Type 1 Diabetes Linked To Coeliac Disease
Type 1 diabetes is an autoimmune disease that causes the body's immune system to mistakenly attack the insulin-producing cells in the pancreas, according to the American Diabetes Association. Parents of young children with type 1 diabetes need to be on the lookout for symptoms of another autoimmune condition – coeliac disease, new research suggests. The study found these youngsters appear to face a nearly tripled risk of developing coeliac disease autoantibodies, which eventually can lead to the disorder, which is chronic and causes an intolerance to gluten, which damages the small intestinal lining. The severity of symptoms differs from person to person. Genetically related "Type 1 diabetes and coeliac disease are closely related genetically," explained study author Dr William Hagopian. "People with one disease tend to get the other. People who have type 1 diabetes autoantibodies should get screened for coeliac autoantibodies," Hagopian said. He directs the diabetes programme at the Pacific Northwest Research Institute in Seattle. Insulin is a hormone that helps to usher the sugar from foods into the body's cells to be used as fuel. Because the autoimmune attack leaves people with type 1 diabetes without enough insulin, they must replace the lost insulin through injections or an insulin pump with a temporary tube inserted under the skin. Coeliac disease is an autoimmune disease that causes the immune system to attack the lining of the small intestine when gluten is consumed, according to the Coeliac Disease Foundation. Gluten is a protein found in wheat. Symptoms of coeliac disease include stomach pain and bloating, diarrhea, vomiting, constipation, weight loss, fatigue and delayed growth and puberty. Early diagnosis important Dr James Grendell is chief of the divisi Continue reading >>
3 Ways Having Type 1 Diabetes Makes Me A Better Parent
There was absolutely a time in my life when I firmly believed I shouldn’t get pregnant and give birth to my own children because of reasons like, “This body isn’t a good environment for a baby to grow inside of” or “My body is under enough stress, why would I put it through pregnancy?” And what about after the baby was born? Surely that baby would interfere with my own self-care of the chronic illnesses I’ve been diagnosed with. And for some, those may be very valid reasons not to become pregnant, but for me, I’m actually pretty darn healthy despite having type 1 diabetes, celiac disease and fibromyalgia. On paper, when you don’t look at those diagnoses, I’m a healthy gal at a healthy weight, healthy blood pressure, yada yada yada. No doctor had ever told me I couldn’t pursue pregnancy. If anything, the opposite was encouraged. About two years after falling in love with my husband, it suddenly dawned on me: I can absolutely handle pregnancy and giving birth to my own children. I can do this. And I want this. I was suddenly done letting fear stand in the way of something I genuinely wanted: creating a family with my husband. Here are three reasons I am so grateful I didn’t let fear prevent me from pursuing pregnancy and motherhood: 1. It gave me a new appreciation for what my body can do. My body can’t produce insulin. My body can’t digest gluten properly. My body severely overreacts with symptoms of intense pain and extreme exhaustion for reasons medical researchers still don’t understand when I use my muscles and joints for anything beyond the mundane tasks of daily life. But my body can create this life. This gorgeous, happy, healthy little baby girl…my body made her. Sure, my husband helped, but my body did the majority of the work. Me Continue reading >>
Newborn Babies To Be Screened For Studies On Type 1 Diabetes And Celiac Disease (gluten Intolerance)
Newborn babies to be screened for studies on type 1 diabetes and celiac disease (gluten intolerance) Can insulin taken as an infant in small doses together with food render the immune system used to insulin and thus prevent type 1 diabetes? Can a gluten-free diet and probiotics prevent celiac disease (so called gluten intolerance)? These questions will be asked by two separate studies that are being planned at Lund University in Sweden. A new comprehensive screening of newborn babies in southern Sweden is projected to commence this spring, in order to identify children with an elevated risk of type 1 diabetes or celiac disease. Lund University has received a grant of more than SEK 3 million over one year from The Leona M. And Harry B. Helmsley Charitable Trust to get ready for screening of newborn children. We will be looking for children with increased hereditary risk for type 1 diabetes or celiac disease with the hope of preventing the onset of these diseases, says Jeanette kerstrm Krdel, who is the study coordinator. The screening is intended to identify children with increased hereditary risk of autoimmune type 1 diabetes or celiac disease and ask the parents to participate with their baby in two new studies. A blood sample will be taken from the childs umbilical cord, which is both risk-free and painless. Half of the children in the autoimmune type 1 diabetes study are planned to be given oral insulin; the other half a placebo. They will receive one dose per day from the ages of 47 months until they turn three years of age. The insulin (or placebo) is an odourless, taste-free powder made up of tiny crystals to be consumed in small portions. It comes in small capsules which are opened and the content is mixed with food. The dosage has been tested in previous studie Continue reading >>
Type 1 Diabetes
Maya — who has — started feeling tired and sluggish all the time, but her blood sugar levels were in a healthy range, so her mom thought she was OK. She didn't realize that another problem could be causing the fatigue until medical tests revealed that Maya had a thyroid problem. Maya's situation isn't uncommon — kids and teens with type 1 diabetes have a greater risk for certain other health problems, many of which also are autoimmune disorders. Although their diabetes health care teams will monitor kids for signs of these problems, parents also should know what to watch for so that they can alert doctors and seek treatment, if necessary. About Autoimmune Disorders In autoimmune disorders, the immune system mistakenly attacks the body's healthy tissues as though they were foreign invaders. A severe attack can get interfere with the function of that body part. Type 1 diabetes is an autoimmune disease in which the pancreas can't make insulin because the immune system attacks it and destroys the cells that produce insulin. Kids and teens with type 1 diabetes are at risk for other autoimmune problems, but these disorders are not actually caused by the diabetes. Doctors still aren't exactly sure why autoimmune diseases occur, but genetic factors probably play an important role because relatives of people with type 1 diabetes are more likely to have autoimmune diseases. Most kids with type 1 diabetes never need treatment for any other autoimmune disorder. But those who do might develop: thyroid disorders celiac disease Addison's disease These disorders, which aren't caused by problems with blood sugar control, can develop before a child is diagnosed with type 1 diabetes or months or years after the diabetes diagnosis. Thyroid Disorders Kids and teens with type 1 diabete Continue reading >>
The Role Of Gluten In Celiac Disease And Type 1 Diabetes
The Role of Gluten in Celiac Disease and Type 1 Diabetes Gloria Serena ,1,2, Stephanie Camhi ,1, Craig Sturgeon ,1,2 Shu Yan ,1 and Alessio Fasano 1,* 1Center for Celiac Research, Mucosal Immunology and Biology Research Center, Massachusetts General Hospital and Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital for Children, Boston, MA 02114, USA; E-Mails: [email protected] (G.S.); [email protected] (S.C.); [email protected] (C.S.); [email protected] (S.Y.) 2Graduate Program in Life Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA 1Center for Celiac Research, Mucosal Immunology and Biology Research Center, Massachusetts General Hospital and Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital for Children, Boston, MA 02114, USA; E-Mails: [email protected] (G.S.); [email protected] (S.C.); [email protected] (C.S.); [email protected] (S.Y.) 1Center for Celiac Research, Mucosal Immunology and Biology Research Center, Massachusetts General Hospital and Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital for Children, Boston, MA 02114, USA; E-Mails: [email protected] (G.S.); [email protected] (S.C.); [email protected] (C.S.); [email protected] (S.Y.) 2Graduate Program in Life Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA 1Center for Celiac Research, Mucosal Immunology and Biology Research Center, Massachusetts General Hospital and Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital for Children, Boston, MA 02114, USA; E-Mails: [email protected] (G.S.); [email protected] (S.C.); [email protected] (C.S.); u Continue reading >>
The Link Between Celiac Disease And Type 1 Diabetes
Home The Link Between Celiac Disease and Type 1 Diabetes The Link Between Celiac Disease and Type 1 Diabetes Managing type 1 diabetes is old hat to 31-year-old Catherine Oddenino. The New Yorker has had the disease since she was 11, and is adept at counting carbohydrates and dosing insulin. But in her mid-20s she was thrown a curveball. Whenever she ate something, she felt like she had food poisoning. After a visit to her doctor, she cut dairy from her diet . But she was also sent to a gastroenterologist who, tipped off by the fact that she had diabetes, immediately tested her for celiac disease . Two weeks later and it was official: the culprit of her poisoning was gluten, not dairy. Now, on top of being keenly aware of how many carbohydrates are in each of her meals and how that will affect her blood sugar levels, Oddenino has to make sure not a speck of gluten is in the food she eats. Oddenino is by no means the only one living with this dietary juggling act. Study results vary but, according to the American Diabetes Association, an estimated one in 20 type 1 diabetics also has celiac disease. In contrast, the rate in the general population is one in 100. Diabetes and celiac disease are auto-immune disorders, along with some thyroid diseases , multiple sclerosis and rheumatoid arthritis, among others. This means an overactive immune system causes the body to attack its own cells. The science is still emerging to explain how type 1 diabetes and celiac disease are related. According to Dr. Alessio Fasano, medical director of the Center for Celiac Research at the University of Maryland, there are two schools of thought: first, the diseases share common genes. A study published inThe New England Journal of Medicine in 2008 found almost every gene associated with celiac Continue reading >>
Eating Right With Celiac Disease And Diabetes
Managing diabetes means monitoring your carbohydrate intake to help prevent spikes in your blood sugar levels. An additional diagnosis of celiac disease adds another layer of complexity to eating. Celiac disease is an autoimmune disorder in which people cannot tolerate gluten.1 Gluten is a protein found in wheat, barley, and rye—it helps dough rise and keep its shape and texture. Treatment of celiac includes eating a gluten-free diet. Common foods that are made with gluten include:2 pasta; bread; cereal; beverages such as beer; couscous; tortillas; crackers; cookies, cakes, muffins, and pastries; dressings, sauces, and gravies; and wheat-based flours such as white flour, wheat flour, kamut, semolina, spelt, and wheat bran. This list might seem overwhelming, but there are a variety of gluten-free versions of popular foods such as bread, pasta, and crackers that can be found in your local grocery store. For people with celiac and diabetes, however, it is important to consider the carb count—especially because many gluten-free foods are made with flours that contain less fiber and have a higher glycemic index. The golden rule? Get in the habit of checking the labels of anything you put in your mouth or on your skin (for both gluten and carbs). Hide-and-Seek with Gluten Labels can sometimes be deceiving. Just because something is labeled as “wheat-free” does not mean it is gluten-free. Always examine labels for buzz words such as wheat, barley, or rye, and if you have any questions, contact the manufacturer directly before eating. Certain additives in packaged foods contain traces of gluten—ask your healthcare provider or a registered dietitian nutritionist (RDN) who specializes in celiac disease for a complete list of unsafe ingredients and foods. It is also impo Continue reading >>
The Diabetes And Celiac Diet
There's no cure for celiac disease, but people can manage it by eliminating gluten from their diet. People with diabetes have additional challenges in going gluten-free, but a healthy diet for blood-sugar management can easily be made into a gluten-free diet with some careful shopping and substituting. Here are some tips for managing this disease duo: Follow a whole-food meal plan. A gluten-free dinner consisting of a serving of protein (broiled or baked), steamed vegetables, a small serving of brown rice, and a small piece of fruit for dessert can also work well for managing your diabetes. Buy gluten-free foods. Health food stores and most mainstream grocery stores now carry gluten-free products. If your diabetes management plan allows for pasta, rice pasta is an excellent substitute, since the taste is very similar to wheat pasta. Watch your blood sugar levels. A diagnosis of celiac disease necessitates what may be a pretty dramatic change in your daily sources of carbohydrate. This means you're going to experience variations in your usual blood-sugar patterns, so be extra vigilant in testing. Continue to track your calories and carbs. Some gluten-free foods such as rice may be calorie- and carbohydrate-dense. Don't assume a sandwich made with gluten-free bread has the same amount of carbohydrates as one made with regular bread. Don't be afraid to dine out. Consult directories of gluten-free restaurants, at sites such as the Gluten-Free Restaurant Awareness Program. If a restaurant isn't advertised as gluten-free, ask your server to tell the chef that you can't have wheat, and find out how dishes are prepared. And be creative—some restaurants may allow you to bring gluten-free products for the chef to prepare. Meet with a registered dietician. It's complicated havin Continue reading >>
Celiac Disease And Type 1 Diabetes: A Connection?
Did you know that people with Type 1 diabetes also are at greater risk of having celiac disease? The odds of having celiac disease are 5 times to 7 times times greater for people with Type 1 diabetes than for the general population. Celiac disease is an autoimmune condition that causes an inflammatory state of the small intestine in genetically predisposed individuals. Inflammation ceases when gluten is removed from the diet. Gluten is a protein that is found in wheat, rye, and barleys; some individuals also experience inflammation from oats, even with oats that haven’t been contaminated by gluten-carrying grains. When people with celiac disease eat foods containing gluten, their immune system responds by damaging the lining of the small intestine, which can then affect how nutrients are absorbed by the body. The Hospital for Sick Children (SickKids) in Toronto is leading a study that looks into whether people with Type 1 diabetes who don’t have symptoms of celiac but test positive for it may benefit from a gluten-free diet. Called the Celiac Disease and Diabetes-Dietary Intervention and Evaluation Trial (CD-DIET), this study is open to children and adults with Type 1 diabetes. It is being led by Dr. Farid Mahmud. Typically, celiac disease can cause symptoms such as diarrhea, weight loss, vomiting, constipation, malnutrition, abdominal pain and bloating, but more than half of people with Type 1 diabetes have no symptoms of celiac disease when they are diagnosed. Because of this, it is recommended that children and adults with diabetes undergo celiac screening. As a part of the research study, SickKids is offering a blood test to determine whether you or your child has celiac disease. The research study is recruiting people (ages 8-45) who’ve had Type 1 diabetes fo Continue reading >>
Celiac Disease
Celiac disease is a digestive disorder that appears to be more common in people with type 1 diabetes than in the general population. Celiac disease is found in 4 to 9% of children with type 1 diabetes but, in 60 to 70% of these children, the disease is asymptomatic (‘silent’ celiac disease). Children with type 1 diabetes are at increased risk for celiac disease during the first 10 years of diabetes. What is celiac disease? Celiac disease is an autoimmune condition in which the body cannot tolerate gluten – a protein found in wheat, rye, barley and triticale. It is the gluten in the flour that helps bread and other baked goods bind and prevents crumbling. This feature has made gluten widely used in the production of many processed and packaged foods. If you have celiac disease and eat food with gluten, your immune system responds by damaging the small intestine and preventing the body from properly absorbing nutrients in your food, including protein, fat, carbohydrates, vitamins and minerals. Celiac disease is an inherited condition. First degree relatives (parents, brothers, sisters and children) of people with celiac disease are at the highest risk of having unrecognized celiac disease (5-15%). It can appear at any time in the life of a person with a hereditary predisposition to it. Environmental factors such as emotional stress, pregnancy, surgery, or an infection (e.g., travellers’ diarrhea, pneumonia) can sometimes trigger the onset of symptoms. For more information, please visit the Canadian Celiac Association. What are the symptoms of celiac disease? Many people with celiac disease don’t have any symptoms at all, which is why the disease is often undiagnosed. In people who do experience symptoms, they can vary from obvious digestive problems such as seve Continue reading >>
Balancing Diabetes And Celiac Disease
Have you ever stood in the middle of a see-saw, right over the center with one foot on each side? Trying hard not to put more weight on one side to keep it stable? Unless you are incredibly focused, it can be very difficult to keep a proper balance without one side touching the ground. The struggle is similar when trying to balance two medical conditions, such as diabetes and celiac disease. While each one has specific needs, they both need to stay balanced which can be hard to achieve. This article explains celiac disease and its relationship with diabetes. What is celiac disease? It’s a condition where the body recognizes gluten, a protein found in some foods, as a poison. The body tries to attack it to prevent it from being digested and entering into the bloodstream. When someone with celiac eats gluten (which is found in foods that are made with rye, wheat, or barley), the small intestines react by changing the lining. Normally, there are long, fingerlike structures that line our intestines that absorb the nutrients in the food that we eat. With celiac disease, those finger-like structures become flat to protect the body from absorbing the gluten. Additionally, the gut stops making digestive enzymes, to also prevent from any absorption. The image below gives a good illustration of what happens in the small intestines when gluten is eaten. The problem with this is that over time, it permanently damages the small intestines and prevents nutrients and vitamins from being absorbed. Long-term malabsorption can cause issues such as: Osteoporosis Anemia Infertility Organ disorders Delayed puberty Stunted growth Inability to gain weight Weak tooth enamel Seizures Depression Currently, 1 in 133 healthy people have celiac disease, and that number seems to be increasing. Bec Continue reading >>
Type 1 And Type 2 Diabetes In Celiac Disease: Prevalence And Effect On Clinical And Histological Presentation
Abstract Association between celiac disease and type 1 diabetes in adults is still somewhat unclear, and that between celiac disease and type 2 diabetes even less known. We studied these issues in a large cohort of adult celiac disease patients. The prevalence of type 1 and type 2 diabetes in 1358 celiac patients was compared with the population-based values. Furthermore, patients with celiac disease and concomitant type 1 or type 2 diabetes and those with celiac disease only underwent comparisons of clinical and histological features and adherence to gluten-free diet. The prevalence of type 1 diabetes (men/women) was 8.0 % /1.8 % in celiac patients and 0.7 % /0.3 % in the population, and that of type 2 diabetes 4.3 % /2.5 % and 4.4 % /3.0 %, respectively. Celiac patients with concomitant type 1 diabetes were younger (45 years vs 65 years and 52 years, P < 0.001) and more often screen-detected (43 % vs 13 % and 14 %, P < 0.001), had less other gastrointestinal diseases (8 % vs 40 % and 25 %, P = 0.028), more thyroidal diseases (18 % vs 16 % and 13 %, P = 0.043) and lower dietary adherence (71 % vs 95 % and 96 %, P < 0.001) compared with celiac patients with concomitant type 2 diabetes and patients with celiac disease only. Patients with concomitant type 2 diabetes had more hypercholesterolemia than the other groups (8 % vs 6 % and 4 %, P = 0.024), and both diabetes groups more hypertension (47 % and 31 % vs 15 %, P < 0.001) and coronary artery disease (29 % and 18 % vs 3 %, P < 0.001) than the patients with celiac disease only. Type 1 diabetes was markedly overrepresented in celiac disease, especially in men, whereas the prevalence of type 2 diabetes was comparable with the population. Concomitant type 1 or type 2 diabetes predisposes celiac patients to severe co-morbid Continue reading >>
Screening For Celiac Disease In Type 1 Diabetes: A Systematic Review
Abstract BACKGROUND AND OBJECTIVES: Prevalence rates of type 1 diabetes (T1D) and celiac disease (CD) vary from 1.6% to 16.4% worldwide. Screening guidelines are variable and not evidence based. Our aim was to conduct a systematic review of CD in T1D. METHODS: Medline, Embase, and the Cochrane Library were searched. Studies were limited to those in English and in humans. We selected longitudinal cohort studies screening for CD in T1D with at least 5 years of follow-up. Screening rates, characteristics, and prevalence of biopsy-proven CD in people with T1D were extracted. RESULTS: We identified 457 nonduplicate citations; 48 were selected for full-text review. Nine longitudinal cohort studies in 11 157 children and adolescents with 587 cases of biopsy-proven CD met the inclusion criteria. Median follow-up was 10 years (range: 5–18 years). The weighted pooled prevalence of CD was 5.1% (95% confidence interval: 3.1–7.4%). After excluding 41 cases with CD onset before T1D, CD was diagnosed in 218 of 546 (40%) subjects within 1 year, in 55% within 2 years, and in 79% within 5 years of diabetes duration. Two studies (478 cases) reported higher rates of CD in children aged <5 years at T1D diagnosis. The duration of follow-up varied across the included studies. CD screening frequency progressively decreased with increased T1D duration. CONCLUSIONS: Because most cases of CD are diagnosed within 5 years of T1D diagnosis, screening should be considered at T1D diagnosis and within 2 and 5 years thereafter. CD screening should be considered at other times in patients with symptoms suggestive of CD. More research is required to determine the screening frequency beyond 5 years of diabetes duration. The association between type 1 diabetes (T1D) and celiac disease (CD) is well docum Continue reading >>
Should I Screen My Child For Type 1 Diabetes And Celiac Disease?
I was diagnosed with Type 1 diabetes when I was 10 years old. No one in my family had ever been diagnosed with an autoimmune disease, and my parents could not have foreseen that their little girl would end up comatose in an emergency room with blood glucose levels 10 times the normal level. But what if there had been a way for my parents to know I was at risk for Type 1 diabetes? Would they have been overcome with worry? Would they have parented differently? Twenty years after my diabetes diagnosis I gave birth to the first of my two children. Curiosity about my kids’ futures with potential autoimmune diseases came along with the packages of diapers, but we agreed early on that we were not going to succumb to fear or worry. My husband and I have always felt that we’d be well-equipped to face diabetes if it came our way. Many parents I know with diabetes themselves, or who have one child with diabetes, occasionally check the blood sugar level of a particularly thirsty non-diabetic toddler or a seems-sleepier-than-usual non-diabetic sibling. But there is no palm reading for as-of-yet unpricked fingers. I can’t sit around worrying for what may or may not happen. I am sure I will see the symptoms if they appear. I’m sure I’m equipped to handle a diagnosis. Why put myself or my kid through unnecessary worry, stress, or pain? Unless something might be done to catch it earlier. That’s where TrialNet, an international network of researchers who are exploring ways to prevent, delay and reverse the progression of Type 1 diabetes, comes in. I remember over 20 years ago when a researcher came into my hospital room and offered to screen my older brother for Type 1 diabetes. He was 16 and decided that he didn’t want to be screened and didn’t want to know. I respected Continue reading >>
Celiac Disease And Type 1 Diabetes: | Naomi Berrie Diabetes Center
Matt Gagne, an editor at Sports Illustrated in New York City, may never forget the summer leading into his senior year at Bates College in Lewiston, Maine. He was 21 years old and home for the summer in Rochester, New Hampshire when he became too sick to work at his job cleaning swimming pools. I had no energy, constant achiness throughout my body and I slept all the time recalled Matt, now 31. For answers, Matt sought the help of an army of doctors, including his general practitioner, a dermatologist, a dentist, an eye doctor and a psychologist, who all gave him a clean bill of health. I went back to school in the fall and basically stopped complaining about feeling sick, said Matt. But, I was a mess. I got fatigued walking up a flight of stairs. I couldnt get up before noon. I looked at other people around me and I figured that they must have something in life that I didnt have. I couldnt explain it. As it turned out, it was Matt who had a few things that others did not. For one, he had type 1 diabetes, which wasnt diagnosed until the February of his senior year, when he lost more than 30 pounds over the course of one week and was dragged to the emergency room one night by his girlfriend and roommate. Matt also had celiac disease, which, in retrospect, was likely present well before his diabetes diagnosis and was responsible for many of the vague and persistent symptoms hed been feeling since he was a kid. matt-gagne-400-pixels-wide-option2 copy.jpg However, his celiac disease was not diagnosed until seven years after his diabetes diagnosis, when he moved to New York City and transferred his care to the Naomi Berrie Diabetes Center. Matt complained to his new doctor at the Berrie Center that he still wasnt feeling well on a daily basis. It was as simple as checking o Continue reading >>
