Combination Of Stem Cell And Drug Therapy Could Reverse Type 2 Diabetes
Stem cell research is heralding a new age of possiblemedical treatments as scientists use them to grow transplantable cells andorgans. Now, it appears those new treatments might include one fortype 2 diabetes. Existing research has already found avenues to treat type 1diabetes. This less-common, early-onset form of diabetes occurs when the body’simmune system attacks and destroys insulin-producing cells in the pancreas,often while fighting an infection elsewhere in the body. By using stem cells,doctors can grow new insulin-producing cells to replace those that the pancreashas lost. However, type 2 diabetes – which makes up 90 percent ofdiabetes cases worldwide – is harder to treat. It typically occurs in adults asa result of excess weight or hormonal imbalances. While people with type 2 diabetes do lose some of theirinsulin-producing cells, their primary problem is elsewhere. Their cells havebecome resistant to insulin. Although insulin is present in the body, the cellscan no longer use insulin to keep blood sugar levels in check. Simply regrowingthe missing insulin-producing cells is not enough to solve the problem. Now, in new research published in StemCell Reports, scientists may have found a way. Read More: Scientists Make Insulin-Producing Cells from Stem Cells to Cure Type 1 Diabetes » A Two-Pronged Approach To create a mouse model of type 2 diabetes, the researchersput mice on a high-fat, high-carb diet. The symptoms of type 2 diabetes soonfollowed. The mice became overweight, intolerant to glucose (blood sugar), andresistant to insulin. Their blood sugar levels skyrocketed. Next came the attempt to reverse the induced diabetic state.The research team cultured human embryonic stem cells and prepared them to besafely implanted into the diabetic mice. Once t Continue reading >>
Diabetes Type 2 - Stem Cells Treatment Clinic
Diabetes Type 2 Stem Cell Treatment Diabetes type 2 is a metabolic disorder that is characterized by high blood sugar and lack of insulin, a hormone produced in the pancreas that regulates the metabolism of carbohydrates. It is typically a chronic disease with a ten-year shortened life expectancy and symptoms such as: increased thirst, frequent urination, and constant hunger. There are a number of associated complications including: two to four times the risk of a cardiovascular disease and stroke, a 20-fold increase in lower limb amputations, and increased hospitalizations. Type 2 diabetes is the largest cause of non-traumatic blindness and kidney failure. It is associated with an increased risk of cognitive dysfunction and dementia, such as Alzheimer's disease. Other complications include: sexual dysfunction and frequent infections. Causes of type 2 diabetes: - obesity - poor diet - low activity level - genetics and family history Other diabetes risk factors include old age, high blood pressure, history of gestational diabetes, polycystic ovarian syndrome, impaired glucose intolerance and ethnicity, as African Americans, Hispanic Americans, and Native Americans are prone to an increased incidence of diabetes because of a history of gestational diabetes. With Type 2 Diabetes the body becomes insensitive and less able to produce insulin, which transports glucose from the bloodstream into body tissues. Instead the sugar volume in the blood builds up. The pancreas may increase insulin production but it does not rectify the problem. Other symptoms of this disease include blurred vision, fatigue, increased appetite, thirst and urination, slow-healing or frequent infections and erectile dysfunction. In both forms of diabetes, unless treated, blood sugar will rise uncontrolla Continue reading >>
Type 2 Diabetes Stem Cell Treatment Supported By Research
Ongoing clinical research continues to support Type 2 Diabetes stem cell treatment that is available today in medical clinics across the country like NSI Stem Cell in Florida. The success of stem cell treatment for a wide array of ailments, injuries and chronic pain is already familiar to a growing segment of the U.S. population. Relief from respiratory conditions like COPD, nerve damage like Peripheral Neuropathy just a couple of examples of the types of stem cell therapy that has dramatically improved the lives of many thousands.* Even so, those who suffer from Type 2 Diabetes are often surprised to learn that there is a Type 2 Diabetes stem cell treatment readily available now that is supported by reams of medical research.* Who Is Affected By Type 2 Diabetes? At least twenty-nine million Americans suffer from diabetes. This chronic disease affects the way the body processes blood sugar. Left untreated, Type 2 Diabetes can cause heart and blood vessel disease, damage the kidneys and cause loss of hearing or eyesight. It can damage nerves, and lead to severe infections as well as foot or leg amputations. It can also play a role in the development of Alzheimer’s disease and death. Controlling one’s blood sugar levels is critical in combating the effects of diabetes. How Type 2 Diabetes Stem Cell Treatment Helps Stem cells are multi-potent cells capable of differentiating into a multitude of different types of cells for the repair and regeneration of the body. This includes cells that help restore the healthy functioning of the pancreas, which controls insulin and blood sugar levels.* The key to Type 2 Diabetes stem cell treatment in clinics like NSI Stem Cell is the use of adipose-derived adult stem cells commonly abbreviated ASCs (also A-MSCs). Following the guide Continue reading >>
Diabetes And Stem Cell Research
Stem cell research is in progress for the treatment of diabetes Understanding the root causes of diabetes has eluded researchers for many years now. The way in which the immune system causes the destruction of precious beta islet cells within the pancreas of type 1 diabetics is generally understood to be the key. The ultimate goal, which has so far proved elusive, is a cure for diabetes , which could potentially be available for both types of diabetes through stem cell research. Stem cells are a form of cell that is yet to develop a specific set of traits. However, what stem cells have in abundance is the potential to develop into a number of different forms. Stem cell research covers the scientific study of these stem cells. Stem cell research allows researchers to grow specific varieties of human cells in the lab and research how they behave and interact under different conditions. Stem cells open up a wide spectrum of diabetes research possibilities. In one example of diabetes stem cell research, researchers took cells from human intestine cells and disabled a gene which enabled the cells to produce insulin. Stem cells for the treatment of diabetes are able to come from a variety of sources. Stem cells in the research of type 1 diabetes Within recent years, stem cell research has become a very important part of the scientific understanding of type 1 diabetes. Research has demonstrated that stem cells can be grown in the lab. In 2004, the University of Pittsburgh grew insulin producing beta cells by introducing two genes cdk and cyclin d via a virus. The researchers were able to deactivate the virus and also prevent stem cells from growing further. The research could lead to a better availability of beta cells for future research purposes. Progenitor cells, related t Continue reading >>
Stem Cell Treatment & Therapy For Diabetes Type 2 In Chicago, Il
Why Choose Stem Cell Therapy For Type 2 Diabetes? For people suffering from Type 2 diabetes, stem cell therapy can offer a respite from the symptoms of the disease. Although stem cell therapy cannot cure it, receiving stem cell therapy for diabetes Type 2 from TruStem Cell Therapy has the potential to improve a patients quality of life significantly by reducing symptoms and complications related to Type 2 diabetes, as well as slowing its progression. For patients receiving stem cell diabetes treatment, it is possible to see improvements in any one or multiple disease-related complications such as stabilization of blood sugar levels, lower blood sugar levels, frequent urination, fatigue, poor wound healing, etc. How Does Stem Cell Diabetes Treatment Work? TruStem Cell Therapy provides access to diabetes treatment that utilizes a patients stem cells isolated from his or her own fat tissue. There are multiple benefits afforded by the utilization of adipose-derived stem cells, including their ability to differentiate into a broad variety of cell types (neurons, bone, cartilage, muscle, tendon, etc.), they are present at comparatively much higher levels than other stem cell types; possess higher immunomodulatory capacity; and they do not endanger a patients health the way other stem cells might. There are three steps to the treatment process: Approximately 150 to 250 ccs of a patients own fat tissue is harvested through a minimally invasive procedure. Generally, this fat tissue is collected from around the patients belly region. Process and activate. Harvested fat tissue is taken immediately to the on-site laboratory for processing. At this stage, an optimized protocol is used to isolate the maximum number of stem cells from collected fat tissue. Administer. TruStem Cell Th Continue reading >>
New Diabetes Treatment Teaches Rogue Immune Cells To Behave
(Getty Images) A treatment targeting wayward immune cells in people with Type 1 or Type 2 diabetes may help even years later, a new study finds. For the treatment, researchers take blood from a person with diabetes and separate out the immune system cells (lymphocytes). They briefly expose those cells to stem cells from umbilical cord blood from an unrelated infant. Then they return the lymphocytes to the patient's body. The researchers have dubbed this treatment "stem cell educator therapy," because when exposed to the stem cells, the errant lymphocytes seem to re-learn how they should behave. "Stem cell educator therapy is a safe approach" with long-term effectiveness, said the study's lead author, Dr. Yong Zhao, an associate scientist at Hackensack University Medical Center in New Jersey. Type 1 diabetes, an autoimmune disease, occurs when the body's immune system cells mistakenly attack the insulin-producing (beta) cells in the pancreas. This leaves people with Type 1 diabetes with little to no insulin. They need insulin injections to survive. Researchers have long thought that any cure for Type 1 diabetes would have to stop the autoimmune attack, while regenerating or transplanting beta cells. But Zhao and his team developed a new approach to the problem — educating the immune cells that had been destroying beta cells so they stop attacking. In Type 2 diabetes, Zhao said immune cell dysfunction is responsible for chronic inflammation that causes insulin resistance. When someone is insulin-resistant, their body's cells can't properly use insulin to usher sugar from foods into cells for use as energy. Instead, the sugar builds up in the blood. The researchers hoped the stem cell educator would help decrease insulin resistance for people with Type 2 diabetes. In ear Continue reading >>
Diabetes | Harvard Stem Cell Institute (hsci)
HOME / RESEARCH / DISEASE PROGRAMS / DIABETES PROGRAM / It stands to reason that only by understanding the root causes of diseases like diabetes can we hope to develop effective therapies. Modern biomedical research is best at finding treatments for diseases that have relatively simple causes and well-understood genetic risk factors. Unfortunately, type 1 diabetes (T1D) has very complex genetics, with many genes each making relatively small, poorly understood contributions to disease risk. Further, there are no animal models that accurately reflect the human disease. Thus, despite the expenditure of hundreds of millions of research dollars, no cures for T1D have been developed. T1D is particularly challenging to study in human patients. By the time a patient is diagnosed with T1D, also known as juvenile diabetes, the destruction of insulin-producing beta cells by the immune system is nearly complete. Because of this, there is no way to discover what it was that led the persons immune system to attack the beta cells in the first place. Even if it were possible to identify future T1D patients before the immune attack on beta cells began, disease onset and progression could not be studied in these individuals due to the inaccessibility of the pancreas where beta cells are found in a living person. Harvard Stem Cell Institute (HSCI) scientists are attempting an ambitious, long-term, and high-risk project to create the first animal model for T1D. Engineered mice will allow researchers to better understand the disease and increase the odds of developing effective therapies. Recent advances in stem cell biology have opened the door to new ways of studying T1D. Specifically, it is now possible to reprogram a skin cell from a T1D patient (or any other person) into a cell that c Continue reading >>
Mesenchymal Stem Cell Therapy In Type 2 Diabetes Mellitus
Type 2 diabetes mellitus (T2DM), which is characterized by the combination of relative insulin deficiency and insulin resistance, cannot be reversed with existing therapeutic strategies. Transplantation of insulin-producing cells (IPCs) was once thought to be the most promising strategy for treating diabetes, but the pace from the laboratory to clinical application has been obstructed due to its drawbacks. Mesenchymal stem cells (MSCs) harbor differentiation potential, immunosuppressive properties, and anti-inflammatory effects, and they are considered an ideal candidate cell type for treatment of DM. MSC-related research has demonstrated exciting therapeutic effects in glycemic control both in vivo and in vitro, and these results now have been translated into clinical practice. However, some critical potential problems have emerged from current clinical trials. Multi-center, large-scale, double-blind, and placebo-controlled studies with strict supervision are required before MSC transplantation can become a routine therapeutic approach for T2DM. We briefly review the molecular mechanism of MSC treatment for T2DM as well as the merits and drawbacks identified in current clinical trials. Mesenchymal stem cellsType 2 diabetes mellitusInsulin resistance Over recent decades, diabetes mellitus (DM) has become one of the major public healthcare problems worldwide [ 1 ]. It is estimated that 415 million adults have diabetes worldwide, and a further 318 million adults are estimated to have impaired glucose tolerance, and thus, be at high risk of developing diabetes in the future [ 2 ]. DM is a major risk factor for ischemic heart disease and stroke, which collectively account for high rates of morbidity and mortality among adult patients [ 3 ]. In addition, DM is the most comm Continue reading >>
Enhanced Stem Cells For Treating Diabetes Mellitus Type 1 & 2
Updated November 22, 2017 – In the unfortunate event you or perhaps a family member are coping with diabetes you should be aware of its consequences on the body and mind. Diabetes is usually termed the “silent killer” mainly because it strikes the body slowly and without warning. Newly diagnosed diabetic patients are usually not worried about it since their symptoms are often no more severe than recurrent urination and increased thirst. A number of other individuals have no symptoms at all. Treating Diabetics With Stem Cells As time goes by however, the effects of both kinds of diabetes become increasingly serious and may lead to death. These symptoms include heart disease, eye issues, kidney failure, nerve damage and erectile dysfunction, to name a few. Hypoglycemia (acute low blood sugar) and hyperglycemia (high level of blood sugar) are the key contributors to the effects of diabetes. According to recent research, some of the oral diabetes medications can also help contribute to heart malfunction.(Kao and Chen 2012)* That is exactly why it’s important that women and men who are clinically diagnosed as “diabetic” immediately seek treatment to relieve hypoglycemia and hyperglycemia. These conditions often trigger the more harmful, degenerative ailments. The regeneration center can help treat DM with our innovative enriched and expanded Mesenchymal cells treatment for Diabetes safely and without any artificial medicines or need for regular insulin dependency.(Yong Zhao et al. 2013)* Reverse Hyperglycemia with Insulin Producing Beta-Cells Stem Cell treatments for diabetes fights the disease at its origins in the pancreas. Decreasing hyperglycemia as well as associated complications (see above). According to recent research, it can also relieve hypoglycemia or Continue reading >>
An Overview
Nearly 400 million people worldwide are living with diabetes, and that number is expected to jump to almost 600 million by 2035, according to the International Diabetes Federation. For many people, diabetes can be controlled with diet, exercise and, often, insulin or other drugs. However, complications from diabetes can be serious and include kidney failure, nerve damage, vision loss, heart disease and a host of other health issues. In this section: What is diabetes? How is diabetes treated? How are we using stem cells to understand diabetes? What is the potential for stem cells to treat diabetes? At its most basic, diabetes is a condition in which the body cannot regulate or properly use sugar (called glucose) in the blood. The pancreas, which helps the small intestine digest food, has hundreds of thousands of cell clusters called islets of Langerhans where beta cells live. Beta cells produce insulin, which is released into the bloodstream when blood sugar levels reach a certain threshold. The insulin signals other cells in the body to take up sugar, the primary energy source for all the body’s cells. Type 1, also known as juvenile diabetes. In type 1 diabetes, the body’s immune system attacks the beta cells in the pancreas. When the beta cells are damaged, they don’t produce insulin, or at least not enough insulin. Other cells never get the signal to take up sugar, so they don’t get the energy they need to function properly, and high sugar levels in the blood end up causing damage to the kidneys, eyes, nervous system and other organs. Type 2 diabetes, also called adult-onset diabetes. In type 2 diabetes, cells in the body become resistant to insulin. They don’t respond to the signals insulin sends out, so they don’t take up sugar from the blood. The beta c Continue reading >>
Bone Marrow Derived Stem Cell Therapy For Type 2 Diabetes Mellitus
Bone marrow derived stem cell therapy for type 2 diabetes mellitus 1Hematology Department, the Lebanese Canadian and Notre Dame University Hospitals, Beirut, Lebanon; 2Neurosurgery Department, the Lebanese Canadian Hospital, Beirut, Lebanon; 3Endocrinology Department, Al-Saydet Hospital, Zgharta, Lebanon; 4Endocrinology Department, The Middle East and Notre Dame University Hospitals, Beirut, Lebanon; 5Endocrinology Department, the Lebanese Canadian Hospital, Beirut, Lebanon Correspondence to: Tarek Wehbe, MD. The Notre Dame University Hospital, Notre Dame St., Jounieh, Lebanon. Email: moc.liamg@4ebhewwt . Received 2016 Sep 2; Accepted 2016 Nov 21. Copyright 2016 Stem Cell Investigation. All rights reserved. In this study, 6 patients with type 2 diabetes (T2D) underwent autologous bone marrow mononuclear stem cell (BM-MNSC) infusion into the celiac and superior mesenteric arteries without pretreatment with any myeloablative or immune-suppressive therapy. Five of 6 (83%) showed normalization of their fasting glucose and the glycosylated hemoglobin (HbA1C) with significant reduction of their medication requirements. The HbA1C dropped on average 2.2 points. The three patients with diabetic complications showed improvement or stabilization and most patients reported improved energy and stamina. The durations of response varied between 6 months and 2 years. No patients had any significant adverse effects. Keywords: Type 2 diabetes (T2D), stem cells, bone marrow mononuclear cells, glycosylated hemoglobin Diabetes incidence is on the rise, afflicting 810% of the world population with as many suspected of having pre-diabetes. This incidence will likely double in the next few decades due to the widespread sedentary lifestyles and dietary indiscretions. Ninety-five percent of the Continue reading >>
Type 2 Diabetes Mellitus
Type 2 diabetes mellitus (T2DM), the most common form of diabetes, is considered a metabolic disorder that results in high-blood glucose levels (hyperglycemia) caused by an insulin resistance and deficiency. A normally functioning pancreas will secrete the insulin hormone in low amounts after eating a meal. The glucose (sugar) found in the foods we eat stimulate the secretion of the insulin hormone proportional to the size of each meal. The main role of insulin is to help move specific nutrients into the body’s cells, mainly sugar, which they use as a source of energy. When glucose levels in the bloodstream rise, the beta cells located in the pancreas increase the secretion of insulin to avoid hyperglycemia. In type 2 diabetes, this process works improperly. Instead of moving into your cells to be used as a source of energy, glucose builds up in your bloodstream. Unlike people diagnosed with type 1, the bodies of people with type 2 diabetes produce the hormone insulin. The two main problems caused by type 2 diabetes is the pancreas not producing enough insulin and the body not using the insulin sufficiently. A diagnosis of T2DM occurs when the body does not use the hormone insulin properly. The process of improper secretion and absorption is referred to as insulin resistance. In the early stages, the pancreas makes extra insulin to regulate the high blood glucose (sugar) levels, but over time it is not able to make enough insulin to keep your blood glucose at normal levels. When there isn’t enough insulin or the insulin is not used properly, glucose can’t get into the body’s cells as it should, causing body’s cells to not function normally. Although it is diagnosed far more than type 1 diabetes, the causes of type 2 diabetes are considered to be less understoo Continue reading >>
- Women in India with Gestational Diabetes Mellitus Strategy (WINGS): Methodology and development of model of care for gestational diabetes mellitus (WINGS 4)
- Postprandial Blood Glucose Is a Stronger Predictor of Cardiovascular Events Than Fasting Blood Glucose in Type 2 Diabetes Mellitus, Particularly in Women: Lessons from the San Luigi Gonzaga Diabetes Study
- Metabolic surgery for treating type 2 diabetes mellitus: Now supported by the world's leading diabetes organizations
Updates On Harvard’s Diabetes Stem Cell Research From Ada 2015
Twitter Summary: @Harvard #diabetes stem cell lab wows crowd at #2015ADA, plans to produce full pancreatic islets w/ beta + alpha cells. Still early stages. There was a lot of interest this ADA in the Harvard Stem Cell Institute’s diabetes research, which has previously shown the ability to produce mature, insulin-producing beta cells from human stem cells. These beta cells can effectively cure type 1 diabetes in mice. (Normally, beta cells produce insulin and are found in the pancreas). While other groups are also working on stem cell based therapies for diabetes, the Harvard group is unique in that they are able to produce mature beta cells from stem cells. For comparison, the prominent diabetes stem cell research group at ViaCyte is only able to create “parent” cells that, after implantation in the body, could later develop into functional beta cells. Another group called BetaLogics, which is owned by J&J, can produce human “beta-like” cells that, while not identical to human beta cells, would already be mature (i.e. able to produce insulin in response to glucose levels) upon implantation. The Harvard group can also produce an extremely large quantity of cells, which is a critical need given the current deficit of beta cells for the millions of people with type 1 diabetes and type 2 diabetes who can no longer sufficiently produce insulin. Dr. Douglas Melton from Harvard wowed the crowd with his update on the team’s latest discoveries, most notably the announcement that his team can now not only produce beta cells from stem cells, but also alpha cells (which produce glucagon, another important hormone) and delta cells. All of these cells are found together in ‘islets’ in the pancreas, and Dr. Melton believes that his team will in the future be able to Continue reading >>
Stem Cell-based Therapy For Type 2 Diabetes Shows Promise
Stem cell-based therapy for type 2 diabetes shows promise In a new study published in the journal Stem Cell Reports, researchers reveal how a combination of stem cell transplantation and antidiabetic medication successfully treated mice with type 2 diabetes. This image shows the transplanted pancreatic beta cells derived from human embryonic stem cells. Image credit: Jennifer Bruin, University of British Columbia Senior study author Timothy Kieffer, of the University of British Columbia in Canada, and colleagues say the findings could lead the way for the first ever stem cell-based insulin replacement therapy being tested in humans with type 2 diabetes . It is estimated that more than 29 million people in the US have diabetes . Type 2 diabetes accounts for around 90-95% of these cases. The condition occurs as a result of the body being unable to produce enough of the hormone insulin or use it effectively. This leads to high blood glucose levels. In order to manage blood glucose levels, patients with type 2 diabetes are often treated with oral medication - such as metformin - insulin injections, or a combination of both. Kieffer and colleagues note, however, that such treatments can cause gastrointestinal problems, weight gain and low blood glucose levels, and some patients may not even respond to them. With these factors in mind, the team tested a potential alternative treatment approach for patients with type 2 diabetes. Improved glucose metabolism, insulin sensitivity with beta cell transplantation The team created a mouse model of type 2 diabetes by inducing some markers of the disease in the animals - obesity , low response to insulin and high blood glucose levels - by feeding them a high-fat diet. Next, the team transplanted mice with encapsulated pancreatic proge Continue reading >>
Diabetes: How Could Stem Cells Help?
Diabetes is a common life-long condition and the number of children being diagnosed with type 1 diabetes is increasing. The symptoms can be controlled but there is no cure. For many, diabetes means living with daily insulin injections and the possibility of long-term damage to their health. All the cells in your body need energy. This energy is carried around the body as sugar (glucose) in the blood. There are several types of diabetes. What they all have in common is a problem with regulating normal levels of sugar in the blood. Normally, blood sugar levels are controlled by the release of the hormone insulin. Insulin is made by cells in the pancreas called beta cells that are arranged into clusters together with other pancreas cells. These clusters are called islets of Langerhans. In one human pancreas there are roughly one million islets. Where is the pancreas?: located in the abdomen, next to the small intestine and stomach. The cells in the pancreas that make insulin (beta cells) are highlighted in red in this video by Dror Sever and Anne Grapin-Botton. Continue reading >>
