Kidney Disease Of Diabetes
Each year in the United States, more than 100,000 people are diagnosed with kidney failure, a serious condition in which the kidneys fail to rid the body of wastes. Kidney failure is the final stage of kidney disease, also known as nephropathy. Diabetes is the most common cause of kidney failure, accounting for nearly 45 percent of new cases. Even when diabetes is controlled, the disease can lead to nephropathy and kidney failure. Most people with diabetes do not develop nephropathy that is severe enough to cause kidney failure. About 18 million people in the United States have diabetes, and more than 150,000 people are living with kidney failure as a result of diabetes. People with kidney failure undergo either dialysis, which substitutes for some of the filtering functions of the kidneys, or transplantation to receive a healthy donor kidney. Most U.S. citizens who develop kidney failure are eligible for federally funded care. In 2003, care for patients with kidney failure cost the Nation more than $27 billion. African Americans, American Indians, and Hispanics/Latinos develop diabetes, nephropathy, and kidney failure at rates higher than Caucasions. Scientists have not been able to explain these higher rates. Nor can they explain fully the interplay of factors leading to diabetic nephropathy—factors including heredity, diet, and other medical conditions, such as high blood pressure. They have found that high blood pressure and high levels of blood glucose increase the risk that a person with diabetes will progress to kidney failure. There are two types of diabetes. In both types, the body does not properly process and use food. The human body normally converts food to glucose, the simple sugar that is the main source of energy for the body’s cells. To enter cells, Continue reading >>
Type 1 Diabetes: What Is It?
Diabetes is a disease that affects how the body uses glucose , the main type of sugar in the blood. Our bodies break down the foods we eat into glucose and other nutrients we need, which are then absorbed into the bloodstream from the gastrointestinal tract. The glucose level in the blood rises after a meal and triggers the pancreas to make the hormone insulin and release it into the bloodstream. But in people with diabetes, the body either can't make or can't respond to insulin properly. Insulin works like a key that opens the doors to cells and lets the glucose in. Without insulin, glucose can't get into the cells (the doors are "locked" and there is no key) and so it stays in the bloodstream. As a result, the level of sugar in the blood remains higher than normal. High blood sugar levels are a problem because they can cause a number of health problems. The two types of diabetes are type 1 and type 2. Both make blood sugar levels higher than normal but they do so in different ways. In type 1 diabetes, the pancreas loses its ability to make insulin because the body's immune system attacks and destroys the cells that produce insulin. No one knows exactly why this happens, but scientists think it has something to do with genes. But just getting the genes for diabetes isn't usually enough. A person probably would then have to be exposed to something else — like a virus — to get type 1 diabetes. In type 2 diabetes , the pancreas still makes insulin but the body doesn't respond to it normally. Glucose is less able to enter the cells and do its job of supplying energy (a problem called insulin resistance ). This raises the blood sugar level, so the pancreas works hard to make even more insulin. Eventually, this strain can make the pancreas unable to produce enough ins Continue reading >>
The Signs, Diagnosis & Types Of Diabetes Mellitus In Cats
There are certain signs or symptoms which are commonly seen in cats with diabetes mellitus. Unfortunately, these signs also occur in other diseases and conditions. Therefore, laboratory tests are necessary to diagnose diabetes mellitus in cats. The following article includes a discussion of how this diagnosis is made and the types of diabetes found in cats. What are the signs of diabetes mellitus in cats and why do they occur? Depending on how severely insulin production is impaired, there may be few signs of disease, or the signs may be severe. Dogs with diabetes often develop cataracts; cats do not. The most common signs of diabetes are: Increased thirst (polydipsia) and urination (polyuria) Change in appetite Weight loss Change in gait (walking) Decreased activity, weakness, depression Vomiting Increased Thirst and Urination: Because the glucose cannot enter the cells, the glucose levels in the blood become abnormally high (hyperglycemia). The glucose is filtered out by the kidneys and is found in the urine (glucosuria). When it is filtered out, it carries water with it. The animal, then, is losing more water through the urine than normal and has to make up for it by drinking more. Inappropriate Elimination: The increased urination may result in the cat not always urinating in the litter box. This inappropriate urination may be one of the first signs of diabetes in cats. In addition, cats with diabetes can often develop urinary tract infections, which may also result in inappropriate elimination. Change in Appetite: Some diabetic cats eat less, because frankly, they do not feel well. Other cats may have voracious appetites and eat a lot (polyphagia) because their hypothalamus keeps telling them they are hungry. Weight Loss: Because the cat cannot use the calories he Continue reading >>
Is It Possible For Type 2 Diabetes To Turn Into Type 1?
Type 2 diabetes can’t turn into type 1 diabetes, since the two conditions have different causes. Type 1 diabetes is an autoimmune disease. It occurs when the insulin-producing islet cells in the pancreas are completely destroyed, so the body can’t produce any insulin. In Type 2 diabetes, the islet cells are still working. However, the body is resistant to insulin. In other words, the body no longer uses insulin efficiently. Type 1 diabetes is far less common than type 2. It used to be called juvenile diabetes because the condition is typically diagnosed in early childhood. Type 2 diabetes is more commonly diagnosed in adults, though we’re now seeing more and more children being diagnosed with this disease. It’s more commonly seen in those who are overweight or obese. It’s possible for someone with type 2 diabetes to be misdiagnosed. They may have many of the symptoms of type 2 diabetes, but actually have another condition that may be more closely related to type 1 diabetes. This condition is called latent autoimmune diabetes in adults (LADA). Researchers estimate that between 4 and 14 percent of people diagnosed with type 2 diabetes might actually have LADA. Many physicians are still unfamiliar with the condition and will assume a person has type 2 diabetes because of their age and symptoms. In general, a misdiagnosis is possible because: both LADA and type 2 diabetes typically develop in adults the initial symptoms of LADA — such as excessive thirst, blurred vision, and high blood sugar — mimic those of type 2 diabetes doctors don’t typically run tests for LADA when diagnosing diabetes initially, the pancreas in people with LADA still produces some insulin diet, exercise, and oral drugs usually used to treat type 2 diabetes work well in people with LADA Continue reading >>
What Type Of Diabetes Do I Have?
When you were diagnosed, you were probably told you had either Type 1 or Type 2 diabetes. Clear-cut and tidy. Since diabetes typically occurs in two types, you have to fit into one of them. Many people fit clearly into one of these categories, but others do not. And those who clearly fit one type when diagnosed may find these clear lines begin to smudge over time. Are there really only two types? Are you really the type you were told you were? Could you have more than one type of diabetes? Is your original diagnosis still correct after all these years? A Short History Of Types Described and treated since ancient times, diabetes has certain characteristics that have long been recognized. Before the discovery of insulin, people found to have sugar in their urine under the age of 20 usually died in their youth, while those diagnosed when over the age of 40 could live for many years with this condition. Beginning in the mid 1920s, those who got diabetes when young (juvenile onset) were put on insulin, and those who got it when older (adult onset) often were not. However, the mechanisms that led to this difference in treatment were unknown. The only marker that differentiated the two types at that time was the presence in the urine of moderate or large levels of ketones when blood sugars were high. When significant ketones were present because the person could no longer make Tenough insulin, injected insulin was needed to control the glucose and they were called insulin-dependent. Differences In The Three Major Types Of Diabetes Type 1 Type 1.5/LADA Type 2 Avg. age at start 12 35 60 Typical age at start 3-40* 20-70* 35-80* % of all diabetes 10% (25%**) 15% 75% Insulin problem absence deficiency resistance Antibodies ICA, IA2, GAD65, IAA mostly GAD65 none Early treatment insu Continue reading >>
Prediabetes And Diabetes Prevention
It is estimated that one in three American adults have prediabetes, or 84 million adults. Within the Intermountain Medical Group, 17,000 patients meet criteria for prediabetes, and another 80,000 have risk factors for the disease. What is Prediabetes? Prediabetes is a condition in which individuals have high blood glucose levels but not high enough to be classified as diabetes. People with prediabetes have an increased risk of developing type 2 diabetes, heart disease, and stroke, but not everyone with prediabetes will progress to diabetes. Lifestyle changes resulting in weight loss and increased physical activity can prevent or delay type 2 diabetes and in some cases return blood glucose levels to within the normal range. While prediabetes can progress to type 2 diabetes, there are three forms of diabetes that you should be aware of: Type 1 diabetes is when your body does not produce insulin. This type of diabetes is usually diagnosed in children and young adults. Type 2 diabetes is when your body does not use insulin properly. This form of diabetes is the most common form of the disease. Gestational diabetes occurs when your body is not able to make and use all the insulin it needs for pregnancy. Many women develop gestational diabetes around the 24th week of pregnancy. Continue reading >>
- Role of Fenugreek in the prevention of type 2 diabetes mellitus in prediabetes
- Olive oil in the prevention and management of type 2 diabetes mellitus: a systematic review and meta-analysis of cohort studies and intervention trials
- Prevalence of diabetes and prediabetes in 15 states of India: results from the ICMR–INDIAB population-based cross-sectional study
The Stages Of Type 1 Diabetes (it Starts Earlier Than We Thought)
My daughter Bisi was diagnosed with type 1 diabetes three years ago at the age of six. The first night after she was diagnosed, once she finally fell asleep in her hospital bed, tossing and turning despite the IV in her arm, I remember standing outside in the hall with my husband and a couple of medical residents, talking with them about her diagnosis. “Could this have been coming on for a while?” we asked them. I described how for a couple of years, Bisi had been almost unbearably cranky when she was hungry—to the point where I’d asked her pediatrician more than once if something might be wrong. No, the residents told us. Type 1 diabetes comes on very suddenly, in a matter of weeks, as the body’s beta cells suddenly die out under attack from the immune system. Every doctor or nurse we spoke with during the three days in the hospital (except for one, who said that our instincts were probably right), echoed what the two residents, fresh from medical school, told us. But it turns out they were wrong. JDRF and the American Diabetes Association, supported by other organizations in the field, recently put forth a new staging system for type 1 diabetes, where full-blown disease, like what landed Bisi in the hospital, is characterized as stage 3, part of an extended auto-immune process that often starts in infancy. This fall, Dr. Richard Insel, JDRF’s Chief Scientific Officer, explained the classification system to a group of reporters, talking through the importance of early diagnosis, and the hope that diagnosing the disease at an earlier stage could lead to breakthroughs in stopping the beta-cell destruction process—essentially, stopping the disease before it starts. Insel explained that stage 1 is when people test positive for multiple pancreatic islet auto-a Continue reading >>
The importance of both diabetes and these comorbidities will continue to increase as the population ages. Therapies that have proven to reduce microvascular and macrovascular complications will need to be assessed in light of the newly identified comorbidities. Lifestyle change has been proven effective in preventing or delaying the onset of type 2 diabetes in high-risk individuals. Based on this, new public health approaches are emerging that may deserve monitoring at the national level. For example, the Diabetes Prevention Program research trial demonstrated that lifestyle intervention had its greatest impact in older adults and was effective in all racial and ethnic groups. Translational studies of this work have also shown that delivery of the lifestyle intervention in group settings at the community level are also effective at reducing type 2 diabetes risk. The National Diabetes Prevention Program has now been established to implement the lifestyle intervention nationwide. Another emerging issue is the effect on public health of new laboratory based criteria, such as introducing the use of A1c for diagnosis of type 2 diabetes or for recognizing high risk for type 2 diabetes. These changes may impact the number of individuals with undiagnosed diabetes and facilitate the introduction of type 2 diabetes prevention at a public health level. Several studies have suggested that process indicators such as foot exams, eye exams, and measurement of A1c may not be sensitive enough to capture all aspects of quality of care that ultimately result in reduced morbidity. New diabetes quality-of-care indicators are currently under development and may help determine whether appropriate, timely, evidence-based care is linked to risk factor reduction. In addition, the scientific evid Continue reading >>
Type 1 Diabetes
Type 1 diabetes is a condition in which the pancreas stops producing insulin, an important hormone that helps control blood glucose (sugar) levels. What happens to the pancreas with diabetes? Type 1 diabetes is an autoimmune condition. In type 1 diabetes, the pancreas is attacked by the body’s defense system also known as the immune system. Normally the immune system helps protect our bodies by making antibodies, which are special proteins that fight off infection. In patients with type 1 diabetes, the body mistakenly makes antibodies that attack the beta cells in the pancreas, which produce insulin. Over time, more and more beta cells are damaged and less and less insulin is produced. This eventually leads to type 1 diabetes. What are the signs and symptoms of type 1 diabetes? When someone eats food or drinks fluids with carbohydrates, the carbohydrates are broken down (digested) and glucose (sugar) is released. This sugar travels through the bloodstream. Insulin opens up channels on the cell surface that let sugar in. For a child with type 1 diabetes, because the pancreas is unable to make insulin, insulin cannot help sugar move into the cells. When the sugar remains locked out of the cells, the child may become tired because the cells are starved for energy. Meanwhile, sugar continues to build up in the blood and the body tries to use other sources of energy, which can have harmful side effects. The kidneys have the job of filtering blood and getting rid of substances that might otherwise harm the body. When the kidneys sense a high level of sugar in the blood, they start eliminating it through the urine. The excess sugar in the blood is transported to the kidneys from where it is peed out. As a result, the child urinates more often and in larger amounts just Continue reading >>
Diabetes Symptoms You Can’t Afford To Ignore & What You Can Do About Them
In the U.S., diabetes — or diabetes mellitus (DM) — is full-blown epidemic, and that’s not hyperbole. An estimated 29 million Americans have some form of diabetes, nearly 10 percent of the population, and even more alarming, the average American has a one in three chance of developing diabetes symptoms at some point in his or her lifetime. (1) The statistics are alarming, and they get even worse. Another 86 million people have prediabetes, with up to 30 percent of them developing type 2 diabetes within five years. And perhaps the most concerning, about a third of people who have diabetes — approximately 8 million adults — are believed to be undiagnosed and unaware. That’s why it’s so vital to understand and recognize diabetes symptoms. And there’s actually good news. While there’s technically no known “cure” for diabetes — whether it’s type 1, type 2 or gestational diabetes — there’s plenty that can be done to help reverse diabetes naturally, control diabetes symptoms and prevent diabetes complications. The Most Common Diabetes Symptoms Diabetes mellitus is a metabolic disorder that results from problems controlling the hormone insulin. Diabetes symptoms are a result of higher-than-normal levels of glucose (sugar) in your blood. With type 1 diabetes, symptoms usually develop sooner and at a younger age than with type 2 diabetes. Type 1 diabetes also normally causes more severe symptoms. In fact, because type 2 diabetes signs and symptoms can be minimal in some cases, it sometimes can go diagnosed for a long period of time, causing the problem to worsen and long-term damage to develop. While it’s still not entirely known how this happens, prolonged exposure to high blood sugar can damage nerve fibers that affect the blood vessels, heart, e Continue reading >>
How To Reverse Type 2 Diabetes, Why Insulin May Actually Accelerate Death, And Other Ignored Facts
In the US, about 80 million, or one in four, has some form of diabetes or pre-diabetes Even worse, more than one-third of British adults are now pre-diabetic. In 2003, 11.6 percent of Britons had pre-diabetes. By 2011, that figure had more than tripled, reaching 35.3 percent Between 2001 and 2009, incidence of type 1 diabetes among American children under the age of 19 rose by 21 percent. Incidence of type 2 diabetes among children aged 10-19 rose by 30 percent Type 2 diabetes is a disease rooted in insulin resistance and perhaps more importantly, a malfunction of leptin signaling, caused by chronically elevated insulin and leptin levels One of the driving forces behind type 2 diabetes is excessive dietary fructose, which has adverse effects on insulin and leptin, so it’s important to address the fructose and other sugars in your diet that come in many forms A growing body of research suggests there’s a powerful connection between your diet and your risk of both Alzheimer's disease and glaucoma, via similar pathways that cause type 2 diabetes By Dr. Mercola Great Britain, like the United States, has seen a remarkably rapid rise in pre-diabetes and type 2 diabetes over the last decade. According to a recent BBC News1 report, more than one-third of British adults are now pre-diabetic. In 2003, 11.6 percent of Britons had pre-diabetes. By 2011, that figure had more than tripled, reaching 35.3 percent. Researchers warn that this will lead to a massive avalanche of type 2 diabetics in upcoming years, which will have serious consequences for health care and life expectancy. In the United States, nearly 80 million people, or one in four has some form of diabetes or pre-diabetes. What's worse, both type 1 and type 2 diabetes among children and teens has also skyrocketed. Th Continue reading >>
Doctors 'wrong To Assume Type 1 Diabetes Is Childhood Illness'
Doctors are wrong to assume that type 1 diabetes mainly affects children, according to a new study that shows it is equally prevalent in adults. The findings, published in the journal Lancet Diabetes & Endocrinology, overturn previous thinking that the form of diabetes, an auto-immune condition, is primarily a childhood illness. Scientists from Exeter University found that in a lot of cases it was actually misdiagnosed among adults. “Diabetes textbooks for doctors say that type 1 diabetes is a childhood illness. But our study shows that it is prevalent throughout life. The assumption among many doctors is that adults presenting with the symptoms of diabetes will have type 2 but this misconception can lead to misdiagnosis with potentially serious consequences,” said Dr Richard Oram, a senior lecturer at the University of Exeter and consultant physician. The research, funded by the Wellcome Trust and Diabetes UK, was based on the UK Biobank, a resource which includes data and genetic information from 500,000 people aged between 40 and 69 from across the country. Participants provided blood, urine and saliva samples for future analysis, detailed information about themselves and agreed to have their health followed. “The key thing we were looking for with this study was whether people presented with type 1 diabetes in adulthood and at what age this occurred. This was only possible because of the unique combination of health records and genetic data,” said Oram. “What was really surprising in our research is that nearly 50% of type 1 diabetes cases occurred in adulthood and over 40% occurred after the age of 30 … Although type 1 occurs with the same frequency in adults and children, it can sometimes be hidden in adulthood by the sheer number of type 2 cases.” T Continue reading >>
How Weight Loss Can Reverse Type 2 Diabetes
TIME Health For more, visit TIME Health. An analysis published in The BMJ aims to let doctors and the public in on a little-known secret: Type 2 diabetes, in many cases, is curable. People can reverse their diabetes by losing about 33 pounds, say the authors of the new paper, despite popular belief that the diagnosis is always a permanent one. If more people were striving for this goal, and if more doctors were documenting instances of diabetes remission, complication rates and health-care costs could both be reduced dramatically, the authors say. The analysis is based on evidence from recent clinical trials. In one from 2011, people who were recently diagnosed with Type 2 diabetes returned their blood sugar levels to normal when they lost weight on a calorie-restrictive diet. In a 2016 follow-up study, people who had been diabetic for up to 10 years were able to reverse their condition when they lost about 33 pounds. TIME Health Newsletter Get the latest health and science news, plus: burning questions and expert tips. View Sample Sign Up Now Mike Lean, professor of human nutrition at the University of Glasgow in Scotland, is an author of both the new analysis and of those earlier trials. He says a person’s likelihood of remission from diabetes is greatest in the first five years after being diagnosed. Type 2 diabetes, he wrote in an email, is a disease “best avoided by avoiding the weight gain that drives it.” For people who do develop it, he believes that evidence-based weight-loss programs could help them achieve lasting remission. “Not all can do it, but they should all be given the chance with good support,” Lean writes. “Taking tablets or injections for life to reduce blood sugar is a poor second rate treatment.” Current guidelines for the managemen Continue reading >>
Diabetes: Types, Symptoms And Treatments
Diabetes mellitus (DM), commonly referred to as diabetes, is a group of metabolic diseases in which there are high blood sugar levels over a prolonged period. Symptoms of high blood sugar include frequent urination, increased thirst, and increased hunger. If left untreated, diabetes can cause many complications. Acute complications include diabetic ketoacidosis and nonketotic hyperosmolar coma. Serious long-term complications include cardiovascular disease, stroke, kidney failure, foot ulcers and damage to the eyes. Diabetes is due to either the pancreas not producing enough insulin or the cells of the body not responding properly to the insulin produced. Main Document Diabetes is referred to by the medical world as, 'Diabetes Mellitus,' and is a set of diseases where the person's body is unable to regulate the amount of sugar in their blood. The particular form of sugar that the person with diabetes is unable to regulate is called, 'glucose,' and is used in the body to give the person energy in order to do things in daily life such as walking, running, riding a bike, exercising, or other tasks. From food that people eat, the liver produces glucose and puts it into their blood. In persons without diabetes, glucose levels are regulated by a number of hormones including one known as, 'Insulin.' An organ called the, 'Pancreas,' produces insulin, and also secretes additional enzymes which aid in the digestion of food. Insulin helps the movement of glucose through a person's blood into different cells, including muscle, fat, and liver cells so it can be used to fuel activity. Several forms of diabetes involve the inability to both produce or use insulin properly. Persons with diabetes are unable to move glucose from their blood into their cells. The result is that the glucos Continue reading >>
What Is The Difference Between Type 1 And Type 2 Diabetes?
There are three major types of diabetes: type 1, type 2, and gestational diabetes. All types of diabetes cause blood glucose levels to be higher than normal, but they do this in different ways Type 1 diabetes Type 1 diabetes can occur at any age, but is most commonly diagnosed from infancy to the late 30s. With this type of diabetes, a person’s pancreas produces no insulin. It occurs when the body’s own defence system (the immune system) attacks and destroys the insulin-producing cells in the pancreas. What causes the immune system to do this is not yet completely understood, but we are funding research to find out. Type 2 diabetes Type 2 diabetes is by far the most common type of diabetes – in the UK over 90 per cent of people with diabetes have type 2. Type 2 diabetes usually affects those over 40, or 25 if you’re of South Asian descent. However, it is becoming more common among young people due to lifestyle. The symptoms of type 2 diabetes are not always obvious and, unlike with type 1, they can take a long time to develop. People with type 2 diabetes either don’t make enough insulin or don’t make insulin that the body can use properly. The cells in the body become resistant to insulin, making a greater amount of insulin necessary to keep blood glucose levels within a normal range. Eventually, the pancreas can wear out from producing extra insulin, and it may start making less and less. Type 2 can usually be managed through diet, exercise, and self-monitoring blood glucose, at least in the first few years following diagnosis. However, type 2 diabetes is a progressive condition, and most people will need to take tablets and/or inject insulin after living with it for five to 10 years. LADA Up to a third of people who were initially diagnosed as having type Continue reading >>