diabetestalk.net

Causes Of Impaired Glucose Tolerance

9 Symptoms Of Glucose Intolerance You Should Be Aware Of

9 Symptoms Of Glucose Intolerance You Should Be Aware Of

Could you be glucose intolerant? You’ll be surprised at some people who are without even realizing it. They suffer the common symptoms without ever thinking about them, believing them to be normal parts of life. It’s only when they suffer a major health problem that they realize those symptoms have never been good. You need to put your health first. It’s essential that you look out for common symptoms that indicate there is a major problem. These symptoms can be minor at first, but they will get worse over time. When it comes to glucose intolerance, you want to be aware of the following nine symptoms. Seek medical attention if you do have them. Glucose Intolerance Is Known as Prediabetes Most people right now will wonder what glucose intolerance is. Your body naturally creates this, so how could you possibly be intolerant to it? The medical term is impaired glucose intolerance (IGT) or prediabetes. It’s a term given to individuals who are at a higher than normal risk of developing diabetes at some point, especially if they continue with the current lifestyle that they have. This isn’t just about your diet, though. It could be that your body doesn’t produce enough insulin or that the normal hepatic glucose output is higher than it should be. Some doctors have linked the intolerance to the poor disposal of blood sugar from the system. Doctors wanted to remove the social stigma of having diabetes. At the same time, they needed a way to note if someone was a higher risk, as well as note those who were at a higher risk of developing cardiovascular disease. Now that you know more about what glucose intolerance is, it’s time to note the main symptoms. This will help you get an official diagnosis and help to avoid this issue turning into full-blown diabetes. Feeli Continue reading >>

Pre-diabetes Impaired Glucose Tolerance

Pre-diabetes Impaired Glucose Tolerance

In pre-diabetes (impaired glucose tolerance), your blood sugar (glucose) is raised beyond the normal range. Whilst this raised glucose level is not so high that you have diabetes, you are at increased risk of developing diabetes when you have pre-diabetes. You are also at increased risk of developing conditions such as heart disease, peripheral arterial disease and stroke (cardiovascular diseases). If pre-diabetes is treated, it can help to prevent the development of diabetes and cardiovascular disease. The most effective treatment is lifestyle changes, including eating a healthy balanced diet, losing weight if you are overweight, and doing regular physical activity. What is pre-diabetes? Play VideoPlayMute0:00/0:00Loaded: 0%Progress: 0%Stream TypeLIVE0:00Playback Rate1xChapters Chapters Descriptions descriptions off, selected Subtitles undefined settings, opens undefined settings dialog captions and subtitles off, selected Audio TrackFullscreen This is a modal window. Beginning of dialog window. Escape will cancel and close the window. TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal Dialog End of dialog window. If you have pre-diabetes (impaired glucose tolerance), your blood sugar (glucose) is raised beyond the normal range but it is not so high that you have diabetes. However, if y Continue reading >>

Impaired Glucose Tolerance And Impaired Fasting Glucose

Impaired Glucose Tolerance And Impaired Fasting Glucose

Impaired glucose tolerance and impaired fasting glucose form an intermediate stage in the natural history of diabetes mellitus. From 10 to 15 percent of adults in the United States have one of these conditions. Impaired glucose tolerance is defined as two-hour glucose levels of 140 to 199 mg per dL (7.8 to 11.0 mmol) on the 75-g oral glucose tolerance test, and impaired fasting glucose is defined as glucose levels of 100 to 125 mg per dL (5.6 to 6.9 mmol per L) in fasting patients. These glucose levels are above normal but below the level that is diagnostic for diabetes. Patients with impaired glucose tolerance or impaired fasting glucose have a significant risk of developing diabetes and thus are an important target group for primary prevention. Risk factors for diabetes include family history of diabetes, body mass index greater than 25 kg per m2, sedentary lifestyle, hypertension, dyslipidemia, history of gestational diabetes or large-for-gestational-age infant, and polycystic ovary syndrome. Blacks, Latin Americans, Native Americans, and Asian-Pacific Islanders also are at increased risk for diabetes. Patients at higher risk should be screened with a fasting plasma glucose level. When the diagnosis of impaired glucose tolerance or impaired fasting glucose is made, physicians should counsel patients to lose 5 to 7 percent of their body weight and engage in moderate physical activity for at least 150 minutes per week. Drug therapy with metformin or acarbose has been shown to delay or prevent the onset of diabetes. However, medications are not as effective as lifestyle changes, and it is not known if treatment with these drugs is cost effective in the management of impaired glucose tolerance. Definitions and Epidemiology An expert committee sponsored by the American Di Continue reading >>

Drugs That Can Impair Glucose Tolerance And Cause Diabetes Mellitus

Drugs That Can Impair Glucose Tolerance And Cause Diabetes Mellitus

Drugs that can impair glucose tolerance and cause Diabetes Mellitus Drugs that can impair glucose tolerance and cause Diabetes Mellitus There are over sixteen different classes of drugs that can affect the ability of the body to utilize glucose and or cause the body to become diabetic. Many people and physicians are often unaware of these risks when taking or prescribing medications, respectively. Here we will review some of the categories associated with this risk. Fluoroquinolones (medications ending in floxacin) are used to treat infections cause altered insulin secretion. The HIV anti-retrovirals that fall under the classes of protease inhibitors and nucleoside reverse transcriptase inhibitors can cause increased peripheral insulin resistance. Antipsychotic medications (chlorpromazine, clozapine, olanzapine, quetiapine,..) appear to involve increased insulin resistance and diminished insulin secretion. Cardiovascular classes of medications can promote worsening of diabetes. These medications include beta-blockers by decreased insulin sensitivity. Statins by impaired glucose tolerance. Thiazide diuretics by reduced total-body potassium, decreased insulin secretion and increased insulin resistance. Vasopressor medications (epinephrine and norepinephrine) used in the intensive care unit cause activation of glycogenolysis, increased hepatic gluconeogenesis, stimulation of glucagon an cortisol, and inhibition of insulin secretion. Glucocorticoids produce significant drug-induced hyperglycemia by increased hepatic glucose production, increased insulin resistance, and increased expression of peroxisome proliferator activated gamma receptors of which regulate fatty acid storage and glucose metabolism. Oral contraceptives with combination estrogen-progestogen can cause alte Continue reading >>

Prediabetes

Prediabetes

What Is Prediabetes? Prediabetes is a “pre-diagnosis” of diabetes—you can think of it as a warning sign. It’s when your blood glucose level (blood sugar level) is higher than normal, but it’s not high enough to be considered diabetes. Prediabetes is an indication that you could develop type 2 diabetes if you don’t make some lifestyle changes. But here's the good news: . Eating healthy food, losing weight and staying at a healthy weight, and being physically active can help you bring your blood glucose level back into the normal range. Diabetes develops very gradually, so when you’re in the prediabetes stage—when your blood glucose level is higher than it should be—you may not have any symptoms at all. You may, however, notice that: you’re hungrier than normal you’re losing weight, despite eating more you’re thirstier than normal you have to go to the bathroom more frequently you’re more tired than usual All of those are typical symptoms associated with diabetes, so if you’re in the early stages of diabetes, you may notice them. Prediabetes develops when your body begins to have trouble using the hormone insulin. Insulin is necessary to transport glucose—what your body uses for energy—into the cells via the bloodstream. In pre-diabetes, your body either doesn’t make enough insulin or it doesn’t use it well (that’s called insulin resistance). If you don’t have enough insulin or if you’re insulin resistant, you can build up too much glucose in your blood, leading to a higher-than-normal blood glucose level and perhaps prediabetes. Researchers aren’t sure what exactly causes the insulin process to go awry in some people. There are several risk factors, though, that make it more likely that you’ll develop pre-diabetes. These are Continue reading >>

Impaired Glucose Tolerance

Impaired Glucose Tolerance

More than 3 million Canadians have diabetes, and many of them don't know they have it. Many people with type 2 diabetes develop a condition called impaired glucose tolerance (IGT) before being diagnosed with diabetes. IGT is also known as prediabetes. What is impaired glucose tolerance (IGT)? IGT means that the body has become less sensitive to the effects of insulin, and has to work harder to control blood glucose levels. A person with IGT has blood sugar (glucose) levels that are higher than normal but not high enough to say they have diabetes. As in type 2 diabetes, the body produces insulin, but there may be less of it, or it may not work properly. People with IGT are not only at increased risk for type 2 diabetes, but are also 50% more likely to develop high blood pressure and high cholesterol levels factors that contribute to heart disease and stroke. A friend of mine has insulin resistance... is this the same as IGT? No, not necessarily. Insulin resistance occurs when the body stops responding as well to insulin. To compensate, the body makes more insulin. But because the body doesn't respond as well to insulin, the higher insulin levels cannot control blood glucose as effectively. As insulin resistance increases, blood sugar levels will rise and diabetes can eventually result. People that are extremely overweight or obese are at risk of developing IGT, especially those people carrying extra weight around their middle. This is because carrying extra body fat inhibits the effects of insulin. With weight loss, glucose levels will likely return to normal levels. Because there is less resistance to insulin, more glucose is transported from the blood into tissue cells. Losing weight will also help reduce the risk of developing type 2 diabetes. Your risk of developing Continue reading >>

Glucose Intolerance

Glucose Intolerance

Tweet Glucose intolerance is term for metabolic conditions which result in high blood glucose levels. Pre-diabetes, type 2 diabetes, impaired fasting glucose and impaired glucose tolerance are all conditions which fall under the term glucose intolerant. Glucose intolerance is defined by the World Health Organisation as: A blood sugar level of 6.0 mmol/l or above whilst fasting A blood glucose level of over 7.8 mmol/l 2 hours after consuming 75g of glucose The figures above are based on the assumption that people are not taking blood glucose lowering medication. The symptoms of glucose intolerance may not be so easy to spot. The symptoms may include: Feeling thirsty Being tired or lethargic Needing to urinate more than usual Itchiness around the genitals People with impaired glucose tolerance are more likely to notice symptoms after meals. Whereas people with impaired fasting glucose will notice the symptoms through other parts of the day including during the night. Glucose intolerance will often be diagnosed by a fasting plasma glucose test or by a glucose tolerance test. A plasma glucose test is when a blood sample is taken, usually from your arm, and the blood glucose levels measured. A glucose tolerance test involves taking a set amount of glucose orally, usually 75g of glucose, and then taking your blood glucose levels over regular periods of time over the next few hours. Glucose intolerance can be treated through diet and lifestyle changes or with assistance from anti-diabetic medication, such as tablets and/or insulin. Your doctor will measure your long term blood glucose control via an HbA1c test. Your doctor may also prescribe you with blood glucose testing supplies to allow you to make diet choices and to indentify and prevent high or low blood glucose levels. Continue reading >>

Impaired Glucose Tolerance

Impaired Glucose Tolerance

Impaired Glucose Tolerance means that blood glucose is raised beyond normal levels Impaired glucose tolerance means that blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis . With impaired glucose tolerance you face a much greater risk of developing diabetes and cardiovascular disease. Treating impaired glucose tolerance may help to prevent diabetes development and lower the risk of cardiovascular disease. Eating a healthy, balanced diet is a key way of treating impaired glucose tolerance. Other ways to lower the risk include losing weight if you are overweight, and also taking regular physical exercise . Blood glucose levels are the amount of glucose in the blood, and normal blood glucose levels range from between 4-8 mmol/L. Blood glucose levels are often higher after eating and lower first thing in the morning. How often does impaired glucose tolerance develop into diabetes? 1-3 out of every 4 people with impaired glucose tolerance will develop diabetes within a decade. What else does impaired glucose tolerance leave you at risk of? People with impaired glucose tolerance face a greater risk of cardiovascular disease, including high blood pressure , increased cholesterol levels, being overweight or obese . What defines having impaired glucose tolerance? The WHO (World Health Organisation) indicates that impaired glucose tolerance may be present if people have: Blood glucose of 7.8 mmol/L or more but less than 11.1mmol/L after a 2-hour oral glucose tolerance test OGTT (see below). How common is impaired glucose tolerance? Because there are no symptoms of impaired glucose tolerance, many people have the condition and are unaware of it. Diabetes UK estimates that some seven million people in the UK have impaired glucose tole Continue reading >>

Glucose Intolerance (problems With Blood Glucose Control)

Glucose Intolerance (problems With Blood Glucose Control)

Home Current Health Articles Glucose Intolerance (Problems with Blood Glucose Control) Glucose Intolerance (Problems with Blood Glucose Control) Glucose intolerance is a broad term encompassing several conditions that leads to abnormally high blood glucose levels (hyperglycemia). It is often confused with impaired glucose tolerance (IGT), one of the conditions listed under the term glucose intolerance. Sometimes glucose intolerance is also mistaken for a digestive disorder where glucose in not digested or absorbed, like with lactose intolerance or gluten intolerance. However, glucose intolerance actually means conditions where the body is not processing glucose as it should leading to elevated glucose levels in the blood. Since glucose intolerance is a broad term that includes conditions like diabetes mellitus, it is fair to say that the glucose tolerance is common and on the rise globally. The second most common form, diabetes mellitus, is closely linked to genetic factors and obesity. About 20 million people in the United States suffer with diabetes mellitus and it is estimated that about 30% cases are undiagnosed. Even more common is impaired glucose tolerance (IGT) but the majority of cases are never diagnosed until it has progressed to diabetes. Glucose intolerance includes several categories : Diabetes type 1 and type 2 diabetes mellitus and gestational diabetes (diabetes of pregnancy) Impaired glucose metabolism impaired glucose tolerance and impaired fasting gluse In addition, there may be other specific types of diabetes that arise with certain conditions like liver disease. In diabetes mellitus, there is either a lack of insulin (type 1), diminished response to insulin (type 2) or the presence of high levels of other hormones that affect insulin activity (ges Continue reading >>

Medical Definition Of Impaired Glucose Tolerance

Medical Definition Of Impaired Glucose Tolerance

Amputations. INVOKANA® may increase your risk of lower-limb amputations. Amputations mainly involve removal of the toe or part of the foot; however, amputations involving the leg, below and above the knee, have also occurred. Some people had more than one amputation, some on both sides of the body. Youmay be at a higher risk of lower-limb amputation if you: have a history of amputation, have heart disease or are at risk for heart disease, have had blocked or narrowed blood vessels (usually in leg), have damage to the nerves (neuropathy)in the leg, or have had diabetic foot ulcers or sores. Call your doctor right away if you have new pain or tenderness, any sores, ulcers, or infections in your leg or foot. Your doctor may decide to stop your INVOKANA®. Talk to your doctor about proper foot care Dehydration. INVOKANA® can cause some people to become dehydrated (the loss of too much body water), which may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand up (orthostatic hypotension). Youmay be at higher risk of dehydration if you have low blood pressure, take medicines to lower your blood pressure (including diuretics [water pills]), are on a low sodium (salt) diet, have kidney problems, or are 65 years of age orolder Yeast infection of the penis (balanitis or balanoposthitis).Men who take INVOKANA® may get a yeast infection of the skin around the penis. Symptoms include: redness, itching, or swelling of the penis; rash of the penis; foul-smelling discharge from the penis;or pain in the skin around penis Before you take INVOKANA®, tell your doctor if you have a history of amputation; heart disease or are at risk for heart disease; blocked or narrowed blood vessels (usually in leg); damage to the nerves (neuropathy) of your leg; diabetic f Continue reading >>

What Causes Impaired Glucose Tolerance To Deteriorate Or Normalize?

What Causes Impaired Glucose Tolerance To Deteriorate Or Normalize?

What causes impaired glucose tolerance to deteriorate or normalize? Cederholm J, et al. Scand J Clin Lab Invest. 1992. Department of Internal Medicine, University Hospital, Uppsala, Sweden. Scand J Clin Lab Invest. 1992 Oct;52(6):491-6. Twenty-five middle-aged subjects with impaired glucose tolerance (IGT) were analysed 5 years later, showing normal glucose tolerance in 28% and persistent glucose deterioration in 72%. Body mass index (strongly) and 2-h glucose levels were clinically useful predictors, in the newly detected IGT-subjects, of persistent glucose deterioration (IGT or NIDDM) 5 years later. The frequency of hypertension was 36% in the newly-detected IGT subjects. Five years later this frequency increased to 54% in the persistently hyperglycaemic group, and decreased to none in the normalized group. Predictors of hypertension at the follow-up were baseline blood pressure and parts of the hyperinsulinaemic syndrome, such as serum triglyceride at baseline, BMI and 2-h glucose at the follow-up. Microalbuminuria (greater than 20 mg day-1) was not found at the 5-years follow-up, either if the subjects then had NIDDM, IGT or normal glucose tolerance. ECG abnormalities (ST segment and T wave changes) were two-fold more prevalent in the group with IGT or NIDDM than in the normalized group at the follow-up. Predictors were baseline BMI and incremental BMI. In conclusion, obesity and high 2-h glucose in newly-detected IGT-subjects seemed to predict the persistence of IGT 5 years later. Hypertension, but not microalbuminuria, was frequent when glucose deterioration persisted. Continue reading >>

Insulin Resistance As The Major Cause Of Impaired Glucose Tolerance: A Self-fulfilling Prophesy?

Insulin Resistance As The Major Cause Of Impaired Glucose Tolerance: A Self-fulfilling Prophesy?

Abstract Summary Non-insulin-dependent diabetes (NIDDM) is a heterogeneous state involving various degrees of β-cell dysfunction and insulin resistance, although the relative importance of these two factors is controversial. Several single gene disorders of carbohydrate metabolism have their main pathophysiological defect largely restricted to the β-cell or to insulin-sensitive tissues. We have noted that with insulin resistance the fasting plasma glucose is often normal and severe hyperglycaemia occurs after a glucose load. By contrast, in glucokinase- deficient diabetes, which is characterised by reduced insulin secretion, the reverse is the case. Supportive evidence showing that β-cell dysfunction and insulin resistance may have different effects on fasting and post-prandial glucose concentrations comes from studies of identical twins of NIDDM patients, hemi-pancreatectomised normal subjects, and insulin-resistant Asian subjects. NIDDM is usually preceded by a period of less severe hyperglycemia, referred to as impaired glucose tolerance (IGT). Studies of the IGT phase usually conclude that insulin resistance is the major abnormality and is thus the primary defect in NIDDM. However, the definition of IGT is based on the 2 h plasma glucose after an oral glucose-tolerance test without consideration of the fasting glucose concentrations (provided these concentrations are non-diabetic). Our observations suggest that this definition of IGT may result in the over-representation of insulin-resistant individuals and the under-representation of subjects with β-cell dysfunction in any cross sectional study of IGT. The belief that the prediabetic state of IGT is dominated by insulin resistance may be a self-fulfilling prophesy because of the excessive emphasis put on the po Continue reading >>

Impaired Glucose Tolerance

Impaired Glucose Tolerance

Prediabetes is a condition that is marked by high blood sugar levels. IN prediabetes, blood sugar levels, also called glucose levels, are higher than normal, but not considered high enough to qualify as type 2 diabetes . Prediabetes is however, a risk factor for the development of type 2 diabetes . In the U.S. about one in four adults over the age of 20 years has prediabetes, according to the U.S. Department of Health and Human Services. The consequences of prediabetes can be serious. At this time most people with prediabetes do go on to develop type 2 diabetes within about 10 years. People with prediabetes are also at risk for developing cardiovascular disease. In these conditions, abnormally high levels of glucose in the blood, also called hyperglycemia , damages the body's blood vessels. Left unchecked, this process can lead to many complications that affect nearly every organ in the body. These include kidney failure , diabetic retinopathy and blindness , peripheral neuropathy , kidney failure , serious skin infections, gangrene , stroke , disability , osteoporosis , Alzheimer's disease , hearing damage, hyperosmolar hyperglycemic nonketotic syndrome , and death. Prediabetes develops when the body does not respond to the effects of the hormone insulin. This is known as insulin resistance . In addition, some people with prediabetes also may not produce sufficient amounts of insulin in the pancreas. The role of insulin is to facilitate movement of sugar (glucose) from the bloodstream into the body's cells, where it is used for energy. Insulin also helps the liver to store excess glucose. When the body cannot process and use glucose properly, the body's cells do not get the energy they need. Medically, this is known as an inability to metabolize glucose, which results Continue reading >>

Diagnosing Impaired Glucose Tolerance (igt)

Diagnosing Impaired Glucose Tolerance (igt)

People with IGT have blood glucose levels that are higher than normal but not high enough to say they have diabetes. This condition is diagnosed using the oral glucose tolerance test (OGTT). After a fast of 8 to12 hours, a person's blood glucose is measured before and 2 hours after drinking a glucose-containing solution. In normal glucose tolerance, blood glucose rises no higher than 140 mg/dl 2 hours after the drink. In impaired glucose tolerance (IGT), the 2-hour blood glucose is between 140 and 199 mg/dl. If the 2-hour blood glucose rises to 200 mg/dl or above, a person has diabetes. How does the fasting blood glucose test differ from the oral glucose tolerance test? In the fasting blood glucose test, a person's blood glucose is measured after a fast of 8 to 12 hours: A person with normal blood glucose has a blood glucose level below 100. A person with impaired fasting glucose has a blood glucose level between 100 and 125 mg/dl. If the fasting blood glucose level rises to126 mg/dl or above, a person has diabetes. The OGTT includes measures of blood glucose levels after a fast and after a glucose challenge. In 1997, an American Diabetes Association (ADA) expert panel recommended that doctors use the fasting blood glucose test to screen their patients for diabetes because the test is easier and less costly than the OGTT. Though the fasting glucose test detects most diabetes cases, the OGTT is more sensitive in identifying people with blood glucose problems that may first appear only after a glucose challenge. For a person with IGT, what is the risk of developing type 2 diabetes? As few as 1 to as many as 10 of every 100 persons with IGT will develop diabetes per year. The risk of getting diabetes rises as people become more overweight and more sedentary, have a stronge Continue reading >>

Impaired Glucose Tolerance

Impaired Glucose Tolerance

Impaired glucose tolerance (IGT) is a pre-diabetic state of hyperglycemia that is associated with insulin resistance and increased risk of cardiovascular pathology. IGT may precede type 2 diabetes mellitus by many years. IGT is also a risk factor for mortality.[1] Diagnosis[edit] According to the criteria of the World Health Organization and the American Diabetes Association, impaired glucose tolerance is defined as:[2][3][4] two-hour glucose levels of 140 to 199 mg per dL (7.8 to 11.0 mmol/l) on the 75-g oral glucose tolerance test. A patient is said to be under the condition of IGT when he/she has an intermediately raised glucose level after 2 hours, but less than the level that would qualify for type 2 diabetes mellitus. The fasting glucose may be either normal or mildly elevated. From 10 to 15 percent of adults in the United States have impaired glucose tolerance or impaired fasting glucose.[5] Treatment[edit] Main article: Prevention of diabetes mellitus type 2 The risk of progression to diabetes and development of cardiovascular disease is greater than for impaired fasting glucose.[6] Although some drugs can delay the onset of diabetes, lifestyle modifications play a greater role in the prevention of diabetes.[5][7] Patients identified as having an IGT may be able to prevent diabetes through a combination of increased exercise and reduction of body weight.[5] "Drug therapy can be considered when aggressive lifestyle interventions are unsuccessful."[5] See also[edit] Glucose tolerance test Impaired fasting glucose [edit] Further reading[edit] Melanie J Davies; I Peter Gray (3 February 1996). "Impaired glucose tolerance". British Medical Journal. 312 (7026): 264–65. doi:10.1136/bmj.312.7026.264. PMC 2349870 . PMID 8611769. – Editorial review Nathan, DM; Davidson Continue reading >>

More in diabetes