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Can Stem Cells Help Diabetes?

Researchers Study Cure For Type 1 Diabetes In Stem Cell Transplantations

Researchers Study Cure For Type 1 Diabetes In Stem Cell Transplantations

Clinical trial shows promising results from risky procedure, identifies path for personalized therapies DUARTE, Calif. — Some type 1 diabetes (T1D) patients can be cured from the disease, at least for a number of years, with a stem cell transplant – those were the results of a clinical trial monitored by City of Hope’s Bart Roep, Ph.D., the Chan Soon-Shiong Shapiro Distinguished Chair in Diabetes and professor/founding chair, Department of Diabetes Immunology. The results were published recently in the journal, Frontiers in Immunology. “This means we can cure type 1 diabetes, be it with a risky therapy — although one that is also very successful in cancer, and one for which City of Hope is a world-renowned expert, with more than 14,000 patients having received similar treatment for blood cancers,” said Roep, director of The Wanek Family Project for Type 1 Diabetes, which aims to find a cure for T1D in six years. “We now understand stem cell transplants can succeed in treating diabetes for some, but not in others, and we can predict either outcome before the therapy is administered by 'reading' the immune signature of the patient with a novel nanotechnology that I developed.” An international team of researchers, including Roep, conducted the trial in Brazil. It showed that autologous hematopoietic stem cell transplantation (AHSCT), which uses a person’s own stem cells, increases C-peptide levels — that show how much insulin is being made by the pancreas — and induces insulin independence in patients with T1D. This is possible because the transplanted stem cells are able to balance the immune system. The study also aimed to understand why some patients saw long-term clinical benefit from the transplantation while others did not. Twenty-one T1D patie Continue reading >>

Diabetes | Harvard Stem Cell Institute (hsci)

Diabetes | Harvard Stem Cell Institute (hsci)

HOME / RESEARCH / DISEASE PROGRAMS / DIABETES PROGRAM / It stands to reason that only by understanding the root causes of diseases like diabetes can we hope to develop effective therapies. Modern biomedical research is best at finding treatments for diseases that have relatively simple causes and well-understood genetic risk factors. Unfortunately, type 1 diabetes (T1D) has very complex genetics, with many genes each making relatively small, poorly understood contributions to disease risk. Further, there are no animal models that accurately reflect the human disease. Thus, despite the expenditure of hundreds of millions of research dollars, no cures for T1D have been developed. T1D is particularly challenging to study in human patients. By the time a patient is diagnosed with T1D, also known as juvenile diabetes, the destruction of insulin-producing beta cells by the immune system is nearly complete. Because of this, there is no way to discover what it was that led the persons immune system to attack the beta cells in the first place. Even if it were possible to identify future T1D patients before the immune attack on beta cells began, disease onset and progression could not be studied in these individuals due to the inaccessibility of the pancreas where beta cells are found in a living person. Harvard Stem Cell Institute (HSCI) scientists are attempting an ambitious, long-term, and high-risk project to create the first animal model for T1D. Engineered mice will allow researchers to better understand the disease and increase the odds of developing effective therapies. Recent advances in stem cell biology have opened the door to new ways of studying T1D. Specifically, it is now possible to reprogram a skin cell from a T1D patient (or any other person) into a cell that c Continue reading >>

Dri Biohub: Supply

Dri Biohub: Supply

Islet transplantation has clearlyshown the ability to restore natural insulin production and normalize blood sugar levels in people with type 1 diabetes. But, some hurdles remain before this cell replacement therapy can be offered more broadly to those who can benefit. Two notable ones are the complex challengesof the immune system and the shortage of insulin-producing cells available for transplant. Currently, islets used for transplantation come from the pancreases of deceased donors. With organ donation in the United States at critically low levels, there are clearly not enough cellsfor everyone. The DRI is developing several pioneeering strategies to create areliable supplyof insulin-producing cells. Scientists have discovered that different types ofcells within the non-insulin producing portion of the pancreas, which makes up 98 percent of the organ, have the ability to become insulin-producing cells. In particular, they have focused on a unique population of stem cells that remain intact after the autoimmune attack in a large percentage of patients. The DRI's Cell Supply team has been developing methods to stimulate these pancreatic stem cells to turn into insulin-producing cells with very promising results. Using a natrually occurring protein called bone morphogenetic protein 7 (BMP-7), DRI reseachers demonstrated that these stem cells within the non-endocrine tissue can become new islets when cultured in the lab. Their pioneering findings using this FDA-approved molecule were published in the journal Diabetes . In itself, the discovery could potentially open the door to transplanting multiple patients from a single donor pancreas, but the results have other promising implications. After observing that these stem cells remained in the pancreas after the onset of Continue reading >>

A Potential Cure For Diabetes Through Stem Cells

A Potential Cure For Diabetes Through Stem Cells

Type 1 Diabetes Type 1 Diabetes (T1D) develops when a person’s own immune system mistakenly destroys the insulin-producing cells in the pancreas, called “beta cells.” Blood sugar levels can spike when this happens, causing organ and nerve damage, heart disease, limb amputation, or even death. While artificial insulin can control Type 1 diabetes, it does not replace the insulin-producing beta cells that are destroyed. Treatment, therefore, is a chronic regimen consisting of multiple daily injections of insulin (11 per day, on average) to maintain blood sugar levels. This leads to constant worry and stress for the patient—even with the best treatment, perfect control of blood sugar levels is impossible. “11 million: That’s the number of the number of insulin injections Type 1 diabetes patients self-administer daily in the US alone to manage their illness.” Type 1 diabetes is a lifelong disease; patients are always at risk for life-threatening complications, not to mention the impact of constant monitoring of glucose, dietary restrictions and multiple daily insulin injections on their quality of life. Progress Towards A Cure Scientists have begun to explore a revolutionary concept: What if, instead of trying to replace the function of the beta cells by injecting insulin, we could replace the lost beta cells themselves? A group of scientists at ViaCyte, Inc., is working on this idea, using an embryonic stem cell therapy approach to treat Type 1 diabetes. Their work is jointly funded by California Institute for Regenerative Medicine (CIRM) and the International Juvenile Diabetes Research Foundation (JDRF). “What if we could replace the lost beta cells themselves?” After many years of work, the ViaCyte team has invented a recipe to turn human embryonic stem Continue reading >>

Stem Cell Therapy For Diabetes Type 1 And Diabetes Type 2

Stem Cell Therapy For Diabetes Type 1 And Diabetes Type 2

New treatments and advances in research are giving new hope to people affected by Diabetes Type 1 and Diabetes Type 2. StemGenex Medical Group provides adult stem cell Diabetes therapies to help those with unmet clinical needs achieve optimum health and better quality of life. Mesenchymal stem cell therapy for Diabetes Type 1 & Diabetes Type 2 may help patients who don’t respond to typical drug treatment, want to reduce their reliance on medication, or are looking to try stem cell therapy before starting drug treatment. To learn more about becoming a patient and receiving adult stem cell therapy through StemGenex Medical Group, please contact one of our Patient Advocates at (800) 609-7795. Below are some frequently asked questions about stem cell therapy for Diabetes Type 1 and Diabetes Type 2. Continue reading >>

Combination Of Stem Cell And Drug Therapy Could Reverse Type 2 Diabetes

Combination Of Stem Cell And Drug Therapy Could Reverse Type 2 Diabetes

Stem cell research is heralding a new age of possiblemedical treatments as scientists use them to grow transplantable cells andorgans. Now, it appears those new treatments might include one fortype 2 diabetes. Existing research has already found avenues to treat type 1diabetes. This less-common, early-onset form of diabetes occurs when the body’simmune system attacks and destroys insulin-producing cells in the pancreas,often while fighting an infection elsewhere in the body. By using stem cells,doctors can grow new insulin-producing cells to replace those that the pancreashas lost. However, type 2 diabetes – which makes up 90 percent ofdiabetes cases worldwide – is harder to treat. It typically occurs in adults asa result of excess weight or hormonal imbalances. While people with type 2 diabetes do lose some of theirinsulin-producing cells, their primary problem is elsewhere. Their cells havebecome resistant to insulin. Although insulin is present in the body, the cellscan no longer use insulin to keep blood sugar levels in check. Simply regrowingthe missing insulin-producing cells is not enough to solve the problem. Now, in new research published in StemCell Reports, scientists may have found a way. Read More: Scientists Make Insulin-Producing Cells from Stem Cells to Cure Type 1 Diabetes » A Two-Pronged Approach To create a mouse model of type 2 diabetes, the researchersput mice on a high-fat, high-carb diet. The symptoms of type 2 diabetes soonfollowed. The mice became overweight, intolerant to glucose (blood sugar), andresistant to insulin. Their blood sugar levels skyrocketed. Next came the attempt to reverse the induced diabetic state.The research team cultured human embryonic stem cells and prepared them to besafely implanted into the diabetic mice. Once t Continue reading >>

Stories Of Hope: A Stem Cell Therapy For Diabetes

Stories Of Hope: A Stem Cell Therapy For Diabetes

Home Stories of Hope: A Stem Cell Therapy for Diabetes Stories of Hope: A Stem Cell Therapy for Diabetes The last thing Maria Torres expected was to be diagnosed with type 2 diabetes. She exercised, ate well and kept her weight under control. There had to be some mistake. Maria asked her doctor to repeat the tests, but the results were the same. At 43, for reasons no one could fully explain, she had diabetes, and her life was going to change dramatically. It really scared me, says Maria. I thought I was going to die soon. That Maria doubted her diagnosis is no surprise. Type 2 diabetes is often associated with obesity, and she didnt fit the profile. Most likely, some undiscovered genetic component had made her susceptible to the disease. Regardless, she now had to rework her life to manage the diabetes. Her cells had developed a condition called insulin resistance. Though her pancreas was producing insulin, which tells cells to take in blood sugar, the cells were not cooperating. As a result, glucose was accumulating in her blood, putting her at risk for heart disease, nerve damage, eye issues and a host of other problems. To help her cells absorb glucose, she needs regular insulin injections. Maria injects the hormone five times a day and must often measure her blood sugar levels even more frequently. Faithfully following this regimen has kept her alive for 20 years, but insulin is not a cure. Even with the regular injections, she faces dramatic mood swings and more serious complications as glucose levels rise and fall. One of the most promising strategies to cure diabetes is to transplant beta cells, which sense blood sugar levels and produce insulin to reduce them. Patients with type 1 diabetes would benefit because new beta cells would replace the ones theyd lost t Continue reading >>

Enhanced Stem Cells For Treating Diabetes Mellitus Type 1 & 2

Enhanced Stem Cells For Treating Diabetes Mellitus Type 1 & 2

Updated November 22, 2017 – In the unfortunate event you or perhaps a family member are coping with diabetes you should be aware of its consequences on the body and mind. Diabetes is usually termed the “silent killer” mainly because it strikes the body slowly and without warning. Newly diagnosed diabetic patients are usually not worried about it since their symptoms are often no more severe than recurrent urination and increased thirst. A number of other individuals have no symptoms at all. Treating Diabetics With Stem Cells As time goes by however, the effects of both kinds of diabetes become increasingly serious and may lead to death. These symptoms include heart disease, eye issues, kidney failure, nerve damage and erectile dysfunction, to name a few. Hypoglycemia (acute low blood sugar) and hyperglycemia (high level of blood sugar) are the key contributors to the effects of diabetes. According to recent research, some of the oral diabetes medications can also help contribute to heart malfunction.(Kao and Chen 2012)* That is exactly why it’s important that women and men who are clinically diagnosed as “diabetic” immediately seek treatment to relieve hypoglycemia and hyperglycemia. These conditions often trigger the more harmful, degenerative ailments. The regeneration center can help treat DM with our innovative enriched and expanded Mesenchymal cells treatment for Diabetes safely and without any artificial medicines or need for regular insulin dependency.(Yong Zhao et al. 2013)* Reverse Hyperglycemia with Insulin Producing Beta-Cells Stem Cell treatments for diabetes fights the disease at its origins in the pancreas. Decreasing hyperglycemia as well as associated complications (see above). According to recent research, it can also relieve hypoglycemia or Continue reading >>

Diabetes And Stem Cell Research

Diabetes And Stem Cell Research

Stem cell research is in progress for the treatment of diabetes Understanding the root causes of diabetes has eluded researchers for many years now. The way in which the immune system causes the destruction of precious beta islet cells within the pancreas of type 1 diabetics is generally understood to be the key. The ultimate goal, which has so far proved elusive, is a cure for diabetes , which could potentially be available for both types of diabetes through stem cell research. Stem cells are a form of cell that is yet to develop a specific set of traits. However, what stem cells have in abundance is the potential to develop into a number of different forms. Stem cell research covers the scientific study of these stem cells. Stem cell research allows researchers to grow specific varieties of human cells in the lab and research how they behave and interact under different conditions. Stem cells open up a wide spectrum of diabetes research possibilities. In one example of diabetes stem cell research, researchers took cells from human intestine cells and disabled a gene which enabled the cells to produce insulin. Stem cells for the treatment of diabetes are able to come from a variety of sources. Stem cells in the research of type 1 diabetes Within recent years, stem cell research has become a very important part of the scientific understanding of type 1 diabetes. Research has demonstrated that stem cells can be grown in the lab. In 2004, the University of Pittsburgh grew insulin producing beta cells by introducing two genes cdk and cyclin d via a virus. The researchers were able to deactivate the virus and also prevent stem cells from growing further. The research could lead to a better availability of beta cells for future research purposes. Progenitor cells, related t Continue reading >>

Can Stem Cells Help Diabetes?

Can Stem Cells Help Diabetes?

Stem cell research was big news back when Christopher Reeve, the actor who played Superman in the 1970s and 1980s, became famous again in the 2000s for trying to get laws changed so that research with human embryonic stem cells could expand. After breaking his neck in a horse-riding accident, he used his fame to become an advocate for stem cell research funding. The big problem with this kind of research was that it typically required human embryos that had been donated to science after fertilization therapy for women who were trying to get pregnant. Because of the deep moral issue, I wanted to understand more. For one thing, what on earth was a stem cell? Why were scientists all over the world studying them with such excitement? Every cell in your body is programmed by the genes inside it to do a specific thing. Muscle cells cannot do what blood cells do. Blood cells cannot do what nerve cells do. But every living creature that grows from an egg begins as an embryo made up of a few cells. Every one of those cells has the ability to become whatever the creature will need. When these cells were discovered, they were christened stem cells because of this incredible power. Scientists looked at the stem cells in a mouse embryo and saw a future where they could grow new hearts and repair nerve damage so that people like Christopher Reeve could walk again. A new branch of medical science was born. However, the discovery of these cells brought with it more questions than answers. How did a stem cell learn what it would turn into? What turned the genetic code on and off? Could stem cells be safely grown in the laboratory? If researchers could figure out how to control stem cells, they could use them to make tissues, even replace organs and repair damaged nerves. But that kind Continue reading >>

Diabetes Type 2 - Stem Cells Treatment Clinic

Diabetes Type 2 - Stem Cells Treatment Clinic

Diabetes Type 2 Stem Cell Treatment Diabetes type 2 is a metabolic disorder that is characterized by high blood sugar and lack of insulin, a hormone produced in the pancreas that regulates the metabolism of carbohydrates. It is typically a chronic disease with a ten-year shortened life expectancy and symptoms such as: increased thirst, frequent urination, and constant hunger. There are a number of associated complications including: two to four times the risk of a cardiovascular disease and stroke, a 20-fold increase in lower limb amputations, and increased hospitalizations. Type 2 diabetes is the largest cause of non-traumatic blindness and kidney failure. It is associated with an increased risk of cognitive dysfunction and dementia, such as Alzheimer's disease. Other complications include: sexual dysfunction and frequent infections. Causes of type 2 diabetes: - obesity - poor diet - low activity level - genetics and family history Other diabetes risk factors include old age, high blood pressure, history of gestational diabetes, polycystic ovarian syndrome, impaired glucose intolerance and ethnicity, as African Americans, Hispanic Americans, and Native Americans are prone to an increased incidence of diabetes because of a history of gestational diabetes. With Type 2 Diabetes the body becomes insensitive and less able to produce insulin, which transports glucose from the bloodstream into body tissues. Instead the sugar volume in the blood builds up. The pancreas may increase insulin production but it does not rectify the problem. Other symptoms of this disease include blurred vision, fatigue, increased appetite, thirst and urination, slow-healing or frequent infections and erectile dysfunction. In both forms of diabetes, unless treated, blood sugar will rise uncontrolla Continue reading >>

Are Stem Cells The Next Frontier For Diabetes Treatment?

Are Stem Cells The Next Frontier For Diabetes Treatment?

Are Stem Cells the Next Frontier for diabetes treatment? Diabetes is a devastating disease that affects millions of people worldwide. The major forms of the disease are type 1 and type 2 diabetes. In type 1 diabetes, the body's immune system aberrantly destroys the insulin-producing beta cells (b-cells) of the pancreas. Type 2 diabetes, the more common form, is characterized both by insulin resistance, a condition in which various tissues in the body no longer respond properly to insulin action, and by subsequent progressive decline in b-cell function to the point that the cells can no longer produce enough additional insulin to overcome the insulin resistance. Researchers are actively exploring cell replacement therapy as a potential strategy to treat type 1 diabetes, because patients with this disease have lost all or nearly all b-cell function. However, if a safe and cost-effective means for replenishing b-cells were developed, such a treatment strategy could also be useful for the larger population with type 2 diabetes. One of the major challenges of cell replacement therapy is the current insufficient supply of b-cells from human organ donors. This article focuses on stem cells as potential sources for deriving new b-cells. Diabetes: A Critical Health Issue for the 21st Century According to the International Diabetes Federation, diabetes currently affects 7% of the world's population nearly 250 million individuals worldwide. 1 This total is expected to rise to 380 million by 2025 as a result of aging populations, changing lifestyles, and a recent worldwide increase in obesity. Although projections for increases in diabetes prevalence suggest that the greatest percentage gains will occur in Asia and South America, 2 , 3 all nations will experience a rising disease Continue reading >>

Type 1 Diabetes Reversed With Stem Cells From Cord Blood

Type 1 Diabetes Reversed With Stem Cells From Cord Blood

Type 1 Diabetes Reversed With Stem Cells From Cord Blood Stem cells from cord blood "re-educated" the immune system T cells of people with type 1 diabetes so their pancreas started producing insulin again, thereby reducing the amount of insulin they needed to inject. These are the findings of a study led by Dr Yong Zhao, from University of Illinois at Chicago that were published online on Tuesday in the open access journal BMC Medicine. Type 1 diabetes develops when the body's own immune system attacks and destroys the insulin-producing islet beta cells in the pancreas. As a result, the body can't make insulin, causing blood glucose to reach dangerous levels and damage all the organs in the body. In their background information, the researchers note that tests on mice and cells of patients with diabetes have shown that multipotent cells derived from cord blood "can control autoimmune responses by altering regulatory T cells (Tregs) and human islet beta cell-specific T cell clones". Cord blood is blood that is collected from the placenta and umbilical cord after childbirth. It is a rich source of stem cells that can treat a range of blood and genetic disorders. In their paper the researchers describe how they developed a procedure they called "Stem Cell Educator therapy" where the diabetic patient's blood is circulated through a closed-loop system that separates lymphocytes (a class of immune cell that includes T cells) from the whole blood and co-cultures them with cord blood stem cells from healthy donors for two to three hours before returning the "re-educated lymphocytes" to the patient's circulation. For this small, open-label, phase1/phase 2 study they recruited 15 patients with type 1 diabetes aged from 15 to 41 years (median 29) with a diabetic history ranging f Continue reading >>

Diabetes: How Could Stem Cells Help?

Diabetes: How Could Stem Cells Help?

Diabetes is a common life-long condition and the number of children being diagnosed with type 1 diabetes is increasing. The symptoms can be controlled but there is no cure. For many, diabetes means living with daily insulin injections and the possibility of long-term damage to their health. All the cells in your body need energy. This energy is carried around the body as sugar (glucose) in the blood. There are several types of diabetes. What they all have in common is a problem with regulating normal levels of sugar in the blood. Normally, blood sugar levels are controlled by the release of the hormone insulin. Insulin is made by cells in the pancreas called beta cells that are arranged into clusters together with other pancreas cells. These clusters are called islets of Langerhans. In one human pancreas there are roughly one million islets. Where is the pancreas?: located in the abdomen, next to the small intestine and stomach. The cells in the pancreas that make insulin (beta cells) are highlighted in red in this video by Dror Sever and Anne Grapin-Botton. Continue reading >>

An Overview

An Overview

Nearly 400 million people worldwide are living with diabetes, and that number is expected to jump to almost 600 million by 2035, according to the International Diabetes Federation. For many people, diabetes can be controlled with diet, exercise and, often, insulin or other drugs. However, complications from diabetes can be serious and include kidney failure, nerve damage, vision loss, heart disease and a host of other health issues. In this section: What is diabetes? How is diabetes treated? How are we using stem cells to understand diabetes? What is the potential for stem cells to treat diabetes? At its most basic, diabetes is a condition in which the body cannot regulate or properly use sugar (called glucose) in the blood. The pancreas, which helps the small intestine digest food, has hundreds of thousands of cell clusters called islets of Langerhans where beta cells live. Beta cells produce insulin, which is released into the bloodstream when blood sugar levels reach a certain threshold. The insulin signals other cells in the body to take up sugar, the primary energy source for all the body’s cells. Type 1, also known as juvenile diabetes. In type 1 diabetes, the body’s immune system attacks the beta cells in the pancreas. When the beta cells are damaged, they don’t produce insulin, or at least not enough insulin. Other cells never get the signal to take up sugar, so they don’t get the energy they need to function properly, and high sugar levels in the blood end up causing damage to the kidneys, eyes, nervous system and other organs. Type 2 diabetes, also called adult-onset diabetes. In type 2 diabetes, cells in the body become resistant to insulin. They don’t respond to the signals insulin sends out, so they don’t take up sugar from the blood. The beta c Continue reading >>

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