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Cinsulin Vs Metformin

Supplementation Of Vitamin C Reduces Blood Glucose And Improves Glycosylated Hemoglobin In Type 2 Diabetes Mellitus: A Randomized, Double-blind Study

Supplementation Of Vitamin C Reduces Blood Glucose And Improves Glycosylated Hemoglobin In Type 2 Diabetes Mellitus: A Randomized, Double-blind Study

Advances in Pharmacological Sciences Volume 2011 (2011), Article ID 195271, 5 pages 1Department of Pharmacology, Indira Gandhi Government Medical College, Nagpur 440018, India 2Department of Pharmacology, Shree Sathya Sai Medical College and Research Institute, Chennai 603108, India Academic Editor: Mustafa F. Lokhandwala Copyright © 2011 Ganesh N. Dakhale et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract No study has ever examined the effect of vitamin C with metformin on fasting (FBS) and postmeal blood glucose (PMBG) as well as glycosylated hemoglobin (HbA1c) in the treatment of type 2 diabetes mellitus (DM). The goal was to examine the effect of oral vitamin C with metformin on FBS, PMBG, HbA1c, and plasma ascorbic acid level (PAA) with type 2 DM. Seventy patients with type 2 DM participated in a prospective, double-blind, placebo-controlled, 12-week study. The patients with type 2 DM were divided randomly into placebo and vitamin C group of 35 each. Both groups received the treatment for twelve weeks. Decreased PAA levels were found in patients with type 2 diabetes mellitus. This level was reversed significantly after treatment with vitamin C along with metformin compared to placebo with metformin. FBS, PMBG, and HbA1c levels showed significant improvement after 12 weeks of treatment with vitamin C. In conclusion, oral supplementation of vitamin C with metformin reverses ascorbic acid levels, reduces FBS, PMBG, and improves HbA1c. Hence, both the drugs in combination may be used in the treatment of type 2 DM to maintain good glycemic control. 1. Introduction Diabetes mellitus (DM) is Continue reading >>

The Drug Virtually Everyone Should Ask Their Doctor About

The Drug Virtually Everyone Should Ask Their Doctor About

With each passing year, fresh scientific evidence emerges to vindicate Life Extension®’s contention that aging humans can derive enormous benefit from an antidiabetic drug called metformin. In 2010 alone, scientists at top-ranked institutions made landmark discoveries that broaden its use to combat degenerative disease. The ability of metformin to help facilitate weight loss has long been known. What few doctors understand are the unique mechanisms by which metformin can prevent and even help treat certain cancers. In a remarkable finding, a team of Swiss researchers found that diabetic women on a long-term metformin regimen (5 years or more) experienced a 56% reduction in breast cancer risk!1 It also slashed pancreatic cancer rates by 62% in diabetics and may cut lung cancer rates in smokers.2,3 In this article, a novel link between impaired glucose control and cancer is detailed. You will discover the growing list of cancers metformin may effectively combat, including those of the colon, uterus, and prostate. You will also learn of a striking connection between the anti-cancer mechanisms of metformin and calorie restriction! Why Metformin Should Be Viewed Differently than Other Drugs Many Life Extension members like to brag that they do not need to take any prescription drugs. Given the lethal side effects posed by so many FDA-approved medications, avoiding them whenever possible makes sense. Metformin is an exception! Its broad-spectrum anti-aging properties make it a drug that most longevity enthusiasts should seriously consider asking their doctors about. Since it long ago came off patent, metformin is a super-low cost generic that everyone can afford. Metformin Was Originally a Botanical Compound Although it is sold as a prescription drug today, metformin has a Continue reading >>

Can You Lower Blood Sugar With Cinnamon?

Can You Lower Blood Sugar With Cinnamon?

You’ve no doubt heard that type 2 diabetes has reached epidemic levels in this country and many others. That means that millions more people have pre-diabetes, blood sugar that is headed in the wrong direction though it doesn’t yet qualify as outright diabetes. There are ways to reverse this condition. In fact, you might be able to lower blood sugar with cinnamon. How to Lower Blood Sugar Naturally: Q. My doctor says I have pre-diabetes. I have read your columns about the advantages of Ceylon cinnamon for people with diabetes. Would this help me with my pre-diabetes? Ceylon cinnamon is hard to find. Would Saigon cinnamon work as well? Are there other natural herbs or spices I should consider taking? Which Cinnamon Helps Lower Blood Sugar? A. Cinnamon and other spices and herbs rich in plant polyphenols can help control blood sugar and insulin spikes after meals (Bozzetto et al, Diabetologia, July 2015). One placebo-controlled trial found that a supplement containing cassia cinnamon, chromium and carnosine successfully lowered fasting blood sugar in people with pre-diabetes (Liu et al, PLOS One, Sep. 25, 2015). Polyphenols, compounds found in cinnamon as well as tea, coffee, grapes, wine, cocoa and berries, slow the absorption of glucose (sugar) from the digestive tract and stimulate insulin secretion (Kim et al, Nutrients, Jan. 5, 2016). Most studies of cinnamon to lower blood sugar have used ordinary cassia cinnamon (Cinnamomum cassia) rather than the more expensive Ceylon cinnamon (Cinnamomum zeylonicum). Cassia cinnamon is the kind usually found on grocery store shelves. Saigon cinnamon is closely related to cassia cinnamon. Must It Be Ceylon Cinnamon to Lower Blood Sugar? You shouldn’t need Ceylon cinnamon to get the blood sugar benefits. If you take either ca Continue reading >>

Cinnamon And Other Herbal Remedies

Cinnamon And Other Herbal Remedies

Can herbs and spices replace some or all diabetes medicines? For some people they can, but you have to be really careful with these and any other alternative treatments. Here are some herbal approaches to managing diabetes and some things to consider if you want to try them. Last fall, Amy Campbell wrote eight blog entries about different herbs and spices and their health benefits. Definitely check these pieces out. But there are many other herbs used around the world to treat and prevent diabetes. Almost all categories of diabetes drug have herbal analogs. Any discussion of herbs for diabetes has to start with cinnamon. Cinnamon is thought to possibly act as an insulin sensitizer, like metformin (brand name Glucophage and others) and the thiazolidinedione drugs (such as Actos). A Pakistani study of 60 adults with Type 2 in Diabetes Care showed an average glucose level drop of 18% to 29% in those who took cinnamon, and better cholesterol levels compared to placebo (inactive treatment). Even though there is generally no money to study herbs, people started to get excited and some small follow-up studies were done. One, also published in Diabetes Care, was done in Oklahoma City. Forty-three adults with Type 2 were split into two groups, and no significant differences were found between cinnamon and placebo groups. That’s why studies can be so confusing. A lot depends on who is being studied. Quite probably, the Pakistani subjects may have been more sensitive to cinnamon, or had different diets, or some other difference from the Americans. Over the next few years, other cinnamon studies were reported; some indicating significant benefits, some not. But if you look at the comments section of this Diabetes Self-Management blog entry, you can see that many readers have foun Continue reading >>

Cinsulin Review (updated 2018): Don't Buy Before You Read This!

Cinsulin Review (updated 2018): Don't Buy Before You Read This!

CinSulin Review (UPDATED 2018): Don't Buy Before You Read This! By Richard(Senior Reviewer) July 6, 2016 Advertising Disclosure CinSulin is a patented weight loss ingredient made to lower blood sugar, while also reducing body fat. Its currently found in 3 different weight loss supplements, all which feature this ingredient as its main additive. This ingredient is a treated form of cinnamon, said to have all of its benefits, without any side effects. It claims to have studies showing a benefit for stabilizing both glucose and insulin, all while helping reduce stress buildup in the body. Are any of these claims actually true? What have others experienced from this ingredient? This CinSulin review will help you understand whether or not this is a safe and effective ingredient. Heres the ingredients list to a bottle of Trunature, which claims to offer an advanced strength amount of CinSulin: Cholecalciferol: A form of vitamin D3 thats used to help the body absorb phosphorus and calcium. Its also used as a rodenticide, since large amounts of it can cause cardiac failure, renal failure, and hypertension. Chromium Picolinate (Chromax): A patented form of chromium picolinate, which is a mineral added to help reduce blood sugar, improve the brain and immune system, and to help with reducing appetite and weight management. Miami Research Associates performed a clinical study on the effects of this ingredient: Continued research on the positive effects is needed some people respond better to chromium picolinate than do others More information is needed to help determine what kind of an effect this may have. Possible side effects that people have experienced includes: Skin irritations and allergic type reactions. In certain people this ingredient isnt very effective. Also, chromiu Continue reading >>

Cinnamon May Not Be Best For Diabetes

Cinnamon May Not Be Best For Diabetes

Cinnamon has been talked about for years because of its supposed benefits for people with diabetes. The common spice is thought to lower both blood glucose and A1C levels. How? By improving your cells’ sensitivity to the hormone insulin, which controls blood glucose levels. That is why many people want to know if they can use cinnamon instead of their diabetes medicines. The research Studies looking into these claims about cinnamon have mostly involved small groups of 60-100 people, and have only lasted 5 to 16 weeks. On the other hand, studies that look at diabetes medicines can sometimes take years. For example, Metformin, the drug of choice for type 2 diabetes, has been studied in very large trials of thousands of patients over the course of many years. This level of study was able to show that not only does Metformin lower blood glucose and A1C, but it also increases lifespan and decreases complications of those who take it. Because of the low numbers of patients involved in cinnamon studies, in 2013, the Cochrane Library independent organization pooled together 10 cinnamon trials with 577 people. When the data from all the different trials were combined, it was found that taking cinnamon did not significantly lower blood glucose or A1C. In addition, none of the trials looked at the effectiveness of cinnamon in preventing diabetes complications. The common claim that cinnamon improves insulin sensitivity has not been proven in clinical trials, either. The takeaway If you enjoy cinnamon for its aroma and spicy sweetness, go ahead and enjoy it, but don’t count on it to control your diabetes. Looking for a natural and safe option is the smart way to go about caring for your health, but make sure you choose therapies that have been proven to work: Lose weight, or ma Continue reading >>

Metformin-induced Changes Of The Coding Transcriptome And Non-coding Rnas In The Livers Of Non-alcoholic Fatty Liver Disease Mice

Metformin-induced Changes Of The Coding Transcriptome And Non-coding Rnas In The Livers Of Non-alcoholic Fatty Liver Disease Mice

Metformin-Induced Changes of the Coding Transcriptome and Non-Coding RNAs in the Livers of Non-Alcoholic Fatty Liver Disease Mice Guo J.a Zhou Y.b Cheng Y.c Fang W.a Hu G.a Wei J.a Lin Y.a Man Y.a Guo L.c Sun M.d Cui Q.b Li J.a aThe MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing, China bDepartment of Physiology and Pathophysiology, Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing, China cDepartment of Endocrinology, Beijing Hospital, National Center of Gerontology, Beijing, China dDepartment of Endocrinology, Beijing EDEN Hospital, Beijing, China The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Department of Physiology and Pathophysiology, Department of Biomedical Informatics (China) E-Mail [email protected]/[email protected]/[email protected] Background/Aims: Recent studies have suggested that changes in non-coding mRNA play a key role in the progression of non-alcoholic fatty liver disease (NAFLD). Metformin is now recommended and effective for the treatment of NAFLD. We hope the current analyses of the non-coding mRNA transcriptome will provide a better presentation of the potential roles of mRNAs and long non-coding RNAs (lncRNAs) that underlie NAFLD and metformin intervention. Methods: The present study mainly analysed changes in the coding transcriptome and non-coding RNAs after the application of a five-week metformin intervention. Liver samples from three groups of mice were harvested for transcriptome profiling, which covered mRNA, lncRNA, microRNA (miRNA) and circular RNA (circRNA), using a microarray technique. Results: A systematic alleviation of high-fat diet (HFD)-induced Continue reading >>

Struggling With Pcos

Struggling With Pcos

I wonder if anyone is experiencing the same kind of issues as me? I was diagnosed with Pcos 4 years ago and have suffered miscarriages since. I was referred for grievance counselling then told as I wasn't suicidal, I wasn't a priority. I couldn't cope and my relationship broke down as a result. I sank further into depression and lost my job, home and car. A couple of years on after seeing many Drs, I was prescribed metformin. At first, the pills made me paranoid, sick, gave me horrendous migraines, hallucinations and made my depression worse. After a few weeks, it got a little better but I was still on edge for about 18 months. i had gained 4 stones by this point and due to arthritis following a m injury unable to exercise and relied on diet alone. It didn't work. I saw a fertility specialist who told me to lose weight or the nhs wouldn't help me - lost 2-3 stones or forget it was the gist. Since then I have only managed to lose 7lb in about a year. I went back to docs who increased my metformin, the symptoms came back. I nearly lost my job and new partner over it - it was like the worst case of pmt. I stopped the tablets against doc advice. He said if you want to lose weight you must take them otherwise if you don't lose weight you won't get pregnant. I cannot take tablets that make me crazy and suicidal, I told him. It's either put up with the side effects or continue to gain weight was his reply. I have come to terms with the fact that I will gain weight and never have children. I am 35. I'm so sorry to hear you have had such an awful time with pcos. Can I ask what dosage of metformin you were on? And we're you on the slow release tablet or normal one? I'm on metformin 1500mg slow release tablets once a day luckily they seem to suit me and I have lost weight taking Continue reading >>

The Glycaemic Outcomes Of Cinnamon, A Review Of The Experimental Evidence And Clinical Trials

The Glycaemic Outcomes Of Cinnamon, A Review Of The Experimental Evidence And Clinical Trials

The glycaemic outcomes of Cinnamon, a review of the experimental evidence and clinical trials Department of Medicine, Senior Lecturer in Medicine, University of Peradeniya, Peradeniya, Sri Lanka Arjuna B. Medagama, Email: [email protected] . Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( ) applies to the data made available in this article, unless otherwise stated. This article has been cited by other articles in PMC. Cinnamon is currently marketed as a remedy for obesity, glucose intolerance, diabetes mellitus and dyslipidaemia. Integrative medicine is a new concept that combines conventional treatment with evidence-based complementary therapies. The aim of this review is to critically evaluate the experimental evidence available for cinnamon in improving glycaemic targets in animal models and humans. Insulin receptor auto-phosphorlylation and de-phosphorylation, glucose transporter 4 (GLUT-4 ) receptor synthesis and translocation, modulation of hepatic glucose metabolism through changes in Pyruvate kinase (PK) and Phosphenol Pyruvate Carboxikinase (PEPCK), altering the expression of PPAR () and inhibition of intestinal glucosidases are some of the mechanisms responsible for improving glycaemic control with cinnamon therapy. We reviewed 8 clinical trials that used Cinnamomum cassia in aqueous or powder form in doses ranging from 500mg to 6g per day for a duration lasting from 40days to 4months as Continue reading >>

Metformin Rapidly Increases Insulin Receptor Activation In Human Liver And Signals Preferentially Through Insulin-receptor Substrate-2

Metformin Rapidly Increases Insulin Receptor Activation In Human Liver And Signals Preferentially Through Insulin-receptor Substrate-2

Metformin decreases endogenous glucose production by the liver. Few studies have examined the effect of metformin on the insulin-signaling pathway in liver models, and none have presented data on the effect in normal human liver. Huh7 human hepatoma cells and primary human hepatocytes were used. Insulin receptor (IR) and IR substrates (IRS)-1 and -2 were assessed by immunoprecipitation and immunoblot. Normal human liver was used to assay IR kinase activity (IR-KA). Tyrphostin AG1024 was used to inhibit IR-KA and examine effects on deoxyglucose uptake. Metformin (1 μg/ml) increased IR tyrosine phosphorylation by 78% (P = 0.0007) in 30 min in human hepatocytes and Huh7 cells and increased IRS-2 but not IRS-1 activation, and the downstream increase in deoxyglucose uptake was mediated via increased translocation of GLUT-1 to the plasma membrane. Metformin did not augment maximal or submaximal insulin-stimulated IR activation. Metformin increased basal IR-KA by 150% (P = 0.0001). AG1024 inhibited metformin-induced IR-β phosphorylation in a concentration-dependent manner and abolished metformin-induced 2-deoxyglucose uptake. This study demonstrates that the mechanism of action of metformin in liver involves IR activation, followed by selective IRS-2 activation, and increased glucose uptake via increased GLUT-1 translocation. The effect of metformin was completely blocked by an IR inhibitor. Estrogen, which acts through estrogen receptors (ERs) α and β, has been implicated in the pathogenesis of benign and malignant human prostatic tumors, i.e. benign prostatic hyperplasia and prostate cancer, thought to originate from different zones of the prostate [the transition zone (TZ) and peripheral zone (PZ), respectively]. Here, we examined the cellular distribution of ERα and E Continue reading >>

Does Cinnamon Conflict With Metformin?

Does Cinnamon Conflict With Metformin?

I've heard that cinnamon helps control blood sugar. How much truth is there to this, and would it in any way conflict with me taking metformin? Continue reading >>

Cinsulin

Cinsulin

I purchased CinSulin (daily suplement) at Costco. It's supposed to help use glucose efficiently. I have type 2 diabetes. Has anybody tried this product or know anything about it? Please share. I, too, purchased CinSulin from Costco. For me, it's a MIRACLE remedy. It brought down my fbg by about 20 points, give or take a few. So now my usual fbg is about 77 to 91 (on bad days). I have to REALLY eat high carb to bring it over 100. (Like a large plate full of Fetuccine Alfredo or Beef Chow Fun.) Even then, it's only a couple of points over 100. I do avoid this but I tried each one once just to see what would happen. But I can eat those foods in moderation and I thought I would never taste them again. The only thing I rarely eat (if ever) is added sugar. The naturally occurring sugar in certain foods doesn't seem to affect me but I do avoid food (such as fruit) which has higher levels of sugar. I do eat some fruit, but not a lot. I hope they never stop making CinSulin, as it has restored my quality of life. I used to be "starving" all the time and my fbg was higher. Good luck! A quote from the Medicinal Research section of the Wiki article "Two studies have shown that including cinnamon and cinnamon extract in the diet may help type 2 diabetics to control blood glucose levels. One study used C. cassia,[44] while the other study used an extract (made from "Chinese Cinnamomum aromaticum", an older name for C. cassia).[45] Apart from the most common flavanol (epi)catechin and (epi)afzelechin, cinnamon proanthocyanidins contain (epi)catechingallate and (epi)gallocatechin units.[46] Furthermore, these proanthocyanidins are bioavailable and may have an effect on the target tissues.[47] However a Cochrane review study published in 2012 showed that cinnamon is not more effective t Continue reading >>

Anyone Try Cinsulin - Type 2 Diabetes - Diabetes Forums

Anyone Try Cinsulin - Type 2 Diabetes - Diabetes Forums

Registration is fast, simple and absolutely free so please,join our community todayto contribute and support the site. This topic is now archived and is closed to further replies. I saw this in my monthly Costco Magazine. It's a product called Cinsulin by TruNature. Has anyone tried it? Any comments about products like these? Didn't have much luck with the Cin, but I do take Chromium Pich. They shouldn't be permitted by some one to label thier product like that. If you do a search on here and google for Cinnamon and Diabetes you will get alot of controversy if it helps or not. All Cinsulin is is a caplet form of Cinnamon. Some have said it helps control their levels and some have said it does nothing. I have been taking CinSulin (by TruNature from COSTCO), for over a year now and it does work for me. I take 2 in the morning and 2 in the evening. My A1C is around 5.7. The doctor has taken me off of Metformin and now I control the diabetes with walking and diet (lo-carb). Like anything else some stuff works and some stuff doesn't - must be the bodies chemistry. I've been off Metformin now for 3 weeks and my blood sugar levels have remained normal - fasting under 100, 2 hours after dinner between 115 - 120. That's why I believe the CinSulin helps. The problem with supplements is proving that they are responsible for doing some thing. If you are active and eating right, proving any given supplement is responsible for reducing you BG readings would be hard to prove conclusively - particularly over a long period of time (greater than 3 months). Factor in the lack of a double blind test and you are let with more questions than answers about what is going on and why it is happening. Things like stress do more to cause a change in my BG readings than anything I eat, and are pro Continue reading >>

Ada: Cardiovascular Benefits Seen With Long-term Metformin Use In Adults With Type 1 Diabetes

Ada: Cardiovascular Benefits Seen With Long-term Metformin Use In Adults With Type 1 Diabetes

Home / Conditions / Type 1 Diabetes / ADA: Cardiovascular Benefits seen with Long-Term Metformin Use in Adults with Type 1 Diabetes ADA: Cardiovascular Benefits seen with Long-Term Metformin Use in Adults with Type 1 Diabetes Results from the REMOVAL trial revealed reduction in the risk of cardiovascular disease among other benefits with metformin in type 1 diabetes patients. Atherosclerosis leads to macrovascular complications in diabetes. These complications contribute to the majority of deaths in patients with diabetes. The use of metformin in previous studies have established a reduction in risk of cardiovascular disease in patients with type 2 diabetes. This is one of the reasons why metformin is currently recommended as first line therapy for these patients. However, it is only recommended for off label use in overweight or obese patients with type 1 diabetes to assist in weight loss and to decrease insulin dose requirements. Researchers wanted to investigate the potential use of metformin in patients with type 1 diabetes, to evaluate if these patients could also benefit from the reduction in risk of cardiovascular disease. An international, double-blind study called the REducing with MetfOrmin Vascular Adverse Lesions (REMOVAL) study enrolled 493 participants over the age of 40 with a minimum of five year duration of type 1 diabetes and at least three cardiovascular risk factors. The ten defined risk factors in the study include known CVD, strong family history of CVD, diabetes duration > 20 years, a BMI 28 kg/m2, HbA1c > 8.0%, current smoker, microalbuminuria, eGFR < 90 mL/min/1.732, hypertension and dyslipidemia. After a 3 month run in period, 428 participants were randomized to receive either placebo or 1000 mg of metformin twice a day. All baseline character Continue reading >>

Original Article Cinnamon Extract Lowers Glucose, Insulin And Cholesterol In People With Elevated Serum Glucose

Original Article Cinnamon Extract Lowers Glucose, Insulin And Cholesterol In People With Elevated Serum Glucose

Abstract Cinnamon (肉桂 ròu guì) has in vitro insulin potentiating activity, and proanthocyanidins from cinnamon prevent in vitro formation of advanced glycation end products. Some human studies were equivocal, but several have shown beneficial effects of cinnamon supplementation on circulating glucose, lipids, and/or insulin. This placebo-controlled double-blind trial tested the effects of a dried water extract of cinnamon (Cinnamomum cassia) on circulating glucose, lipids, insulin, and insulin resistance. Men and women from Beijing and Dalian, China, were invited to participate if they had fasting serum glucose >6.1 mmol/L or 2-h glucose >7.8 mmol/L. Participants, (173 were enrolled and 137 completed the study) were randomly assigned to receive either a spray-dried, water extract of cinnamon (CinSulin®), 250 mg/capsule, or a placebo, twice a day for two months. Mean ± SEM age of participants was 61.3 ± 0.8 years, BMI was 25.3 ± 0.3 and M/F ratio was 65/72. After 2 mo, fasting glucose decreased (p < 0.001) in the cinnamon extract-supplemented group (8.85 ± 0.36 to 8.19 ± 0.29 mmol/L) compared with the placebo group (8.57 ± 0.32 to 8.44 ± 0.34 mmol/L, p = 0.45). Glucose 2 h after a 75 g carbohydrate load, fasting insulin, and HOMA-IR also decreased with cinnamon extract compared with placebo. Total and LDL-cholesterol decreased with cinnamon extract and HDL-cholesterol decreased in both the cinnamon-extract and placebo groups. In conclusion, supplementation with 500 mg of water-extract of cinnamon for two months reduced fasting insulin, glucose, total cholesterol, and LDL cholesterol and enhanced insulin sensitivity of subjects with elevated blood glucose. Continue reading >>

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