>

Metformin And D-ribose Drug Interactions - From Fda Reports - Ehealthme

Metformin and D-ribose drug interactions - from FDA reports Drug interactions are reported only by a few people who take Metformin and D-ribose together. This review analyzes the effectiveness and drug interactions between Metformin and D-ribose. It is created by eHealthMe based on reports of 2 people who take the same drugs from FDA, and is updated regularly. On eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA since 1977. Our original studies have been referenced on 400+ peer-reviewed medical publications, including: The Lancet, and Mayo Clinic Proceedings. 2 people who take Metformin, D-ribose are studied. Most common drug interactions by gender *: Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves) Nausea (feeling of having an urge to vomit) Nausea (feeling of having an urge to vomit) * Approximation only. Some reports may have incomplete information. How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood. Want to find out more about the FDA reports used in the study? You can request them from FDA. Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. ( latest outcomes from Metformin 206,762 users ) D-ribose has active ingredients of ribose. ( latest outcomes from D-ribose 61 users ) Interactions between Metformin and drugs from A to Z a b c d e f g h i j k l m n o p q r s t u v w x y z Interactions between D-ribose and drugs from A to Z a b c d e f g h i j k l m n o p q r s t u v w x y z Browse all drug interactions of Metformin and D-ribose Related publications that referenced our studies Wiwanitkit S, Wiwanitkit V, "Metformin Continue reading >>