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Can Stem Cells Be Used To Cure Diabetes?

Updates On Harvard’s Diabetes Stem Cell Research From Ada 2015

Updates On Harvard’s Diabetes Stem Cell Research From Ada 2015

Twitter Summary: @Harvard #diabetes stem cell lab wows crowd at #2015ADA, plans to produce full pancreatic islets w/ beta + alpha cells. Still early stages. There was a lot of interest this ADA in the Harvard Stem Cell Institute’s diabetes research, which has previously shown the ability to produce mature, insulin-producing beta cells from human stem cells. These beta cells can effectively cure type 1 diabetes in mice. (Normally, beta cells produce insulin and are found in the pancreas). While other groups are also working on stem cell based therapies for diabetes, the Harvard group is unique in that they are able to produce mature beta cells from stem cells. For comparison, the prominent diabetes stem cell research group at ViaCyte is only able to create “parent” cells that, after implantation in the body, could later develop into functional beta cells. Another group called BetaLogics, which is owned by J&J, can produce human “beta-like” cells that, while not identical to human beta cells, would already be mature (i.e. able to produce insulin in response to glucose levels) upon implantation. The Harvard group can also produce an extremely large quantity of cells, which is a critical need given the current deficit of beta cells for the millions of people with type 1 diabetes and type 2 diabetes who can no longer sufficiently produce insulin. Dr. Douglas Melton from Harvard wowed the crowd with his update on the team’s latest discoveries, most notably the announcement that his team can now not only produce beta cells from stem cells, but also alpha cells (which produce glucagon, another important hormone) and delta cells. All of these cells are found together in ‘islets’ in the pancreas, and Dr. Melton believes that his team will in the future be able to Continue reading >>

An Overview

An Overview

Nearly 400 million people worldwide are living with diabetes, and that number is expected to jump to almost 600 million by 2035, according to the International Diabetes Federation. For many people, diabetes can be controlled with diet, exercise and, often, insulin or other drugs. However, complications from diabetes can be serious and include kidney failure, nerve damage, vision loss, heart disease and a host of other health issues. In this section: What is diabetes? How is diabetes treated? How are we using stem cells to understand diabetes? What is the potential for stem cells to treat diabetes? At its most basic, diabetes is a condition in which the body cannot regulate or properly use sugar (called glucose) in the blood. The pancreas, which helps the small intestine digest food, has hundreds of thousands of cell clusters called islets of Langerhans where beta cells live. Beta cells produce insulin, which is released into the bloodstream when blood sugar levels reach a certain threshold. The insulin signals other cells in the body to take up sugar, the primary energy source for all the body’s cells. Type 1, also known as juvenile diabetes. In type 1 diabetes, the body’s immune system attacks the beta cells in the pancreas. When the beta cells are damaged, they don’t produce insulin, or at least not enough insulin. Other cells never get the signal to take up sugar, so they don’t get the energy they need to function properly, and high sugar levels in the blood end up causing damage to the kidneys, eyes, nervous system and other organs. Type 2 diabetes, also called adult-onset diabetes. In type 2 diabetes, cells in the body become resistant to insulin. They don’t respond to the signals insulin sends out, so they don’t take up sugar from the blood. The beta c Continue reading >>

Stem Cell Treatment & Therapy For Diabetes Type 2 In Chicago, Il

Stem Cell Treatment & Therapy For Diabetes Type 2 In Chicago, Il

Why Choose Stem Cell Therapy For Type 2 Diabetes? For people suffering from Type 2 diabetes, stem cell therapy can offer a respite from the symptoms of the disease. Although stem cell therapy cannot cure it, receiving stem cell therapy for diabetes Type 2 from TruStem Cell Therapy has the potential to improve a patients quality of life significantly by reducing symptoms and complications related to Type 2 diabetes, as well as slowing its progression. For patients receiving stem cell diabetes treatment, it is possible to see improvements in any one or multiple disease-related complications such as stabilization of blood sugar levels, lower blood sugar levels, frequent urination, fatigue, poor wound healing, etc. How Does Stem Cell Diabetes Treatment Work? TruStem Cell Therapy provides access to diabetes treatment that utilizes a patients stem cells isolated from his or her own fat tissue. There are multiple benefits afforded by the utilization of adipose-derived stem cells, including their ability to differentiate into a broad variety of cell types (neurons, bone, cartilage, muscle, tendon, etc.), they are present at comparatively much higher levels than other stem cell types; possess higher immunomodulatory capacity; and they do not endanger a patients health the way other stem cells might. There are three steps to the treatment process: Approximately 150 to 250 ccs of a patients own fat tissue is harvested through a minimally invasive procedure. Generally, this fat tissue is collected from around the patients belly region. Process and activate. Harvested fat tissue is taken immediately to the on-site laboratory for processing. At this stage, an optimized protocol is used to isolate the maximum number of stem cells from collected fat tissue. Administer. TruStem Cell Th Continue reading >>

Are Stem Cells The Next Frontier For Diabetes Treatment?

Are Stem Cells The Next Frontier For Diabetes Treatment?

Are Stem Cells the Next Frontier for diabetes treatment? Diabetes is a devastating disease that affects millions of people worldwide. The major forms of the disease are type 1 and type 2 diabetes. In type 1 diabetes, the body's immune system aberrantly destroys the insulin-producing beta cells (b-cells) of the pancreas. Type 2 diabetes, the more common form, is characterized both by insulin resistance, a condition in which various tissues in the body no longer respond properly to insulin action, and by subsequent progressive decline in b-cell function to the point that the cells can no longer produce enough additional insulin to overcome the insulin resistance. Researchers are actively exploring cell replacement therapy as a potential strategy to treat type 1 diabetes, because patients with this disease have lost all or nearly all b-cell function. However, if a safe and cost-effective means for replenishing b-cells were developed, such a treatment strategy could also be useful for the larger population with type 2 diabetes. One of the major challenges of cell replacement therapy is the current insufficient supply of b-cells from human organ donors. This article focuses on stem cells as potential sources for deriving new b-cells. Diabetes: A Critical Health Issue for the 21st Century According to the International Diabetes Federation, diabetes currently affects 7% of the world's population nearly 250 million individuals worldwide. 1 This total is expected to rise to 380 million by 2025 as a result of aging populations, changing lifestyles, and a recent worldwide increase in obesity. Although projections for increases in diabetes prevalence suggest that the greatest percentage gains will occur in Asia and South America, 2 , 3 all nations will experience a rising disease Continue reading >>

Diabetes: How Could Stem Cells Help?

Diabetes: How Could Stem Cells Help?

Diabetes is a common life-long condition and the number of children being diagnosed with type 1 diabetes is increasing. The symptoms can be controlled but there is no cure. For many, diabetes means living with daily insulin injections and the possibility of long-term damage to their health. All the cells in your body need energy. This energy is carried around the body as sugar (glucose) in the blood. There are several types of diabetes. What they all have in common is a problem with regulating normal levels of sugar in the blood. Normally, blood sugar levels are controlled by the release of the hormone insulin. Insulin is made by cells in the pancreas called beta cells that are arranged into clusters together with other pancreas cells. These clusters are called islets of Langerhans. In one human pancreas there are roughly one million islets. Where is the pancreas?: located in the abdomen, next to the small intestine and stomach. The cells in the pancreas that make insulin (beta cells) are highlighted in red in this video by Dror Sever and Anne Grapin-Botton. Continue reading >>

Enhanced Stem Cells For Treating Diabetes Mellitus Type 1 & 2

Enhanced Stem Cells For Treating Diabetes Mellitus Type 1 & 2

Updated November 22, 2017 – In the unfortunate event you or perhaps a family member are coping with diabetes you should be aware of its consequences on the body and mind. Diabetes is usually termed the “silent killer” mainly because it strikes the body slowly and without warning. Newly diagnosed diabetic patients are usually not worried about it since their symptoms are often no more severe than recurrent urination and increased thirst. A number of other individuals have no symptoms at all. Treating Diabetics With Stem Cells As time goes by however, the effects of both kinds of diabetes become increasingly serious and may lead to death. These symptoms include heart disease, eye issues, kidney failure, nerve damage and erectile dysfunction, to name a few. Hypoglycemia (acute low blood sugar) and hyperglycemia (high level of blood sugar) are the key contributors to the effects of diabetes. According to recent research, some of the oral diabetes medications can also help contribute to heart malfunction.(Kao and Chen 2012)* That is exactly why it’s important that women and men who are clinically diagnosed as “diabetic” immediately seek treatment to relieve hypoglycemia and hyperglycemia. These conditions often trigger the more harmful, degenerative ailments. The regeneration center can help treat DM with our innovative enriched and expanded Mesenchymal cells treatment for Diabetes safely and without any artificial medicines or need for regular insulin dependency.(Yong Zhao et al. 2013)* Reverse Hyperglycemia with Insulin Producing Beta-Cells Stem Cell treatments for diabetes fights the disease at its origins in the pancreas. Decreasing hyperglycemia as well as associated complications (see above). According to recent research, it can also relieve hypoglycemia or Continue reading >>

Diabetes And Stem Cell Research

Diabetes And Stem Cell Research

Stem cell research is in progress for the treatment of diabetes Understanding the root causes of diabetes has eluded researchers for many years now. The way in which the immune system causes the destruction of precious beta islet cells within the pancreas of type 1 diabetics is generally understood to be the key. The ultimate goal, which has so far proved elusive, is a cure for diabetes , which could potentially be available for both types of diabetes through stem cell research. Stem cells are a form of cell that is yet to develop a specific set of traits. However, what stem cells have in abundance is the potential to develop into a number of different forms. Stem cell research covers the scientific study of these stem cells. Stem cell research allows researchers to grow specific varieties of human cells in the lab and research how they behave and interact under different conditions. Stem cells open up a wide spectrum of diabetes research possibilities. In one example of diabetes stem cell research, researchers took cells from human intestine cells and disabled a gene which enabled the cells to produce insulin. Stem cells for the treatment of diabetes are able to come from a variety of sources. Stem cells in the research of type 1 diabetes Within recent years, stem cell research has become a very important part of the scientific understanding of type 1 diabetes. Research has demonstrated that stem cells can be grown in the lab. In 2004, the University of Pittsburgh grew insulin producing beta cells by introducing two genes cdk and cyclin d via a virus. The researchers were able to deactivate the virus and also prevent stem cells from growing further. The research could lead to a better availability of beta cells for future research purposes. Progenitor cells, related t Continue reading >>

Diabetes | Harvard Stem Cell Institute (hsci)

Diabetes | Harvard Stem Cell Institute (hsci)

HOME / RESEARCH / DISEASE PROGRAMS / DIABETES PROGRAM / It stands to reason that only by understanding the root causes of diseases like diabetes can we hope to develop effective therapies. Modern biomedical research is best at finding treatments for diseases that have relatively simple causes and well-understood genetic risk factors. Unfortunately, type 1 diabetes (T1D) has very complex genetics, with many genes each making relatively small, poorly understood contributions to disease risk. Further, there are no animal models that accurately reflect the human disease. Thus, despite the expenditure of hundreds of millions of research dollars, no cures for T1D have been developed. T1D is particularly challenging to study in human patients. By the time a patient is diagnosed with T1D, also known as juvenile diabetes, the destruction of insulin-producing beta cells by the immune system is nearly complete. Because of this, there is no way to discover what it was that led the persons immune system to attack the beta cells in the first place. Even if it were possible to identify future T1D patients before the immune attack on beta cells began, disease onset and progression could not be studied in these individuals due to the inaccessibility of the pancreas where beta cells are found in a living person. Harvard Stem Cell Institute (HSCI) scientists are attempting an ambitious, long-term, and high-risk project to create the first animal model for T1D. Engineered mice will allow researchers to better understand the disease and increase the odds of developing effective therapies. Recent advances in stem cell biology have opened the door to new ways of studying T1D. Specifically, it is now possible to reprogram a skin cell from a T1D patient (or any other person) into a cell that c Continue reading >>

Diabetes | Canadian Stem Cell Foundation

Diabetes | Canadian Stem Cell Foundation

Are there stem cell therapies available for type 1 diabetes? To our knowledge, no stem cell therapy has received Health Canada or U.S. Food and Drug Administration approval for treatment of type 1 diabetes at this time. Patients who are researching their options may come across companies with Web sites or materials that say otherwise and offer fee-based stem cell treatments for curing this disease. Many of these claims are not supported by sound scientific evidence and patients considering these therapies are encouraged to review some of the links below before making crucial decisions about their treatment plan. For the latest developments read our blog entries here . More about stem cell clinical trials for diabetesclick here . (For printed version: How close are we? What do we know about type 1 diabetes? The insulin-producing beta cells of the pancreas are attacked and destroyed by the bodys immune system cells. A persons environment, genetics and the infections they are exposed to over their lifetime all play a role in triggering the attack on beta cells. When the beta cells are destroyed, the production of insulin drops and our cells can no longer take in the sugar glucose. When glucose is left circulating in the blood at very high levels the blood vessels, eyes, kidneys, nerves and heart can be damaged. If type 1 diabetes is not diagnosed and treated in time with injections of insulin, a patient could fall into a life-threatening coma. Just a few teaspoonfuls of pancreatic islet cells can temporarily reverse type 1 diabetes. There is a shortage of donor pancreatic islet cells for treating patients with type 1 diabetes. Type 1 diabetes is an ideal candidate for a stem cell therapy because the disease can be traced to the loss of a single cell type the beta cell. St Continue reading >>

Stem Cells For The Treatment Of Type I Diabetes

Stem Cells For The Treatment Of Type I Diabetes

Stem cell treatments are gaining momentum as a viable option for successfully slowing down -- or potentially halting -- the progression of type 1 diabetes. According to the Juvenile Diabetes Research Foundation (JDRF), Type 1 diabetes affects as many as three million Americans. In addition, more than 15,000 children and young adults are newly diagnosed each year. This averages about 40 children per day. Currently, there is no cure for diabetes, although experts and researchers are working with this as a goal. As a type of autoimmune disease, diabetes is caused when the body’s immune system misinterprets the insulin-producing cells in the pancreas, called islets, and destroys them. There is no definitive cause for diabetes, however it is believed that there are both genetic factors as well as environmental factors, such as viruses or allergens. Type 1 diabetes presents the risk for many other complications, including blindness, kidney disease, heart disease and stroke. Another possible long-term complication is neuropathy, or nerve damage, which may result in loss of feeling and even amputations. Stabilizing insulin levels is the key to managing diabetes. The standard treatment today focuses supplementing the body’s insulin, typically through injection (needles) or insulin pumps, which are worn outside the body. This requires the patient testing his/her blood sugar levels several times per day, and carefully maintaining blood insulin levels. While this is recognized as the best standard of care today, the goal is to find a way to help the body produce and/or regulate its own insulin levels. The latest scientific breakthroughs, which use stem cells to create the insulin-producing islets, are widely viewed as the most promising of treatments being used and further deve Continue reading >>

Researchers Study Cure For Type 1 Diabetes In Stem Cell Transplantations

Researchers Study Cure For Type 1 Diabetes In Stem Cell Transplantations

Clinical trial shows promising results from risky procedure, identifies path for personalized therapies DUARTE, Calif. — Some type 1 diabetes (T1D) patients can be cured from the disease, at least for a number of years, with a stem cell transplant – those were the results of a clinical trial monitored by City of Hope’s Bart Roep, Ph.D., the Chan Soon-Shiong Shapiro Distinguished Chair in Diabetes and professor/founding chair, Department of Diabetes Immunology. The results were published recently in the journal, Frontiers in Immunology. “This means we can cure type 1 diabetes, be it with a risky therapy — although one that is also very successful in cancer, and one for which City of Hope is a world-renowned expert, with more than 14,000 patients having received similar treatment for blood cancers,” said Roep, director of The Wanek Family Project for Type 1 Diabetes, which aims to find a cure for T1D in six years. “We now understand stem cell transplants can succeed in treating diabetes for some, but not in others, and we can predict either outcome before the therapy is administered by 'reading' the immune signature of the patient with a novel nanotechnology that I developed.” An international team of researchers, including Roep, conducted the trial in Brazil. It showed that autologous hematopoietic stem cell transplantation (AHSCT), which uses a person’s own stem cells, increases C-peptide levels — that show how much insulin is being made by the pancreas — and induces insulin independence in patients with T1D. This is possible because the transplanted stem cells are able to balance the immune system. The study also aimed to understand why some patients saw long-term clinical benefit from the transplantation while others did not. Twenty-one T1D patie Continue reading >>

Stories Of Hope: A Stem Cell Therapy For Diabetes

Stories Of Hope: A Stem Cell Therapy For Diabetes

Home Stories of Hope: A Stem Cell Therapy for Diabetes Stories of Hope: A Stem Cell Therapy for Diabetes The last thing Maria Torres expected was to be diagnosed with type 2 diabetes. She exercised, ate well and kept her weight under control. There had to be some mistake. Maria asked her doctor to repeat the tests, but the results were the same. At 43, for reasons no one could fully explain, she had diabetes, and her life was going to change dramatically. It really scared me, says Maria. I thought I was going to die soon. That Maria doubted her diagnosis is no surprise. Type 2 diabetes is often associated with obesity, and she didnt fit the profile. Most likely, some undiscovered genetic component had made her susceptible to the disease. Regardless, she now had to rework her life to manage the diabetes. Her cells had developed a condition called insulin resistance. Though her pancreas was producing insulin, which tells cells to take in blood sugar, the cells were not cooperating. As a result, glucose was accumulating in her blood, putting her at risk for heart disease, nerve damage, eye issues and a host of other problems. To help her cells absorb glucose, she needs regular insulin injections. Maria injects the hormone five times a day and must often measure her blood sugar levels even more frequently. Faithfully following this regimen has kept her alive for 20 years, but insulin is not a cure. Even with the regular injections, she faces dramatic mood swings and more serious complications as glucose levels rise and fall. One of the most promising strategies to cure diabetes is to transplant beta cells, which sense blood sugar levels and produce insulin to reduce them. Patients with type 1 diabetes would benefit because new beta cells would replace the ones theyd lost t Continue reading >>

Stem Cell Therapy For Diabetes Type 1 And Diabetes Type 2

Stem Cell Therapy For Diabetes Type 1 And Diabetes Type 2

New treatments and advances in research are giving new hope to people affected by Diabetes Type 1 and Diabetes Type 2. StemGenex Medical Group provides adult stem cell Diabetes therapies to help those with unmet clinical needs achieve optimum health and better quality of life. Mesenchymal stem cell therapy for Diabetes Type 1 & Diabetes Type 2 may help patients who don’t respond to typical drug treatment, want to reduce their reliance on medication, or are looking to try stem cell therapy before starting drug treatment. To learn more about becoming a patient and receiving adult stem cell therapy through StemGenex Medical Group, please contact one of our Patient Advocates at (800) 609-7795. Below are some frequently asked questions about stem cell therapy for Diabetes Type 1 and Diabetes Type 2. Continue reading >>

Diabetes Type 2 - Stem Cells Treatment Clinic

Diabetes Type 2 - Stem Cells Treatment Clinic

Diabetes Type 2 Stem Cell Treatment Diabetes type 2 is a metabolic disorder that is characterized by high blood sugar and lack of insulin, a hormone produced in the pancreas that regulates the metabolism of carbohydrates. It is typically a chronic disease with a ten-year shortened life expectancy and symptoms such as: increased thirst, frequent urination, and constant hunger. There are a number of associated complications including: two to four times the risk of a cardiovascular disease and stroke, a 20-fold increase in lower limb amputations, and increased hospitalizations. Type 2 diabetes is the largest cause of non-traumatic blindness and kidney failure. It is associated with an increased risk of cognitive dysfunction and dementia, such as Alzheimer's disease. Other complications include: sexual dysfunction and frequent infections. Causes of type 2 diabetes: - obesity - poor diet - low activity level - genetics and family history Other diabetes risk factors include old age, high blood pressure, history of gestational diabetes, polycystic ovarian syndrome, impaired glucose intolerance and ethnicity, as African Americans, Hispanic Americans, and Native Americans are prone to an increased incidence of diabetes because of a history of gestational diabetes. With Type 2 Diabetes the body becomes insensitive and less able to produce insulin, which transports glucose from the bloodstream into body tissues. Instead the sugar volume in the blood builds up. The pancreas may increase insulin production but it does not rectify the problem. Other symptoms of this disease include blurred vision, fatigue, increased appetite, thirst and urination, slow-healing or frequent infections and erectile dysfunction. In both forms of diabetes, unless treated, blood sugar will rise uncontrolla Continue reading >>

What Stem Cells Can Do Today Opens Doorways To Even More, Tomorrow…

What Stem Cells Can Do Today Opens Doorways To Even More, Tomorrow…

Diabetes refers to a family of diseases where the body is unable to effectively produce or use insulin, the hormone required to convert food into energy. The cause of diabetes is not known, and so far there is no cure. Diabetes is the seventh leading cause of death in the United States today. According to the American Diabetes Association, "there are 23.6 million children and adults in the United States, or 7.8% of the population, who have diabetes. While an estimated 17.9 million have been diagnosed with diabetes, unfortunately, 5.7 million people (or nearly one quarter) are unaware that they have the disease." There are three main types of Diabetes: Type 1 - an auto-immune disease Type 2 - associated with hereditary and lifestyle risk factors Gestational Diabetes - occurring during pregnancy Type 1 Diabetes is characterized by the body’s inability to produce insulin and therefore necessitates daily injections of insulin. Because it most often develops in children, it is often referred to as "juvenile diabetes." The Juvenile Diabetes Research Foundation (JDRF) reports that as many as three million Americans may have type 1 diabetes and an average of 40 children each day (more than 15,000 per year) are diagnosed. There are clinical trials underway to treat diabetes with stem cells in general, as well as with cord blood stem cells specifically. Researchers at the University of Florida Health say they have found a way to expand certain preserved cord blood cells that could potentially serve as a long-term treatment for type 1 diabetes. The cells are called thymic regulatory T cells, or tTregs for short. They are a type of white blood cell that helps prevent autoimmune responses, which is when a person’s immune system attacks him- or herself. A clinical trial conducted Continue reading >>

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