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Cialis Daily And Diabetes

Effects Of Tadalafil On Erectile Dysfunction In Men With Diabetes

Effects Of Tadalafil On Erectile Dysfunction In Men With Diabetes

Abstract OBJECTIVE—To evaluate the efficacy and safety of tadalafil taken as needed before sexual activity by men with diabetes and erectile dysfunction (ED). RESEARCH DESIGN AND METHODS—Men with type 1 or type 2 diabetes and a minimum 3-month history of ED were randomly allocated to one of three groups: placebo (n = 71), tadalafil 10 mg (n = 73), or tadalafil 20 mg (n = 72) taken up to once daily for 12 weeks. Changes from baseline in mean scores on the erectile function domain of the International Index of Erectile Function (IIEF) and changes from baseline in the proportion of “yes” responses to question 2, “Were you able to penetrate?,” and 3, “Were you able to complete intercourse?,” of the Sexual Encounter Profile were coprimary outcome measures. RESULTS—A total of 191 (88%) of 216 patients completed the study. Treatment with tadalafil significantly improved all primary efficacy variables, regardless of baseline HbA1c level. Therapy with tadalafil also significantly improved a number of secondary outcome measures, including changes in other IIEF domains, individual IIEF questions, and percentage of positive responses to a global assessment question measuring erection improvement. Treatment with tadalafil did not alter mean HbA1c levels. Tadalafil was well tolerated, with headache and dyspepsia being the most frequent adverse events with active treatment. CONCLUSIONS—Tadalafil therapy significantly enhanced erectile function and was well tolerated by men with diabetes and ED. RESEARCH DESIGN AND METHODS This multicenter, randomized, double-blind, placebo-controlled, parallel-group trial was conducted at 18 sites in Spain from December 1999 through August 2000. A total of 216 men aged ≥18 years with a clinical diagnosis of type 1 or type 2 diabe Continue reading >>

Effects Of Tadalafil Once Daily In Men With Diabetes And Erectile Dysfunction

Effects Of Tadalafil Once Daily In Men With Diabetes And Erectile Dysfunction

Erectile dysfunction (ED) is a common comorbidity in men with diabetes mellitus. Tadalafil 10 or 20 mg taken on demand is efficacious and safe for men with diabetes and ED. Recently, continuous treatment with tadalafil has been proposed, addressing ED management as any other chronic condition. This study examined whether once-daily tadalafil 2.5 and 5 mg is efficacious for men with diabetes and ED.This randomized, double-blind, placebo-controlled, multicentre, 12-week study enrolled 298 men with diabetes and ED to once-daily treatment with placebo, tadalafil 2.5 mg or tadalafil 5 mg. Primary efficacy measures were International Index of Erectile Function Erectile Function (IIEF EF) Domain score, and patient success rates for vaginal penetration and completion of intercourse. Patient satisfaction, endothelial function biomarkers, and safety were also assessed.Patients receiving either dose of tadalafil had clinically and statistically significant improvements in IIEF EF and statistically significant improvements in mean success rates for vaginal penetration, completion of intercourse, and overall treatment satisfaction (P < or = 0.005 tadalafil vs. placebo, all measures). Endothelial dysfunction biomarkers were unchanged. The most common adverse events were headache, back pain and dyspepsia.In this first study of men with diabetes and ED, once-daily tadalafil 2.5 and 5 mg was efficacious and well tolerated, suggesting this may be an alternative to on-demand treatment for some men, eliminating the need to plan sex within a limited timeframe. Do you want to read the rest of this article? ... In a study of men with ED and DM who received tadalafil once daily, mean IIEF-EF domain scores after 12 weeks of treatment were 18.3 (2.5 mg) and 17.2 (5 mg), respectively. The propor Continue reading >>

Viagra For Type 2 Diabetes: 'little Blue Pill' Reduces Insulin Resistance Without Risk Of Heart And Kidney Disease

Viagra For Type 2 Diabetes: 'little Blue Pill' Reduces Insulin Resistance Without Risk Of Heart And Kidney Disease

Viagra For Type 2 Diabetes: 'Little Blue Pill' Reduces Insulin Resistance Without Risk Of Heart And Kidney Disease The little blue pill not only helps men get it up during sex, it may also up insulin sensitivity among diabetics. A recent study published in the Journal of Clinical Endocrinology and Metabolism found sildenafil the drug that treats erectile dysfunction (ED) can ward off type 2 diabetes in those with prediabetes, while reducing the risk of heart and kidney disease. In the U.S., 29 million Americans have diabetes and three in 10 adults have prediabetes, according to the Societys Endocrine Facts and Figures report . Without intervention, 30 percent of people with prediabetes are likely to develop type 2 diabetes within five years. Dr. Nancy J. Brown, author of the study from Vanderbilt University School of Medicine in Nashville, Tenn., believes additional strategies, like sildenafil, are necessary to help slow the progression from prediabetes to diabetes. "Weight loss and exercise regimens can be difficult to maintain, and some current medications have been limited by concerns about adverse effects. Sildenafil and related drugs could offer a potential avenue for addressing the rising number of diabetes diagnoses," she saidin the press release . Sildenafil, typically known for treating ED, works by inhibiting an enzyme that breaks down the natural blood vessel-relaxing chemical, cGMP. The drug has been proven to increase insulin sensitivity in mice, but the effectof the drug on humans with prediabetes hasbeen unknown. Someone who is insulin sensitive requires smaller amounts of insulin to lower blood sugar levels than someone who has a low sensitivity, or is insulin resistant. Insulin resistance occurs when there are high blood sugar levels in the bodyand the Continue reading >>

Efficacy Of Continuous Dosing Of Tadalafil Once Daily Vs Tadalafil On Demand In Clinical Subgroups Of Men With Erectile Dysfunction: A Descriptive Comparison Using The Integrated Tadalafil Databases - Sciencedirect

Efficacy Of Continuous Dosing Of Tadalafil Once Daily Vs Tadalafil On Demand In Clinical Subgroups Of Men With Erectile Dysfunction: A Descriptive Comparison Using The Integrated Tadalafil Databases - Sciencedirect

Volume 13, Issue 5 , May 2016, Pages 860-875 Efficacy of Continuous Dosing of Tadalafil Once Daily vs Tadalafil On Demand in Clinical Subgroups of Men With Erectile Dysfunction: A Descriptive Comparison Using the Integrated Tadalafil Databases Various factors play a role in the development of erectile dysfunction (ED). To provide a descriptive comparison of erectile function response for tadalafil on-demand (PRN) and once-daily (OAD) dosing regimens in patients with common comorbid conditions, treatments, or risk factors that can be considered when treating ED. In total, 17 PRN and 4 OAD placebo-controlled studies were included in the integrated database in these pooled analyses. Data were analyzed from patients treated with placebo, tadalafil 10 mg (low dose), and 20mg (high dose) for the PRN studies and placebo, tadalafil 2.5 mg (low dose), and 5 mg (high dose) for the OAD studies. The effects of tadalafil were measured using the International Index of Erectile Function administered from baseline to week 12. A descriptive comparison of the efficacy of tadalafil PRN vs OAD was examined in the clinical populations. Baseline characteristics of 4,354 men were comparable between the PRN and OAD groups, with differences seen only in the variables of race, body mass index (BMI) of at least 30 kg/m2, and alcohol use. Tadalafil was efficacious at improving erectile function for all clinical populations, except for the low-dose OAD group, which demonstrated a weaker effect vs placebo than the high-dose OAD group, and the low- and high-dose PRN groups vs placebo for patients with BMI of at least 30 kg/m2 for patients without a cardiovascular disorder, smokers, patients with ED duration shorter than 1 year, and patients without previous phosphodiesterase type 5 inhibitor use. Ta Continue reading >>

Erectile Dysfunction And Diabetes: Frequently Asked Questions

Erectile Dysfunction And Diabetes: Frequently Asked Questions

Diabetes and erectile dysfunction are two conditions that often go together. Here are the answers to several common questions about diabetes and how it affects sexual function in men. How prevalent is ED in men with diabetes? Anywhere from 35% to 75% of men with diabetes will experience erectile dysfunction (ED) during their lifetime. Men who have diabetes tend to develop ED about a decade sooner than non-diabetic men. After age 50, approximately 50 to 60% of men with diabetes experience ED. After age 70, up to 95% of diabetic men experience some degree of ED. Overall, men who are diabetic are two to three times more likely to experience ED than non-diabetic men. How does diabetic nerve damage contribute to ED? Progressive nerve damage is common in diabetics. Some nerves can be controlled consciously: for example, when a person wants to raise their arm, the brain transmits nerve impulses to the affected muscles. But nerve signals also control bodily processes that a person does not have conscious control over, such as the process of digestion. The nerves that control internal organs are called autonomic nerves, and these nerves may gradually become damaged due to diabetes. A man’s response to sexual stimuli is governed by autonomic nerve signals to the sexual organs, and when these nerves are damaged by diabetes, ED can result. The name for this type of nerve damage is autonomic neuropathy. How does diabetic blood vessel damage contribute to ED? Normal erections require adequate blood flow to the sex organs. In a normal erection, the pressure within what is called the intracavernosal space within the penis increases, choking off outflow of blood. With more blood flowing into the penis than out, the result is an erection. Adequate levels of nitric oxide within the sexu Continue reading >>

When Viagra Doesn’t Work

When Viagra Doesn’t Work

Treating Erectile Dysfunction Erectile dysfunction is a common occurrence in men with diabetes. The incidence of erectile dysfunction increases progressively with age, from 5% in men age 20 to 75% in men over age 65. The cause of erectile dysfunction in men with diabetes is usually related to a decrease in the blood supply to the penis as well as to injury to the nerves that are responsible for the erection mechanism. A decrease in testosterone production has also been identified as the cause in some men with diabetes. Since 1998, when sildenafil (brand name Viagra) first came on the market, oral therapy has been successfully used to treat erectile dysfunction in many men with diabetes. (Sildenafil was followed in 2003 by the drugs tadalafil [Cialis], vardenafil [Levitra] and avanafil [Stendra], which work in much the same way.) Some 50% of men with Type 1 diabetes who try the drugs report improved erections, and some 60% men with Type 2 diabetes do, too. However, that leaves a large percentage of men with diabetes and erectile dysfunction who do not respond to therapy with one of these pills. This article takes a look at what can be done to treat those men who do not respond to oral therapy. Why therapy fails There are a number of reasons a man may not achieve the desired result from an oral erectile dysfunction drug. In some cases, a man may experience drug side effects severe enough to outweigh any potential benefit of taking the drug. Possible side effects of these drugs include headache, facial flushing, nasal congestion, and transient abnormal vision. (In October 2007, the FDA added a warning about sudden hearing loss to the package labels of oral erectile dysfunction drugs. While it’s not absolutely clear that the drugs can cause sudden hearing loss, a number o Continue reading >>

Efficacy Of Tadalafil Once Daily In Men With Diabetes Mellitus And Erectile Dysfunction.

Efficacy Of Tadalafil Once Daily In Men With Diabetes Mellitus And Erectile Dysfunction.

Abstract AIMS: Erectile dysfunction (ED) is a common comorbidity in men with diabetes mellitus. Tadalafil 10 or 20 mg taken on demand is efficacious and safe for men with diabetes and ED. Recently, continuous treatment with tadalafil has been proposed, addressing ED management as any other chronic condition. This study examined whether once-daily tadalafil 2.5 and 5 mg is efficacious for men with diabetes and ED. METHODS: This randomized, double-blind, placebo-controlled, multicentre, 12-week study enrolled 298 men with diabetes and ED to once-daily treatment with placebo, tadalafil 2.5 mg or tadalafil 5 mg. Primary efficacy measures were International Index of Erectile Function Erectile Function (IIEF EF) Domain score, and patient success rates for vaginal penetration and completion of intercourse. Patient satisfaction, endothelial function biomarkers, and safety were also assessed. RESULTS: Patients receiving either dose of tadalafil had clinically and statistically significant improvements in IIEF EF and statistically significant improvements in mean success rates for vaginal penetration, completion of intercourse, and overall treatment satisfaction (P < or = 0.005 tadalafil vs. placebo, all measures). Endothelial dysfunction biomarkers were unchanged. The most common adverse events were headache, back pain and dyspepsia. CONCLUSIONS: In this first study of men with diabetes and ED, once-daily tadalafil 2.5 and 5 mg was efficacious and well tolerated, suggesting this may be an alternative to on-demand treatment for some men, eliminating the need to plan sex within a limited timeframe. Continue reading >>

Daily Tadalafil Prevents Erectile Dysfunction In Diabetic Men

Daily Tadalafil Prevents Erectile Dysfunction In Diabetic Men

Daily Tadalafil Prevents Erectile Dysfunction in Diabetic Men This feature requires the newest version of Flash. You can download it here . This is the Medscape Medical Minute. I'm Dr. George Lundberg. Diabetic men frequently have erectile dysfunction. Tadalafil (trade name Cialis), 10-20 mg, is a safe and effective treatment when taken on demand. Nine investigators in Greece studied whether the once-daily use of smaller doses, 2.5 or 5 mg, would also work. They performed a randomized, double-blind, placebo-controlled, multicenter, 12-week study of 298 diabetic men with erectile dysfunction. They measured patient satisfaction, vaginal penetration, completion of intercourse, and the International Index of Erectile Function Domain scores to assess success. Adverse effects included back pain, headache, and dyspepsia. As reported in Diabetic Medicine[ 1 ] in 2008, either low dose taken daily produced statistically significant improvement suggesting that daily therapy offers a safe and effective alternative and could eliminate the need to plan sex in a limited timeframe. This article is selected from Medscape Best Evidence.[ 2 ] I'm Dr. George Lundberg. Continue reading >>

Cialis & Diabetes

Cialis & Diabetes

In recent years there have been many studies done to assess the way that Cialis affects men with diabetes. These studies have shown that men with diabetes who are suffering from the symptoms of erectile dysfunction that use Cialis have had a positive great success rate with more men having greater satisfaction with their erections and the amount of times that they are able to penetrate during sexual intercourse due to the drug. The men who had erectile dysfunction that took the 10mg dosage of Cialis had a 57% satisfaction rate when it came to vaginal penetration and a 48% satisfaction rate that their erection lasted long enough to have full sexual intercourse. The men that took the 20mg dosage of Cialis still have a good satisfaction rate although it was a percent less than the lower dosage drug. Cialis and Type 2 Diabetes If you suffer from type 2 diabetes you are more likely to suffer from erectile dysfunction than men with type 1 diabetes. This could be due to the fact that men with type 2 diabetes tend to have high blood pressure which is caused by a bad diet and an unhealthy lifestyle. So it is very important that you help yourself when it comes to treating erectile problems as Cialis and other erectile dysfunction drugs can only work for so long. It is also important to remember that you should not take Cialis when you blood sugar levels are unregulated or poorly managed as this can increase the chance that the side effects that could potentially occur do and they are often more serious. Continue reading >>

Sex With Diabetes: Mens Awkward Bedroom Questions, Answered

Sex With Diabetes: Mens Awkward Bedroom Questions, Answered

Sex With Diabetes: Mens Awkward Bedroom Questions, Answered Diabetes can lead to erectile dysfunction, reduced libido, low testosterone, and other sex problems in men. Here's how to address them. Having sex when you have diabetes may affect your libido, among other issues. Youve probably heard that having diabetes can impact sex. After all, high blood glucose affects your whole body, even your most private parts. For a lot of people, their sexual life is important, says Evan Sisson, PharmD, CDE , an associate professor at the school of pharmacy at Virginia Commonwealth University in Richmond, adding that checkups should leave time for an open conversation about a patients sexual life and concerns. Why Arent My Erections Like They Used to Be? For years, it has been well known that erectile dysfunction (ED) is more common in men who have diabetes . A study published in July 2017 in the journalDiabetic Medicine offers clues on the prevalence of this issue: Men with diabetes are 3.5 times more likely to have ED than men without diabetes. High blood glucose damages nerves, meaning the lets have sex signal doesnt make it to the penis. It also narrows the peniss blood vessels so you dont get enough blood to the penis for an erection. You cant reverse damage to nerves and blood vessels in your penis, but you can prevent further damage by lowering your A1C , says urologist Ajay Nangia , bacholorof medicine and bachelor of surgery, a professor of urology at the University of Kansas Medical Center in Kansas City. Treatments for ED include pills, such as Viagra (sildenafil) , Cialis (tadalafil) , and Levitra (vardenafil) . Dr.Sisson says these pills can be highly effective, especially if you can still sometimes get an erection. People who take nitrates for chest pain should not ta Continue reading >>

Choosing The Right Pill To Treat Ed

Choosing The Right Pill To Treat Ed

The most common sexual dysfunctions in men include lack of interest, premature ejaculation and erectile dysfunction. The latter affects 52% of men between the ages of 40 and 70, including mild, moderate and complete forms of ED. Organic or physical causes for sexual dysfunction in men include vascular, hormonal and neurologic factors. Concerning vascular causes, the risk factors for atherosclerosis (including smoking, high blood pressure, diabetes (diabetics do not respond well to pills like sildenafil (Viagra)) and high cholesterol are ALSO risk factors for erectile dysfunction. Since a straddle injury or use of a narrow saddle can obstruct and impair arteries to the penis, bicycle riding is also considered a risk factor for erectile dysfunction. Little attention has been paid to endocrine factors. Testosterone modulates desire, arousal and orgasmic function. Concerning the orgasmic response, testosterone modulates the integrity of genital sensory receptors. Concerning the arousal response, decreased testosterone blood levels can influence the efficacy of sildenafil (Viagra). If the sildenafil response is not reliably improving erection, the physician should first check if the patient is taking the pill correctly. The physician should also check the patient’s testosterone level. One investigator in Italy gave testosterone to patients with low testosterone who did not respond to sildenafil (Viagra). When daily testosterone was given, subsequent sildenafil (Viagra) use resulted in IIEF (the International Index of Erectile Function questionnaire used to determine erectile function) scores improving significantly. Other risk factors for erectile dysfunction include neurologic problems (multiple sclerosis, stroke), depression and medications for treating diabetes, hyperte Continue reading >>

Diabetes Pills Costing Just 2p Each Could Give Men's Love Lives A Lift

Diabetes Pills Costing Just 2p Each Could Give Men's Love Lives A Lift

Tablets costing just 2p each could be a new treatment for men with erection problems. New research suggests the medicine, called metformin, could boost a man's performance in the bedroom. The drug has been widely used on the NHS for many years to treat patients with type 2 diabetes. But now scientists think it may also work as an alternative to anti-impotence drugs such as Viagra or Cialis. Laboratory tests at the Georgia Health Sciences University in the U.S. show the diabetes drug boosts erectile function by relaxing blood vessels in the genital area, allowing blood to flow more freely into the penis. Although it has yet to be tested in humans, it could quickly emerge as a new treatment because it is readily available, extremely cheap and has an excellent safety record. One in ten men in the UK suffers erectile dysfunction at some point in their lives. Although drugs such as Viagra, Cialis and Levitra have revolutionised treatment in the last ten years, around 30 per cent of men who take them experience no improvement. For these men, the only other options are to inject drugs straight into the penis, or use a pump that manually increases blood supply to the organ. Neither is very popular. Metformin has been attracting a great deal of attention from researchers in recent years, mostly because it seems to hold promise as a potentially powerful new weapon against certain cancers, such as prostate, breast and ovarian tumours. The drug belongs to a class of medicines known as biguanides, which have been used for decades to treat type 2 diabetes - the form of the disease that normally affects obese people and those over 40. Taken twice a day, it works by reducing the amount of glucose produced by the liver and helping cells mop up sugar that is circulating in the bloodstrea Continue reading >>

Cialis Side Effects Center

Cialis Side Effects Center

Cialis (tadalafil) is a phosphodiesterase inhibitor used for treating impotence (erectile dysfunction, or ED). Common side effects of Cialis include: flushing (redness or warmth of the face, neck, or chest), headaches, stomach upset, diarrhea, flu-like symptoms (such as stuffy nose, sneezing, or sore throat), memory problems, muscle or back pain, nausea, low blood pressure, dizziness, blurred vision and changes in color vision, abnormal ejaculation, and prolonged erections (priapism). Tell your doctor if you have rare but serious side effects of Cialis including: a painful or prolonged erection lasting 4 or more hours; sudden decreased vision (including permanent blindness, in one or both eyes); a sudden decrease or loss of hearing, sometimes with ringing in the ears and dizziness. The recommended dose of Cialis is 5-20 mg per day taken before sexual activity. Cialis may interact with rifamycins, antibiotics, antifungals, antidepressants, barbiturates, drugs to treat high blood pressure or a prostate disorder, heart or blood pressure medications, HIV or AIDS medications or seizure medications. Tell your doctor all medications and supplements you use. Cialis is not approved for use in women and has not been evaluated in women who are breastfeeding. Our Cialis Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Continue reading >>

Ed In Patients With Diabetes: Most Effective Treatment Options

Ed In Patients With Diabetes: Most Effective Treatment Options

If you have any questions, to schedule a consultation or if you need a second opinion, please contact us or call 1-(646) 663-5211. What is Diabetes? Diabetes is a condition in which the body is unable to control blood glucose levels resulting in higher than normal blood glucose values. Whenever glucose levels in the body increase, there is secretion of insulin from the pancreas. Insulin causes uptake of glucose into the cells, where it is either stored in the form of glycogen or utilized for production of energy. In diabetes, either the insulin production is decreased, or the cells become insensitive to insulin. There are two types of diabetes. In Type I diabetes the production of insulin is impaired; it typically occurs in younger people. Type II diabetes occurs later in life, usually caused by decreased sensitivity of cells to circulating insulin. Cause of Erectile Dysfunction in Diabetic Men Elevated glucose levels over long periods of time (years) damage nerves, blood vessels and muscles in the body. This damage is responsible for a number of complications of diabetes including impotence, neuropathy (loss of sensation or abnormal sensation). Erectile dysfunction, or difficulty with obtaining and maintaining erections, results from damage to nerves, blood vessels and smooth muscles caused by diabetes. Diabetes induced damage to nerves and blood vessels of the penis causes decreased blood flow to the penis. Because erections depend on high blood flow to the penis, decreased blood flow causes weak erections that are difficult to keep hard. Over time as many as 70% of all diabetics will experience some level of erectile dysfunction with incidence increasing with age and duration of diabetes. Among men older than 60 years old with diabetes, 50-60% experience erectile dys Continue reading >>

Nuances Of Cialis Use In Diabetes Patients

Nuances Of Cialis Use In Diabetes Patients

Erectile dysfunction is often associated with the process of aging, but unfortunately, it also affects younger men due to a number of reasons, ranging from poor lifestyle choices to serious medical conditions such as cardiovascular disorders and diabetes. Erectile problems are quite common in men who suffer from diabetes, particularly type 2 diabetes, which is often accompanied by blood pressure disorders. A lot of diabetes patients eventually overcome their ED symptoms by exercising, eating healthier food, and giving up smoking. These lifestyle choices contribute to the health of the cardiovascular system, which is crucial to developing and maintaining an erection. However, it might take a long time for the body to adapt to these changes and show any improvement, and most men do not want to wait for months or even years before they can resume their normal sexual life. They choose to resort to ED treatments, which are currently available in abundance so that they can suffer minimum disruption to their sexual activities. As a relatively new ED medication, Cialis is growing more and more popular among men who experience problems in the bedroom, diabetes patients are also starting to discover this potent medication which can bring immediate relief for their ED symptoms. Using Cialis in men with diabetes is generally safe, but there are still some tips and recommendations that you’d better be aware of before you start using Cialis. Do not use Cialis if your blood sugar levels are out of control or temporarily unregulated Even though Cialis mechanism of action does not seem to be dependent on the user’s blood sugar levels, studies have shown that men with unregulated blood sugar levels tend to more develop more serious adverse reactions to Cialis as compared to patients Continue reading >>

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