Can Type One Diabetes Be Cured?

Major Breakthrough In Search For Cure Of Type 1 Diabetes, Researchers Say

Major breakthrough in search for cure of Type 1 diabetes, researchers say Researchers announced Tuesday a major breakthrough in the search for a cure of Type 1 diabetes. In a study published inNature Cell Biology, researchers at University of California San Francisco said they have, for the first time, transformed human stem cells into mature insulin-producing cells, according to a news release . Replacing these insulin-producing cells, which are lost in patients with Type 1diabetes, has long been a dream of regenerative medicine, but until now, scientists didnt know how to produce cells in a lab dish that work as they would inhealthy adults. Affecting 1.5 million people, Type 1 diabetes, once known as juvenile diabetes or insulin-dependent diabetes, is a chronic and incurable condition in which the pancreas produces little or no insulin, according to Mayo Clinic . Contributing factors to the condition include genetics and some viruses. Complications can, over a period of time, affect the heart, blood vessels, nerves, eyes and kidneys, among others. Maintaining normal blood sugar levels perhaps through regular insulin shots can reduce the risk of many complications. This promising announcement is quite timely in light of a November 2018 study projecting a major insulin shortage by 2030 . We can now generate insulin-producing cells that look and act a lot like the pancreatic beta cells you and I have in our bodies, senior author Matthias Hebrok of the University of California San Francisco said in a statement. This is a critical step towards our goal of creating cells that could be transplanted into patients with diabetes. Stem cells can be changed into other types of human cells, making them rather versatile in terms of possible treatments.According to the New York Pos Continue reading >>

Introduction To Type I Diabetes

Three Articles On Type I Diabetes: Article #1: Introduction to Type I Diabetes (This Article) Article #2: Possible Causes of Type I Diabetes Article #3: The Treatment of Type I Diabetes Introduction to Type I Diabetes Did you know that there are two products that have cured advanced Type I diabetes cases? Both of them will be discussed in this article. But more importantly, one of these products can reverse cumulative severe side-effects of Type I or Type 2 diabetes. Type I diabetes is actually a set of symptoms, meaning it can be caused by several different things. The symptoms are that the blood lacks insulin. There are actually several things that can cause an abnormally low level of insulin in the blood. Type I diabetes is a very severe disease. The average lifespan of Type I diabetic is 5-8 years shorter than an average person. But death is not the worst thing about Type I diabetes. Here is a list of some of the health problems it can lead to: Amputation of limbs Blindness (retinopathy) – diabetes is the leading cause of new cases of blindness in America — 12,000 to 24,000 case annually Kidney failure (nephropathy) – frequently leading to dialysis or a kidney/pancreas transplant Liver disease Arteriosclerosis (hardening of the arteries) Heart disease Stroke (e.g. paralysis) High blood pressure Nerve damage (neuropathy) Dementia Urinary tract infection (mostly in women) Depression – Note: Aspartame (e.g. Equal, NutraSweet, etc.) and sugar are the leading causes of depression in non-diabetics. However, because the average diabetic consumes more aspartame than the average person, it is highly possible that aspartame is by far the REAL cause of depression in diabetics!! A diabetic should absolutely avoid aspartame and all other artificial sweeteners! Bone quali Continue reading >>

Treatment For Type 1 Diabetes

Tweet Central to the treatment of type 1 diabetes is to keep a balance of the right amount of insulin to keep blood glucose levels from being either too high or too low. In type 1 diabetes the body’s immune system kills of the insulin producing cells leaving the pancreas unable to produce enough insulin to keep blood glucose levels at healthy levels. As a result, insulin needs to be taken by injection or another delivery means such as by infusion with an insulin pump. Insulin is a hormone in the body that helps to move glucose out of the blood and into cells for energy. Your health team Your diabetes health team are an important part of your diabetes treatment. Your GP and consultants, between them, will be able to offer you advice on controlling diabetes and refer you to any medical specialists you may need to see. Your health team will also be responsible for making sure you get all the diabetes health checks that are recommended for people with diabetes. The health checks will help you health team to spot any signs of damage caused by diabetes and ensure these are treated to prevent the damage becoming more serious. Insulin injections Tweet Type 2 diabetes mellitus is a metabolic disorder that results in hyperglycemia (high blood glucose levels) due to the body: Being ineffective at using the insulin it has produced; also known as insulin resistance and/or Being unable to produce enough insulin Type 2 diabetes is characterised by the body being unable to metabolise glucose (a simple sugar). This leads to high levels of blood glucose which over time may damage the organs of the body. From this, it can be understood that for someone with diabetes something that is food for ordinary people can become a sort of metabolic poison. This is why people with diabetes are adv Continue reading >>

Cure Type 1 Diabetes - Cure Diabetes - Islet Sheet - Hanuman Medical Foundation - The Long Road To A Cure

Checking blood sugar levels with a finger-stick device. Well, I hope for the best cause Im 26 and Ive been type 1 for like 2 to 3 years. Ive been looking for a cure and a way out of using needles every day. I will say that its made me healthy, but I just want to be the old great person I was before this all came along into my life. Right now I finally got health insurance from my job and Im thinking about getting the pump but I just dont like the idea. Well anyway, I hope the best in your research and for a day that I dont have to use a pump or needles anymore. Brad Ham, commenting on a blogpost in The Sheet Finding a cure for type 1 diabetes has been a roller-coaster of high hopes and deep disappointments. At the time of the great discovery of insulin, people thought that surely a permanent cure couldnt be far off? Decade by decade we learned more about this complex disease and how to control it, so that diabetics could live long and productively. Yet close to a century after that great breakthrough, living with type 1 is still a formidable challenge, and the promise of a real cure seems to retreat into the indefinite future. Diabetes is unlike other diseases where the cause is unknown and a cure might not be easily recognized. We know what conditions cause diabetes and we know how to recognize a cure, but still none has been found. In diabetes, the parameters are clearly defined: a therapy that results in normal blood sugars all the time is a cure. This makes it all the more frustrating when the available therapies are so imperfect. People define a cure for type 1 in different ways. Some insist that the only true cure would be to eliminate the causeto somehow turn off the immune system malfunction that attacks the insulin-producing beta cells. Much effort is being de Continue reading >>

Type 1 Diabetes: How Is It Treated?

KidsHealth / For Teens / Type 1 Diabetes: How Is It Treated? en espaolDiabetes tipo 1: Cul es el tratamiento? Your teachers follow a lesson plan that outlines what you'll study each day. Your parents may have a plan to help you pay for college. And your weekend social plans determine whether you're seeing a movie, heading to a concert, or playing basketball at the gym. People with type 1 diabetes need to follow a different type of plan. A treatment plan, also called a diabetes management plan, helps people to manage their diabetes and stay healthy and active. Everyone's plan is different, based on a person's health needs and the suggestions of the diabetes health care team. The first thing to understand when it comes to treating diabetes is your blood glucose level, which is the amount of glucose in the blood. Glucose isa sugar that comes from the foods we eat and also is formed and stored inside the body. It's the main source of energy for the cells of the body, and is carried to each cell through the blood. Glucose gets into the cells with the help of the hormone insulin . So how do blood glucose levels relate to type 1 diabetes? People with type 1 diabetes can no longer produce insulin. This means that glucose stays in the bloodstream and doesn't get into the cells, causing blood glucose levels to go too high. High blood sugar levels can make people with type 1 diabetes feel sick, so their treatment plan involves keeping their blood sugar levels within a healthy range, while making sure they grow and develop normally. To do that, people with type 1 diabetes need to: eat a healthy, balanced diet and stick to a diabetes meal plan check their blood sugar levels several times a day Following the treatment plan can help a person stay healthy, but it's not a cure for diab Continue reading >>

Cure Research

Our cure research will give people with type 1 diabetes the ability to make their own insulin again. A cure for type 1 diabetes must do two things: stop the immune system destroying the cells that make insulin, and replace the cells that have been lost. Beta cells are the highly specialised cells that make insulin. They are found in clumps of around 100 cells in the pancreas. These clumps are called the islets of Langerhans – or islets for short. A large part of the cure research we fund is about understanding beta cells and islets: how they grow, how they stay healthy and how we can give new ones to people with type 1. Giving people insulin-producing cells that are protected from immune attack Giving new cells to people with type 1 is something we can already do. You can read about islet and pancreas transplantation here. So why are we still researching it? Unfortunately there are problems with the process. Transplants require people to take drugs for the rest of their lives to stop their bodies from rejecting the new cells. These drugs are in themselves risky, and even with them, people are not insulin free forever. This means that for most people with type 1, the risks of a transplant vastly outweigh the benefits. Another problem is that there are not enough organ donors to meet the needs of the people who currently need a pancreas or islet transplant. So our cure research is helping to develop new sources of cells that could be used for transplantation – and to develop new ways of protecting the new cells from rejection, and autoimmune destruction. We call this ‘encapsulation’. Encapsulation means putting the precious beta cells in a protective coating before putting them into the body. Find out more about our encapsulation research. Getting the body to grow Continue reading >>

Type 1 Diabetes Cured In Mice Using Gene Therapy

Researchers from the University of Texas Health Science Center in San Antonio have found a way to cure type 1 diabetes in mice. It is hoped that the novel technique - which boosts insulin secretion in the pancreas - will reach human clinical trials in the next 3 years. Study co-author Dr. Bruno Doiron, Ph.D., of the Division of Diabetes, and colleagues recently reported their findings in the journal Current Pharmaceutical Biotechnology. Type 1 diabetes is estimated to affect around 1.25 million children and adults in the United States. Onset of the condition is most common in childhood, but it can arise at any age. In type 1 diabetes, the immune system destroys the insulin-producing beta cells of the pancreas. Insulin is the hormone that regulates blood glucose levels. As a result, blood glucose levels become too high. There is currently no cure for type 1 diabetes; the condition is managed through diet and insulin therapy. However, in recent years, researchers have investigated replacing beta cells as a means of eradicating type 1 diabetes once and for all. Dr. Doiron and colleagues have taken a different approach with their new study. The team reveals how they used a method called gene transfer to coax other pancreatic cells into producing insulin. Using this technique, the researchers have managed to cure type 1 diabetes in mice, bringing us one step closer to curing the condition in humans. Gene transfer method led to long-term insulin secretion in mice The gene transfer technique - called Cellular Networking, Integration and Processing - involves introducing specific genes into the pancreas using a virus as a vector. The team notes that beta cells are rejected in patients with type 1 diabetes. With the gene transfer method, the newly introduced genes encourage non- Continue reading >>

Clinical Trials And The Type 1 Diabetes Cure

WRITTEN BY: Stephen Gitelman, MD I am often asked the question, “Where is the cure for Type 1 diabetes (T1D)?” For those with long-standing diabetes, we are very close to replicating insulin producing beta cell functionality or the actual replacement of those cells — either with closed loop systems with continuous glucose sensor driving an insulin pump, or use of replacement beta cells derived from stem cells. However, as a Pediatrician, I think the ultimate cure for T1D will be prevention. Why can’t we screen and predict who is at risk, and then prevent someone from getting Type 1 diabetes in the first place? It turns out that T1D occurs in about 1 in 300 people in the general population, but if you already have someone in your family with diabetes, like a brother or sister, then the risk jumps to a 1 in 20 chance of developing Type 1 diabetes. This is why researchers in an NIH sponsored international research effort called TrialNet have been focusing prevention efforts on families with at least one T1D. T1D results from both underlying genetic risk and environmental exposures, but researchers are still working to determine these specific factors. Thanks to some of this work, we now have the ability to predict who will get T1D, in some cases as long as 10-20 years before it happens (see figure). Researchers use three different pieces of information for prediction. First, we look at the immune system. This is done with a simple blood test, measuring up to five different autoantibodies that the immune system might produce against beta cells. If no abnormality is found, then your risk of developing Type 1 diabetes in the near future is very low. However, if there is any abnormality found in the antibody profile, then additional tests are necessary to further defin Continue reading >>

Boy Is 'cured' Of Type 1 Diabetes Through Complimentary Therapies

In 2008, The Incurables, a U.S reality television series about people who overcome series medical conditions, aired an episode about a boy called Zachary Swerdlow who suffers from type 1 diabetes. Zachary’s parents, who prefer homeopathic solutions to Western medication, began investigating alternative treatments shortly after his diagnosis. They consulted a natural pharmacist, Robert Kress, who believed that Zachary’s diabetes was caused by infections and parasites in the body, placing his internal organs under strain. Despite Kress's beliefs, it is important to note that the exact cause of type 1 diabetes is not yet fully understood. Zachary was placed on a strict diet aimed at detoxifying his liver. Kress believed that this would reduce the strain on Zachary’s “overworked” pancreas, enabling it to function better. He was also advised to apply regular mudpacks to the areas of the abdomen in which his kidneys are located. This was intended to remove harmful toxins from the kidneys. Zachary was also taken to Alan Maynard, a chiropractor who informed the family that the vertebrae in Zachary’s spine responsible for the pancreas, were significantly out of alignment. Maynard began treating Zachary with the aim of “addressing the cause of his diabetes”. While Zachary’s parents believed that when Zachary swam in a salt water pool, it would have the most significant effect on lowering his blood sugar. Using the above methods, amongst others, Zachary’s parents claim that he no longer requires insulin. Watch some of the footage from the episode here: Did alternative therapies cure Zachary? Whilst it cannot be denied that these different therapies may have helped to improve Zachary’s blood glucose control, they cannot be suggested as a cure for type 1 diabet Continue reading >>

Us Facility Aims To Cure Type 1 Diabetes Within Six Years

A diabetes research facility in the US has set the goal of curing type 1 diabetes within six years. The City of Hope's Diabetes and Metabolism Research Institute, based in California, is aiming to cure type 1 diabetes using $50 million (£40m) of funding from the Wanek family, who owns Ashley Furniture Industries, the world's largest home furniture manufacturer. City of Hope will be collaborating with the Wanek Family Project for Type 1 Diabetes on the six-year project, using an integrated approach to curing type 1 diabetes. These techniques include: Immunotherapy: Unlocking the immune system's role within diabetes and how stem cell-based therapies could reverse the immune attack on pancreatic beta cells Beta cell transplantation: Improving ways of boosting beta cells and encouraging their long-term survival following transplantation Preventing diabetes complications: Intervening at a genetic level to reverse complications and predict their development Dr Bart Roep, director of City of Hope's research team, says that the key to curing type 1 diabetes will be to understand what causes it to develop. From there, research can begin on treatments, which could vary from person to person. "[It's] something we call personalised medicine or precision medicine, which is very much in vogue in cancer. That means we need to understand where patients differ and then tailor the immune therapies to their specific needs," said Roep. Robert W. Stone, president and chief executive officer at City of Hope, added: "City of Hope is best positioned to take on this challenge. This is thanks to our 40-year institutional legacy of pioneering treatment and research advances in diabetes." City of Hope is an independent research and treatment centre for diabetes, cancer and other life-threatening Continue reading >>

Can Synthetic Biology Finally Cure The Autoimmune Disease?

Lev Dolgachov/Thinkstock Type 1 diabetes is a discouraging disease. Despite the availability of synthetic insulin and increasingly sophisticated monitoring technology, it’s still a condition that requires incessant vigilance: Diabetics must constantly track their blood sugar levels and carefully use that information to calibrate drug doses. Even if you manage to do all of that well, bad days remain almost inevitable. Take too much insulin, and you can spiral into a hypoglycemic delirium. Take too little, and your glucose levels will rise, filling the body with dangerous levels of ketones. Less immediately frustrating—but no less familiar for diabetics—is the state of diabetes research. Possible cures routinely pop up only to fade from view, their benefits never quite surpassing the simple efficacy of an insulin injection. More recently, though, the field of synthetic biology—a hybrid discipline that aims to construct or redesign biological components and systems—has shown the potential to produce a novel set of treatments. The solutions remain speculative, but they do offer cautious reasons for hope. “Type 1 diabetes, in theory, should be relatively easy to solve. That has been the mantra of researchers for the last 30 years. And I still take insulin every day.” John Glass, a researcher working on one such new effort, knows how maddening false hope can be, having lived with the disease for decades. “Type 1 diabetes, in theory, should be relatively easy to solve,” he told me over the phone. “That has been the mantra of type 1 diabetes researchers for the last 30 years. And I still take insulin every day.” I had originally called Glass, a synthetic biologist with the J. Craig Venter Institute, in the hopes of better understanding how his burgeoning f Continue reading >>

Cure For Type 1 Diabetes A Step Closer

Research into a possible cure for type 1 diabetes has taken an "important step forward," according to the latest research by scientists at the Massachusetts Institute of Technology and Harvard University. The study, which was published in journals Nature Medicine and Nature Biotechnology on Monday, builds on work by the Harvard Stem Cell Institute which last year discovered a way of creating beta cells (whose primary function is to store and release insulin) which could then be implanted in mice and, it is hoped in future, humans with diabetes. Now, in the latest development, scientists and researchers at MIT and Harvard, in collaboration with other university experts, have developed an implantable device that could prevent those implanted insulin-producing cells from being attacked by the immune system for six months – effectively allowing the insulin-producing cells to do their job. Diabetes is a lifelong condition that causes a person's blood sugar (glucose) level to become too high. Type 1 diabetes is an autoimmune disease in which the immune system kills off the insulin-producing beta cells in the pancreas. Daily injections of insulin are the primary treatment, but are only partially successful in regulating patients' metabolism. If a device could be implanted into diabetics that could prevent those insulin-producing cells from being attacked, it could be a huge leap forward in terms of research. The results could have an impact on health provision around the world as diabetes ranks as one of the leading causes of death in America. Type 1 diabetes differs from type 2, where the pancreas doesn't produce enough insulin, or the body's cells don't react to insulin. Pregnant women can also develop a usually more short-term form of gestational diabetes. Diabetes affect Continue reading >>

Can Diabetes Be Cured? A Review Of Therapies And Lifestyle Changes

Diabetes is a condition that affects blood sugar levels and causes many serious health problems if not managed well. The health impacts of diabetes can be limited, but can it ever be "cured"? Type 1 diabetes is an autoimmune disease that develops when the body destroys the cells in the pancreas that produce insulin. This means people with type 1 diabetes do not make insulin. In those with type 2 diabetes, there is a decreased sensitivity to insulin and the body does not make or use as much insulin as it needs. Type 2 diabetes is much more common than type 1 diabetes. This article reviews therapies and lifestyle changes that can help reduce the effects of diabetes on a person's health. It also explores whether these treatments can help "cure" diabetes, or if they are simply helpful ways to manage the condition. Contents of this article: Is diabetes curable? Medically speaking, there is no cure for diabetes but it can go into "remission." Diabetes in remission simply means the body does not show any signs of diabetes. However, the disease is technically still there. According to Diabetes Care, remission can take different forms: Partial remission: When a person has had a blood glucose level lower than that of a person with diabetes for at least 1 year without any diabetes medication. Complete remission: When the blood glucose level returns to normal, not simply pre-diabetic levels, for at least 1 year without any medications. Prolonged remission: When complete remission lasts for at least 5 years. Even if a person has had normal blood sugar levels for 20 years, their diabetes is still considered to be in remission rather than "cured." There is no known cure for diabetes. The good news is that remission is possible in many cases and can be as simple as making some lifestyl Continue reading >>

Reversal Of Type 1 Diabetes Using Plant-based Diet: A Case Study.

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal. Case Report - Biomedical Research (2019) Volume 30, Issue 3 Reversal of type 1 diabetes using plant-based diet: A case study. Medical Nutritionist, Indo-Vietnam Medical Board, India Medical Nutritionist Indo-Vietnam Medical Board India Visit for more related articles at Biomedical Research Type-1 diabetes is an autoimmune disease characterized by hyperglycemia, inability to produce insulin due to self-destruction of beta cells in the pancreas. The epidemic of type-1 diabetes causes irreversible suffering like retinopathy, nephropathy, neuropathy, foot complications, high blood pressure, etc, and put patients on a life sentence with insulin. The common perception in medical science is that sugar levels cannot be normalized without the help of medication. However, in the present study we examined a type 1 patient by putting her on a diet plan with regular follow ups and studied all diabetes-related biochemical parameters. We were successfully able to eliminate her medication and insulin dependency. Diabetes is one of the most common metabolic disordersassociated with many life-threatening complications whichmake the life of a diabetic person worse. Diabetes is of twotypes- type 1 diabetes and type 2 diabetes. Type 2 is the morecommon type of diabetes worldwide (90-95%), marked by anincreased blood sugar level, frequent urination and weight loss.The other is type 1 or gestational diabetes (5-10%). In type 2diabetes, impaired receptors do not respond to insulin,eventually leading to insulin resistance while in type 1 there isa deficiency of insulin [ 1 ]. According to a re Continue reading >>

Scientists Cure Type 1 Diabetes For A Year Without Side Effects

A potential cure for Type 1 diabetes looms on the horizon – and the novel approach would also allow Type 2 diabetics to stop insulin shots. The treatment totally cured diabetes in mice for an entire year without any side effects. The discovery, made at UT Health San Antonio, works by increasing the types of pancreatic cells that secrete insulin. “It worked perfectly,” said Dr. Bruno Doiron, assistant professor of medicine at UT Health. “We cured mice for one year without any side effects. That’s never been seen.” CHECK OUT: First Ever Quadriplegic Treated With Stem Cells Regains Motor Control in His Upper Body Insulin, which lowers blood sugar, is only made by beta cells. In Type 1 diabetes, beta cells are destroyed by the immune system and the person has no insulin. In Type 2 diabetes, beta cells fail and insulin decreases. At the same time in Type 2, the body doesn’t use insulin efficiently. The therapy is accomplished by a technique called gene transfer. A virus is used as a vector, or carrier, to introduce selected genes into the pancreas. These genes become incorporated and cause digestive enzymes and other cell types to make insulin. Unlike beta cells, which the body rejects in Type 1 diabetes, the other cell populations of the pancreas co-exist with the body’s immune defenses. Gene transfer using a viral vector has been approved nearly 50 times by the U.S. Food and Drug Administration to treat various diseases. MORE: After Marrying On Her ‘Deathbed,’ This Bride Made a Miraculous Recovery After Quitting 1 Food “The pancreas has many other cell types besides beta cells, and our approach is to alter these cells so that they start to secrete insulin, but only in response to glucose [sugar],” said co-inventor Ralph DeFronzo. “This is basicall Continue reading >>