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Capsaicin Diabetes

Current Research Into Cures For Type-1 Diabetes

Current Research Into Cures For Type-1 Diabetes

Current Research into Cures for Type-1 Diabetes News and updates on potential cures for type-1 diabetes, that are in human (or clinical) trials. Substance P Starts a Phase-I Clinical Trial Substance P is a peptide (a part of a protein) which is used by several different organs and for several different purposes. Research done in the early 2000s found that a specific type of neuron (called "TRPV1(+) pancreatic sensory neurons") control islet inflammation and insulin resistance. Removing these neurons from NOD mice prevented diabetes from developing. Injecting NOD mice with Substance P, which affects these neurons, cured diabetes. This clinical trial will test this same treatment in people, rather than mice. People who have followed type-1 diabetes research for a long time might remember the news stories that injectingcapsaicin (the active ingredient in hot chilis) would cure type-1 diabetes. They were first published in 2006 and get recycled every now and then. (Usually as examples of the grand conspiracy to suppress type-1 cures, especially cheap, natural cures.) Anyway, the idea that capsaicin would cure type-1 diabetes comes out of this same line of research in NOD mice. Capsaicin and Substance P are different, but they affect the same neurons in the pancreas, and the researchers tested both and reported on both in the same journal article. The clinical trial is Substance P only, no capsaicin. This Phase-I trial will start out enrolling 12 kids (between 10 and 18 years old) and later expand to 40 kids. They are looking for people who were diagnosed "recently" but have already passed through their honeymoon period. Their definition of "done with the honeymoon" is needing to inject more than 1/2 a unit of insulin per kilogram of body weight per day. They are testing fo Continue reading >>

Capsaicin Reduces Blood Glucose By Increasing Insulin Levels And Glycogen Content Better Than Capsiate In Streptozotocin-induced Diabetic Rats.

Capsaicin Reduces Blood Glucose By Increasing Insulin Levels And Glycogen Content Better Than Capsiate In Streptozotocin-induced Diabetic Rats.

Capsaicin Reduces Blood Glucose by Increasing Insulin Levels and Glycogen Content Better than Capsiate in Streptozotocin-Induced Diabetic Rats. College of Food Science, Southwest University , Tiansheng Road 2, Chongqing 400715, People's Republic of China. College of Life Science, Chongqing Normal University , Chongqing 401331, People's Republic of China. J Agric Food Chem. 2017 Mar 22;65(11):2323-2330. doi: 10.1021/acs.jafc.7b00132. Epub 2017 Mar 2. Chili peppers exhibit antiobesity, anticancer, antidiabetic, and pain- and itch-relieving effects on animals and humans; these effects are due to capsaicin, which is the main pungent and biologically active component of pepper. Capsiate, a nonpungent capsaicin analogue, is similar to capsaicin in terms of structure and biological activity. In this study, we investigated whether capsaicin and capsiate exhibit the same hypoglycemic effects on rats with type 1 diabetes (T1D). Experimental rats were categorized into four groups: control, model, capsaicin, and capsiate groups. The two treatment groups were treated orally with 6 mg/kg bw capsaicin and capsiate daily for 28 days. Treatment with capsaicin and capsiate increased body weight, increased glycogen content, and inhibited intestinal absorption of sugar in T1D rats. Particularly, insulin levels were increased from 14.9 0.76 mIU/L (model group) to 22.4 1.39 mIU/L (capsaicin group), but the capsiate group (16.7 0.79 mIU/L) was increased by only 12.2%. Analysis of the related genes suggested that the transient receptor potential vanilloid 1 (TRPV1) receptor was activated by capsaicin. Liver X receptor and pancreatic duodenum homeobox 1 controlled the glycometabolism balance by regulating the expression levels of glucose kinase, glucose transport protein 2 (GLUT2), phosphoenol Continue reading >>

Chili Peppers Diabetes Diet Benefits

Chili Peppers Diabetes Diet Benefits

Capsaicin Blood Glucose Lowering Diabetes Benefits What makes hot chile peppers and others the hot peppers they are is the compound called capsaicin. Capsaicin derives its name (or visa versa) from the name of the pepper family capsicum which includes hot peppers like habanero peppers , cayenne peppers, chili peppers, tobasco peppers and others. It turns out that, quite dramatically for us, capsaicin has an even larger and longer lasting impact on our blood glucose levels. I will post some habanero pepper diabetes tests charts and data tables showing what a huge difference eating a meal with habanero pepper diabetes control vs. without habanero pepper diabetes benefits has on my blood glucose levels - even as far as the fasting blood glucose levels the next morning. My type 2 diabetes capsaicin diabetes control discovery story is in the ' Discovering Foods ' segment and tells about habanero peppers diabetes control benefits which I have seen. Because the benefits of hot peppers diabetes control arise from the actual benefits of capsaicin diabetes control influence, and capsaicin is what gives the hot peppers their 'heat', your sense of how hot the meal is will be an easy guide to how much the hot chile peppers diabetes impact will likely be from any given meal. The amount of pepper required to see a large difference will definitely let you know it is there when you eat it, but even smaller amounts of capsaicin will benefit you. in my habanero peppers diabetes tests, I find that I see a substantial difference which stretches into the next morning's fasting blood glucose lowered levels when I use just 1/2 of a medium to small fresh habanero pepper of good quality. I do not see this benefit of habanerno peppers diminishing with time, even though my taste buds may become m Continue reading >>

Does Capsaicin Cream Help With Diabetes?

Does Capsaicin Cream Help With Diabetes?

Capsaicin cream, a topical ointment made with cayenne, has been reported by some patients to help lower pain in the hands and feet from diabetic neuropathy. But people with loss of sensation in the hands or feet should use caution when using capsaicin, as they may not be able to fully feel any burning sensation. Check with your doctor if you are thinking of trying this product. WebMD Health News: "FDA Restricts Use of Diabetes Drug Avandia." News release, FDA: '' Actos (pioglitazone): Ongoing Safety Review - Potential Increased Risk of Bladder Cancer." Reviewed by Jennifer Robinson on January 12, 2018 WebMD Health News: "FDA Restricts Use of Diabetes Drug Avandia." News release, FDA: '' Actos (pioglitazone): Ongoing Safety Review - Potential Increased Risk of Bladder Cancer." How can you treat minor skin problems if you have diabetes? THIS TOOL DOES NOT PROVIDE MEDICAL ADVICE. It is intended for general informational purposes only and does not address individual circumstances. It is not a substitute for professional medical advice, diagnosis or treatment and should not be relied on to make decisions about your health. Never ignore professional medical advice in seeking treatment because of something you have read on the WebMD Site. If you think you may have a medical emergency, immediately call your doctor or dial 911. This tool does not provide medical advice. See additional information. Continue reading >>

Chili Peppers | Diabetes | Capsaicin | Obesity | Products | Pills

Chili Peppers | Diabetes | Capsaicin | Obesity | Products | Pills

this area have been extensively research. Capsaicin can be applied as a patch or cream and is effective for some pain conditions. Neurophatic pain, post surgical pain. Here are somereviews ofthe conditions under which capsaicin-containing pharmaceutical agents can best used.[ 1 ], [ 2 ], [ 3 ], [ 4 ] Capsaicin sensitive neurons are associated with several gastrointestinal functions. Even though the action is known to be real, the effective of capsaicin in treating gastrointestinal conditions is not well understood. Controversy exist due to known aggressive effects of chili peppers have on the stomach lining causing severe irritation dyspepsia and peptic ulcers. Spicy food and its ability to enhance energy expenditure have been known since the 1980s. A meal containing 3 grams of chili sauce can increase metabolic rate by 25%.The impact of red pepper on oxidation of carbohydrate, fat, and protein is not supported by all studies. Fat oxidation appears to be higher when capsaicin is consumed. Indiabetes studies, capsaicin also has been reported to affect glucose and insulin homeostasis.There is good evidence that TRPV1 is involved in serum glucose regulation. The effects of cancer are inconclusive and inconsistent. Epidemiological literature suggest that high consumption of chili peppers can increase the risk of stomach, liver, bladder and pancreatic cancer. Results of studies are not consistent. In some studies cancer preventive effects have been noted. Capsaicin and its analogs have been noted as potential cancer chemopreventive or chemotherapeutic agents like prevention of prostate cancer. Chili pepper component TRPV1 is involved in glucose regulation. It is an important regulator because it is detected in the pancreas and beta islet cells. TRPV1 has an important relati Continue reading >>

Capsaicin And Diabetes - Pubmed Result

Capsaicin And Diabetes - Pubmed Result

1: Sarkar P, Bhowmick A, Banu S. Comparative analysis of different dietaryantioxidants on oxidative stress pathway genes in L6 myotubes under oxidativestress. Cytotechnology. 2018 Mar 14. doi: 10.1007/s10616-018-0209-5. [Epub ahead of print] PubMed PMID: 29541961.2: Lam D, Momeni Z, Theaker M, Jagadeeshan S, Yamamoto Y, Ianowski JP, CampanucciVA. RAGE-dependent potentiation of TRPV1 currents in sensory neurons exposed tohigh glucose. PLoS One. 2018 Feb 23;13(2):e0193312. doi:10.1371/journal.pone.0193312. eCollection 2018. PubMed PMID: 29474476; PubMedCentral PMCID: PMC5825096.3: Malone M, Tsai G. The evidence for herbal and botanical remedies, Part 1. JFam Pract. 2018 Jan;67(1):10-16. PubMed PMID: 29309469.4: Georgescu SR, Srbu MI, Matei C, Ilie MA, Caruntu C, Constantin C, Neagu M,Tampa M. Capsaicin: Friend or Foe in Skin Cancer and Other Related Malignancies? Nutrients. 2017 Dec 16;9(12). pii: E1365. doi: 10.3390/nu9121365. Review. PubMed PMID: 29258175; PubMed Central PMCID: PMC5748815.5: Pierelli G, Stanzione R, Forte M, Migliarino S, Perelli M, Volpe M, Rubattu S.Uncoupling Protein 2: A Key Player and a Potential Therapeutic Target in VascularDiseases. Oxid Med Cell Longev. 2017;2017:7348372. doi: 10.1155/2017/7348372.Epub 2017 Oct 15. Review. PubMed PMID: 29163755; PubMed Central PMCID:PMC5661070.6: Sharopov BR, Gulak KL, Philyppov IB, Sotkis AV, Shuba YM. TRPV1 alterations inurinary bladder dysfunction in a rat model of STZ-induced diabetes. Life Sci.2018 Jan 15;193:207-213. doi: 10.1016/j.lfs.2017.10.042. Epub 2017 Oct 31. PubMedPMID: 29100756.7: Musharraf MU, Ahmad Z, Yaqub Z. Comparison of topical capsaicin and topicalturpentine Oil for treatment of painful diabetic neuropathy. J Ayub Med CollAbbottabad. 2017 Jul-Sep;29(3):384-387. PubMed PMID: 29076666.8: Os Continue reading >>

Cool Down Diabetes With Chili Peppers

Cool Down Diabetes With Chili Peppers

Spicing your life up with hot chili peppers, cayenne, and other capsaicin-containing seasonings can help turn the tables on diabetes. Theres new evidence showing capsaicin makes your cells more sensitive to insulin and improves the balance between blood sugar and insulin in your body. The answer lies in inflammation and how the heat of capsaicin cools those flames. Inflammation may play an important role in the development of obesity, insulin resistance, and diabetes. In fact, some diabetes drugs are also anti-inflammatory, and your blood sugar drops as inflammation decreases. Think of inflammatory compounds as boats floating around your body. They plug into special TRPV1 receptors on some nerve cells, like boats docking in a harbor. This triggers the nerves to release a chemical called CGRP. CGRP causes your body to release more inflammatory compounds, which in turn triggers the release of more CGRP. Its a vicious cycle of disease development, because high levels of CGRP lead to insulin resistance and possibly obesity. Did you know that there is a seasoning in your spice rack that keeps your brain sharp? Discover this and other surprising health and money savers in The Kitchen Table Book . Capsaicin steps in and destroys nerves with TRPV1 docks. This cuts off the production of CGRP, which may prevent insulin resistance and improve glucose tolerance. Capsaicin puts a lid on other inflammatory compounds, too, and boosts levels of adiponectin, a chemical in your body that fights inflammation. By getting inflammation under control, you can dodge insulin resistance, type 2 diabetes, and atherosclerosis. Start seasoning your food with chili pepper or cayenne. People who added a total of three tablespoons of chili pepper to meals every day evened out insulin and blood sugar Continue reading >>

Capsiate Improves Glucose Metabolism By Improving Insulin Sensitivity Better Than Capsaicin In Diabetic Rats.

Capsiate Improves Glucose Metabolism By Improving Insulin Sensitivity Better Than Capsaicin In Diabetic Rats.

Capsiate improves glucose metabolism by improving insulin sensitivity better than capsaicin in diabetic rats. Food Functional Research Division, Korean Food Research Institutes, Sungnam 463-746, Korea. J Nutr Biochem. 2013 Jun;24(6):1078-85. doi: 10.1016/j.jnutbio.2012.08.006. Epub 2012 Sep 29. Red peppers and red pepper paste are reported to have anti-obesity, analgesic and anti-inflammatory effects in animals and humans due to the capsaicin in red pepper. We investigated whether consuming capsaicin and capsiate, a nonpungent capsaicin analogue, modifies glucose-stimulated insulin secretion, pancreatic -cell survival and insulin sensitivity in 90% pancreatectomized (Px) diabetic rats, a moderate and non-obese type 2 diabetic animal model. Px diabetic rats were divided into 3 treatment groups: 1) capsaicin (Px-CPA), 2) capsiate (Px-CPI) or 3) dextrose (Px-CON) and provided high fat diets (40 energy % fat) containing assigned components (0.025% capsaicin, capsiate, or dextrose) for 8 weeks. Both capsaicin and capsiate reduced body weight gain, visceral fat accumulation, serum leptin levels and improved glucose tolerance without modulating energy intake in diabetic rats. In comparison to the control, both capsaicin and capsiate potentiated first and second and phase insulin secretion during hyperglycemic clamp. Both also increased -cell mass by increasing proliferation and decreasing apoptosis of -cells by potentiating insulin/IGF-1 signaling. However, only capsiate enhanced hepatic insulin sensitivity during euglycemic hyperinuslinemic clamp. Capsiate reduced hepatic glucose output and increased triglyceride accumulation in the hyperinsulinemic state and capsiate alone significantly increased glycogen storage. This was related to enhanced pAktPEPCK and pAMPK signaling. Continue reading >>

Cayenne Pepper And Blood Sugar

Cayenne Pepper And Blood Sugar

The capsaicin in cayenne may help to regulate your blood sugar level. Cayenne pepper, a Capsicum species, contains compounds called capsaicinoids, notably capsaicin. Capsaicin interacts with a sensory receptor protein in your mouth and gastrointestinal tract called the capsaicin receptor, or TRPV1, which gives you a hot sensation. Including cayenne in your diet may reduce your body fat, but the published effects of cayenne on blood glucose levels and diabetes risk are less conclusive. Furthermore, experiments specifically involving cayenne, human subjects and blood glucose measurements are scarce. Nevertheless, some evidence from both human and animal trials suggests that the capsaicin in cayenne pepper influences the way that your body processes the glucose in your blood. Dietary carbohydrates are broken down to glucose in your small intestine, and the glucose is absorbed into your blood. Various spices, including cayenne, may stimulate digestive processes in your small intestine. In this regard, a Hungarian study with human subjects published in the March 18, 2006 issue of the European Journal of Pharmacology reported that capsaicin ingestion stimulated glucose absorption from the small intestine. Blood glucose levels were higher between 30 minutes and 150 minutes after beginning the test in subjects given both capsaicin and glucose compared to subjects given only glucose. In contrast, a study published in the July 2006 issue of The American Journal of Clinical Nutrition found that blood glucose levels were lower between 20 minutes and 120 minutes after a cayenne-containing meal in human subjects. Lower blood glucose levels were accompanied by lower blood insulin levels, especially in a subgroup of subjects that had consumed a cayenne-containing diet for an entire mo Continue reading >>

Diabetes & Cayenne Pepper

Diabetes & Cayenne Pepper

Ireland Wolfe has been writing professionally since 2009, contributing to Toonari Post, Africana Online and Winzer Insurance. She obtained her Bachelor of Arts in psychology and Master of Arts in mental health counseling. She is also a licensed mental health counselor, registered nutritionist and yoga teacher. Dried cayenne peppers in a mortar and pestle.Photo Credit: Ken Weinrich/iStock/Getty Images Diabetes is a serious illness affecting 23.6 million people in the United States, according to the National Diabetes Information Clearinghouse as of 2011. No cure for diabetes has been discovered but treatment options are available. Prescription medication and lifestyle changes are the most common treatment regimen for people diagnosed with diabetes. Cayenne pepper has many health benefits and research suggests that it might help reduce or control diabetes. Diabetes is a metabolic disorder. When food is consumed it is converted into glucose, which is used for energy. Insulin is produced by the pancreas to move the glucose from the blood stream into cells where it is needed for growth and energy. In healthy humans, the right amount of insulin is created by the pancreas. However, people with diabetes have too little or no insulin. Without insulin, the glucose will build up and exit the body through urine, leaving a diabetic with no energy. Cayenne pepper, or red pepper, is made from the red chili peppers. Dried pods of chili peppers are used as a seasoning to add spice and taste to a number of dishes. Chili peppers contain capsaicin, which potentially has many health benefits. Proponents have suggested that capsaicin helps increase metabolism, acts as an anti-inflammatory, relieves headaches and acts as an antibacterial agent. Some research has also suggested that capsaicin Continue reading >>

Capsaicin Reduces Alzheimer-associated Tau Changes In The Hippocampus Of Type 2 Diabetes Rats

Capsaicin Reduces Alzheimer-associated Tau Changes In The Hippocampus Of Type 2 Diabetes Rats

Capsaicin reduces Alzheimer-associated tau changes in the hippocampus of type 2 diabetes rats Affiliation Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China Affiliation Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China Affiliation Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China Affiliation Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China * E-mail: [email protected] (YL); [email protected] (YY) Affiliation Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China * E-mail: [email protected] (YL); [email protected] (YY) Affiliation Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China Capsaicin reduces Alzheimer-associated tau changes in the hippocampus of type 2 diabetes rats Type 2 diabetes (T2D) is a high-risk factor for Alzheimers disease (AD) due to impaired insulin signaling pathway in brain. Capsaicin is a specific transient receptor potential vanilloid 1 (TRPV1) agonist which was proved to ameliorate insulin resistance. In this study, we investigated whether dietary capsaicin could reduce the risk of AD in T2D. T2D rats were fed with capsaicin-containing high fat (HF) diet for 10 consecutive days (T2D+CAP). Pair-fed T2D rats (T2D+PF) fed with the HF-diet of average dose of T2D+CAP group were included to control for the effects of reduced food intake and body weight. Capsaicin-con Continue reading >>

Cure Diabetes

Cure Diabetes

Eat the LCHF diet -low carbohydrates high fat This diet is very popular in Sweden now. Quote from annikadahlqvist.com "First we should eat less carbohydrates, sugar and starch (starch found mainly in cereals, potatoes, corn and rice) because they raise blood sugar and insulin, which is bad for our health." Shortly: Stop eating so much carbohydrates like sugar, corn syrup, french fries, chips, cornflakes, potatoes, rice, pasta, pizza, buns, cookies and bisquits. Don't eat light butter, light margarine. Eat real butter and real cream! The light products harm you. Eat real food. This diet is good for people with diabetes. Swedish retreats with LCHF courses and lectures Cure diabetes with vegan diet and raw food Reverse diabetes with raw food Youtube videos Diabetes breakthrough! No more diabetes, capsaicin is the cure Pure capsaicin is about to be prohibited from being sold within the EU starting from January 1 2013 so we should hurry up. (From mashangel.com) According to a study done by scientists at Toronto Medical Center, when capsaicin (the active compound in chili pepper) was injected directly into the pancreas of mice, it was stimulated to start producing insulin! This is a research that went viral when it was published in 2007.The scientists at United States Agricultural Department are considering the benefits of cinnamon in preventing diabetes in people with borderline diabetes. When the people participating in the study included a cinnamon extract in their diet for a period of three months, their blood glucose levels significantly decreased. (From canada.com) In a discovery that has stunned even those behind it, scientists at a Toronto hospital say they have proof the body's nervous system helps trigger diabetes, opening the door to a potential near-cure of the d Continue reading >>

Mice Cured Of Type 1 Diabetes With Capsaicin

Mice Cured Of Type 1 Diabetes With Capsaicin

Mice cured of type 1 diabetes with capsaicin A few weeks ago I read an interesting story that was again hopeful for many diabetics who are waiting for a scientific cure for type 1 diabetes. The journal Cell published a new Canadian study with animals, where mice were injected with capsaicin, the substance that makes chili peppers spicy, and they were quickly cured of type 1 diabetes. Researchers from the Hospital for Sick Children in Toronto believe that Type 1 diabetes the most serious form of the disease that usually appears in childhood is caused by malfunctioning pain nerves that surround cells in the pancreas. In patients suffering from Type 1 diabetes, the pancreas fails to produce sufficient levels of insulin, causing inflammation and death of insulin-producing islet cells in the pancreas. Experts have long believed that the condition was caused by the bodys immune system turning against itself, but the Toronto researchers immunologist Dr. Hans Michael Dosch and pain expert Dr. Michael Salter theorized faulty pancreatic pain neurons could be to blame. Dosch had observed in previous research that islet cells in diabetics were surrounded by an enormous number of pain nerves that signaled the brain that the pancreatic tissue was damaged. To test their theory, Dosch and Salter injected capsaicin into mice that had Type 1 diabetes, to kill the animals pancreatic pain nerves. The researchers said they were stunned to discover that the injected mices islet cells began producing insulin normally almost immediately. I couldnt believe it, Salter said. Mice with diabetes suddenly didnt have diabetes anymore. Dosch and Salter discovered on further research that the pancreatic nerve cells were a vital part of the functioning of islet cells, by secreting neuropeptides that te Continue reading >>

Diabetes In Mice Cured With Capsaicin In Chili Peppers

Diabetes In Mice Cured With Capsaicin In Chili Peppers

TheEffects of Capsaicin in Hot Chili Peppers on Type 1 Diabetes ________________________________________________________________ Thiswas the headlineon the front cover of the National Postnewspaper on Dec.15.06. It's slowly becoming more and more well knownthat one of the major components to healing/curing any kind of diseaseissimply NUTRITION from fruits and vegetables, and that's more or lesswhat these scientists discovered. The diabetic mice were injectedhowever, not fed, capsaicin, an active ingredient in chili peppers.Virtually overnight thediabetes was gone and the mice werehealthy. Capsaicin is a potent inhibitorof "substance P", a neuropeptide associated with inflammatory processes. Pancreas problems and insulinreistance in diabetics is partly due to the inflammation ofinsulin-producing islet cells. Until now, mainstream sciencebelieved that Type 1 diabetes was the result of the body's immunesystem turning againstitself, but it now appears as thoughthe nervous system plays a major part in the disease. Thediscovery happened when the scientists attempted tokillpancreatic sensory nerves with the substance Pneuropeptide. A single injection has kept the mice healthy for up tofour months. Readthe full article on the NationalPost website. Not included with the onlinearticle is this illustration that was in the newspaper: Somepeople might want to give thisa try for themselvesand the only problem there might be is that chili peppers canbe difficult to eat due to the hotness. And how many peppers would berequired? It turns out there is a much simpler way of putting this topractice, although the hot issue still remains. How about a pureorganic chili extract that's made using a proprietaryextraction process that results in a highlyconcentratedliquidcontaining the power of Continue reading >>

Capsaicin From Chili Peppers Can Improve Health In Diabetic And Obese Persons

Capsaicin From Chili Peppers Can Improve Health In Diabetic And Obese Persons

Capsaicin from chili peppers can improve health in diabetic and obese persons Friday, June 06, 2014 by: David Gutierrez, staff writer (NaturalNews) The activity of a specific pain receptor may be behind the beneficial effects of chili peppers on metabolism, according to a study conducted by researchers from the University of California-Berkeley and the Salk Institute for Biological Studies in La Jolla, Calif., and published in the journal Cell on May 22. Blocking that pain receptor (as frequent exposure to hot peppers seems to do) was found to lengthen the lives of mice, improve their insulin response and keep their metabolisms young. Previous research has shown that mice which lack the pain receptor TRPV1 are less likely to become obese, indicating that the receptor plays some role in regulating metabolism. TRPV1, found in the nerves, skin and joints, is sensitive to painful stimuli such as extremely high temperatures. In the nerves that connect to the pancreas, TRPV1 is known to stimulate the release of chemicals that prevent the release of insulin and cause inflammation. This implies that the sensation of pain may actually cause more inflammation and higher blood sugar levels, two risk factors for diabetes and cardiovascular disease. In the current study, researchers found that mice which had been genetically engineered to lack TRPV1 lived about 14 percent longer than non-engineered mice. They also had lower levels of CGRP, a peptide that TRPV1 stimulates the pancreas to produce in order to block insulin release. These low levels of CGRP were linked to a more youthful metabolism, even in old age. Specifically, the bodies of low-CGRP mice rapidly cleared sugar from the blood, rather than demonstrating the slower sugar-removing response associated with aging. The mice Continue reading >>

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