Drug-induced Diabetes
DIABETES is a well-known disease these days. It occurs when the sugar or glucose levels rise inside the human body. This rise in blood sugar levels takes place due to abnormal functioning of the cells known as β-cells of pancreas. Under normal conditions, these cells release insulin on requirement to transfer glucose from blood to the tissues/cells for energy. This transfer balances blood sugar levels. The misconduct of these β-cells disturbs the balance of blood sugar levels and causes diabetes. The activity of β-cells can be disturbed due to many reasons. One of those reasons is the consumption of some therapeutic agents. THERAPEUTIC AGENTS can influence the development of diabetes, especially when pre-existing risk factors are present and these may cause glucose control to deteriorate if administered to those with existing diabetes. It has been found that drug-induced diabetes can develop at the age of 20 years but it is more prone at the age between 40-60 years. The chances of development of drug-induced diabetes are found to be more in females (70%) as compared to males (30%). ACTION OF DRUGS INDUCING DIABETES Therapeutic agents causing diabetes may act either by increasing insulin resistance or by affecting the secretion of insulin or both. Drugs that cause diabetes by interfering with insulin production & secretion are: β-receptor antagonist (used in hypoglycemia) Tacrolimus (immunosuppressant used in organ transplant) Priminil (Vacor) (used as rodenticide) Didanosine (used as anti-retroviral therapy) Pentamidine (antimicrobial medication in used in pneumonia) L-asparaginase (as anti-cancer agent) Diphenylhydantoin (used as anticonvulsant or antilepptic drug) Opiates (used as pain reliever) Drugs that cause diabetes by developing insulin resistance: Glucocort Continue reading >>
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Steroid Diabetes
Steroid diabetes (also "steroid-induced diabetes") is a medical term referring to prolonged hyperglycemia due to glucocorticoid therapy for another medical condition. It is usually, but not always, a transient condition. Medical conditions[edit] The most common glucocorticoids which cause steroid diabetes are prednisolone and dexamethasone given systemically in "pharmacologic doses" for days or weeks. Typical medical conditions in which steroid diabetes arises during high-dose glucocorticoid treatment include severe asthma, organ transplantation, cystic fibrosis, inflammatory bowel disease, and induction chemotherapy for leukemia or other cancers. Insulin[edit] Glucocorticoids oppose insulin action and stimulate gluconeogenesis, especially in the liver, resulting in a net increase in hepatic glucose output. Most people can produce enough extra insulin to compensate for this effect and maintain normal glucose levels, but those who cannot develop steroid diabetes. Criteria[edit] The diagnostic criteria for steroid diabetes are those of diabetes (fasting glucoses persistently above 125 mg/dl (7 mM) or random levels above 200 mg/dl (11 mM)) occurring in the context of high-dose glucocorticoid therapy. Insulin levels are usually detectable, and sometimes elevated, but inadequate to control the glucose. In extreme cases the hyperglycemia may be severe enough to cause nonketotic hyperosmolar coma. Treatment[edit] Treatment depends on the severity of the hyperglycemia and the estimated duration of the steroid treatment. Mild hyperglycemia in an immunocompetent patient may not require treatment if the steroids will be discontinued in a week or two. Moderate hyperglycemia carries an increased risk of infection, especially fungal, and especially in people with other risk factors s Continue reading >>
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Medicationinduced Diabetes Mellitus
Department of Pediatrics, University of Virginia, Charlottesville Corresponding Author: David R. Repaske, Department of Pediatrics, University of Virginia, Charlottesville, VA ( Department of Pediatrics, University of Virginia, Charlottesville Corresponding Author: David R. Repaske, Department of Pediatrics, University of Virginia, Charlottesville, VA ( Please review our Terms and Conditions of Use and check box below to share full-text version of article. I have read and accept the Wiley Online Library Terms and Conditions of Use. Use the link below to share a full-text version of this article with your friends and colleagues. Learn more. Epidemiological studies and case reports have demonstrated an increased rate of development of diabetes mellitus consequent to taking diverse types of medication. This review explores this evidence linking these medications and development of diabetes and presents postulated mechanisms by which the medications might cause diabetes. Some medications are associated with a reduction in insulin production, some with reduction in insulin sensitivity, and some appear to be associated with both reduction in insulin production and insulin sensitivity. A variety of medications have been associated with development of diabetes. Establishing a precise cause and effect relationship between a medication and development of diabetes is challenging for several reasons. Side effects of most medications are rare and clinical studies of medications typically evaluate effectiveness and are not powered to evaluate side effects. Diabetes is a common disease and there is always a question of whether it would have developed if the person had not taken the medication in question. Patients are often taking multiple medications and so it is hard to determine w Continue reading >>
Drug-induced Diabetes Mellitus.
1. Expert Opin Drug Saf. 2005 Nov;4(6):1097-109. Izzedine H(1), Launay-Vacher V, Deybach C, Bourry E, Barrou B, Deray G. (1)Department of Nephrology, Pitie-SalPetriere Hospital, Paris, France. [email protected] AIMS: To review the medications that influence glucose metabolism with a focus onhypertensive, transplant and HIV-infected patient populations.METHODS: Literature obtained from a MEDLINE search from 1970 to present,including studies published in the English language. The search strategy linkeddrugs, hyperglycaemia and diabetes mellitus, HIV, transplantation, hypertensionand psychiatric patients.RESULTS: Many common therapeutic agents influence glucose metabolism. Multiplemechanisms of action on glucose metabolism exist through pancreatic, hepatic and peripheral effects. The prevalence of hyperglycaemia was higher with the use ofthiazide diuretic, beta-blocker, calcineurin, protease inhibitors and atypicalantipsychotic drugs.CONCLUSIONS: Patients treated with those drugs appear to be at increased risk fordeveloping diabetes. It is prudent to monitor plasma glucose values when it isnot possible to avoid prescription of medication with known effects oncarbohydrate metabolism. Continue reading >>
Effect Of L-arginine-nitric Oxide System On The Metabolism Of Essential Fatty Acids In Chemical-induced Diabetes Mellitus - Sciencedirect
Effect of L-arginine-nitric oxide system on the metabolism of essential fatty acids in chemical-induced diabetes mellitus Author links open overlay panel I.Krishna Mohana U.N.Dasab Get rights and content Several studies have shown that the activities of delta-6-desaturase and delta-5-desaturase are depressed in experimental diabetes and in humans with insulin- and non-insulin-dependent diabetes mellitus (type I and type II diabetes mellitus respectively). Furthermore, treatment with insulin is known to correct the defects in desaturases in rats and humans with diabetes, especially in type I. In a recent study, we demonstrated that L-arginine and nitric oxide can prevent alloxan-induced cell damage, and the severity of diabetes, and restore the antioxidant status to near normal levels. But, no information is available as to the relationship between L-arginine-nitric oxide system and the metabolism of essential fatty acids in diabetes mellitus. In the present study, it was noted that the plasma levels of saturated fatty acids: stearic and palmitic were increased where as unsaturated fatty acids such as oleic, linoleic, -linolenic and eicosapentaenoic acids (OA, LA, GLA and EPA respectively) were decreased in alloxan-induced diabetic rats. In the liver phospholipid (PL) fraction, GLA, DGLA (dihomo-GLA) and -linolenic acid (ALA) were decreased in the alloxan-treated group; in the muscle PL fraction, LA, GLA and DGLA were low, whereas an increase in the saturated fatty acid content was noted. L-arginine (the precursor of nitric oxide) and sodium nitroprusside (a nitric oxide donor) treatment of alloxan-induced diabetic rats enhanced the levels of LA, GLA and DGLA. Further, nitric oxide synthase inhibitor, L-NMMA, prevented this beneficial action of L-arginine-nitric oxide s Continue reading >>
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2018 Icd-10-cm Diagnosis Code E09.51
E09- Drug or chemical induced diabetes mellitus Drug or chemical induced diabetes mellitus with diabetic peripheral angiopathy without gangrene E09.51 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. Short description: Drug/chem diabetes w diabetic prph angiopath w/o gangrene The 2018 edition of ICD-10-CM E09.51 became effective on October 1, 2017. This is the American ICD-10-CM version of E09.51 - other international versions of ICD-10 E09.51 may differ. The following code(s) above E09.51 contain annotation back-references In this context, annotation back-references refer to codes that contain: Endocrine, nutritional and metabolic diseases All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8 , E07.0 , E16 - E31 , E34.- ) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere. transitory endocrine and metabolic disorders specific to newborn ( P70-P74 ) Endocrine, nutritional and metabolic diseases Drug or chemical induced diabetes mellitus 2016 2017 2018 Non-Billable/Non-Specific Code poisoning due to drug or toxin, if applicable ( T36 - T65 with fifth or sixth character 1-4 or 6) secondary diabetes mellitus NEC ( E13.- ) code for adverse effect, if applicable, to identify drug ( T36-T50 with fifth or sixth character 5) Drug or chemical induced diabetes mellitus Drug induced diabetes with peripheral vascular disease Peripheral vascular disease without gangrene due to drug induced diabetes mellitus ICD-10-CM E09.51 is grouped within Diagnostic Related Group(s) (MS- Continue reading >>
Icd 10 Code For Drug Or Chemical Induced Diabetes Mellitus With Ophthalmic Complications E09.3
Questions related to E09.3 Drug or chemical induced diabetes mellitus with ophthalmic complications The word 'Includes' appears immediately under certain categories to further define, or give examples of, the content of thecategory. A type 1 Excludes note is a pure excludes. It means 'NOT CODED HERE!' An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition. A type 2 Excludes note represents 'Not included here'. An Excludes2 note indicates that the condition excluded is not part of the condition it is excluded from but a patient may have both conditions at the same time. When an Excludes2 note appears under a code it is acceptable to use both the code and the excluded code together. A code also note instructs that 2 codes may be required to fully describe a condition but the sequencing of the two codes is discretionary, depending on the severity of the conditions and the reason for the encounter. Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists there is a 'use additional code' note at the etiology code, and a 'code first' note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation. In most cases the manifestation codes will have in the code title, 'in diseases classified elsewhere.' Codes with this title area component of the etiolo Continue reading >>
Chemically And Hormonally Induced Diabetes Mellitus
Chemically and Hormonally Induced Diabetes Mellitus The purpose of this chapter is to provide a review of the literature pertaining to chemically induced diabetes mellitus since 1977, the year when the first edition of this book was published. A thorough historical account (prior to 1977) of this topic has been published.1 This chapter is divided into four sections. The first two parts discuss the two chemical agents most widely used to induce diabetes mellitus in animals: streptozotocin and alloxan. The third section encompases various agents that cause transient or permanent hyperglycemia in man or experimental animal models. These agents include -cytotoxic chemicals (dithizone, benzothiazides, Vacor, etc.), L-asparaginase, and a compound damaging the ventromedial hypothalamus (monosodium glutamate). The fourth section discusses the insulin-counteracting hormones, i.e., glucagon, growth hormone, sex hormones, and catecholamines. Growth HormonePancreatic IsletTestosterone TreatmentMonosodium GlutamateGlucagon Release These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves. This is a preview of subscription content, log in to check access Unable to display preview. Download preview PDF. Dulin, W. E., and Soret, M. G.: In: The Diabetic Pancreas. Edited by B. W. Volk and K. F. Wellmann. Plenum Press, New York, 1977, p. 425. Google Scholar Craighead, J.E.: Monog. Pathol 21:166, 1980. Google Scholar Mordes, J. P., and Rossini, A.A.: Am. J. Med., 70:353, 1981. PubMed Google Scholar Rudas, B.: Arzneim. Forsch., 22:830, 1972. Google Scholar Phares, C. K.: Experientia, 36:681, 1980. PubMed Google Scholar Marshall, M.: Res. Exp. Med., 175:187, 1979. Google Scholar Stangassinger, Continue reading >>
Medication-induced Diabetes Mellitus
Abstract Epidemiological studies and case reports have demonstrated an increased rate of development of diabetes mellitus consequent to taking diverse types of medication. This review explores this evidence linking these medications and development of diabetes and presents postulated mechanisms by which the medications might cause diabetes. Some medications are associated with a reduction in insulin production, some with reduction in insulin sensitivity, and some appear to be associated with both reduction in insulin production and insulin sensitivity. 1 INTRODUCTION A variety of medications have been associated with development of diabetes. Establishing a precise cause and effect relationship between a medication and development of diabetes is challenging for several reasons. Side effects of most medications are rare and clinical studies of medications typically evaluate effectiveness and are not powered to evaluate side effects. Diabetes is a common disease and there is always a question of whether it would have developed if the person had not taken the medication in question. Patients are often taking multiple medications and so it is hard to determine which medication was responsible for the side effect. For example, organ transplant patients may be taking a glucocorticoid and a calcineurin inhibitor, so an epidemiological study has difficulty ascribing the side effect to one or the other or the combination of these medications. There are also covariants such as the weight gain associated with steroids or antipsychotics making it difficult to know if development of diabetes was a primary or secondary effect of the medication. When we turn to deciphering the mechanism by which a medication caused diabetes, there are often multiple plausible molecular mechanisms ident Continue reading >>
Drug-induced Diabetes
Many therapeutic agents can predispose to or precipitate diabetes, especially when pre-existing risk factors are present, and these may cause glucose control to deteriorate if administered to those with existing diabetes. They may act by increasing insulin resistance, by affecting the secretion of insulin, or both. For convenience, these agents may be subdivided into widely used medications that are weakly diabetogenic, and drugs used for special indications that are more strongly diabetogenic. Examples of the former include antihypertensive agents and statins, and examples of the latter include steroids, antipsychotics and a range of immunosuppressive agents. There are also a number of known beta cell poisons including the insecticide Vacor, alloxan and streptozotocin. Introduction A wide range of therapeutic agents may affect glucose tolerance, and the list of known or suspected drugs is lengthy. This entry summarizes evidence concerning the agents most frequently implicated. Widely used medications A number of drugs used to reduce cardiovascular risk also predispose to the development of diabetes. These include the thiazide diuretics, beta-blockers and statins. It should however be appreciated that these are commonly offered to individuals who are at increased risk of diabetes by virtue of risk factors such as obesity and hypertension, and that risk association does not necessarily mean causation. Thiazides: Thiazide diuretics revolutionized the treatment of hypertension in the 1960s, but were soon noted to increase the risk of diabetes[1]. Subsequent experience showed that that this risk is greatly reduced by low-dose therapy, whose benefits therefore outweigh its risks. The thiazides have a weak inhibitory effect upon release of insulin from the beta cell. This eff Continue reading >>
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- Leeds diabetes clinical champion raises awareness of gestational diabetes for World Diabetes Day
- Diabetes doctors: Which specialists treat diabetes?
Drug Or Chemical Induced Diabetes Mellitus W/o Complications
ICD-10: E09.9 Short Description: Drug or chemical induced diabetes mellitus w/o complications Long Description: Drug or chemical induced diabetes mellitus without complications This is the 2018 version of the ICD-10-CM diagnosis code E09.9 Valid for Submission The code E09.9 is valid for submission for HIPAA-covered transactions. Code Classification Endocrine, nutritional and metabolic diseases (E00–E90) Diabetes mellitus (E08-E13) Drug or chemical induced diabetes mellitus (E09) Convert to ICD-9 Synonyms Diabetes mellitus caused by drug without complication Diabetes mellitus caused by non-steroid drugs Diabetes mellitus caused by non-steroid drugs without complication Drug-induced diabetes mellitus Drug-induced diabetes mellitus Steroid-induced diabetes Steroid-induced diabetes mellitus without complication Diabetes Also called: DM, Diabetes mellitus Diabetes is a disease in which your blood glucose, or blood sugar, levels are too high. Glucose comes from the foods you eat. Insulin is a hormone that helps the glucose get into your cells to give them energy. With type 1 diabetes, your body does not make insulin. With type 2 diabetes, the more common type, your body does not make or use insulin well. Without enough insulin, the glucose stays in your blood. You can also have prediabetes. This means that your blood sugar is higher than normal but not high enough to be called diabetes. Having prediabetes puts you at a higher risk of getting type 2 diabetes. Over time, having too much glucose in your blood can cause serious problems. It can damage your eyes, kidneys, and nerves. Diabetes can also cause heart disease, stroke and even the need to remove a limb. Pregnant women can also get diabetes, called gestational diabetes. Blood tests can show if you have diabetes. One t Continue reading >>
E09.0 Drug Or Chemical Induced Diabetes Mellitus With Hyperosmolarity
E09.0 Drug or chemical induced diabetes mellitus with hyperosmolarity Drug or chemical induced diabetes mellitus with hyperosmolarity Drug or chemical induced diabetes mellitus with hyperosmolarity Synonym for Drug or chemical induced diabetes mellitus with hyperosmolarity E00-E89 Endocrine, nutritional and metabolic diseases (E00-E89)|E08-E13 Diabetes mellitus (E08-E13)|E09 Drug or chemical induced diabetes mellitus Results for Drug or chemical induced diabetes mellitus with hyperosmolarity and additional synonyms Drug or chemical induced diabetes mellitus with hyperosmolarity Drug or chemical induced diabetes mellitus with hyperosmolarity E09.00 Drug or chemical induced diabetes mellitus with hyperosmolarity without nonketotic hyperglycemic-hyperosmolar coma (NKHHC)|E09.01 Drug or chemical induced diabetes mellitus with hyperosmolarity with coma All content of the ICD-10 CM Search is based on the classifications and codes of the Centers for Medicare and Medicaid Services (CMS) and the National Center for Health Statistics (NCHS) . The accumulation of synonyms is carried out by Averbis GmbH with Healthcare Natural Language Processing . All information is provided without guarantee. Errors and omissions excepted. We expressly reserve the right to make changes, additions or deletions to the information or links provided at any time without prior notice. Our offer is non-binding. For correctness, completeness and topicality or designations no liability is assumed. ICD-Search ICD 10 CM (Clinical Modification) 2017 ICD-Code / International Statistical Classification of Diseases and Related Health Problems (ICD) for: Drug or chemical induced diabetes mellitus with hyperosmolarity ICD Code an Classification Drug or chemical induced diabetes mellitus with hyperosmolarity Chap Continue reading >>
Drug Or Chemical Induced Diabetes Mellitus With Hyperglycemia
E09.65 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. Short description: Drug or chemical induced diabetes mellitus w hyperglycemia This is the American ICD-10-CM version of E09.65 - other international versions of ICD-10 E09.65 may differ. Continue reading >>
E09.3 Drug Or Chemical Induced Diabetes Mellitus With Ophthalmic Complications
E09.3 Drug or chemical induced diabetes mellitus with ophthalmic complications Drug or chemical induced diabetes mellitus with ophthalmic complications Drug or chemical induced diabetes mellitus with ophthalmic complications Synonym for Drug or chemical induced diabetes mellitus with ophthalmic complications E00-E89 Endocrine, nutritional and metabolic diseases (E00-E89)|E08-E13 Diabetes mellitus (E08-E13)|E09 Drug or chemical induced diabetes mellitus Results for Drug or chemical induced diabetes mellitus with ophthalmic complications and additional synonyms Drug or chemical induced diabetes mellitus with ophthalmic complications Drug or chemical induced diabetes mellitus with ophthalmic complications E09.31 Drug or chemical induced diabetes mellitus with unspecified diabetic retinopathy|E09.32 Drug or chemical induced diabetes mellitus with mild nonproliferative diabetic retinopathy|E09.33 Drug or chemical induced diabetes mellitus with moderate nonproliferative diabetic retinopathy|E09.34 Drug or chemical induced diabetes mellitus with severe nonproliferative diabetic retinopathy|E09.35 Drug or chemical induced diabetes mellitus with proliferative diabetic retinopathy|E09.36 Drug or chemical induced diabetes mellitus with diabetic cataract|E09.37 Drug or chemical induced diabetes mellitus with diabetic macular edema, resolved following treatment|E09.39 Drug or chemical induced diabetes mellitus with other diabetic ophthalmic complication All content of the ICD-10 CM Search is based on the classifications and codes of the Centers for Medicare and Medicaid Services (CMS) and the National Center for Health Statistics (NCHS) . The accumulation of synonyms is carried out by Averbis GmbH with Healthcare Natural Language Processing . All information is provided without gua Continue reading >>
2018 Icd-10-cm Codes E09*: Drug Or Chemical Induced Diabetes Mellitus
E08 Diabetes mellitus due to underlying condition... E08.0 Diabetes mellitus due to underlying condition... E08.00 Diabetes mellitus due to underlying condition... E08.01 Diabetes mellitus due to underlying condition... E08.1 Diabetes mellitus due to underlying condition... E08.10 Diabetes mellitus due to underlying condition... E08.11 Diabetes mellitus due to underlying condition... E08.2 Diabetes mellitus due to underlying condition... E08.21 Diabetes mellitus due to underlying condition... E08.22 Diabetes mellitus due to underlying condition... E08.29 Diabetes mellitus due to underlying condition... E08.3 Diabetes mellitus due to underlying condition... E08.31 Diabetes mellitus due to underlying condition... E08.311 Diabetes mellitus due to underlying condition... E08.319 Diabetes mellitus due to underlying condition... E08.32 Diabetes mellitus due to underlying condition... E08.321 Diabetes mellitus due to underlying condition... E08.3211 Diabetes mellitus due to underlying condition... E08.3212 Diabetes mellitus due to underlying condition... E08.3213 Diabetes mellitus due to underlying condition... E08.3219 Diabetes mellitus due to underlying condition... E08.329 Diabetes mellitus due to underlying condition... E08.3291 Diabetes mellitus due to underlying condition... E08.3292 Diabetes mellitus due to underlying condition... E08.3293 Diabetes mellitus due to underlying condition... E08.3299 Diabetes mellitus due to underlying condition... E08.33 Diabetes mellitus due to underlying condition... E08.331 Diabetes mellitus due to underlying condition... E08.3311 Diabetes mellitus due to underlying condition... E08.3312 Diabetes mellitus due to underlying condition... E08.3313 Diabetes mellitus due to underlying condition... E08.3319 Diabetes mellitus due to underlyin Continue reading >>
