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Cla And Metformin

Effects Of Conjugated Linoleic Acid And Metformin On Insulin Sensitivity In Obese Children: Randomized Clinical Trial

Effects Of Conjugated Linoleic Acid And Metformin On Insulin Sensitivity In Obese Children: Randomized Clinical Trial

Effects of Conjugated Linoleic Acid and Metformin on Insulin Sensitivity in Obese Children: Randomized Clinical Trial Department of Human Genetics, Hospital General de Mxico Eduardo LiceagaFacultad de Medicina, Universidad Nacional Autnoma de Mxico, 04510 Mexico City, Mexico; Search for other works by this author on: Department of Human Genetics, Hospital General de Mxico Eduardo LiceagaFacultad de Medicina, Universidad Nacional Autnoma de Mxico, 04510 Mexico City, Mexico; Search for other works by this author on: Search for other works by this author on: Search for other works by this author on: Specialized Center for Diabetes Control, Public Health Services, Mexico City, Mexico 11340; Search for other works by this author on: Basic Medical Sciences Department, TEC-ABC School of Medicine, Tecnolgico de Monterrey, Mexico 05300; and Search for other works by this author on: School of Medicine, South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Edinburg, Texas 78539 Search for other works by this author on: Department of Human Genetics, Hospital General de Mxico Eduardo LiceagaFacultad de Medicina, Universidad Nacional Autnoma de Mxico, 04510 Mexico City, Mexico; Search for other works by this author on: Department of Human Genetics, Hospital General de Mxico Eduardo LiceagaFacultad de Medicina, Universidad Nacional Autnoma de Mxico, 04510 Mexico City, Mexico; Search for other works by this author on: Department of Surgery, Hospital General de Mxico Eduardo Liceaga, 06726 Mexico City, Mexico; Search for other works by this author on: Department of Human Genetics, Hospital General de Mxico Eduardo LiceagaFacultad de Medicina, Universidad Nacional Autnoma de Mxico, 04510 Mexico City, Mexico; Search for other works by this author on: School o Continue reading >>

Metformin And Pcos Treatment - 3 Fat Chicks On A Diet Weight Loss Community

Metformin And Pcos Treatment - 3 Fat Chicks On A Diet Weight Loss Community

If you have polycystic ovary syndrome (PCOS), there's a good chance your doctor has prescribed a drug called metformin (brand name "Glucophage" or "Glucophage XR"). Metformin offers both benefits and risks. They are summarized below. We also offer some suggestions if you are now taking metformin. A small number of medical studies are mentioned in this article in order to give you some context for understanding the benefits and risks of metformin. Some of the purported benefits of metformin are controversial or unproven, and the studies cited below are not conclusive proof of benefits. Other relevant studies have not been included because of lack of space. Metformin is a drug that has been used to help control blood glucose levels in people with Type 2 Diabetes. Although metformin has been used in Europe for over 25 years, it was not available in the US until 1995. The FDA has approved metformin only for the treatment of Type 2 Diabetes. Consequently, some physicians don't have much clinical experience with metformin, or are reluctant to use it unless the patient has diabetes.(1) Metformin appears to work in three ways. First, it decreases the absorption of dietary carbohydrates through the intestines. Second, it reduces the production of glucose by the liver.(2) The liver uses the raw material in your food to create a reserve supply of blood sugar. When your body experiences stress, the liver releases the reserve glucose to supply your brain and muscles with an immediate source of energy to cope with the stress. Metformin suppresses the production of this reserve fuel. Third, and perhaps most importantly, metformin increases the sensitivity of muscle cells to insulin.(2) Insulin is the hormone that delivers glucose into your cells to be burned as fuel, or stored. Women Continue reading >>

Conjugated Linoleic Acid

Conjugated Linoleic Acid

Washington State, Pacific Northwest of United States Does anyone know about the fat burning benefits of supplementing with Conjugated Linoleic Acid (CLA)? When we went to the drug store to refill my metformin prescription, my wife saw a bottle of CLA pills. The blurb on the packet says it is fat burning supplement. My wife thinks she has fat to lose (which is strictly not true) and wants desperately to have a slim and trim appearance by the time we go to India on a brief vacation in the middle of next month. Of course she exercises regularly but wants something to 'accelerate' the process of fat burning. She wanted me to buy it but I said let us collect more information on CLA and then consider buying it. The pill has 800 mg of CLA extracted from safflower oil. The warning on the packet says "do not use if you are pregnant or breast-feeding." Does this drug have any adverse side effects? I googled the drug and read it up on Wikipedia but would appreciate feedback from DD members. D.D. Family T2 since 1996 and struggling to be healthy. Does anyone know about the fat burning benefits of supplementing with Conjugated Linoleic Acid (CLA)? When we went to the drug store to refill my metformin prescription, my wife saw a bottle of CLA pills. The blurb on the packet says it is fat burning supplement. My wife thinks she has fat to lose (which is strictly not true) and wants desperately to have a slim and trim appearance by the time we go to India on a brief vacation in the middle of next month. Of course she exercises regularly but wants something to 'accelerate' the process of fat burning. She wanted me to buy it but I said let us collect more information on CLA and then consider buying it. The pill has 800 mg of CLA extracted from safflower oil. The warning on the packet say Continue reading >>

Safflower Oil Each Day May Keep The Doctor Away

Safflower Oil Each Day May Keep The Doctor Away

Safflower Oil Each Day May Keep the Doctor Away According to a recent study from Ohio State University, daily consumption of safflower oil over the course of 16 weeks can improve health markers such as blood glucose level, insulin sensitivity, cholesterol level, and inflammation in certain people with Type 2 diabetes. As reported by DiabetesSelfManagement.com in 2009 , previous research by the same team showed that daily supplementation with safflower oil reduced abdominal fat, increased muscle tissue, and lowered fasting blood glucose levels. Safflower oil, commonly used in cooking, contains linoleic acid, a polyunsaturated fatty acid (PUFA). Decades of research suggest that PUFAs from plant sources can help protect against heart disease. In their previous study with this oil, the researchers had 35 obese, postmenopausal women with Type 2 diabetes take 8 grams per day (slightly less than 2 teaspoons) of either safflower oil or conjugated linoleic acid (CLA, naturally found in some meats and dairy products), then the same amount of the other type of oil, for 16 weeks each. The subjects were instructed not to change their diet or exercise regimens so that the effects of only the supplements could be measured. At the end of the study period, the researchers were surprised to find that daily consumption of safflower oil had reduced abdominal obesity in the participants. Performing further research on the data from this original trial, the researchers discovered that CLA reduced total body fat, but did not affect blood glucose or cholesterol control in the women. Safflower oil, on the other hand, increased insulin sensitivity by about 2.7% ( insulin resistance is a hallmark of Type 2 diabetes) and decreased A1C by 0.64%. Levels of C-reactive protein, a marker of inflammati Continue reading >>

What Are The Dangers Of Tonalin Cla?

What Are The Dangers Of Tonalin Cla?

Kelli Cooper has been a writer since 2009, specializing in health and fitness. She holds a Bachelor of Arts in political science from Rutgers University and is a certified personal trainer with the American Council on Exercise. CLA supplements might impair blood sugar control. Conjugated linolenic acid, or CLA, is a type of fatty acid naturally found in certain foods. In supplement form, it is mainly touted as a weight loss aid, but a meta-analysis of numerous studies, published in a 2005 issue of the Asia Pacific Journal of Clinical Nutrition, found it provided minimal benefit at best. While considered generally safe, some safety concerns exist. Before using Tonalin CLA or any other brand, talk to your doctor first. Studies have produced mixed evidence on whether CLA raises blood sugar levels and decreases insulin sensitivity, or how well your bodys tissues respond to this hormone trying to move sugar into them and out of the bloodstream. Given these mixed findings, it is probably a good idea to talk to your doctor before using Tonalin CLA if you have diabetes or prediabetes. A study by Irish researchers published in the October 2004 issue of The American Journal of Clinical Nutrition compared the effects of taking 3 grams of CLA daily for eight weeks to a placebo on the blood sugar in individuals with type 2 diabetes. They found that CLA supplementation appeared to significantly increase fasting glucose levels and decrease insulin sensitivity. A more recent study, published in the July 2007 issue of The International Journal of Obesity, found no significant differences in fasting glucose or insulin sensitivity in the treatment group compared to the placebo group. This study used a more accepted method of measuring insulin resistance than other studies. Laboratory tes Continue reading >>

Effects Of Conjugated Linoleic Acid And Metformin On Insulin Sensitivity In Obese Children: Randomized Clinical Trial.

Effects Of Conjugated Linoleic Acid And Metformin On Insulin Sensitivity In Obese Children: Randomized Clinical Trial.

Effects of Conjugated Linoleic Acid and Metformin on Insulin Sensitivity in Obese Children: Randomized Clinical Trial. Department of Human Genetics, Hospital General de Mxico Eduardo Liceaga-Facultad de Medicina, Universidad Nacional Autnoma de Mxico, 04510 Mexico City, Mexico. Specialized Center for Diabetes Control, Public Health Services, Mexico City, Mexico 11340. Basic Medical Sciences Department, TEC-ABC School of Medicine, Tecnolgico de Monterrey, Mexico 05300; and. School of Medicine, South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Edinburg, Texas 78539. Department of Surgery, Hospital General de Mxico Eduardo Liceaga, 06726 Mexico City, Mexico. J Clin Endocrinol Metab. 2017 Jan 1;102(1):132-140. doi: 10.1210/jc.2016-2701. Context: Insulin resistance precedes metabolic syndrome abnormalities and may promote cardiovascular disease and type 2 diabetes in children with obesity. Results of lifestyle modification programs have been discouraging, and the use of adjuvant strategies has been necessary. Objective: This study aimed to evaluate the effects of metformin and conjugated linoleic acid (CLA) on insulin sensitivity, measured via euglycemic-hyperinsulinemic clamp technique and insulin pathway expression molecules in muscle biopsies of children with obesity. Design: A randomized, double-blinded, placebo-controlled clinical trial was conducted. Setting: Children with obesity were randomly assigned to receive metformin, CLA, or placebo. Results: Intervention had a positive effect in all groups. For insulin sensitivity Rd value (mg/kg/min), there was a statistically significant difference between the CLA vs placebo (6.53 2.54 vs 5.05 1.46, P = 0.035). Insulinemia and homeostatic model assessment of insulin resistance significantly Continue reading >>

Effect Of Conjugated Linoleic Acid And Metformin On Insulin Sensitivity, Measured By Euglycemic-hyperinsulinemic Clamp Technique, In Children With Obesity: A Randomized, Double-blinded, Placebo-controlled Trial

Effect Of Conjugated Linoleic Acid And Metformin On Insulin Sensitivity, Measured By Euglycemic-hyperinsulinemic Clamp Technique, In Children With Obesity: A Randomized, Double-blinded, Placebo-controlled Trial

Effect of Conjugated Linoleic Acid and Metformin on Insulin Sensitivity, Measured by Euglycemic-Hyperinsulinemic Clamp Technique, in Children with obesity: A Randomized, Double-Blinded, Placebo-Controlled Trial Nayely Garibaya,b, Juan Carlos Lopez Alvarengae, Flor Alvareza, Mayra Bustosc, Erendira Villanuevaa, Mireya Leonc, Fabiola Serratosc, Estibalitz Laresgoitid, Teresa Maciasa, Fernando Ramireza,b & Gloria Queipoa,b aGenetic Department Hospital General De Mexico, Mexico City, Mexico; bUniversidad Nacional Autonoma De Mexico, Mexico City, Mexico; cResearch Unit. Hospital General De Mexico, Mexico City, Mexico; dBasic Medical Sciences Department, TEC-ABC School of Medicine, Tecnolgico de Monterrey., Mexico City, Mexico; eSouth Texas Diabetes and Obesity Institute University of Texas Rio Grande Valley, South Texas, Mexico Background: Insulin resistance precedes metabolic syndrome abnormalities, and may promote cardiovascular disease and type 2 diabetes in obese children. Lifestyle modification programs have been proposed as the gold standard of care in these individuals. However, results have been discouraging and the use of adjuvant strategies has been necessary. Metformin has beneficial effects on weight reduction, favoring a decrease in body mass index (BMI) and insulin resistance in obese non-diabetic individuals. Furthermore, several studies have acknowledged the beneficial effects of CLA isomers on body composition, insulin sensitivity and lipid metabolism in experimental animals and humans. Objective and hypotheses: Evaluate metformin and Conjugated Linoleic Acid (CLA) effects on insulin sensitivity, measured by the gold standard Euglycemic-Hyperinsulinemic Clamp Technique, in obese Mexican children. We hypothesized that Metformin and CLA would exceed lifestyle Continue reading >>

Cla And Diabetes | Livestrong.com

Cla And Diabetes | Livestrong.com

Milk, cheese and other diary items.Photo Credit: olegkalina/iStock/Getty Images William Gamonski is a graduate of St. Francis College, where he earned a Bachelor of Science degree in health promotion and sciences. He was a dietetic intern at Rivington House and has been a personal trainer for the past two years. He is currently pursuing a Master of Science degree in nutrition. Dairy foods and meat contain conjugated linoleic acid (CLA). It is also available as a dietary supplement. CLA contains a mixture of different chemical forms -- or isomers -- of linoleic acid, a type of fat your body needs to function properly. Preliminary findings, based largely on animal studies, suggest that CLA may have both beneficial and harmful effects with respect to diabetes, as well as other diseases. Because of the inconsistent data, anyone with diabetes should consult their doctor before using this supplement. CLA is found naturally in milk fat and the meat of ruminants -- animals that chew their cud, like cows and sheep. The amount of CLA in these foods depends on what the animal has eaten. For example, according to an October 1999 article in the "Journal of Dairy Science," the CLA content of milk from grass-fed cows is five times higher than that from grain-fed cows. CLA is also sold as a dietary supplement. The supplements are not derived from ruminants, but are instead made by chemically altering vegetable oils. Because of this, the two sources have slightly different chemical structures. The effect of CLA on diabetes is mixed. For example, studies of rats with diabetes published in the July 2003 issue of the "American Journal of Physiology -- Endocrinology and Metabolism" and the May 2001 issue of "Diabetes" have demonstrated that CLA makes cells more responsive to insulin -- the Continue reading >>

The Cla: Metformin May Help Obese Teen Girls Lose Weight (reuters)

The Cla: Metformin May Help Obese Teen Girls Lose Weight (reuters)

Metformin may help obese teen girls lose weight (Reuters) Reuters - The addition of the type 2 diabetes drug metformin to a lifestyle modification program may help female adolescents lose weight loss if they also make dietary changes, according to a new study. As the US population grows, the quest for weight loss supplements expands in concert. Supplement-seekers desire compounds that are effective, affordable, and devoid of the characteristic "jittery" side effects of many weight loss supplements. "CLA" is a group of dietary fats that many impact the body in a counter-intuitive way--eat fat to lose fat? CLA has many different chemical forms; they are called "isomers" of CLA. There are two different isomers that are commonly found in supplements on the market, cis-9,trans-11 CT) and trans-10,cis-12 (TC). Furthermore, misleading marketing and labeling of CLA refers to it as a "natural" product of Safflower oil; however, the CLA supplements in stores a chemically manipulated product of safflower oil. The major known truly natural source of CLA comes from the body fat or milk-fat of ruminant animals. For most people, cow milk or beef fat is the primary source; however, goats, sheep and deer are also ruminants and their products contain CLA. The CLA is actually buy bulk cinnamon powder extract in these animals by the bacteria in their stomachs and then it is absorbed and added to their own body fat. The natural form of CLA is mostly the CT form; the lab created form can be either CT or TC, but is usually roughly a 1:1 ratio of each. Without a doubt, the stuff works in animals-rodents and beef have been studied extensively. With supplementation of CLA, these animals typically may show 1) More lean body mass; 2) Less body fat; and 3) Less fat production in milk; or 4) lower Continue reading >>

How To Fix Pcos Using Supplements & Progesterone Cream

How To Fix Pcos Using Supplements & Progesterone Cream

Im a 23-year-old girl with PCOS and I am on 50ug Levothyroxine, and am also taking Metformin, but have not found it very effective. I was 128 lbs in October 2012 though I still had a large amount of belly fat. However, I rapidly gained weight despite a strict exercise and diet regime, and ballooned to 155 lbs in a few months (even after having worked down from 198 lbs in June 2011, when I rapidly put on weight in college). I want to try to fix my PCOS through the use of supplements and progesterone cream. I have ordered Vitex (400 mg tablets), Maca Root (500 mg tablets), DIM-Plus (100 mg), MSM (1500 mg tablets). How much of each supplement should I take daily? And is it safe to take CLA and Raspberry Ketones to help weight loss? And in terms of progesterone cream, when do you recommend I use it? I have heard during two weeks of the luteal period, counting backwards from expected next period date (since my periods are not necessarily 28 days). I love that you are taking YOUR health into your own hands, and I suspect youre feel intuitively guided to do so. I get that youre not happy with where youve ended up. Your search to draw quality information to you has brought you to this website, and Im confident youll get the answers youre looking for. You see, Katie, I have two daughters who, in their 20s, were faced with PCOS health challenges not dissimilar to yours. You might find their story and my guided comments of interest to you and take appropriate steps to get reclaim your health. Certainly the bulk of knowledge Id wish to impart today can be found in the link above, and stepped out in my self-help ebook Progesterone & PCOS: A 60 Day Guide to Using Natural Progesterone . You share that you are taking Metformin, an oral diabetes medicine that helps control blood sugar Continue reading >>

Metformin Vs Conjugated Linoleic Acid And An Intervention Program With Healthy Habits In Obese Children

Metformin Vs Conjugated Linoleic Acid And An Intervention Program With Healthy Habits In Obese Children

You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Metformin vs Conjugated Linoleic Acid and an Intervention Program With Healthy Habits in Obese Children The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. ClinicalTrials.gov Identifier: NCT02063802 Verified February 2014 by Laboratorios Silanes S.A. de C.V.. Information provided by (Responsible Party): Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information The purpose of this clinical trial is to examine the effects of conjugated linoleic acid (CLA) vs metformin along with an intervention program with healthy habits on body composition, weight, M value in CLAMP and clinical laboratory values, as well as molecular and genetic changes in obese children. Patients from the pediatric service of the Hospital from 8 to 18 years old with a body mass index Pc 95 and 35kg/m2 are randomized to either interventional group for 4 months. Drug: metformin Dietary Supplement: Conjugated Linoleic Acid Drug: Placebo Behavioral: Healthy habits program Effect of an Intervention Program With Healthy Habits Plus Metformin or Conjugated Linoleic Acid Over Clinical Parameters and Molecular Pathways of Insulin Resistance in Obese Pediatric Patients Active Comparator: metformin and healthy habits program 1 gr per day. (250mg tablets). The patient takes 2 tablets with breakfast and 2 tablets with dinner and 2 placebo tablets with food by mouth for four months. total dose: 1 gr per day (250mg tablets). The patient takes 2 tablets with b Continue reading >>

Conjugated Linoleic Acid

Conjugated Linoleic Acid

View clinical references for this vitamin or supplement Sakono, M., Miyanaga, F., Kawahara, S., Yamauchi, K., Fukuda, N., Watanabe, K., Iwata, T., and Sugano, M. Dietary conjugated linoleic acid reciprocally modifies ketogenesis and lipid secretion by the rat liver. Lipids 1999;34(9):997-1000. View abstract. Sakuma, S., Nishioka, Y., Imanishi, R., Nishikawa, K., Sakamoto, H., Fujisawa, J., Wada, K., Kamisaki, Y., and Fujimoto, Y. cis9, trans11-Conjugated Linoleic Acid Differentiates Mouse 3T3-L1 Preadipocytes into Mature Small Adipocytes through Induction of Peroxisome Proliferator-activated Receptor gamma. J Clin.Biochem.Nutr 2010;47(2):167-173. View abstract. Salas-Salvado, J., Marquez-Sandoval, F., and Bullo, M. Conjugated linoleic acid intake in humans: a systematic review focusing on its effect on body composition, glucose, and lipid metabolism. Crit Rev.Food Sci.Nutr. 2006;46(6):479-488. View abstract. Salva, B. K., Zumalacarregui, J. M., Figueira, A. C., Osorio, M. T., and Mateo, J. Nutrient composition and technological quality of meat from alpacas reared in Peru. Meat.Sci 2-28-2009; View abstract. Santercole, V., Mazzette, R., De Santis, E. P., Banni, S., Goonewardene, L., and Kramer, J. K. Total lipids of Sarda sheep meat that include the fatty acid and alkenyl composition and the CLA and trans-18:1 isomers. Lipids 2007;42(4):361-382. View abstract. Santillo, A., Albenzio, M., Quinto, M., Caroprese, M., Marino, R., and Sevi, A. Probiotic in lamb rennet paste enhances rennet lipolytic activity, and conjugated linoleic acid and linoleic acid content in Pecorino cheese. J Dairy Sci 2009;92(4):1330-1337. View abstract. Santillo, A., Quinto, M., Dentico, M., Muscio, A., Sevi, A., and Albenzio, M. Rennet paste from lambs fed a milk substitute supplemented with Lact Continue reading >>

Linoleic Acid And Metformin Interaction | Treato

Linoleic Acid And Metformin Interaction | Treato

fatty acids an increased inflammatory activity deriving ... "On Thu, 08 Nov 2007 17:08:55 -0500, Jackie Patti Had anyone more luck in locating the original paper and maybe found a description of the diets' fatty compositions? With a deficit in n-3 fatty acids an increased inflammatory activity deriving from a relative surplus of linoleic acid (building arachidonic acid supporting COX-2 activity) wouldn't surprise. We mustn't forget, that this simplified macronutrient back and forth is only one aspect of the read more... /> There isn't a full paper, just an abstract. It was a poster I hadn't read Eades blog for a while. He certainly tears that paper (should I say poster?) to shreds with logic and It wasn't a peer-reviewed research paper and it wasn't the Randy, I would suggest you take the time to read Eades As far as the original version goes, this is an extract from I emailed the publicist for the University of Maryland Medical Center for an abstract of this talk, and he kindly sent it to me within minutes. (I've converted it to PDF for you: miller-2007-aha-abstract-diet.pdf.) Remember, this is all there is. Just an abstract, not a real paper. We can tell only a little about what really went on in this study. now I am continuing my Metformin, doing a low carb diet, I have secondary infertility from PCOS and have done 3 cycles, an IUI on Clomid, an IVF, and an IUI on injectables, with no successful pregnancy. Before trying ovarian drilling I am taking a few months off to lose weight and lower my BMI which is at 29.5 right now. Right now I am continuing my Metformin, doing a low carb diet, cutting out processed foods, doing cardio 4 days a week and strength training 3 times a week. So far it's been working well, I have lost 12 pounds in 3 weeks! I was read more... wonde Continue reading >>

Is It Safe To Take Supplements If You Have Diabetes?

Is It Safe To Take Supplements If You Have Diabetes?

You will find supplements for anything and everything these days. Even when you do not suffer from an ailment, supplements are suggested to keep you healthy and ailment-free. According to CDC, use of supplements is common among US adult population – over 50% adults used supplements during 2003-2006, with multivitamins/multiminerals being the most commonly used. So when you are a diabetic, especially if you have prediabetes and type-2 diabetes, you may find yourself confronting a large number of options for supplements that claim to support, reduce and even cure your diabetes. Diabetes is quite a frustrating disorder and you may find yourself tempted to try out these supplements one after another. But is it really safe to take supplements when you are a diabetic? Let us find out. But before that you need to understand what exactly supplements are. Defining Supplements As the name suggests, a supplement is anything that adds on to something. A dietary supplement is therefore something that one takes in addition to one’s diet to get proper nutrition. US Congress in the Dietary Supplement Health and Education Act defines dietary supplements as having the following characteristics: It is a product that is intended to supplement the diet; It contains one or more dietary ingredients (including vitamins, minerals, herbs and other botanicals, amino acids, and other substances) or their constituents; It is intended to be taken by mouth as a pill, capsule, tablet, or liquid; It is not represented for use as a conventional food or as sole item of a mean or a diet; and, It is labeled on the front panel as being a dietary supplement. Now let us look at some general benefits and risks of taking supplements. We will discuss these in context of diabetes later in the article. Benefit Continue reading >>

Effects Of Conjugated Linoleic Acid And Metformin On Insulin Sensitivity In Obese Children: Randomized Clinical Trial

Effects Of Conjugated Linoleic Acid And Metformin On Insulin Sensitivity In Obese Children: Randomized Clinical Trial

Insulin resistance precedes metabolic syndrome abnormalities and may promote cardiovascular disease and type 2 diabetes in children with obesity. Results of lifestyle modification programs have been discouraging, and the use of adjuvant strategies has been necessary. This study aimed to evaluate the effects of metformin and conjugated linoleic acid (CLA) on insulin sensitivity, measured via euglycemic-hyperinsulinemic clamp technique and insulin pathway expression molecules in muscle biopsies of children with obesity. Intervention had a positive effect in all groups. For insulin sensitivity Rd value (mg/kg/min), there was a statistically significant difference between the CLA vs placebo (6.53 ± 2.54 vs 5.05 ± 1.46, P = 0.035). Insulinemia and homeostatic model assessment of insulin resistance significantly improved in the CLA group (P = 0.045). After analysis of covariance was performed and the influence of body mass index, age, Tanner stage, prescribed diet, and fitness achievement was controlled, a clinically relevant effect size on insulin sensitivity remained evident in the CLA group (37%) and exceeded lifestyle program benefits. Moreover, upregulated expression of the insulin receptor substrate 2 was evident in muscle biopsies of the CLA group. Continue reading >>

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