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Trends In Diabetes And Pre-diabetes Prevalence And Diabetes Awareness, Treatment And Control Across Socioeconomic Gradients In Rural Southwest China

Trends In Diabetes And Pre-diabetes Prevalence And Diabetes Awareness, Treatment And Control Across Socioeconomic Gradients In Rural Southwest China

This study aimed to determine trends in pre-diabetes and diabetes prevalence and diabetes awareness, treatment and control across socioeconomic gradients in rural southwest China. Data were collected from two cross-sectional health interviews and examination surveys among individuals aged 35 years in rural China. Fasting blood sugar levels were measured for each participant. From 2009 to 2016, the overall prevalence of pre-diabetes and diabetes increased from 8.4 and 7.7% to 19.0 and 9.5%, respectively, while awareness, treatment and control of diabetes increased from 32.7, 20.0 and 6.1% to 49.3, 32.1 and 13.5%, respectively (P < 0.01). Participants with higher annual incomes had higher diabetes prevalence and treatment levels than their counterparts and showed a remarkably high increase in rate of pre-diabetes (P < 0.01). Whereas prevalence of pre-diabetes and diabetes increased across all ethnic groups during the study period, increased rates of diabetes awareness, treatment and control were only observed among Han Chinese (P < 0.01). Diabetic patients with higher levels of education had higher awareness, control and treatment of diabetes than their counterparts (P < 0.05). The prevalence of pre-diabetes and diabetes and the level of diabetes awareness, treatment and control increased substantially across all socioeconomic gradients in rural southwest China. Continue reading >>

Rate Of Diabetes In China “explosive”

Rate Of Diabetes In China “explosive”

Healthy diet and exercise key to turning the tide BEIJING, 6 April 2016 - Almost 10% of all adults in China – about 110 million people – currently live with diabetes. Without urgent action to reduce lifestyle risk factors like unhealthy diet and lack of physical activity, that number is expected to increase to 150 million by 2040 – with major health, social and economic consequences. The theme of this year’s World Health Day is ‘Beat Diabetes’. This provides an opportunity to reflect on the causes of the increasing prevalence of the disease in China, as well as to discuss what can be done to stem the tide. Type 1 diabetes (sometimes called juvenile diabetes) is characterized by deficient insulin production and requires daily administration of insulin. The cause of Type 1 diabetes is unknown. Type 2 diabetes results from the body’s ineffective use of insulin. Type 2 diabetes comprises 90% of people with diabetes around the world, and is largely the result of excess body weight and physical inactivity. “Rates of Type 2 diabetes in China have exploded in the last couple of decades. In 1980, less than 5% of Chinese men had diabetes. Now, more than 10% do. This increase has been largely driven by unhealthy lifestyles – diets that are too high in sugar and fat, and people not getting enough physical activity,” said Dr Bernhard Schwartländer, WHO Representative in China. Even more startling is the fact that almost half of all adults in China – close to 500 million people – have prediabetes. Not only does this pose a risk factor for developing Type 2 diabetes, but also for other conditions such as cardiovascular disease. Unhealthy diets and lack of physical activity are driving increasing rates of overweight and obesity in China – which are themselves Continue reading >>

Optimal Haemoglobin A1c Cutoff Value For Diabetes Mellitus And Pre-diabetes In Pudong New Area, Shanghai, China | Xianfeng Zhou | Center For Disease Control And Prevention, China | Epidemiology 2017 | Conferenceseries Ltd

Optimal Haemoglobin A1c Cutoff Value For Diabetes Mellitus And Pre-diabetes In Pudong New Area, Shanghai, China | Xianfeng Zhou | Center For Disease Control And Prevention, China | Epidemiology 2017 | Conferenceseries Ltd

Center for Disease Control and Prevention, China Title: Optimal haemoglobin A1c cutoff value for diabetes mellitus and pre-diabetes in Pudong new area, Shanghai, China Introduction: The latest China Guideline for Type 2 diabetes mellitus (T2DM) in 2013 didnt recommend HbA1c for diagnosis of diabetes and pre-diabetes. It requires considerable research to evaluate HbA1c diagnostic threshold for diagnosis of hyperglycaemia. Materials & Methods: We included 7909 subjects aged 15 without known diabetes from the baseline of Pudong community cohort in 2013. Participants took oral glucose tolerance test (OGTT) and HbA1c assay. Receiver operating characteristic curve determined the HbA1c threshold in the diagnosis of hyperglycaemia. Results: The optimal HbA1C threshold for diagnosing newly diagnosed diabetes (NDD) and pre-diabetes in this population was 6.0% (AUC=0.798, 95%CI: 0.779-0.818, P<0.001) and 5.6% (AUC=0.655, 95%CI: 0.638-0.671, P=0.008). The sensitivity (pre-diabetes: 51.78%, NDD: 63.60%) and specificity (pre-diabetes: 72.63%, NDD: 84.86%) of pre-diabetes was lower than NDD. The AUC of HbA1c for diagnosing NDD and pre-diabetes in subjects <60 years was larger than older (60 years) subjects (NDD: P=0.002, pre-diabetes: P=0.02). There were 13.81% and 14.34% of participants would be newly detected as NDD and pre-diabetes via HbA1c criteria; meanwhile almost 3.20% and 15.52% diagnosed as NDD and pre-diabetes by OGTT criteria would be missed diagnosis. Conclusions: The optimal HbA1c thresholds for NDD and pre-diabetes were lower than ADA criteria. HbA1c and OGTT are discordant for diagnosis of hyperglycaemia. It is necessary to carefully consider whether choose HbA1c as a diagnostic criterion or combine two diagnostic standards. Age-specific diagnostic thresholds should b Continue reading >>

Association Between The Hypertriglyceridemic Waist Phenotype And Prediabetes In Chinese Adults Aged 40 Years And Older

Association Between The Hypertriglyceridemic Waist Phenotype And Prediabetes In Chinese Adults Aged 40 Years And Older

Association between the Hypertriglyceridemic Waist Phenotype and Prediabetes in Chinese Adults Aged 40 Years and Older Kun Zhao ,1 Shan-Shan Yang ,2 Hai-Bin Wang ,1 Kang Chen ,1 Zhao-Hui Lu ,1 and Yi-Ming Mu 1 1Department of Endocrinology, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, China 2Institute of Geriatrics, Beijing Key Laboratory of Ageing and Geriatrics, and State Key Laboratory of Kidney Disease, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, China Correspondence should be addressed to Yi-Ming Mu ; [email protected] Received 14 March 2018; Revised 21 May 2018; Accepted 27 May 2018; Published 25 June 2018 Copyright 2018 Kun Zhao et al. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective. To investigate the association between the hypertriglyceridemic waist (HTGW) phenotype and prediabetes in Chinese adults aged 40 years and older. Methods. 12757 adults (4101 men and 8656 women) without diabetes or cardiovascular and cerebrovascular diseases, free of using lipid-modified agents, were enrolled in this cross-sectional study. The HTGW phenotype was defined as elevated serum triglyceride concentrations and enlarged waist circumference. A two-hour post 75 g oral glucose tolerance test was performed in all participants. Multiple logistic regression analysis was used to evaluate the relationship of the HTGW phenotype with prediabetes. Results. Individuals with the HTGW phenotype had a higher adjusted odds ratio (OR: 1.70; 95% CI: 1.481.95) of prediabetes than those without the phenotype. There existed a strong relationship of the HTGW phenotype wit Continue reading >>

Bmj: Can We Trust The Numbers That Define Pre-diabetes?

Bmj: Can We Trust The Numbers That Define Pre-diabetes?

Editor’s note: The following post is by Michael Joyce, MD, who joined HealthNewsReview.org this week as a full-time writer/producer. Michael is a Mayo-trained physician who has transitioned into multimedia journalism. He has written and produced video, radio, and photojournalism in both the US and Asia. We are excited about the new capabilities and insight that he brings to our team. He tweets as @mlmjoyce. Numbers, numbers, numbers. They can impress, legitimize, and (supposedly) don’t lie. Some of the biggest numbers you’ll see in healthcare have to do with projections regarding diabetes. Some examples: the American Diabetes Association (ADA) estimates that by 2050, 1 out of 3 Americans will have diabetes; the World Health Organization (WHO) projects 100 million diabetics in India by 2030, and 150 million in China by 2040. Faced with such impressive numbers, our media messengers struggle to communicate the scale of what we’re up against. We have grown accustomed to hearing about a Type 2 diabetes “epidemic” or “crisis.” Adding gravitas to this perception of catastrophe is the growing acceptance of a condition called “pre-diabetes” in which blood sugar levels that were previously considered marginally elevated are now considered harbingers of inevitable (?) disease. This essentially elevates what was once considered a risk factor into a pre-disease. We are now told that 1 out of 3 Americans are pre-diabetic and 90 percent of us don’t even know it. Given current ADA thresholds for pre-diabetes over half the population of China – nearly 500 million people – would be labeled as vulnerable. According to the the ADA, a fasting blood glucose level of 100 to 125 mg/dL qualifies as pre-diabetic. Likewise, a glycated hemoglobin (commonly referred to as Continue reading >>

Prevalence And Ethnic Pattern Of Diabetes And Prediabetes In China In 2013

Prevalence And Ethnic Pattern Of Diabetes And Prediabetes In China In 2013

ImportancePrevious studies have shown increasing prevalence of diabetes in China, which now has the worlds largest diabetes epidemic.ObjectivesTo estimate the recent prevalence and to investigate the ethnic variation of diabetes and prediabetes in the Chinese adult population.Design, Setting, and ParticipantsA nationally representative cross-sectional survey in 2013 in mainland China, which consisted of 170 287 participants.ExposuresFasting plasma glucose and hemoglobin A1c levels were measured for all participants. A 2-hour oral glucose tolerance test was conducted for all participants without diagnosed diabetes.Main Outcomes and MeasuresPrimary outcomes were total diabetes and prediabetes defined according to the 2010 American Diabetes Association criteria. Awareness and treatment were also evaluated. Hemoglobin A1c concentration of less than 7.0% among treated diabetes patients was considered adequate glycemic control. Minority ethnic groups in China with at least 1000 participants (Tibetan, Zhuang, Manchu, Uyghur, and Muslim) were compared with Han participants.ResultsAmong the Chinese adult population, the estimated standardized prevalence of total diagnosed and undiagnosed diabetes was 10.9% (95% CI, 10.4%-11.5%); that of diagnosed diabetes, 4.0% (95% CI, 3.6%-4.3%); and that of prediabetes, 35.7% (95% CI, 34.1%-37.4%). Among persons with diabetes, 36.5% (95% CI, 34.3%-38.6%) were aware of their diagnosis and 32.2% (95% CI, 30.1%-34.2%) were treated; 49.2% (95% CI, 46.9%-51.5%) of patients treated had adequate glycemic control. Tibetan and Muslim Chinese had significantly lower crude prevalence of diabetes than Han participants (14.7% [95% CI, 14.6%-14.9%] for Han, 4.3% [95% CI, 3.5%-5.0%] for Tibetan, and 10.6% [95% CI, 9.3%-11.9%] for Muslim; P < .001 for Tibet Continue reading >>

47% In China Likely Have Prediabetes Or Diabetes

47% In China Likely Have Prediabetes Or Diabetes

Over 10% of China's population has diabetes -- one of the high prevalence rates in the world -- and more than a third are likely to be prediabetic, according to a new nationally representative study. Led by Limin Wang, MPH, of the Chinese Center for Disease Control and Prevention in Beijing, and colleagues, the analysis reported the estimated standardized prevalence for diabetes among China's population for 2013 was pegged at 10.9% (95% CI 10.4%-11.5), which included diagnosed (4%, 95% CI 3.6%-4.3%) and undiagnosed cases of diabetes. Published in the Journal of the American Medical Association, the prevalence of China's prediabetes population was estimated at 35.7% (95% CI 34.1%-37.4%). Compared to the U.S., which had a combined diabetes and prediabetes estimate of 49%-52% between 2011-2012, China was only slightly lower with a combined 47% prevalence rate in 2013. Following a nationwide survey conducted in 2010, China's prediabetes prevalence was estimated at 50.1%, while their diabetes prevalence was estimated at 11.6%. However, Wang's group suspected these numbers overestimated the true prevalence, and therefore aimed to do better in their current study. The research group drew on data from 170,287 adults who participated in the China Chronic Disease and Risk Factors Surveillance study, conducted every three years. The survey included an in-depth questionnaire to gather information on lifestyle risk factors, medical history, and demographics, as well as physical and lab evaluations (similar to NHANES in the U.S.). All participants not previously diagnosed with diabetes underwent a 2-hour plasma glucose level test with 75 grams of glucose, which was the same measure as was in the 2010 national survey. Fasting blood samples were also collected from all participants to Continue reading >>

Nearly Half Of Chinese Adults Have Diabetes Or Prediabetes

Nearly Half Of Chinese Adults Have Diabetes Or Prediabetes

medwireNews: The latest survey of diabetes in China reports that 47% of the adult population had either diabetes or prediabetes in 2013. Writing in JAMA, the researchers Linhong Wang (Chinese Center for Disease Control and Prevention, Beijing) and colleagues say that these figures indicate China “now has the world’s largest diabetes epidemic.” The survey, which was conducted with a nationally representative population of more than 170,000 participants, estimated that 10.9% of Chinese adults had diabetes and 35.7% – 388.1 million Chinese adults – had prediabetes. The prevalence of diabetes was significantly higher among men, those older than 40 years, those living in urban or economically developed areas, and overweight and obese participants (even when Asian-specific body mass index [BMI] cutoffs were used). The prevalence of diabetes was similar to that reported for the USA in 2011–2012, despite the average BMI of the participants being much lower. But analyses by BMI found that overweight Chinese participants had a far higher prevalence of diabetes than overweight US participants. The authors therefore surmise that “Asians may have a higher risk of developing diabetes at a given BMI,” although the difference was reduced when Asian-specific BMI cutoffs were applied. China has 56 ethnic groups, with Chinese Han forming the majority. The large sample size of this study provided, to the researchers’ knowledge, “the first direct comparison of diabetes prevalence among major minority groups in China within 1 survey” and allowed the identification of several interesting variations with respect to the prevalence of diabetes among the major minorities in China. Of the ethnic groups analyzed in this study (those with ≥1000 participants), Tibetan and Musl Continue reading >>

High Prevalence Of Diabetes, Prediabetes In China

High Prevalence Of Diabetes, Prediabetes In China

A large, nationally representative survey in 2013 of adults in China finds that the estimated overall prevalence of diabetes was about 11 percent and that of prediabetes was nearly 36 percent, according to a study published by JAMA. Previous studies have shown increasing prevalence of diabetes in China, which now has the world's largest diabetes epidemic. To provide more recent estimates of the prevalence of diabetes and prediabetes, Linhong Wang, Ph.D., of the Chinese Center for Disease Control and Prevention, Beijing, and Yonghua Hu, M.D., of Peking University, Beijing, and colleagues analyzed data from a nationally representative survey conducted in 2013 in mainland China, which included 170,287 participants. Fasting plasma glucose and hemoglobin A1c levels were measured for all participants. Diabetes and prediabetes were defined according to the 2010 American Diabetes Association criteria. Among the findings: The estimated prevalence of total diagnosed and undiagnosed diabetes was 10.9 percent; that of diagnosed diabetes, 4 percent; and that of prediabetes, 35.7 percent. Among persons with diabetes, 36.5 percent were aware of their diagnosis and 32.2 percent were treated; 49.2 percent of patients treated had adequate glycemic control. Tibetan and Muslim Chinese had significantly lower prevalence of diabetes than Han participants (14.7 percent for Han, 4.3 percent for Tibetan, and 10.6 percent for Muslim). The authors write that the prevalence of diabetes of 10.9 percent was only slightly lower than the prevalence of total diabetes in the U.S. population (12-14 percent) in 2011-2012. The estimated prevalence of prediabetes in China (35.7 percent) was similar to the U.S. (36.5 percent in 2011-2012). Overall, 47 percent of the Chinese adult population was estimated to Continue reading >>

Diabetes, Prediabetes Prevalence High In Chinese Adults

Diabetes, Prediabetes Prevalence High In Chinese Adults

The overall prevalence of diabetes among adults in China reached nearly 11%, and prevalence of prediabetes reached nearly 36% in 2013, according to nationally representative survey results from that country. “The study has yielded several findings about the prevalence and ethnic variation of diabetes among the major minorities in China,” the researchers wrote. Linhong Wang, PhD, of the National Center for Chronic Noncommunicable Diseases Control and Prevention at the Chinese CDC, and colleagues evaluated data from 170,287 respondents (mean age, 43.5 years; mean BMI, 24 kg/m2; 57% women) to a nationally representative cross-sectional survey conducted in 2013 across mainland China to determine prevalence and ethnic variation of diabetes and prediabetes. The estimated overall standardized prevalence of total diabetes was 10.9% (10.2% in women; 11.7% in men). Older adults (P < .001), men (P < .001), urban residents (P < .001), participants living in economically developed areas (P = .003) and participants with overweight or obesity (P < .001) had a higher prevalence of diabetes compared with their counterparts. In the overall population, the estimated prevalence of prediabetes was 35.7% (35% in women; 36.4% in men). Older adults compared with younger (P < .001), participants with overweight or obesity compared with normal weight (P < .001) and participants living in rural areas compared with urban areas (P = .02) had a higher prevalence of prediabetes. Overall, 36.5% of participants were aware of their diabetes condition; more women (39.8%) were aware compared with men (33.5%). Thirty-two percent of participants with diabetes were receiving antidiabetic medications, and among those treated, 49.2% had HbA1c levels less than 7%. Older adults compared with younger (P < .00 Continue reading >>

Isrctn - Isrctn86375169: Prevention Of Pre-diabetes In Adults

Isrctn - Isrctn86375169: Prevention Of Pre-diabetes In Adults

This study focuses on the negative emotions that play an important role in the development of type 2 diabetes mellitus (T2DM) and its complications. Drug therapy, psychological therapy and psychological health education are used in this study to improve the patients blood glucose levels. We are looking for the right scheme for the prevention and management of pre-diabetes and T2DM. We are also looking for some psychological indicators which would be an early warning for T2DM. Individuals seeing a doctor in the participating hospitals in China. Participants are randomly assigned to one of five groups: the control group (conventional diabetes education only), the metformin group, the psychological treatment group, the anti-depressant group, or the psychological health education group. Participants receive the respective treatments according to the group to which they belong; all participants also receive conventional diabetes education. All subjects are interviewed and take an oral glucose tolerance test (OGTT) at the beginning of the study and are followed up after 1 and 2 years of the study. What are the possible benefits and risks of participating? In addition to helping the participants improve negative emotion and lower their blood glucose, the project helped the hospitals and government provide the right scheme for the prevention and management of pre-diabetes and T2DM. There was no significant risk to participants of the study. This study is run from six hospitals in China. When is the study starting and how long is it expected to run for? The study started in May 2011 and ends in July 2014. The study is funded by the National Key Technology R&D Program. 1. Changes of indicators of the oral glucose tolerance test and glycated hemoglobin reflecting the function of Continue reading >>

High Prevalence Of Diabetes, Prediabetes In China

High Prevalence Of Diabetes, Prediabetes In China

Media Advisory: To contact Linhong Wang, Ph.D., email [email protected]; to contact Yonghua Hu, M.D., email [email protected] To place an electronic embedded link to this study in your story This link will be live at the embargo time: JAMA A large, nationally representative survey in 2013 of adults in China finds that the estimated overall prevalence of diabetes was about 11 percent and that of prediabetes was nearly 36 percent, according to a study published by JAMA. Previous studies have shown increasing prevalence of diabetes in China, which now has the world’s largest diabetes epidemic. To provide more recent estimates of the prevalence of diabetes and prediabetes, Linhong Wang, Ph.D., of the Chinese Center for Disease Control and Prevention, Beijing, and Yonghua Hu, M.D., of Peking University, Beijing, and colleagues analyzed data from a nationally representative survey conducted in 2013 in mainland China, which included 170,287 participants. Fasting plasma glucose and hemoglobin A1c levels were measured for all participants. Diabetes and prediabetes were defined according to the 2010 American Diabetes Association criteria. Among the findings: The estimated prevalence of total diagnosed and undiagnosed diabetes was 10.9 percent; that of diagnosed diabetes, 4 percent; and that of prediabetes, 35.7 percent. Among persons with diabetes, 36.5 percent were aware of their diagnosis and 32.2 percent were treated; 49.2 percent of patients treated had adequate glycemic control. Tibetan and Muslim Chinese had significantly lower prevalence of diabetes than Han participants (14.7 percent for Han, 4.3 percent for Tibetan, and 10.6 percent for Muslim). The authors write that the prevalence of diabetes of 10.9 percent was only slightly lower than the prevalence of total Continue reading >>

[geographical Variation And Related Factors In Prediabetes Prevalence In Chinese Adults In 2013].

[geographical Variation And Related Factors In Prediabetes Prevalence In Chinese Adults In 2013].

[Geographical variation and related factors in prediabetes prevalence in Chinese adults in 2013]. National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China. More 1.National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China. DOI: 10.3760/cma.j.issn.0253-9624.2018.02.008 Objective: To investigate the geographical variation of prediabetes in adults in different regions of China, and to analyze the related factors of prediabetes. Methods: Data was obtained from China Chronic Disease and Related Risk Factor Surveillance in 2013. The surveillance adopted multiple-stage stratified cluster random sampling method, which sampled 177 099 residents aged above 18 years old among 298 surveillance points in 31 provinces of Chinese Mainland. Questionnaire interview was used to obtain demographic variables, personal living style, and socio-economical information. Physical examination was conducted and fasting venous blood sample and (oral glucose tolerance test-2 hours, OGTT-2 h) venous blood sample were obtained from the participants. A total of 171 567 residents aged 18 and above were included in the analysis. The prevalence of prediabetes was analyzed by provinces and by China's geographical regions, after complex weighting. Multilevel logistic models were established to explore the related factors of prediabetes on the area level and individual level. Results: The prevalence of prediabetes among residents aged 18 and above was 16.6% (95%CI: 15.6%-17.6%) in China. The prevalence of prediabetes was the highest (18.3%) in the south China and lowest (13.1%) in the northwest area. The difference of Continue reading >>

Half Of China Has Prediabetes

Half Of China Has Prediabetes

My family medicine colleagues and I recently have noticed an alarming increase in our patients blood sugar levels testing high for diabetes and prediabetes, so much so that we figured it must be a lab error. But our lab confirmed these indeed were accurate, and now a recent paper published in the esteemed Journal of the American Medical Association confirms the frightening reality in China: more than half of all persons in China now are prediabetic. Even worse, 11.2% have diabetes, giving China the dubious and unwanted distinction of having the highest prevalence of diabetes in the world. This is now higher than in the USA, an extraordinary statement given the far higher rate of obesity in the USA. As November 14th is World Diabetes Day , I felt a timely urgency to share my advice on how to avoid this disease or at least to slow it down. It helps to think of diabetes as a modern lifestyle disease, mostly caused by all developing countries gains in weight, less physical activity, and changes in diet. Diabetes now is a global pandemic. Tens of millions of people have diabetes, and many people are undiagnosed because theyve never been tested. There are two types of diabetes, and type 2 diabetes accounts for 90 to 95 percent of diagnosed diabetes in adults. Diabetes is a disease caused by your body losing the ability to properly digest and use sugars and starches in your foods, thus leading to high levels in your blood. Too much glucose floating around your bloodstream for many years can cause many toxic problems to your organs if not treated especially with your eyes, kidneys and lower legs. For example, diabetes is the leading cause of kidney failure, non-traumatic lower-limb amputation and new cases of blindness among adults in much of the world. Diabetes also raises yo Continue reading >>

Effect Of Probiotics On Pre-diabetes And Diabetes In China

Effect Of Probiotics On Pre-diabetes And Diabetes In China

You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect of Probiotics on Pre-diabetes and Diabetes in China The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. ClinicalTrials.gov Identifier: NCT03377946 Information provided by (Responsible Party): Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information This study is aimed at verifying the effects of probiotics (KAWAI:dead S.thermophilus) on glucos management among T2DM and pre-diabetes Chinese adult. Additionally, the investigators intend to verify the effects of probiotics on modifying the structure and function of gut microbiome. Methods: double-blind, randomized controlled trial. Number of participants: 160 patients with pre-diabetes and 60 diabetes. Intervention time: 3months. Data and Specimen collection time: at baseline and after the intervention. Physical measurement: gender, age, weight, BMI, waist circumference, hip circumference, waist-to-hip ratio, systolic pressure, diastolic blood pressure. Lifestyle questionnaire: diet, drinking, exercise, sleep and other habits. Blood test: blood glucose, OGTT, blood lipid, TNF-a, il-6, il-10, LPS, glp-1, gut microbiome metabolism products, T2DM related methylation. 4. Gut microbiome detection: gut microbiome 16Sr DNA sequencing, gut microbiome bioinformatics analysis Effect of Probiotics on Pre-diabetes and Diabetes in China-the Role of Gut M Continue reading >>

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