Common Drug Combo Raises Blood Glucose
Researchers have discovered that the commonly used combination of two drugs — the antidepressant paroxetine (brand name Paxil) and the cholesterol-lowering medicine pravastatin (Pravachol) — can cause unexpected increases in blood glucose levels, even though neither medicine has this effect when taken alone. It is estimated that between 500,000 and 1 million people in the United States may be taking this drug combination. It is not unusual for medicines to have effects when taken simultaneously with other medicines that they do not have when taken alone, but since most drugs are approved independently, it can be impossible for physicians to predict these effects. In an effort to keep track of them, the US Food and Drug Administration encourages physicians to report any unexpected side effects to their Adverse Event Reporting System (AERS). To identify combinations of drugs that cause altered blood glucose levels, researchers searched AERS for pairs of medicine that appeared to cause high blood glucose only in combination. They found four such pairs, and focused on the match-up of Paxil and Pravachol because it is such a commonly prescribed combination. None of the people in the AERS taking this combination were directly reported to have high blood glucose — only symptoms of high blood glucose — so the researchers then evaluated the medical records from patients at the Stanford University School of Medicine, Vanderbilt University, and Harvard Medical School who were taking these medicines. They discovered that 135 people without diabetes who had prescriptions for both drugs had experienced an average increase in their random glucose levels of 19 mg/dl since beginning treatment and that 104 people with diabetes had experienced an average increase of 48 mg/dl since Continue reading >>
Zoloft And High Blood Sugar - From Fda Reports
High blood sugar is found among people who take Zoloft, especially for people who are female, 40-49 old , have been taking the drug for 1 - 6 months, also take medication Seroquel, and have Bipolar disorder. This review analyzes which people have High blood sugar with Zoloft. It is created by eHealthMe based on reports of 95,764 people who have side effects when taking Zoloft from FDA , and is updated regularly. What to expect? If you take Zoloft and have High blood sugar, find out what symptoms you could have in 1 year or longer. You are not alone! Join a support group for people who take Zoloft and have High blood sugar Personalized health information On eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA since 1977. Our tools are simple to use, anonymous and free. Start now >>> Number of reports submitted per year: < 1 month: 11.11 % 1 - 6 months: 29.63 % 6 - 12 months: 22.22 % 1 - 2 years: 3.7 % 2 - 5 years: 11.11 % 5 - 10 years: 14.81 % 10+ years: 7.41 % Gender of people who have High blood sugar when taking Zoloft *: female: 59.08 % male: 40.92 % Age of people who have High blood sugar when taking Zoloft *: 0-1: 0.0 % 2-9: 0.0 % 10-19: 0.48 % 20-29: 5.07 % 30-39: 14.98 % 40-49: 31.16 % 50-59: 25.85 % 60+: 22.46 % Top conditions involved for these people *: Bipolar Disorder (91 people, 18.76%) Sleep Disorder (49 people, 10.10%) Schizophrenia (45 people, 9.28%) Pain (44 people, 9.07%) Insomnia (33 people, 6.80%) Top co-used drugs for these people *: Seroquel (212 people, 43.71%) Zyprexa (153 people, 31.55%) Risperdal (93 people, 19.18%) Ambien (89 people, 18.35%) Neurontin (87 people, 17.94%) Top other side effects for these people *: Diabetes (162 people, 33.40%) Type 2 Diabetes (135 people, 27.84%) High Bl Continue reading >>
Zoloft May Prevent Recurrence Of Depression In Patients With Diabetes
A team of researchers at Washington University School of Medicine in St. Louis found that an antidepressant medication may reduce the risk of recurrent depression and increase the length of time between depressive episodes in patients with diabetes. "That's important not only because people with diabetes will feel better if we can control their depression. It's also key to helping manage blood sugar," says Patrick J. Lustman, Ph.D., principal investigator and professor of psychiatry. "As depression improves, glucose levels also tend to improve." Although depression affects about 5 percent of the general population, the rate is about 25 percent for patients with diabetes. Lustman's team previously demonstrated that treatment with antidepressant drugs and psychotherapy is an effective way to treat depression in patients with diabetes, but often depression would quickly redevelop. "As we better understand depression, it's clear that for many patients, it is a chronic and recurring disease," Lustman says. "That appears to be especially true for patients with diabetes compared to those otherwise free of medical illness" Although they knew that short-term treatment with antidepressants was helpful with mood and with control of blood glucose, Lustman's team didn't know whether the drug could prevent the recurrence of depression in patients with diabetes. He also didn't know what would happen to glucose levels in the months following successful depression therapy. So Lustman teamed up with investigators at the University of Arizona, Tucson, and at the University of Washington, Seattle. They studied a total of 152 patients with diabetes at the three sites. The sample included patients with type 2 diabetes and patients with juvenile, or type 1, diabetes. Study participants averag Continue reading >>
When Good Drugs Do Bad
Your head is throbbing, so you keep popping pain relievers to try to feel better. So why in the world is your headache suddenly worse? Surprisingly, some medications you might take to relieve common health complaints can cause the same problems they're designed to treat. That doesn't mean you shouldn't take those drugs; it's just good to be aware of that potential side effect. Here's a rundown of 10 common types of medications that sometimes backfire and what you can do to try to prevent that from happening, or cope if it does. 1. Migraine medications Examples: drugs that end in "triptan," such as rizatriptan (Maxalt) and sumatriptan (Imitrex and generic) How they can backfire. Using migraine pain relievers too often might lead to a condition known as medication-overuse headache, which affects up to two-thirds of patients who seek help at headache treatment centers in the U.S. It can also happen with nonprescription pain relievers. What to try instead. Some types of migraines should not be treated with triptans, so your first step is to get a diagnosis from your doctor. You need to figure out what's triggering your migraines—if you do, you might be able to avoid them. Common triggers are chocolate, shellfish, and wine. Others include beer, cheese, hunger, strong odors, bright lights, the sun, glare from a TV or computer screen, insomnia, and stress. Instead of jumping to migraine meds, talk to your doctor about alternative therapies shown to reduce the frequency or intensity of migraines or to prevent them. Examples: hepatotoxic PA-free herb butterbur (75 milligrams twice daily); coenzyme Q10 (100 milligrams three times a day); and the B vitamin riboflavin (400 milligrams a day). Note that the Co-Q10 might take up to three months to be effective, and it's fairly expen Continue reading >>
Zoloft Cause Low Blood Pressure – 247603
This amazing site, which includes experienced business for 9 years, is one of the leading pharmacies on the Internet. We take your protection seriously. They are available 24 hours each day, 7 days per week, through email, online chat or by mobile. Privacy is vital to us. Everything we do at this amazing site is 100% legal. – Really Amazing prices – NO PRESCRIPTION REQUIRED! – Top Quality Medications! – Discount & Bonuses – Fast and Discreet Shipping Worldwide – 24/7 Customer Support. Free Consultation! – Visa, MasterCard, Amex etc. – – – – – – – – – – Zoloft Cause Low Blood Pressure Sertraline (Oral Route) Precautions – Mayo ClinicThis medicine may cause hyponatremia (low sodium in the blood). This is more common in elderly patients, those who are taking diuretic medicines for high blood pressure, or those who have decreased amounts of fluid in the body due to severe diarrhea or vomiting. Check with your doctor right away if you or your child Zoloft (sertraline generic) Side Effects…Such combinations may lead to confusion, high blood pressure, tremor, hyperactivity, coma, and death. (A period of 14 days without treatment should lapse when switching between Zoloft and MAOIs.) Similar reactions occur when Zoloft is combined with other drugs for example, tryptophan, St. John's wort, meperidine sertraline and low blood pressure -…Throughout my life I have had low blood pressure but this has never been anything that any doctors have been concerned with and/or did anything about. The readzoloft for high blood pressure – MedHelpBut the literature tell us that 140 systolic and 90 diastolic is high blood pressure. Thus, yours is lower than that and subsequently not high blood pressure. Low blood pressure can cause light-headedness, espe Continue reading >>
Zoloft Side Effects By Likelihood And Severity
COMMON side effects If experienced, these tend to have a Severe expression Altered Interest In Having Sexual Intercourse Inability To Have An Erection Sexual Problems If experienced, these tend to have a Less Severe expression Chronic Trouble Sleeping Diarrhea Dizzy Drowsiness Dry Mouth Excessive Sweating Feel Like Throwing Up Feeling Weak Gas Head Pain Intense Abdominal Pain Involuntary Quivering Loss Of Appetite Low Energy Problem With Ejaculation Weight Loss INFREQUENT side effects If experienced, these tend to have a Less Severe expression Abnormal Increase In Muscle Tone Acne Backache Chest Pain Constipation Easily Angered Or Annoyed Feeling Agitated Hair Loss Heart Throbbing Or Pounding Increased Hunger Indigestion Inflammation Of The Nose Muscle Pain Nervous Pain Problems With Eyesight Temporary Redness Of Face And Neck Throwing Up Weight Gain Yawning RARE side effects If experienced, these tend to have a Severe expression A Feeling Of Restlessness With Inability To Sit Still Abnormal Liver Function Tests Acute Renal Failure Atrioventricular Heart Block Behaving With Excessive Cheerfulness And Activity Bleeding Bleeding Of The Stomach Or Intestines Cataracts Decreased Blood Platelets Deficiency Of Granulocytes A Type Of White Blood Cell Diabetes Discharge Of Milk In Men Or Women When Not Breastfeeding Extrapyramidal Reaction Feeling Anger Toward Something Fever Giant Hives Having Thoughts Of Suicide Hepatitis Caused By Drugs High Blood Pressure High Blood Sugar Hives Hypothyroidism Inflammation Of Skin Caused By An Allergy Itching Life Threatening Allergic Reaction Liver Failure Low Amount Of Sodium In The Blood Low Blood Counts Due To Bone Marrow Failure Lupus-Like Syndrome Mild Degree Of Mania Neuroleptic Malignant Syndrome Nosebleed Pancreatitis Prolonged QT I Continue reading >>
Does Zoloft Raise Blood Sugar Levels – 537571
This amazing site, which includes experienced business for 9 years, is one of the leading pharmacies on the Internet. We take your protection seriously. They are available 24 hours each day, 7 days per week, through email, online chat or by mobile. Privacy is vital to us. Everything we do at this amazing site is 100% legal. – 24/7 Customer Support. Free Consultation! – – – – – – – – – – Does Zoloft Raise Blood Sugar Levels Healthy Glucose – $34.99 – Supports Blood Glucose Levels Ad For Optimal Blood Sugar Health. Clinical Studies Show Results! Does Zoloft cause increased blood sugar/urgent urinating like 4 Answers – Posted in: cymbalta, zoloft, Does Zoloft cause increased blood sugar/urgent urinating like It also elevates blood sugar levels and I'm Diabetic Does Zoloft make your Blood Glucose rise if you are a Is this raise in Blood Sugar a known fact or Does Zoloft make your Blood Glucose Certain foods may increase peak blood level while taking Zoloft. zoloft and high blood sugar – MedHelp Zoloft and high blood sugar. Your zoloft level seems very high and you should talk to Basically did not respond well to zoloft either as this would cause Antidepressants That Cause High Blood Sugar | LIVESTRONG.COM High blood sugar–abnormal, even dangerous levels of sugar in the blood–is known as fluoxetine may Medline Plus reports that fluoxetine can cause nausea Does Zoloft Affect My Sugar Level | HealthCentral Zoloft does not directly affect the level of blood sugar. Some people generic viagra who are treated with antidepressants and have a good result, tend to gain weight. This is Will you have High blood sugar with Zoloft – from FDA reports Could Zoloft cause High blood sugar? Whats your experience using allopurinol and impact on your sugar le Continue reading >>
Zoloft (sertraline)
What else should I know about Zoloft (sertraline)? What preparations of Zoloft (sertraline) are available? Tablets: 25, 50, and 100 mg Oral concentrate: 20 mg/ml How should I keep Zoloft (sertraline) stored? Sertraline should be stored at room temperature between 15 C and 30 C (59 F and 86 F). How does Zoloft (sertraline) work? Serotonin is a neurotransmitter (a chemical messenger) produced by nerve cells in the brain that is used by the nerves to communicate with one another. A nerve releases the serotonin it produces into the space surrounding it. The serotonin either travels across the space and attaches to receptors on the surface of nearby nerves, or it attaches to receptors on the surface of the nerve that produced it. It is then taken up by the nerve and released again (a process referred to as re-uptake). A serotonin balance is reached between attachment to the nearby nerves and reuptake. Selective serotonin inhibitors block the reuptake of serotonin, therefore changing the level of serotonin in the brain. It is believed that some illnesses such as depression are caused by disturbances in the balance between serotonin and other neurotransmitters. The leading theory is that drugs such as sertraline restore the chemical balance among neurotransmitters in the brain. When was Zoloft (sertraline) approved by the FDA? The FDA approved sertraline in December 1991. Continue reading >>
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Antidepressants May Lower Blood Sugar
In a new twist on the expression: the best of both worlds, it turns out that treating depression can help diabetics get their blood sugar levels under control. Researchers made this surprising discovery during a study of diabetic minorities living under the poverty line who have trouble keeping their sugar levels within normal range. High Risk It seems that diabetics have a much higher risk for depression than that of the general population. The rates go up even higher when the diabetics are minorities. This group has the most trouble controlling their blood sugar levels. They also tend to have more complications from diabetes and severer depression, say the researchers. Be that as it may, there have been few studies with an aim toward discovering the effects of depression treatment in minorities with out-of-control diabetes. In an effort to rectify this dearth of information, Dr. Mayer B. Davidson along with his colleagues at Los Angeles' Charles Drew University evaluated low-income diabetes patients for depression at a diabetes clinic. 89 patients with both diabetes and depression were chosen as participants in the trial. 45 of these patients were chosen at random to receive Zoloft (sertraline), an antidepressant medication, while 44 participants were given a placebo. All of the study participants attended an educational program for diabetics. Meetings for the education group were held once a month. There were 39 Hispanic patients in each of the two groups; five participants were African American; while one of the participants in the Zoloft group was listed as "other." Significant Drop The investigators found that after 6 months, those in the Zoloft group had experienced a significant drop in their blood sugar levels. Hemoglobin A1C levels, which is a standard measure Continue reading >>
The Effects Of Sertraline On Blood Lipids, Glucose, Insulin And Hba1c Levels: A Prospective Clinical Trial On Depressive Patients.
Abstract BACKGROUND: In this study, we aimed to investigate the possible effects of sertraline on blood glucose and lipid levels as risk factors for cardiovascular disease in depressive patients. METHODS: Eight male and twelve female depressive patients, diagnosed according to DSM-IV criteria, were included in this study. The subjects aged 19-50 years, did not smoke, and had normal body mass index (BMI), homeostasis model assessment-estimated insulin resistance (HOMA-IR) values, blood pressure, blood glucose, insulin and lipid levels. Sertraline therapy (50 mg/day) was started. Patients with diabetes mellitus, heart disease, pregnancy, and those taking other drugs were excluded from the study. Blood glucose, insulin, high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), and triglyceride values were measured in patients before, and at the 4(th), 8(th) and 12(th) weeks after treatment with sertraline. Moreover, HbA1C levels were measured at the beginning and at the end of the treatment (at 12(th) weeks). RESULTS: There were no significant differences in physical examination (blood pressure, BMI, body weight, height, waist circumference) and laboratory findings (glucose, HDL-C, LDL-C, HOMA-IR and HbA1C levels) at the 12(th) week after of treatment with sertraline compared to pretreatment values. However, insulin levels at the 4(th), 8(th) and 12(th) weeks significantly increased compared with pretreatment values. Likewise, triglyceride levels at the 8(th) and 12(th) weeks significantly increased compared with pretreatment values. CONCLUSIONS: Sertraline-treated patients have to be followed up for blood insulin and triglyceride levels. In addition, their treatment plan needs to be adjusted as necessary to prevent possible metabolic chang Continue reading >>
Medication Warnings
Certain veterinary medications for other conditions may seriously affect diabetic patients. This list is provided because some of these medications don't mention their side effects on diabetics in their literature. Many drugs used in veterinary medicine are also used in human medicine under a differently-trademarked name. Learning the human pharma name (if applicable) or generic name of the drug (same in veterinary & human medicine) can often give you additional information regarding possible side effects and how the drug may affect patients with diabetes. Human pharma drugs provide this information--for some reason, veterinary drugs don't always. The criteria for a drug appearing on the human medications list as affecting blood glucose levels is this: the drug is known to have the same effect on the blood glucose levels of someone who doesn't have diabetes. (Who may not have any adverse reactions of either hyperglycemia or hypoglycemia that need to be treated because the non-diabetic has a working pancreas capable of secreting additional insulin and normal counter-regulatory signaling for the body to release extra glucose, whichever may apply.) These effects then have a possibility to be more pronounced when someone with diabetes is taking them. [1] Diabetes In Control has a list of these drugs here. If you are considering alternative or herbal medicine for your diabetic pet, see also Alternative medication warnings. Whenever medication is prescribed, knowing the following when you receive it can make things easier: [2] Name of the drug Condition the drug is meant to treat How the drug is to be given-orally, in the ear or eye, applied to the skin When and how often it is to be used What to do if you miss a dose The effects expected from the drug Possible side effects o Continue reading >>
Sertraline (oral Route)
Precautions Drug information provided by: Micromedex It is very important that your doctor check your or your child's progress at regular visits. This is to allow for changes in your dose and to help reduce any side effects. Do not take sertraline with a monoamine oxidase (MAO) inhibitor (eg, isocarboxazid [Marplan®], phenelzine [Nardil®], selegiline [Eldepryl®], tranylcypromine [Parnate®]). Do not start taking sertraline during the 2 weeks after you stop a MAO inhibitor and wait 2 weeks after stopping sertraline before you start taking a MAO inhibitor. If you take them together or do not wait 2 weeks, you may develop confusion, agitation, restlessness, stomach or intestinal symptoms, a sudden high body temperature, an extremely high blood pressure, or severe convulsions. Do not use pimozide (Orap®) while you are taking this medicine. Do not use the oral liquid form of sertraline if you are also using disulfiram (Antabuse®). Using these medicines together can cause serious problems. Sertraline may cause a serious condition called serotonin syndrome if taken together with some medicines. Do not use sertraline with buspirone (Buspar®), fentanyl (Abstral®, Duragesic®), linezolid (Zyvox®), lithium (Eskalith®, Lithobid®), methylene blue injection, tryptophan, St. John's wort, or some pain or migraine medicines (eg, rizatriptan, sumatriptan, tramadol, Frova®, Imitrex®, Maxalt®, Relpax®, Ultram®, Zomig®). Check with your doctor first before taking any other medicines with sertraline. For some children, teenagers, and young adults, this medicine can increase thoughts of suicide. Tell your doctor right away if you or your child start to feel more depressed and have thoughts about hurting yourselves. Report any unusual thoughts or behaviors that trouble you or y Continue reading >>
Zoloft
How does this medication work? What will it do for me? Sertraline belongs to a class of medications known as selective serotonin reuptake inhibitors (SSRIs). It is used to treat depression, panic disorder, and obsessive-compulsive disorder (OCD). Sertraline works by affecting the balance of chemicals in the brain. Specifically, it increases the level of a neurotransmitter called serotonin in the brain. Increased serotonin levels can help improve mood, reduce panic attacks, and treat OCD. Although improvements may occur earlier, the full response to the medication may not appear until after 4 weeks of treatment or longer. This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here. Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor. Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it. What form(s) does this medication come in? 25 mg Each yellow capsule contains sertraline HCl equivalent to 25 mg of sertraline. Nonmedicinal ingredients: cornstarch, lactose (anhydrous), magnesium stearate, and sodium lauryl sulfate; capsule shell: D&C Yellow No. 10, FD&C Yellow No. 6, gelatin, and titanium dioxide. This medication does not cont Continue reading >>
Acute Effect Of Different Antidepressants On Glycemia In Diabetic And Non-diabetic Rats
R. Gomez, J. Huber, G. Tombini and H.M.T. Barros Divisão de Farmacologia, Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, Porto Alegre, RS, Brasil Diabetic patients have a 20% higher risk of depression than the general population. Treatment with antidepressant drugs can directly interfere with blood glucose levels or may interact with hypoglycemic agents. The treatment of depression in diabetic patients must take into account variations of glycemic levels at different times and a comparison of the available antidepressant agents is important. In the present study we evaluated the interference of antidepressants with blood glucose levels of diabetic and non-diabetic rats. In a first experiment, male adult Wistar rats were fasted for 12 h. Imipramine (5 mg/kg), moclobemide (30 mg/kg), clonazepam (0.25 mg/kg), fluoxetine (20 mg/kg) sertraline (30 mg/kg) or vehicle was administered. After 30 min, fasting glycemia was measured. An oral glucose overload of 1 ml of a 50% glucose solution was given to rats and blood glucose was determined after 30, 60 and 90 min. Imipramine and clonazepam did not change fasting or overload glycemia. Fluoxetine and moclobemide increased blood glucose at different times after the glucose overload. Sertraline neutralized the increase of glycemia induced by oral glucose overload. In the second experiment, non-diabetic and streptozotocin-induced diabetic rats were fasted, and the same procedures were followed for estimation of glucose tolerance 30 min after glucose overload. Again, sertraline neutralized the increase in glycemia after glucose overload both in diabetic and non-diabetic rats. These data raise the question of whether sertraline is the best choice for prolonged use for diabetic individuals, because of its antihyperg Continue reading >>
