Obesity And Vitamin D Deficiency Linked To Insulin Resistance
Obesity and Vitamin D Deficiency Linked to Insulin Resistance The combination of obesity and vitamin D deficiency may put people at even greater risk of insulin resistance than either factor alone, according to new research from the Drexel University School of Public Health recently published early online in the journal Diabetes Care . Insulin resistance is a major risk factor for Type 2 diabetes, a condition that affects 25.6 million adults and is the seventh leading cause of death in the United States. Vitamin D insufficiency and obesity are individual risk factors for insulin resistance and diabetes, said lead author Shaum Kabadi, a doctoral candidate in epidemiology at Drexel. Our results suggest that the combination of these two factors increases the odds of insulin resistance to an even greater degree than would have been expected based on their individual contributions. In the study, obese individuals who had healthy levels of vitamin D had insulin resistance almost 20 times more often than the overall study population. But in obese individuals whose serum vitamin D was low, insulin resistance was much higher: about 32 times more common than the average. Senior author Dr. Longjian Liu , an associate professor in the School of Public Health, noted, Its not clear whether obesity itself causes a low vitamin D level or if its the other way around. Vitamin D is stored in adipose fat tissues, making it unavailable for the body to use; as a result, people who are overweight are already more likely to have low levels of serum vitamin D. Vitamin D deficiency is associated with multiple health conditions including diabetes, cardiovascular diseases including stroke, depression, dementia and other conditions. Kabadi, Liu and co-author Dr. Brian Lee , an assistant professor Continue reading >>
Vitamin D And Its Role In Diabetes
Vitamin D, otherwise known as the “sunshine vitamin,” is vital for bone health but may soon be regarded as an important marker of health similar to cholesterol and blood pressure. Over the last few decades, scientists have looked past the skeletal support this micronutrient offers and are discovering that vitamin D may play a vital role in insulin, glucose, and inflammation regulation as well as potentially being a warning sign for different cardiovascular and endocrine diseases — including type 2 diabetes. So What Exactly Is Vitamin D? Vitamins are chemicals the body needs to function properly and are required to maintain good health. There are two main categories of vitamins: water soluble and fat soluble vitamins. Fat Soluble Vitamins Water Soluble Vitamins Vitamin A (retinol) B1 Thiamine B7 Biotin Vitamin D B2 Riboflavin B9 Folate Vitamin E B3 Naicin B12 Cobalamin K B5 Pantothenic acid C Ascorbic acid B6 Pyridoxine As seen in the table above, water-soluble vitamins like vitamin B and vitamin C are generally excreted and can be replenished daily with little to no worry about toxicity for most people. Fat-soluble vitamins like vitamin D are stored in the liver and fatty tissue and are not always required daily by everyone (depending on your nutritional status). Excessive amounts of vitamin D and other fat-soluble vitamins can be toxic, but being deficient in one of these vitamins can cause numerous other health problems as well. Vitamin D is unlike any other micronutrient in that the body can produce its own from sunlight whereas most other vitamins are acquired by the foods you eat. 3 Ways to Get Vitamin D The three main ways to get vitamin D are through sun exposure, vitamin D supplementation, and dietary intake. Sun/UVB The best way to get vitamin D is to get Continue reading >>
Role Of Vitamin D In Insulin Resistance
1Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan 2Department of Pediatrics, Taoyuan Armed Forces General Hospital, Taoyuan 325, Taiwan 3Department of Medicine, Cardinal Tien Hospital, School of Medicine, Fu Jen Catholic University, New Taipei City 231, Taiwan Received 15 June 2012; Revised 17 August 2012; Accepted 27 August 2012 Copyright 2012 Chih-Chien Sung et al. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Vitamin D is characterized as a regulator of homeostasis of bone and mineral metabolism, but it can also provide nonskeletal actions because vitamin D receptors have been found in various tissues including the brain, prostate, breast, colon, pancreas, and immune cells. Bone metabolism, modulation of the immune response, and regulation of cell proliferation and differentiation are all biological functions of vitamin D. Vitamin D may play an important role in modifying the risk of cardiometabolic outcomes, including diabetes mellitus (DM), hypertension, and cardiovascular disease. The incidence of type 2 DM is increasing worldwide and results from a lack of insulin or inadequate insulin secretion following increases in insulin resistance. Therefore, it has been proposed that vitamin D deficiency plays an important role in insulin resistance resulting in diabetes. The potential role of vitamin D deficiency in insulin resistance has been proposed to be associated with inherited gene polymorphisms including vitamin D-binding protein, vitamin D receptor, and vitamin D 1alpha-hydroxylase gene. Other roles have been propos Continue reading >>
Causal Relationship Between Insulin Resistance And Vit D Deficiency ?
Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community Causal relationship between insulin resistance and vit D deficiency ? There seems to be quite a lot of evidence that many people with insulin resistance are deficient in vitamin D. I think its accepted that there is a correlation (sorry I don't have links its just my impression from reading stuff). However the research I've seen looking at whether vitamin D deficiency causes insulin resistance hasn't found such a causal relationship. This surprised me a bit. Just wondering if the causal relationship is the other way around, ie could it be possible that insulin resistance causes vitamin D deficiency ? Very interesting question! I have suspected some sort of association as well but am yet to find any firm evidence. Don't have time right now to answer this. Saw this the other day (Dr Berg) so pulled up some food for thought for you Ivor Cummins lecture on vitD is very good. I have only viewed it once but 'causal' links to T2 doesn't ring a bell. This lecture is over an hour but there is an abridged version of half that time on youtube. Goodness. I go against the tide on both counts (Vit D and salt) I am neither low nor deficient in either, but am an insulin resistant T2! There seems to be quite a lot of evidence that many people with insulin resistance are deficient in vitamin D. I think its accepted that there is a correlation (sorry I don't have links its just my impression from reading stuff). However the research I've seen looking at whether vitamin D deficiency causes insulin resistance hasn't found such a causal relationship. This surprised me a bit. Just wondering if the causal relationship is the other way around, ie could it be possible that ins Continue reading >>
Small Study: Vitamin D Repletion May Decrease Insulin Resistance
Small study: Vitamin D repletion may decrease insulin resistance Key clinical point: Improved vitamin D levels correlated to lower insulin resistance and reduced adipose fibrosis. Major finding: Of the 19 patients studied, expression of profibrotic genes TGFb-1, HiF-1, MMP7, and Collagen I, V, and VI in those given vitamin D therapy decreased 0.81, 0.72, 0.62,. 0.56, 0.56, and 0.43 times, respectively (P less than .05). Data source: Randomized, double blind, placebo-controlled study of 19 obese, insulin resistant, vitamin D deficient patients. Disclosures: The investigators reported no relevant conflicts of interest. WASHINGTON Normalizing vitamin D levels correlated with lower insulin resistance and decreased adipose fibrosis in obese patients, according to a study presented at the Eastern regional meeting of the American Federation for Medical Research. Approximately 86 million U.S. patients have prediabetes, according to Diabetes Report Card 2014, the most recent estimates from the Centers for Disease Control and Prevention. Vitamin D therapy may be able to help lower that number and prevent diabetes in some patients, Jee Young You, MD, a research fellow at Albert Einstein College of Medicine, New York, said at the meeting. When theres increased adiposity, there is reduction of the blood flow which will further lead to inflammation, macrophage infiltration, and fibrosis, which all together leads to insulin resistance, Dr. You said. It is shown that there are vitamin D receptors present on adipocytes, so we hypothesize repleting vitamin D will help in reducing this inflammation. In a double blind study, Dr. You and her colleagues randomized 11 obese patients, with an average body mass index of 34 kg/m2, insulin resistance, and vitamin D deficiency to vitamin D replet Continue reading >>
Is There A Relationship Between Vitamin D With Insulin Resistance And Diabetes Mellitus?
Is there a relationship between vitamin D with insulin resistance and diabetes mellitus? Kamal AS Al-Shoumer, Division of Endocrinology and Metabolic Medicine, Department of Medicine, Faculty of Medicine, Kuwait University, 13110 Safat, Kuwait Kamal AS Al-Shoumer, Thamer M Al-Essa, Division of Endocrinology and Metabolic Medicine, Department of Medicine, Mubarak Al Kabeer Hospital, 46304 Jabriya, Kuwait Author contributions: Both authors contributed to this work. Correspondence to: Kamal AS Al-Shoumer, MD, FRCP, PhD, FACE, Professor and Consultant, Head, Division of Endocrinology and Metabolic Medicine, Department of Medicine, Faculty of Medicine, Kuwait University, PO Box 24923, 13110 Safat, Kuwait. moc.liamg@remuohsk Telephone: +965-25-319596 Fax: +965-25-313511 Received 2014 Dec 7; Revised 2015 Apr 17; Accepted 2015 May 5. Copyright The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. This article has been cited by other articles in PMC. Available data suggest a possible link between abnormal vitamin D level and abnormal glucose homeostasis, two of the most common chronic medical conditions. Both conditions are associated with inflammation, and the exact mechanism for role of either on the other is not well clear. Literature investigating the link between vitamin D and either pre-diabetic states or diabetes is reviewed. Vitamin D deficiency is detrimental to insulin synthesis and secretion in animal and human studies. In humans, it has been shown by majority of observational studies, that vitamin D is positively correlated with insulin sensitivity and its role is mediated both by direct mechanism through the availability of vitamin D receptors in several tissues and indirectly through the changes in calcium levels. Large number of, Continue reading >>
The Link Between Vitamin D And Insulin Resistance
Important Facts About Cholesterol and Heart Disease Vitamin D is a steroid hormone that influences virtually every cell in your body. Low levels are linked to poor bone health, as well as heart, brain, immune and metabolic dysfunction Animal studies have shown vitamin D is a foundational factor necessary for normal insulin secretion, and that vitamin D improves insulin sensitivity Atypical antipsychotics such as quetiapine, a bipolar medication, can increase your risk of hyperglycemia and diabetes. Research suggests vitamin D3 may counteract these effects Vitamin D is a steroid hormone that influences virtually every cell in your body, which is why maintaining a healthy level is so important. Low vitamin D levels are widely known to harm your bones, leading them to become thin, brittle, soft or misshapen. But vitamin D is equally important for your heart, brain, immune function and much more. For example, there's an important connection between insufficient vitamin D and insulin resistance and/or diabetes , both type 1 1 and type 2. Vitamin D Deficiency May Influence Your Type 2 Diabetes Risk According to recent research, vitamin D deficiency affects your glucose metabolism and may actually be more closely linked to diabetes than obesity. In a study of 118 people, those with low vitamin D levels were more likely to have type 2 diabetes, pre-diabetes or metabolic syndrome, regardless of their weight. Among obese people, those without metabolic disorders had higher levels of vitamin D than those with such disorders, and among lean people, those with metabolic disorders were more likely to have low levels of vitamin D. According to one of the study's authors: 2 "The study suggests that vitamin D deficiency and obesity interact synergistically to heighten the risk of diabe Continue reading >>
Medical Xpress: Vitamin D Improves Insulin Sensitivity In Mice
Vitamin D improves insulin sensitivity in mice European Association for the Study of Diabetes New research presented at this year's European Association for the Study of Diabetes (EASD) meeting in Munich, Germany (12-16 Sept) shows that giving vitamin D improves insulin sensitivity in mice that have become insulin resistant due to a chronic high fat high sugar diet. Vitamin D also reduces the accumulation of fat in muscles (myosteatosis), another sign of improving metabolism. The study is by Dr Elisa Benetti and colleagues from the University of Turin, Italy. Human studies indicate a strong association between vitamin D deficiency and type 2 diabetes. In particular, epidemiological evidence shows that a poor vitamin D status increases the risk of insulin resistance, however the mechanisms underlying this effect are still not completely understood. In addition, early clinical description reported that severe vitamin D deficiency is associated to myopathy, thus suggesting a potential association between vitamin D and muscle function. The aim of this new study was to evaluate the effect of vitamin D administration in a mouse model of diet induced insulin-resistance, focusing on skeletal muscle. A total of 40 male mice were provided with a standard diet or high fat-high sugar diet (HFHS) for 4 months. Subsets of animals were treated with Vitamin D (7 micrograms per kg, 3 times per week) for the last 2 months. Body weight and food intake were recorded weekly. At the end of the treatment, a glucose tolerance test was performed. The expression of markers of fat generation and insulin signalling were analysed. In comparison to standard diet, HFHS diet induced body weight increase (24.8g vs 31.8 g), hyperglycemia (108 vs 145mg/dl) and impaired glucose tolerance. At the muscle l Continue reading >>
The Effect Of Vitamin D Supplementation On Insulin And Glucose Metabolism In Overweight And Obese Individuals: Systematic Review With Meta-analysis
The aim of this systematic review was to assess the effect of vitamin D supplementation on glucose and insulin metabolism in overweight and obese subjects. The search process was based on the selection of publications listed in the databases: PubMed, Scopus, Web of Knowledge, Embase and the Cochrane library that met the inclusion criteria. Twelve randomized controlled trials were included. The analysed population consisted of 1181 individuals with BMIs >23 kg/m2. Changes in the concentration of 25(OH)D, fasting glucose, insulin and the HOMA-IR index were assessed. In the meta-regression analysis, a restricted maximum likelihood method was applied. To combine individual study results, a meta-analysis was performed. Vitamin D supplementation did not have an effect on glucose concentrations, insulin level and HOMA-IR values when the supplemented dose, time of supplementation and baseline of 25(OH)D concentration were taken under consideration in subgroup-analysis. This meta-analysis provides evidence that vitamin D supplementation has no significant effect on glucose and insulin metabolism in overweight and obese individuals. According to the International Diabetes Federation (IDF), in 2013, 8.3% of adults in the world suffered from diabetes1. Around 80–90% of people with type 2 diabetes are obese or overweight (Body Mass Index (BMI) ≥25 kg/m2)2,3. It is well-known that obesity is related to insulin resistance and hyperinsulinemia4,5,6. Therefore, obesity has been recognized as one of the most important single risk factors in the pathogenesis of type 2 diabetes mellitus. Currently, the role of vitamin D in the regulation of insulin secretion is highly investigated7,8. New findings suggest that supplementation with vitamin D could influence insulin secretion and improve Continue reading >>
The Effect Of Vitamin D On Insulin Resistance In Patients With Type 2 Diabetes
Abstract Over the past decade, numerous non-skeletal diseases have been reported to be associated with vitamin D deficiency including type2 diabetes mellitus (T2DM). Different studies provide evidence that vitamin D may play a functional role in glucose tolerance through its effects on insulin secretion and insulin sensitivity. This study evaluates the effects of vitamin D supplementation on insulin resistance in T2DM. Through a before-after study, 100 patients with T2DM, 30–70 years old, were recruited from an Arak diabetes clinic as consecutive attenders. Participants were assessed for clinical and biochemistry. Serum insulin and, 25(OH)D concentration, and HOMA-IR was calculated. All measurements were performed at the beginning and the end of the study. Patients received 50,000 unit of vitamin D 3 orally per week for eight weeks, Statistical analysis was made using SPSS17. The results were analyzed by descriptive tests, and a comparison between variables were made using paired T-tests or Wilcoxon tests, as appropriate. 100 participants including 70 women (70%) and 30 men (30%) took part in the study. All results were presented as Mean±SD, or medians of non-normally distributed. 24% of the participants were Vitamin D deficient {serum 25(OH)D ≤ 20 ng/ml(50 nmol/l)}. Mean serum 25 (OH) D concentration was 43.03± 19.28 ng/ml (107.5±48.2 nmol/l). The results at baseline and at the end, for FPG were 138.48±36.74 and 131.02±39 mg/dl (P=0.05), for insulin, 10.76±9.46 and 8.6±8.25 μIu/ml (P=0.028) and for HOMA-IR, 3.57±3.18 and 2.89±3.28 (P=0.008) respectively. Our data showed significant improvements in serum FPG, insulin and in HOMA-IR after treatment with vitamin D, suggested that vitamin D supplementation could reduce insulin resistance in T2DM. Introduction Continue reading >>
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Does Vitamin D Deficiency Lead To Insulin Resistance In Obese Individuals?
Research Article - Biomedical Research (2017) Volume 28, Issue 17 Does vitamin D deficiency lead to insulin resistance in obese individuals? Zeynep Hlya Durmaz 1 * , Aslhan Dilara Demir 2 , Tuba Ozkan 3 , etin Kln 4 , Rdvan Gkan 4 and Meral Tiryaki 5 1 Department of Biochemistry, Amasya University Research Hospital, Amasya, Turkey 2 Department of Internal Medicine, Amasya University Research Hospital, Amasya, Turkey 3 Department of Nutrition and Dietetics, Amasya University Research Hospital, Amasya, Turkey 4 Department of Microbiology, Amasya University Research Hospital, Amasya, Turkey 5 Department of Pathology, Dkap Yldrm Beyazt Education and Research Hospital, Ankara, Turkey Visit for more related articles at Biomedical Research Aim: Obesity has become an important health problem in developed and developing countries. Nowadays, vitamin D deficiency is very common in obese individuals. Vitamin D deficiency and obesity are associated with cardiovascular disease, metabolic syndrome, type 2 diabetes, and other diseases. In our study, we aimed to investigate the effect of vitamin D deficiency on insulin resistance in obese subjects. Materials and Methods: A total of 170 individuals, (146 females and 24 males) were included in the study. According to Body Mass Index (BMI), patients were divided into 3 groups. Serum vitamin D was compared with insulin resistance and HbA1c. Results: It was shown that serum vitamin D levels were statistically decreased according to BMI. There was also a statistically significant increase in Hba1c level due to increased BMI. There is also a positive correlation between BMI and insulin resistance. Positive correlation was found between HbA1C and insulin resistance. There was no statistically significant difference between the levels of insuli Continue reading >>
Vitamin D Supplementation Reduces Insulin Resistance In T2dm
Home / Resources / Articles / Vitamin D Supplementation Reduces Insulin Resistance in T2DM Vitamin D Supplementation Reduces Insulin Resistance in T2DM There have been studies showing a relationship between T2DM and vitamin D deficiency. Vitamin D deficiency can be seen in diseases such as CVD, metabolic syndrome disorders and osteoporosis. The prevalence of vitamin D deficiency is more common in women with T2DM. Vitamin D plays many different roles in the body such as increasing calcium concentration in the cells, regulating the peroxisome proliferative activated receptor (PPAR), and anti-inflammatory properties. This was an 8-week single blind study, which included 100 patients with T2DM. Patients were given vitamin D3 with their current diet and drug regimen. Patients were told to keep their same medications and diet regimens. After treatment with vitamin D3, FPG and insulin concentration decreased significantly. Hemostatic model assessment-Insulin resistance (HOMA-IR) showed a reduction after vitamin supplementation was given. Mean serum concentration of TC, TG, HDL or LDL cholesterol did not change after eight weeks of supplementation. It appears that 25(OH)D concentration and final FPG has an inverse relationship. The higher concentration of 25(OH)D led to a lower level of FPG. When concentration of vitamin d was 40-60 ng/ml, the effect of vitamin D on insulin resistance was significant. A limitation on the study was that a placebo was not used when comparing the effects of vitamin D in T2DM. T2DM patients have lower concentration of 25(OH)D Prevalence of vitamin D deficiency more common in women with T2DM FPG and insulin concentration decreased after treatment of vitamin D Diabetology & Metabolic Syndrome February 2013 Continue reading >>
Low Levels Of Vitamin D And Minerals Increase Insulin Resistance
Low Levels of Vitamin D and Minerals Increase Insulin Resistance A study published in the Journal of Clinical Diagnostic Research compared the levels of vitamin D3, calcium, and magnesium in diabetic and nondiabetic patients. Researchers examined 30 diabetic patients and 30 matched controls. Glucose, insulin, and vitamin D3 levels were measured using fasting blood samples.1 Compared to vitamin D3 levels (19.55 ng/mL) found in healthy controls, levels (12.29 mg/mL) in the diabetic group were lower.In patients with diabetes, calcium and magnesium levels were low whereas fasting glucose and insulin levels and insulin resistance are high. Higher insulin levels are expected in individuals with insulin resistance. When cells are insulin resistant, theybecome ineffective in transportingglucosemoleculesinto cells. Because of this, theres more glucose circulating in the blood. In the presence of elevated blood glucose, the beta cells of the pancreas work harder to release more insulin. Eventually, the pancreas becomes exhausted and is no longer able to pump out insulin. Together, elevated blood glucose levels and ineffective pancreatic beta cells lead to type 2 diabetes. Circulating blood glucose levels are associated with many other chronic medical conditions like dementia, heart disease, obesity, and cancer. Nutrients are required for various functions in cells. Calcium, magnesium, and vitamin D3 all play important roles in disease prevention and health. When it comes to type 2 diabetes, vitamin D, calcium, and magnesium have been associated with supporting glycemic control. The following table highlights the effects of these nutrients and their food sources: Supports pancreatic beta cell activityBeta cells possess vitamin D receptors2Animal studies show that missing vitamin Continue reading >>
Vitamin D And Diabetes
Tweet Vitamin D is a fat-soluble vitamin that plays a number of important roles in the body, including maintaining the health of your bones, teeth and joints, and assisting immune system function. This underrated vitamin is found in certain foods but is also produced by the body in response to exposure to the sun. When the sun’s ultraviolet-B (UVB) rays are exposed to bare skin, the body converts a cholesterol derivative into Vitamin D. In fact, it’s now known that every cell and tissue within the body has a Vitamin D protein receptor. However, most of us in the UK and other Western countries are deficient in Vitamin D, including many patients with Type 2 diabetes, due to limited sunlight exposure caused by a number of factors, including more time spent at home, in the office or the car, shorter days in winter, sunscreen use in summer and fears of skin cancer. Vitamin D deficiency The signs of Vitamin D deficiency can range from bone pain and muscle weakness to depression and weakened immune system, while longer-term deficiency can result in obesity, high blood pressure, psoriasis, osteoporosis, chronic fatigue, Alzheimer’s disease, cancer and type 2 diabetes. Exposing your skin to the sun for 15-20 minutes each day can help increase your body’s own production of vitamin D and thus reduce your risk of diabetes and other serious medical conditions. Alternatively, you can get your daily intake of vitamin D through dietary supplements and foods such as nuts, oily fish, eggs, powdered milk and some fortified cereals. Effects on diabetes Vitamin D is believed to help improve the body’s sensitivity to insulin – the hormone responsible for regulating blood sugar levels – and thus reduce the risk of insulin resistance, which is often a precursor to type 2 diabetes Continue reading >>
The Relationship Between Vitamin D, Insulin Resistance And Infertility In Pcos Women
Dipanshu Sur* and Ratnabali Chakravorty ILS Hospital, Kolkata, West Bengal, India *Corresponding Author: M.Sc., PGD in Clinical Research Kolkata, West Bengal, India Tel: +919874275456 E-mail: [email protected] Citation: Sur Dipanshu, Chakravorty R (2015) The Relationship between Vitamin D, Insulin Resistance and Infertility in PCOS Women . Gynecol Obstet (Sunnyvale) 5:294. doi: 10.4172/2161-0932.1000294 Copyright: © 2015 Dipanshu S, et al., This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Visit for more related articles at Gynecology & Obstetrics Abstract It has been speculated that the majority of individuals in the India are deficient in Vitamin D and that Vitamin D deficiency has become an epidemic in our country. There is widespread prevalence of varying degrees (50- 90%) of Vitamin D deficiency with low dietary calcium intake in Indian population according to various studies published earlier. A deficiency of Vitamin D not only causes poor bone mineralization but also has been implicated in numerous us chronic diseases. Vitamin D deficiency is common in women with polycystic ovary syndrome (PCOS), with the 67-85% of women with PCOS having serum concentrations of 25-hydroxy Vitamin D (25OHD) <20 ng/ml. Vitamin D deficiency may intensify symptoms of PCOS, with observational studies showing lower 25OHD levels were associated with insulin resistance, ovulatory and menstrual irregularities, lower pregnancy success rate, hirsutism, hyper-androgenism, obesity and elevated cardiovascular disease risk factors. There is some, but limited, evidence for beneficial effects of Vitamin D su Continue reading >>
