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City Of Hope Diabetes

City Of Hope National Medical Center

City Of Hope National Medical Center

City of Hope is a private, not-for-profit clinical research center, hospital and graduate medical school located in Duarte, California, United States. The center's main campus resides on 110 acre of land adjacent to the boundaries of Duarte and Irwindale, with a network of clinical practice locations throughout Southern California, satellite offices in Monrovia and Irwindale, and regional fundraising offices throughout the United States. City of Hope is best known as a cancer treatment center. It has been designated a Comprehensive Cancer Center by the National Cancer Institute. City of Hope has also been ranked one of the nation's Best Cancer Hospitals by U.S. News & World Report for over ten years and is a founding member of the National Comprehensive Cancer Network. City of Hope played a role in the development of synthetic human insulin in 1978. The center has performed 13,000 hematopoietic stem cell transplants as of 2016 with patient outcomes that consistently exceed national averages.[citation needed] History[edit] City of Hope Los Angeles City of Hope - Duarte (Los Angeles County, California) In the late 19th and early 20th centuries, the spread of tuberculosis, also known as "consumption," was a growing concern in the United States and Europe. Owing to advancements in the scientific understanding of its contagious nature, a movement to house and quarantine sufferers became prevalent. Construction of tuberculosis sanatoria, including tent cities, became common in the United States, with many sanatoriums located in the Southwestern United States, where it was believed that the more arid climate would aid sufferers. In 1913, the Jewish Consumptive Relief Association was chartered in Los Angeles, California, with the intent of raising money to establish a free, non Continue reading >>

Researchers Study Cure For Type 1 Diabetes In Stem Cell Transplantations

Researchers Study Cure For Type 1 Diabetes In Stem Cell Transplantations

Bart Roep, Ph.D., the Chan Soon-Shiong Shapiro Distinguished Chair in Diabetes and professor/founding chair of the Department of Diabetes Immunology (Photo: Business Wire) DUARTE, Calif.--(BUSINESS WIRE)--Some type 1 diabetes (T1D) patients can be cured from the disease, at least for a number of years, with a stem cell transplant — those were the results of a clinical trial monitored by City of Hope’s Bart Roep, Ph.D., the Chan Soon-Shiong Shapiro Distinguished Chair in Diabetes and professor/founding chair, Department of Diabetes Immunology. The results were published recently in the journal, Frontiers in Immunology. Trial by @cityofhope researchers shows T1D patients cured, at least for few years, with stem cell transplant Tweet this “This means we can cure type 1 diabetes, be it with a risky therapy — although one that is also very successful in cancer, and one for which City of Hope is a world-renowned expert, with more than 13,000 patients having received similar treatment for blood cancers,” said Roep, director of The Wanek Family Project for Type 1 Diabetes, which aims to find a cure for T1D in six years. “We now understand stem cell transplants can succeed in treating diabetes for some, but not in others, and we can predict either outcome before the therapy is administered by ‘reading’ the immune signature of the patient with a novel nanotechnology that I developed.” An international team of researchers, including Roep, conducted the trial in Brazil. It showed that autologous hematopoietic stem cell transplantation (AHSCT), which uses a person’s own stem cells, increases C-peptide levels — that show how much insulin is being made by the pancreas — and induces insulin independence in patients with T1D. This is possible because the transpla Continue reading >>

City Of Hope Offers Islet Cell Transplant Program To Cure Type 1 Diabetes

City Of Hope Offers Islet Cell Transplant Program To Cure Type 1 Diabetes

For patients with severe type 1 diabetes, a strict diet and insulin shots are sometimes not enough to sufficiently control their disease. What they need are insulin-producing cells of their own - currently only available through a still-experimental procedure known as islet cell transplantation. Physicians in the newly launched Diabetes & Metabolism Research Institute at City of Hope are now providing this transplantation to suitable candidates through a clinical trial that they believe will be the first step in a multipronged effort to permanently cure type 1 diabetes. "We are one of only a few islet cell transplant programs in the country," said Fouad Kandeel, M.D., Ph.D., chair of the Department of Clinical Diabetes, Endocrinology & Metabolism at City of Hope, who is leading the islet cell transplantation trial. "This trial, in addition to providing a much needed potential cure for patients with severe type 1 diabetes, will also be vital in opening the door to other major studies to address the medical needs of these patients." The new phase I/II trial is open to adults with type 1 diabetes who have had the disease for more than five years and who experience frequent episodes of hypoglycemia or hypoglycemia unawareness, in which blood sugar drops precipitously without corresponding symptoms. Diabetic patients who have hypoglycemic unawareness are at risk of injuries and accidents, because the drop in their blood sugar can go undetected until they suddenly lose consciousness. The goal of the trial is to further evaluate the effectiveness of transplantation as a treatment and possible cure for type 1 diabetes. Researchers also hope to gain a better understanding of the mechanisms of islet cell rejection if it occurs. "The immune-suppression strategy that is being used Continue reading >>

City Of Hope- Hoping To Cure Diabetes In 6 Years

City Of Hope- Hoping To Cure Diabetes In 6 Years

City of Hope is known for their stride in Cancer research but has also put a lot of work towards helping people with diabetes. In fact, the synthetic insulin used today by millions of people living with diabetes was developed by one of the researchers at City of Hope in 1978, Arthur D. Riggs. Now, they are taking on an ambitious goal to find a cure for people with Type I Diabetes through immunotherapy and beta cell transplantation. They took this idea and ran with it after a generous donation of 50 million dollars from the Wanek family of Ashley Furniture along with anonymous donors. City of Hope has done extensive research to get an understanding of how complex diabetes truly is and what causes it to occur. With this donation, along with others, City of Hope will be able to continue their research and hopefully reach the goal of having a cure within six years. The goal of six years may seem out of reach since it is extremely ambitious, however, City of Hope already has 40 years of diabetes research under its belt. So, if someone is going to take on the challenge that brings a cure to millions worldwide, they are one of the best equip and ready to do so. Type I Diabetes is when the immune system has attacked the insulin producing cells (beta cells) instead of fighting off infections. It is unknown why the system in people with diabetes has gone off course. When that is discovered, it could lead to a plan of action against diabetes and a plan to cure it. Immunotherapy Immunotherapy and Beta Cell Transplants are some options that will be tested. Immunotherapy is a process that takes substances and cells made by the body or in a laboratory to help the immune system function in the way that it should. The immune system needs to be in full force to help fight infections and Continue reading >>

City Of Hope On Cutting Edge Of Diabetes Research

City Of Hope On Cutting Edge Of Diabetes Research

Type 2 diabetes is by far the most common form of diabetes, accounting for 90 to 95 percent of the 21 million diagnosed diabetes cases in the U.S. (Another 8.1 million are undiagnosed.) But preventive action can be powerful. Diabetes not only increases the risk of death, it can lead to a host of complications such as blindness, heart disease and stroke. Even modest lifestyle changes can greatly decrease the risk of type 2 diabetes. Making one or two small changes per week will, over time, add up to a considerably healthier lifestyle. Doing so may also prevent type 2 diabetes. Listen in as Dr. Fouad Kandeel discusses diabetes, it's treatments and what you can do to keep it in check. Transcription: Melanie Cole (Host): City of Hope’s Diabetes and Metabolism Research Institute offers a comprehensive diabetes and endocrinology program combining groundbreaking research and unique treatments with patient education to help people living with diabetes and other endocrine diseases get the medical care and information they need to achieve an optimal quality of life. My guest today is Dr. Fouad Kandeel. He is the chairman of the Department of Clinical Diabetes, Endocrinology, and Metabolism at City of Hope. Welcome to the show, Dr. Kandeel. Tell us a little bit what’s going on in diabetes, exciting research and treatment today. Dr. Fouad Kandeel (Guest): Diabetes is a major disease, threatening world-wide in the 21st century with incidents that is rising very significantly, and unless actually medical institutes and research centers are able to bring about new strategies for diagnosing and treating those Type 1 and Type 2 diabetes, nobody is going to afford the cost of the disease. City of Hope has done a significant contribution to the care of diabetics over the years, starti Continue reading >>

Top 5 T1d Research Center Profile: City Of Hope

Top 5 T1d Research Center Profile: City Of Hope

This is the first in a series of reports on the top five largest T1D research centers in the U.S. It will feature a profile of the City of Hope (COH) Diabetes & Metabolism Research Institute, located in California. In addition to our initial profile, last week the JDCA attended a COH sponsored research symposium and met with Dr. Bart Roep, the Founding Chair of the Department of Diabetes Immunology and Dr. Debbie Thurmond, Chair of the Department of Molecular & Cellular Endocrinology at COH to discuss institution goals and research. Several other notable researchers were in attendance, including but not limited to, Doug Melton, Ed Damiano, Jane Reusch (the ADA president-elect), and Mark Atkinson (Head of the JDRF Research Advisory Committee and Professor at the University of Florida). Earlier this year, the JDCA published a report on a significant $50m donation to COH, which catapulted COH into a position of being one of the most well-funded institutions working on T1D in the country (click here to view). As part of the gift, COH established the Wanek Family Project to Cure Type 1 Diabetes and set a bold goal of curing type 1 diabetes within six years. COH Structure and T1D Research Pathways City of Hope first established a Division of Diabetes in 1971. It has continued to explore diabetes-related research topics for the past five decades with the goal of understanding the disease, advancing islet cell transplantation, developing drugs, and studying the relationship between diabetes and cancer. It is comprised of six major departments (T1 and T2 focused), including most recently The Wanek Family Project for Type 1 Diabetes, led by Roep. The Wanek Project pursues four main research pathways and the division of the $50m gift across the core focus areas is dependent upon p Continue reading >>

City Of Hope Gets $50 Million Gift And Goal To Cure Type 1 Diabetes In 6 Years

City Of Hope Gets $50 Million Gift And Goal To Cure Type 1 Diabetes In 6 Years

City of Hope, an independent research and treatment center for life-threatening diseases including diabetes, has been given a $50 million dollar gift for the goal of curing type 1 diabetes in 6 years. City of Hope is located in Duarte, California and is nationally renown for their work treating cancer as well as the site of developments in the areas of bone marrow transplants, diabetes, and cancer drugs. City of Hope carried out research that led to the development of synthetic human insulin by Arthur D. Riggs, Ph.D., in 1978. The monumental donation from the Wanek family and gifts from anonymous donors for the City of Hope’s Diabetes and Metabolism Research Institute will provide $50 million to focus on a cure over the next six years. Todd Wanek, the CEO of Ashley Furniture Industries spoke on behalf of his family saying, “Our family is extremely confident that City of Hope is the institution that will find a cure for the more than 1 million Americans who battle type 1 diabetes disease every day,” The President and chief executive officer of City of Hope said in a statement, “City of Hope is best positioned to take on this challenge,” and that “This is thanks to our 40-year institutional legacy of pioneering treatment and research advances in diabetes.” How Will They Try to Cure Type 1? The press release from City of Hope states that they plan on creating a series of “highly-focused” programs that will use an integrated approach to finding the cure since type 1 diabetes is a complex problem to solve as well as hiring world-renowned leaders and top talent to take on the challenge. The three core areas they will focus on include: Immune modulation- Bart Roep, Ph.D., who worked in the Netherlands launching a phase 1 clinical trial for a vaccine cure for Continue reading >>

City Of Hope Marshals $50 Million Toward Type 1 Diabetes Cure

City Of Hope Marshals $50 Million Toward Type 1 Diabetes Cure

City of Hope has an ambitious new goal: Find a cure for Type 1 diabetes in the next six years. The independent research center, which also studies and treats cancer, announced its plan Monday. They've got a good start, too, thanks to more than $50 million they've received in private funding. Type 1 diabetes causes the immune system to attack cells that make insulin. It affects 1 in 200 people in the United States. The key to a cure will lie in understanding what causes the disease, according to Dr. Bart Roep, director of City of Hope's research team. From there, researchers can begin to develop therapies, which can vary from person to person. "[It's] something we call personalized medicine or precision medicine, which is very much in vogue in cancer. That means we need to understand where patients differ and then tailor the immune therapies to their specific needs," Roep said. The funding comes from the Wanek family, which owns Ashley Furniture, and anonymous donors, according to City of Hope. The Waneks have donated to the center for about 20 years, but this was the first time they've specified how money should be used. Continue reading >>

City Of Hope's New Approach Aims To Cure Type 1 Diabetes In Six Years

City Of Hope's New Approach Aims To Cure Type 1 Diabetes In Six Years

CITY OF HOPE SETS NEW GOAL FOR TYPE 1 DIABETES CURE More than $50 million in private funding aims to cure Type 1 diabetes in six years A recent grouping of donations totaling $50 million is outstanding, those in the trenches with diabetes said. But only six years to a cure? Really? You lost us there, some claimed. Dr. Bart Roep, Ph.D., director of the program, now known as the Wanek Family Project at City of Hope, understands that view. Some people give up [on hope for a cure], and I respect that, he said. He admits, too, that six years is a goal, not a promise. I cannot be confident in the six years, he said. If I knew what was needed to do that, Id do it on one year. But, he feels the pathway City of Hope has laid out thanks to the donations leads the diabetes world on a road to better outcomes, and a place that, in six years, will be significantly better than where we are today. What the program plans to do is change the entire way we view a cure, shifting from a one-size-fits-all method of research and goals to a system of precision medicine; a way to offer individualized and personalized therapies for people with diabetes much in the same way cancer treatment does today. The program will draw heavily from a biorepository, something Dr. Roep says will save millions of dollars and many years in helping them embrace the concept of diabetes being unique in almost every individual. Armed with that knowledge they will dig back into human clinical studies that may not have succeeded on a mass scale and look to see if they can help patients on a smaller scale. For instance, if a study failed for 70 percent of the participants, it may have held answers for other 30 percent. The focus at City of Hope will be threefold: to stop the progression of the disease (something Dr. R Continue reading >>

City Of Hope Sets New Goal For Type 1 Diabetes Cure

City Of Hope Sets New Goal For Type 1 Diabetes Cure

Curing type 1 diabetes in six years is the new goal of Duarte, Calif., based City of Hope’s Diabetes and Metabolism Research Institute. Through the generosity of the Wanek family and gifts from anonymous donors, the institution will be able to devote more than $50 million over the next six years to an innovative research effort that seeks to find a cure for type 1 diabetes. The family’s gift will establish the Wanek Family Project for Type 1 Diabetes at City of Hope. City of Hope, which has a long history in diabetes, conducted research that led to the development of synthetic human insulin by Arthur D. Riggs, PhD, in 1978. Insulin is still used today by an estimated 1.5 million Americans with type 1 diabetes and 27 million with type 2 diabetes. Funding for this transformative research is being led by a gift from the Wanek family, who founded and currently owns Ashley Furniture Industries. The project will create a series of highly focused programs based at City of Hope that will use an integrated approach to curing type 1 diabetes, including immunotherapy approaches, as well as research into beta cell transplantation and preventing the body from rejecting those insulin secreting cells. “City of Hope is best positioned to take on this challenge,” said Robert W. Stone, president and CEO of City of Hope. “This is thanks to our 40-year institutional legacy of pioneering treatment and research advances in diabetes. City of Hope’s goal to cure type 1 diabetes will focus on three core areas that are crucial in treating both types of diabetes: Immune modulation – Research is already underway at City of Hope to unlock the immune system’s role in diabetes, including T cell modulation and stem cell-based therapies that may reverse the autoimmune attack on islet ce Continue reading >>

Dr. Bart Roep & Dr. Beth Jenkins On Type 1 Diabetes Research

Dr. Bart Roep & Dr. Beth Jenkins On Type 1 Diabetes Research

Dr. Bart Roep & Dr. Beth Jenkins on Type 1 Diabetes research Dr. Bart Roep & Dr. Beth Jenkins on Type 1 Diabetes research 5-year-old diabetic boy makes video showing daily routine Diabetes affects 422-million people worldwide...and many of those are young adults and very young kids as you can see from this video that just went viral this week. Now what if we told you that in six years, Type 1 Diabetes could be cured? The City Of Hope is the home of one of the most influential diabetes research programs in the world and they say that goal is within reach. Doctor Bart Roep was here from City Of Hope, along with Dr. Beth Jenkins, who is diabetic to talk about the research. Copyright 2017 FOX 11 Los Angeles : Download our mobile app for breaking news alerts or to watch FOX 11 News | Follow us on Facebook, Twitter, Instagram, and YouTube. Be a citizen journalist for FOX 11 and get paid – download the Fresco News App today. Continue reading >>

City Of Hope Aims To Cure Type 1 Diabetes In Six Years

City Of Hope Aims To Cure Type 1 Diabetes In Six Years

It’s an extraordinary goal powered by an extraordinary gift. City of Hope’s Diabetes & Metabolism Research Institute is committed to developing a cure for type 1 diabetes (T1D) within six years, fueled by a $50 million funding program led by the Wanek family. It seems an audacious goal for a comprehensive cancer center, but City of Hope has a long history of groundbreaking work in diabetes. Research conducted by City of Hope led to the development of synthetic human insulin, which is still used today by many of the estimated 1.5 million Americans with T1D and 27 million with type 2 diabetes (T2D). “City of Hope is best positioned to take on this challenge,” said Robert W. Stone, president and chief executive officer of City of Hope. “This is thanks to our 40-year institutional legacy of pioneering treatment and research advances in diabetes.” The funding for the transformative research needed to embark on such an endeavor is led by a gift from the Wanek family, which owns Ashley Furniture Industries, the world’s largest home furniture manufacturer. “City of Hope scientists’ research has revolutionized the understanding and treatment of diabetes,” said Todd Wanek, chief executive officer of Ashley Furniture, speaking on behalf of his family. “It continues today as physicians and scientists gain systemic understanding of diabetes as a complex, multifaceted disease.” Through the generosity of the family and gifts from an anonymous donor, City of Hope will be able to devote more than $50 million over the next six years to an unprecedented research effort: The Wanek Family Project for Type 1 Diabetes at City of Hope. A Multifaceted Approach The Wanek Family Project will result in the creation of a series of highly focused programs at City of Hope. The Continue reading >>

City Of Hope Receives $50 Million To End Diabetes In Six Years

City Of Hope Receives $50 Million To End Diabetes In Six Years

City of Hope in Duarte, California, has announced gifts totaling $50 million in support of an initiative at its Diabetes & Metabolism Research Institute to develop a cure for type 1 diabetes. Led by a gift from Todd Wanek, CEO of Ashley Furniture, the world's largest home furniture manufacturer, and his family, the gifts will support the institute's Wanek Family Project for Type 1 Diabetes, an effort to create highly focused programs aimed at attacking the problem of T1D in novel ways, with the ultimate goal of finding a cure within six years. To that end, the project will focus on three areas, each of which is crucial in treating both type 1 and type 2 diabetes: immune modulation, beta cell expansion and replacement, and preventing diabetes complications. The $50 million total also includes gifts from an anonymous donor, individual supporters, and corporate and foundation partners. Research conducted by City of Hope led to the development of synthetic human insulin, which is still used today by many of the estimated 1.5 million Americans with T1D and 27 million with type 2 diabetes. "City of Hope scientists' research has revolutionized the understanding and treatment of diabetes," said Wanek. "It continues today as physicians and scientists gain systemic understanding of diabetes as a complex, multifaceted disease." Continue reading >>

Experimental Treatment At City Of Hope Could Be Cure To Type 1 Diabetes

Experimental Treatment At City Of Hope Could Be Cure To Type 1 Diabetes

DUARTE (CBSLA.com) — Five months after Susan Weinberg’s wedding, her diabetes became so severe that even eight shots of insulin a day could not prevent a horrific car accident. “I was lucky I didn’t kill myself or kill someone else,” said Weinberg. Soon, her low blood sugar episodes knocked her unconscious daily. She couldn’t be left alone for years. “I became a prisoner in my own body,” she said. “I never knew when it was happening, and I was always afraid.” So afraid, she was willing to try something experimental. She became the first patient in a Type 1 diabetes clinical trial at the City of Hope National Medical Center in Duarte. Dr. Fouad Kandeel, an endocrinologist, gave Susan two islet-cell transplants, a short outpatient procedure, similar to an organ transplant, that replaces cells inside the patient’s pancreas. “I’m very excited. This is a cure in the making,” Kandeel said. “It is personalized, customized therapy for what the patient needs.” Kandeel showed CBS2/KCAL9’s Erica Nochlin images of Weinberg’s wild blood glucose levels before the transplant, compared with how stable they became right after. He said the key was inside the pancreas, where cells produce insulin in healthy patients. But in diabetic patients, those islet cells die. Therefore, insulin cannot be produced. Kendeel can now transplant those dead islet cells with new living cells, reducing Weinberg’s insulin shots to zero. “It was like freedom!” said Weinberg. “It was like I could drive a car. I could go to the market. I could sit at a park with a book and not worry I was going to be found slumped over the pages of the book.” And the results lasted longer than expected. Weinberg lived needle-free for more than 10 years. It was just recently that she Continue reading >>

City Of Hope Sets New Goal For Type 1 Diabetes Cure

City Of Hope Sets New Goal For Type 1 Diabetes Cure

DUARTE, Calif., Jan. 16, 2017 /PRNewswire/ -- A cure for type 1 diabetes (T1D) in six years is the new goal of City of Hope's Diabetes and Metabolism Research Institute, fueled by a $50 million funding program led by the Wanek family. City of Hope, which has a long and groundbreaking history in diabetes, was the first to engineer synthetic human insulin by Arthur D. Riggs, Ph.D., in 1978, which is still used today by many of the estimated 1.5 million Americans with type 1 diabetes, (T1D) and 27 million with type 2 diabetes (T2D). Funding for this transformative research is being led by a gift from the Wanek family, which owns Ashley Furniture Industries, the world's largest home furniture manufacturer. Through the generosity of the family and gifts from an anonymous donor, individuals and corporate and foundation partners across the country, City of Hope will be able to devote more than $50 million over the next six years to an innovative research effort, the Wanek Family Project for Type 1 Diabetes, that seeks to find a cure for T1D. Research results may also benefit the larger T2D population. The project will create a series of highly-focused programs based at City of Hope that will use an integrated approach to curing T1D, including immunotherapy approaches, as well as research into beta cell transplantation and preventing the body from rejecting those insulin secreting cells. "City of Hope is best positioned to take on this challenge," said Robert W. Stone, president and chief executive officer of City of Hope. "This is thanks to our 40-year institutional legacy of pioneering treatment and research advances in diabetes. "City of Hope is extremely grateful for the Wanek family's significant gift that will enable the institution to forward type 1 diabetes research, th Continue reading >>

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