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Can Vitamin D Prevent Diabetes?

How Vitamin D Helps In Diabetes

How Vitamin D Helps In Diabetes

Vitamin D, or the “sunshine vitamin,” is actually made in our skin when it is exposed to sunlight. This vitamin is a vital cog in a machinery that performs a wide range of functions inside our body. More recently, scientists have uncovered the connection between vitamin D and diabetes. Studies suggest that vitamin D can have positive effects on people with type 2 diabetes. Apart from healthy bones, vitamin D is also helpful in the proper functioning of muscles as well as our immune system. Vitamin D also protects us from: Cancers (like that of breast, prostate, colon) Heart disease High blood pressure Multiple sclerosis What Does Research Say about Vitamin D Deficiency and Diabetes? For years, vitamin D was known for its role in bone health. New research is now concluding that this vitamin can actually have an important role in the overall health of a person. Doctors believe that there is an unmistakable link between vitamin D and diabetes. This is because studies have conclusively indicated that people with low levels of vitamin D are at a higher risk of developing diabetes, later in life. A study on 668 elderly individuals, who lived in the northern latitudes (where getting enough sunshine is a problem), found that these individuals were at a greater risk of developing type 2 diabetes due to vitamin D deficiency. The researchers went on to say that vitamin D sufficiency provides protection against type 2 diabetes. A 2011 review looked at various studies that examined how much vitamin D people were getting, by conducting a blood test that assessed the amount of vitamin D in their blood. These people were then followed to see if they got type 2 diabetes later in life. It was found that people with higher amounts of vitamin D in the blood (> 25ng/ml) had a decreased Continue reading >>

Vitamin D In Type 1 Diabetes Prevention

Vitamin D In Type 1 Diabetes Prevention

Presented as part of the symposium Vitamin D Insufficiency: A Significant Risk Factor in Chronic Diseases and Potential Disease-Specific Biomarkers of Vitamin D Sufficiency given at the 2004 Experimental Biology meeting on April 18, 2004, Washington, DC. The symposium was sponsored by the American Society for Nutritional Sciences and supported in part by educational grants from the Centrum Foundation of Canada and The Coca-Cola Company. The proceedings are published as a supplement to The Journal of Nutrition. This supplement is the responsibility of the guest editors to whom the Editor of The Journal of Nutrition has delegated supervision of both technical conformity to the published regulations of The Journal of Nutrition and general oversight of the scientific merit of each article. The opinions expressed in this publication are those of the authors and are not attributable to the sponsors or the publisher, editor, or editorial board of The Journal of Nutrition. The guest editors for the symposium publication are Mona S. Calvo, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD, and Susan J. Whiting, College of Pharmacy and Nutrition, University of Saskatchewan, SK, Canada. The Journal of Nutrition, Volume 135, Issue 2, 1 February 2005, Pages 323325, Limited data from human observational studies suggest that early supplementation with 10 g/d (400 IU/d) or less of vitamin D may not reduce the risk for type 1 diabetes but that doses of 50 g/d (2000 IU/d) and higher may have a strong protective effect. Current U.S. recommendations (525 g/d, 200-1000 IU/d) fall in the largely unstudied dose range in between. All infants and children should receive between 5 g/d and 25 g/d of supplemental vitamin D, particularly if they have limit Continue reading >>

Vitamin D And Diabetes

Vitamin D And Diabetes

Renewed interest in vitamin D, the so-called “sunshine vitamin,” has occurred recently because it has been linked to everything from cancer and heart disease to diabetes.1 Research studies continue to pour into the literature stating that vitamin D is a superstar when it comes to health. However, most of the research is based on observational, epidemiological studies, which are important for generating hypotheses but do not prove causality. A PubMed search in 2011 using the term “vitamin D” and selecting articles published in the past 2 years resulted in more than 2,864 hits. The following diseases and conditions have been researched to assess their relationship with vitamin D status: osteomalacia/osteoporosis,2–5 muscle function and falls,6–8 cancer,9–14 multiple sclerosis,15 hypertension,16 type 1 diabetes,17 rheumatoid arthritis,18 tuberculosis,19,20 mental health,21 cardiovascular events,22,23 infection,24,25 seasonal affective disorder,26 obesity,27 aging,28 and overall mortality.23 The challenge for health care providers and nutrition researchers is to determine whether vitamin D deficiency actually causes or increases the incidence of certain diseases or whether, instead, low levels of vitamin D are simply coincidental given that the majority of the general population, regardless of disease, is likely to have insufficient levels of vitamin D. In other words, do people who develop disease states just happen to be deficient in vitamin D, or do low levels of vitamin D cause the disease? Will supplementation with vitamin D prevent diseases, and can it be used to treat diseases such as diabetes? The purpose of this article is to summarize the latest information related to diabetes and vitamin D. For readers who desire further information, Holick29 has wr Continue reading >>

Vitamin D Can Save You From Diabetes And Dementia

Vitamin D Can Save You From Diabetes And Dementia

By Dr. Mercola Do you know your vitamin D level? If not, a simple blood test called 25(OH)D, or 25-hydroxyvitamin D, can reveal your levels and give you incredible insight into your potential future risk of disease. Low vitamin D levels are widely known to harm your bones, leading them to become thin, brittle, soft, or misshapen. But a lack of vitamin D does not only impact your bones. Far from it. You see, vitamin D isn’t a vitamin at all. It’s a steroid hormone that influences virtually every cell in your body. From your heart to your brain to your immune system, maintaining optimal vitamin D levels is incredibly important. It’s also incredibly easy, because the best way to get vitamin D is to have regular exposure to the sun or a high-quality tanning bed. If those aren’t options, you can take vitamin D3 orally (along with some synergistic nutrients, which I’ll discuss below). It’s one of the least expensive vitamin supplements… The point is, there’s no reason to put your health at risk from low vitamin D levels… yet researchers such Dr. Michael Holick estimate that 50 percent of the general population is at risk of vitamin D deficiency and insufficiency. If you’re among them, new research shows your risk of diabetes and other metabolic disorders may be significantly increased. Vitamin D Deficiency Linked to Diabetes You’re probably aware that obesity is associated with type 2 diabetes, but a new study found low vitamin D levels may be an even more significant factor. In a study of more than 100 people, those with low vitamin D levels were more likely to have type 2 diabetes, pre-diabetes, or metabolic syndrome, regardless of their weight. Among obese people, those without metabolic disorders had higher levels of vitamin D than those with such di Continue reading >>

Vitamin D And Diabetes

Vitamin D And Diabetes

Tweet Vitamin D is a fat-soluble vitamin that plays a number of important roles in the body, including maintaining the health of your bones, teeth and joints, and assisting immune system function. This underrated vitamin is found in certain foods but is also produced by the body in response to exposure to the sun. When the sun’s ultraviolet-B (UVB) rays are exposed to bare skin, the body converts a cholesterol derivative into Vitamin D. In fact, it’s now known that every cell and tissue within the body has a Vitamin D protein receptor. However, most of us in the UK and other Western countries are deficient in Vitamin D, including many patients with Type 2 diabetes, due to limited sunlight exposure caused by a number of factors, including more time spent at home, in the office or the car, shorter days in winter, sunscreen use in summer and fears of skin cancer. Vitamin D deficiency The signs of Vitamin D deficiency can range from bone pain and muscle weakness to depression and weakened immune system, while longer-term deficiency can result in obesity, high blood pressure, psoriasis, osteoporosis, chronic fatigue, Alzheimer’s disease, cancer and type 2 diabetes. Exposing your skin to the sun for 15-20 minutes each day can help increase your body’s own production of vitamin D and thus reduce your risk of diabetes and other serious medical conditions. Alternatively, you can get your daily intake of vitamin D through dietary supplements and foods such as nuts, oily fish, eggs, powdered milk and some fortified cereals. Effects on diabetes Vitamin D is believed to help improve the body’s sensitivity to insulin – the hormone responsible for regulating blood sugar levels – and thus reduce the risk of insulin resistance, which is often a precursor to type 2 diabetes Continue reading >>

Should We Prescribe Vitamin D To Prevent Type 2 Diabetes?

Should We Prescribe Vitamin D To Prevent Type 2 Diabetes?

Should We Prescribe Vitamin D to Prevent Type 2 Diabetes? Ronan Roussel, MD, PhD; Chantal Mathieu, MD, PhD The following is an edited, translated transcript of a conversation taped in June 2015 between Ronan Roussel, MD, PhD, professor of endocrinology at Bichat Hospital, Paris, France, and Chantal Mathieu, MD, PhD, chair of the Division of Clinical Endocrinology at the Catholic University of Leuven, Belgium. Prof Roussel: Hello and welcome to Medscape. Today we're going to look at the relationship between vitamin D deficiency and diabetes risk. For this, I am joined by Prof Chantal Mathieu from the University of Leuven, in Belgium. Hello, Chantal. Prof Roussel: This relationship between vitamin D deficiency and diabetes risk is no doubt quite common. How close is this link? Prof Mathieu: There are epidemiologic studies showing, in fact, that vitamin D deficiency or even vitamin D insufficiencythat is, fairly low levels but short of an actual deficiencycauses an increased risk of developing diabetes, especially type 2. Prof Roussel: In the case of vitamin D deficiency, is the risk increased by 10%? Is it doubled? Prof Mathieu: There are studies showing that, in certain populations, the risk is doubled. However, it is very difficult to interpret these epidemiologic studies. This is because vitamin D deficiency is always accompanied by a specific profile. Most of these vitamin Ddeficient people are also obese, older, and very often of non-European origin. Therefore, several risk factors accompany vitamin D deficiency in type 2 diabetes. Prof Roussel: So you're suggesting that there are confounding factors and that, in the end, this relationship is not one of causality. Prof Mathieu: There are definitely some confounding factors, but when they are adjusted for (obesity, a Continue reading >>

The Effect Of Vitamin D On Insulin Resistance In Patients With Type 2 Diabetes

The Effect Of Vitamin D On Insulin Resistance In Patients With Type 2 Diabetes

Abstract Over the past decade, numerous non-skeletal diseases have been reported to be associated with vitamin D deficiency including type2 diabetes mellitus (T2DM). Different studies provide evidence that vitamin D may play a functional role in glucose tolerance through its effects on insulin secretion and insulin sensitivity. This study evaluates the effects of vitamin D supplementation on insulin resistance in T2DM. Through a before-after study, 100 patients with T2DM, 30–70 years old, were recruited from an Arak diabetes clinic as consecutive attenders. Participants were assessed for clinical and biochemistry. Serum insulin and, 25(OH)D concentration, and HOMA-IR was calculated. All measurements were performed at the beginning and the end of the study. Patients received 50,000 unit of vitamin D 3 orally per week for eight weeks, Statistical analysis was made using SPSS17. The results were analyzed by descriptive tests, and a comparison between variables were made using paired T-tests or Wilcoxon tests, as appropriate. 100 participants including 70 women (70%) and 30 men (30%) took part in the study. All results were presented as Mean±SD, or medians of non-normally distributed. 24% of the participants were Vitamin D deficient {serum 25(OH)D ≤ 20 ng/ml(50 nmol/l)}. Mean serum 25 (OH) D concentration was 43.03± 19.28 ng/ml (107.5±48.2 nmol/l). The results at baseline and at the end, for FPG were 138.48±36.74 and 131.02±39 mg/dl (P=0.05), for insulin, 10.76±9.46 and 8.6±8.25 μIu/ml (P=0.028) and for HOMA-IR, 3.57±3.18 and 2.89±3.28 (P=0.008) respectively. Our data showed significant improvements in serum FPG, insulin and in HOMA-IR after treatment with vitamin D, suggested that vitamin D supplementation could reduce insulin resistance in T2DM. Introduction Continue reading >>

Vitamin D

Vitamin D

What Is Its Role in Diabetes? What is your vitamin D level? Some day – maybe soon – having your vitamin D level measured may become as routine as having your cholesterol checked. According to some advocates of routine vitamin D testing, the results could prove to be a useful piece of medical information. The importance of adequate vitamin D levels in the body has been recognized for decades. In 1921, scientists proved that exposure to the sun hardens bones and prevents diseases of “rubbery,” weak bones called rickets (in children) and osteomalacia (in adults). It was later discovered that it is the vitamin D produced when the skin is exposed to sun that helps the body absorb calcium and strengthen the skeleton. Around the same time, cod liver oil was found to be a potent food source of vitamin D. Popular and scientific interest in vitamin D waned, however, once these diseases became relatively uncommon, particularly in the United States, where milk and some other foods have been routinely fortified with vitamin D since the 1930’s. Recently, however, new research on the so-called sunshine vitamin has shown that it plays a role in many more bodily systems than just the skeletal system. In fact, a deficiency of vitamin D is thought to possibly play a role in the development of numerous diseases, from cardiovascular disease to multiple sclerosis to complications of pregnancy. All of this new attention has made vitamin D a very popular supplement and the subject of renewed scientific inquiry. Vitamin D in the body The human body was designed to get most of its vitamin D through exposure to the ultraviolet (UVB) rays of the sun – the same rays that cause sunburn and skin damage. “Inactive” vitamin D is derived from cholesterol and “waits” in the skin tissu Continue reading >>

Is Vitamin D Deficiency Linked With Diabetes? | Everyday Health

Is Vitamin D Deficiency Linked With Diabetes? | Everyday Health

Some research suggests avoiding vitamin D deficiency may help reduce your risk for heart disease, which people with diabetes are more likely to develop. Youve likely heard of the power of vitamin D, also known as the sunshine vitamin. You can either get vitamin D through the suns rays, which signal your body to make vitamin D, or through certain foods or supplements. Vitamin D is a fat-soluble, rather than water-soluble, vitamin so when you get it through your diet, youll best absorb it alongside a fat-containing food, such as almonds, peanut butter, or avocado. The vitamin is important for your health: Research suggests that it may help with everything from athletic performance to heart disease, and may even help protect against type 2 diabetes . What Does Vitamin D Do for Our Bodies and Our Health? Vitamin D plays many important roles in the body, and helps you maintain healthy bones, joints, and teeth, as well as a well-functioning immune system. Vitamin D aids in the absorption of calcium in the body to promote bone growth, notes Erin Palinski-Wade, RD, CDE , author of The 2-Day Diabetes Diet: Just 2 Days a Week and Dodge Type 2 Diabetes , who is in private practice in Franklin, New Jersey. Some observational studies suggest vitamin D may also play a role in the prevention of certain diseases and disorders, such as diabetes. The sunshine vitamin may also help keep your ticker healthy: A review published in January 2014 in the journalCirculation Research suggested that vitamin D deficiency is detrimental for heart health. This is important to note because people with type 2 diabetes are at a greater risk for heart problems. In fact, the Centers for Disease Control and Prevention (CDC) notes people with diabetes are two times more likely to die from heart disease tha Continue reading >>

Study: Vitamin D May Cut Risk Of Diabetes

Study: Vitamin D May Cut Risk Of Diabetes

Study: Vitamin D May Cut Risk of Diabetes Researchers Say Vitamin D May Be Useful in Protecting Against Diabetes in High-Risk People June 28, 2011 (San Diego) -- Vitamin D may help prevent diabetes in people at high risk of developing the condition, researchers report. The study does not prove cause and effect. "But if confirmed, there are huge implications because vitamin D is easy and inexpensive," Anastassios Pittas, MD, of Tufts Medical Center in Boston, tells WebMD. In a study of over 2,000 people with prediabetes , the higher the level of vitamin D in the blood , the lower the risk of developing type 2 diabetes . Pittas presented the results here at the annual meeting of the American Diabetes Association. The three-year study involved 2,039 people with high blood sugar levels . Their vitamin D levels were measured at the start of the study and six months, one year, two years, and three years later. For every 5 nanograms per milliliter (ng/mL) increase in vitamin D levels, the risk of developing diabetes dropped by 8%, Pittas says. Levels of 30 or higher are considered normal. The participants were divided into three groups. Participants in the group with the highest third of vitamin D levels (average reading of about 30 ng/mL) were 38% less likely to develop diabetes than those in the lowest third (average vitamin D level of 13 ng/mL). A strength of the study is that vitamin D levels were measured at various time points, Pittas says. Past studies often relied on one measurement at the start of the study, which may not accurately reflect their vitamin D status over time. The analysis also took into account a person's body weight , physical activity , and other factors known to decrease diabetes risk. Nonetheless, there could be some unmeasured variable that affect Continue reading >>

Vitamin D Status In Relation To Glucose Metabolism And Type 2 Diabetes In Septuagenarians

Vitamin D Status In Relation To Glucose Metabolism And Type 2 Diabetes In Septuagenarians

OBJECTIVE Vitamin D deficiency is thought to be a risk factor for development of type 2 diabetes, and elderly subjects at northern latitudes may therefore be at particular risk. RESEARCH DESIGN AND METHODS Vitamin D status was assessed from serum concentrations of 25-hydroxyvitamin D3 [25(OH)D3] in 668 Faroese residents aged 70–74 years (64% of eligible population). We determined type 2 diabetes prevalence from past medical histories, fasting plasma concentrations of glucose, and/or glycosylated hemoglobin (HbA1c). RESULTS We observed 70 (11%) new type 2 diabetic subjects, whereas 88 (13%) were previously diagnosed. Having vitamin D status <50 nmol/L doubled the risk of newly diagnosed type 2 diabetes after adjustment for BMI, sex, exposure to polychlorinated biphenyls, serum triacylglyceride concentration, serum HDL concentration, smoking status, and month of blood sampling. Furthermore, the HbA1c concentration decreased at higher serum 25(OH)D3 concentrations independent of covariates. CONCLUSIONS In elderly subjects, vitamin D sufficiency may provide protection against type 2 diabetes. Because the study is cross-sectional, intervention studies are needed to elucidate whether vitamin D could be used to prevent development of type 2 diabetes. Vitamin D plays a pivotal role in calcium metabolism, and vitamin D deficiency may be associated with a range of serious diseases, including cancer, cardiovascular disease, and type 2 diabetes (1). Although the underlying biological mechanisms are poorly understood, the association of low serum 25-hydroxyvitamin D3 [25(OH)D3] concentrations with type 2 diabetes may be mediated through effects on glucose homeostasis and, in particular, a direct effect of vitamin D on the β-cell function, and thus insulin secretion (2). Several s Continue reading >>

Type Ii Diabetes

Type Ii Diabetes

Summary Type II diabetes is a condition in which the body has a hard time managing sugar the right way. Usually you develop type II diabetes in adulthood, past the age of 40, but you can develop it earlier, too. Once you get type II diabetes, it lasts for the rest of your life. If your diabetes isn’t managed, you can develop diabetes symptoms, including eyesight issues, skin conditions, circulation problems, and high blood pressure. Type II diabetes (T2D) usually occurs gradually, meaning that the condition is mild to start but gets worse and worse as time goes by. Most people with the disease are overweight when they are diagnosed. Treatments for T2D require lifelong monitoring of sugar levels in your blood, healthy eating, regular exercising, and possibly diabetes medication. Some people with T2D can manage their condition with diet and exercise alone, but many need additional help with medications. Researchers are interested in whether vitamin D helps your body manage sugar in your blood. Additionally, they’re interested in vitamin D’s role in regulating calcium, which also helps manage sugar in your blood. There is some research showing that young people who have higher vitamin D levels decreased their chances of developing T2D later in life compared to people who had lower vitamin D levels. Studies have also shown that vitamin D supplements can help some symptoms of T2D. At this time, the research is conflicting on whether supplementing people at high risk of developing diabetes is helpful in reducing the risk of T2D. If you are at risk of T2D and want to take vitamin D, it is unlikely to harm you or make your symptoms worse. However, it may not prevent diabetes. There is some evidence that vitamin D will improve symptoms associated with T2D, if you have T2D. Continue reading >>

How Vitamin D Protects Against Type 2 Diabetes

How Vitamin D Protects Against Type 2 Diabetes

How vitamin D protects against type 2 diabetes Vitamin D deficiency may put people at higher risk of developing type 2 diabetes, according to a new study now published in the journal PLOS ONE. Vitamin D deficiency has been linked with type 2 diabetes. The study, which is the work of researchers at the University of California (UC), San Diego School of Medicine and Seoul National University in Korea, is not the first to link higher blood levels of vitamin D to a reduced risk of type 2 diabetes . However, as they note in their journal paper , the authors explain that the evidence to date is "mixed" and omits blood levels of vitamin D that are "above the normal range." Our bodies need vitamin D to absorb calcium during digestion and to furnish calcium and phosphate through the blood to processes that make and maintain healthy bones. Vitamin D is also important for cell growth, muscle function, fighting infection, and reducing inflammation . The body obtains vitamin D from a few natural foods, some fortified foods, dietary supplements, and exposure to the sun. Once in the body, the vitamin undergoes some chemical changes to make it biologically useful. The liver is the main producer of biologically active vitamin D; it converts the inert form into an active form called 25-hydroxyvitamin D (25[OH]D). The level of 25(OH)D in the blood, which is known as "serum concentration," is considered "the best indicator of vitamin D status." At present, there is much debate about what the ideal level of 25(OH)D should be to avoid disease and ensure optimum health. The Institute of Medicine (IOM) suggest that 20 nanograms per milliliter is "adequate for bone and overall health in healthy individuals." Other groups have argued that the cut-off should be much higher, as much as 50 nanogra Continue reading >>

The Role Of Vitamin D In The Prevention Of Type 2 Diabetes: To D Or Not To D?

The Role Of Vitamin D In The Prevention Of Type 2 Diabetes: To D Or Not To D?

1. Endocrinology. 2017 Jul 1;158(7):2013-2021. doi: 10.1210/en.2017-00265. The Role of Vitamin D in the Prevention of Type 2 Diabetes: To D or Not to D? (1)Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Boston, Massachusetts 02111. (2)Department of Medical, Surgical, Neurologic, Metabolic and Aging Sciences, University of Campania Luigi Vanvitelli, Naples 80128, Italy. Evidence on biological plausibility from mechanistic studies and highlyconsistent data from observational studies raise the possibility that optimizing vitamin D status may reduce the risk of type 2 diabetes. However, theobservational nature of cohort studies precludes a definitive assessment of causeand effect because residual confounding or reverse causation cannot be excluded. Confounding is especially problematic with studies of vitamin D because blood25-hydoxyvitamin D concentration is not only an excellent biomarker of vitamin D status, reflecting intake or biosynthesis, but also an excellent marker of goodoverall health. Results from underpowered trials and post hoc analyses of trials designed for nondiabetic outcomes do not support a role of vitamin Dsupplementation for prevention of type 2 diabetes among people with normalglucose tolerance. Whether vitamin D supplementation may have a role in theprevention of diabetes in high-risk populations remains to be seen. Adequatelypowered, randomized trials in well-defined populations (e.g., prediabetes) areongoing and expected to establish whether vitamin D supplementation lowers riskof diabetes.Copyright 2017 Endocrine Society. PMCID: PMC5505219 [Available on 2018-07-01] Diabetes Mellitus, Type 2/prevention & control* Continue reading >>

Vitamin D Deficiency Linked To Greater Risk Of Diabetes

Vitamin D Deficiency Linked To Greater Risk Of Diabetes

Follow all of ScienceDaily's latest research news and top science headlines ! Vitamin D deficiency linked to greater risk of diabetes An epidemiological study suggests that persons deficient in vitamin D may be at much greater risk of developing diabetes. An epidemiological study conducted by researchers at University of California San Diego School of Medicine and Seoul National University suggests that persons deficient in vitamin D may be at much greater risk of developing diabetes. The findings are reported in the April 19, 2018 online issue of PLOS One. The scientists studied a cohort of 903 healthy adults (mean age: 74) with no indications of either pre-diabetes or diabetes during clinic visits from 1997 to 1999, and then followed the participants through 2009. Vitamin D levels in blood were measured during these visits, along with fasting plasma glucose and oral glucose tolerance. Over the course of time, there were 47 new cases of diabetes and 337 new cases of pre-diabetes, in which blood sugar levels are higher than normal but not yet high enough to be categorized as type 2 diabetes. For the study, the researchers identified the minimum healthy level of 25-hydroxyvitamin D in blood plasma to be 30 nanograms per milliliter. This is 10 ng/ml above the level recommended in 2010 by the Institute of Medicine, now part of The National Academies, a health advisory group to the federal government. Many groups, however, have argued for higher blood serum levels of vitamin D, as much as 50 ng/ml. The matter remains hotly debated. "We found that participants with blood levels of 25-hydroxyvitamin D that were above 30 ng/ml had one-third of the risk of diabetes and those with levels above 50 ng/ml had one-fifth of the risk of developing diabetes," said first author Sue K. Continue reading >>

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