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Can Statin Drugs Cause Diabetes?

Does Lipitor Increase My Risk For Diabetes?

Does Lipitor Increase My Risk For Diabetes?

Lipitor (atorvastatin) is intended to treat and lower high cholesterol levels. By doing so, it can reduce a person’s risk of heart attack and stroke. Lipitor and other statins actually block low-density lipoprotein (LDL) cholesterol production in the liver. LDL is known as the “bad” type of cholesterol. People with high levels of LDL are at risk for stroke, heart attack, and other cardiovascular conditions. Statin medications also help your body reabsorb some of the LDL that is already present in your arteries. Millions of Americans rely on statin medications like Lipitor to regulate and treat high cholesterol. Statins: Uses, Side Effects, and More » As with any medication, Lipitor may cause side effects. Studies have shown a possible connection between Lipitor and serious side effects, such as type 2 diabetes. This risk for diabetes may be especially strong in women and postmenopausal women, according to a 2012 study in the Archives of Internal Medicine. Other side effects of Lipitor include: arthritis back pain chest pain fatigue loss of appetite infection insomnia diarrhea rash stomach pain nausea urinary tract infection painful urination difficulty urinating swelling in feet and ankles potential muscle damage memory loss or confusion increased blood sugar levels In 1996, the U.S. Food and Drug Administration (FDA) approved Lipitor for the purpose of lowering cholesterol. Following its release, scientists found that more people who are on statin therapy are diagnosed with type 2 diabetes compared to people who are not on statin therapy. In 2012, the FDA updated their guidelines for the popular statin drug class. They added to the warning information that a “small increased risk” of high blood sugar levels and type 2 diabetes has been reported in individual Continue reading >>

Cholesterol-lowering Drugs May Be Linked To Diabetes

Cholesterol-lowering Drugs May Be Linked To Diabetes

You may have concerns about taking a cholesterol-lowering statin drug, such as atorvastatin (Lipitor and generic), rosuvastatin (Crestor), and simvastatin (Zocor and generic), after a recent study linked those drugs to an increased risk of type 2 diabetes. But Consumer Reports Best Buy Drugs experts say the heart-protective benefit of statins usually outweighs the risk of diabetes, so don’t skip a statin if you need one to lower your cholesterol. Diabetes isn’t a new side effect of statins. The Food and Drug Administration added it to the label of all statins in 2012 based on a review of studies that found a slightly elevated risk. For example, one study that reviewed 13 randomized, controlled clinical trials of statins found that 4.9 percent of people who took one of the drugs for 4 years developed diabetes compared with 4.5 percent of those who didn’t take a statin. Lower Cholesterol vs. Higher Blood Glucose The new study, published in the Journal of General Internal Medicine, raises questions about whether the diabetes risk is higher than previously thought. Researchers looked at medical data of nearly 7,000 men and women with an average age of 53. About 31 percent of those who took a statin for an average of 5.5 years developed diabetes compared with 19 percent of those who didn’t. But since the study was not a randomized, controlled study—the gold standard for determining whether a drug causes a particular side effect—it’s not known for sure that the increase in diabetes was entirely due to statins. The study participants might have had other factors that contributed to the development of diabetes. "All we can say," says Ishak Mansi, M.D., an internist at the Veteran's Hospital in North Texas and co-author of the study, "[is] that in the healthy popul Continue reading >>

How Statins Can Cause Diabetes: Pills Raise The Risk Of Getting Disease By 46 Per Cent

How Statins Can Cause Diabetes: Pills Raise The Risk Of Getting Disease By 46 Per Cent

And the cholesterol-busting drugs do nothing to prolong the lives of those at low-risk of a heart attack, experts found. The conclusions, published today, will put rival British doctors at loggerheads over the safety of the cheap, widely prescribed drugs. One leading cardiologist last night said the benefits of statins, taken by eight million Britons, had been “grossly exaggerated”. But another heart expert insisted “the benefits will outweigh the risks”. Researchers in Finland studied 8,749 non-diabetic men to see whether taking two of the most popular statins increased the chance of developing Type 2 diabetes. They found those who took simvastatin or atorvastatin were 46 per cent more likely to develop the condition and those on higher doses were at even greater risk. Last year, Britain’s National Institute for Health and Care Excellence issued guidance making 40 per cent of adults eligible for statins. It said anyone thought to have a greater than 10 per cent chance of a heart attack or stroke within 10 years should be offered the drug on the NHS. It means virtually all men aged over 55 and women over 65 are encouraged to take statins to stave off fatal cardiovascular disease. But London cardiologist Dr Aseem Malhotra said: “Although the benefits are clear in reducing the risk of death in those with established heart disease this is not the case for a low-risk population. “Millions see them as a magic pill but they are not. “This research shows you are more likely to develop irreversible Type 2 diabetes than prevent a non-fatal heart attack if you are at low risk.” Participants in the study, carried out by the University of Eastern Finland and Kuopio University Hospital, were aged between 45 and 73 and followed for six years. New diabetes was diagno Continue reading >>

Statin-induced Diabetes: Incidence, Mechanisms, And Implications

Statin-induced Diabetes: Incidence, Mechanisms, And Implications

Go to: Emergence of new diabetes in RCTs A clinically relevant concern with statin therapy is a significantly increased risk of new-onset diabetes in patients on statin therapy. The JUPITER trial reported a 25% increase with rosuvastatin 20 mg, over a median follow-up of 1.9 years, compared to those on placebo 9. Since then, several meta-analyses have confirmed a smaller but significant increase with various statins ( Table 1). The analysis by Sattar et al. in 91,140 subjects showed a 9% overall risk in 13 RCTs over a mean period of 4.0 years (odds ratio [OR] 1.09; 95% CI 1.02–1.17) 10. In a subsequent meta-analysis of five intensive-dose statin trials, Preiss et al. reported a significant increase in diabetes incidence with more intensive- vs. moderate-dose statin (OR 1.12; 95% CI 1.04–1.22) in 32,752 subjects over a mean follow-up of 4.9 years 11. In general, there was no relationship between % LDL-C reduction and incident diabetes. Further analysis of baseline characteristics of the various trials reported a strong relationship between features of metabolic syndrome or pre-diabetes (age, body mass index [BMI], hypertension, fasting glucose, and triglycerides) at baseline and subsequent development of diabetes 12– 14. Of note, the risk–benefit ratio for CVD still clearly favored statin therapy in various studies, including JUPITER, in primary prevention 13, several secondary prevention studies 12, 14, and a meta-analysis of secondary prevention studies by Preiss et al. 11. Thus, regardless of whether or not diabetes was diagnosed during statin therapy, the CVD outcomes were reduced on statin therapy compared to those observed with placebo. Authors n Age (years) Duration of follow-up (years) Adjusted odds ratio (95% confidence interval) Comments Sattar et al. 1 Continue reading >>

Statins Linked To Raised Risk Of Type 2 Diabetes

Statins Linked To Raised Risk Of Type 2 Diabetes

HealthDay Reporter WEDNESDAY, March 4, 2015 (HealthDay News) -- Cholesterol-lowering statin drugs may significantly increase a person's risk of developing type 2 diabetes, a new study from Finland suggests. Researchers found that statins were associated with an almost 50 percent higher risk of developing type 2 diabetes, even after adjusting for other factors. Statins appear to increase the risk of type 2 diabetes in several ways, the researchers said. One is that the drugs can increase a person's insulin resistance, and the other is that the cholesterol-lowering drugs seem to impair the ability of the pancreas to secrete insulin, according to the report. Commenting on the study, Dr. Ronald Goldberg, director of the Lipid Disorder Clinic and associate director of the Diabetes Research Institute at the University of Miami, said the researchers "show evidence that statins increased insulin resistance, and that the people who developed diabetes appeared to have less ability to respond to the insulin resistance by making more insulin." The study authors noted, however, that their research only found an association between statin use and diabetes risk. And since the study was limited to white men, it's not clear if the findings would apply to women or other racial groups. More than 29 million people in the United States have diabetes, according to the American Diabetes Association (ADA). Type 2 diabetes occurs when the body becomes resistant to insulin, a hormone needed to process the sugars found in foods. To compensate, the body produces more insulin. Excess weight and a sedentary lifestyle are two important risk factors for type 2 diabetes, according to the ADA. Prior studies have indicated that statins may increase a person's risk of diabetes, the authors said in backgro Continue reading >>

What Statin Is Best For People With Diabetes?

What Statin Is Best For People With Diabetes?

If you have diabetes, you’re at a higher risk for heart disease and stroke. This makes it especially important to control other risk factors for cardiovascular problems, such as high cholesterol. Fortunately, there are medications called statins that are quite effective at lowering your low-density lipoprotein (LDL), or “bad” cholesterol. Which statin is most appropriate if you have diabetes? It depends on your overall cardiovascular risk, but the recommendations lean toward a moderate-intensity or high-intensity statin. There are several different types of statins. Some are more potent than others. They each work a little differently, but they all help lower cholesterol by interfering with a substance your body needs to make cholesterol in the liver. Statins have become some of the most widely prescribed medications in the world. They include atorvastatin (Lipitor), rosuvastatin (Crestor), as well as other generic and brand name versions. The optimal LDL level for most healthy people is between 70 and 100 mg/dL. If your LDL numbers exceed that range, your doctor should look at your overall heart disease and stroke risk to decide whether you should be placed on statins. Recent guidelines presented by the American College of Cardiology and the American Heart Association expanded the number of potential statin users. Doctors used to base their decision to prescribe a statin primarily on a person’s LDL score. Now, other risk factors are also considered. In general, statins are usually recommended for people who have: diagnosed cardiovascular disease an LDL cholesterol level of 190 mg/dL or higher diabetes and an LDL of 70 mg/dL or higher a 10-year heart attack risk of 7.5 percent or higher and an LDL of at least 100 mg/dL Statins and diabetes risk: What you need to Continue reading >>

Statins Raise Diabetes Risk: Experts Sound New Alarm Over Cholesterol Pill

Statins Raise Diabetes Risk: Experts Sound New Alarm Over Cholesterol Pill

Those on high doses of the cholesterol-busting pills are more prone to suffer dangerous spikes in blood sugar levels. Scientists say an unwanted by-product of the drug is a link to the chronic condition. Studies show those prescribed statins are less likely to develop heart disease but the downside is it appears to make them more vulnerable to Type 2 diabetes. Researchers found over-75s are a third more likely to be struck down if they are taking statins. But the risk increased to 50 per cent for those on higher doses of the tablets. Dr Mark Jones, who led the research, said: “We found almost 50 per cent of women in their late-70s and 80s in the study took statins and five per cent were diagnosed with new onset diabetes. What is most concerning was we found a ‘dose effect’ where the risk of diabetes increased as the dosage of statins increased. “Over the 10 years of the study most of the women progressed to higher doses of statins. GPs and their elderly female patients should be aware of the risks.” The study will reignite debate over the safety of a drug taken by millions of Britons each day. A large-scale British review last year showed statins were the safest and most effective way of preventing heart attack and stroke but they still remain highly controversial. Professor Alan Sinclair, director of the Foundation for Diabetes Research in Older People, said: “Statin use and increased diabetes risk is not new and clinicians must continue to minimise risk due to the adverse effects of these drugs by careful prescribing but at the same time recognise clear cardiovascular benefits from their use. We found almost 50 per cent of women in their late-70s and 80s in the study took statins “In older people, who are already at increased diabetes risk from other cau Continue reading >>

Statin Use Linked To Increased Risk Of Type 2 Diabetes

Statin Use Linked To Increased Risk Of Type 2 Diabetes

Statin use is linked to an increased risk of type 2 diabetes among high-risk individuals, a new study reports. Statins are cholesterol-lowering drugs prescribed to reduce cardiovascular risks, but a variety of studies have shown the drugs have an association with type 2 diabetes development. These new findings were from a long-term US study of 3,234 patients at high risk of type 2 diabetes, all of whom had elevated BMIs and blood sugar levels. Participants took part in the US Diabetes Prevention Program Outcomes Study (DPPOS) and were randomised to receive different interventions to prevent type 2 diabetes. These included an intensive lifestyle programme, metformin treatment or a placebo drug. They were then followed for an average of 10 years. Fewer than four per cent of participants took statins at the study's start, but this figure increased to around a third of participants after 10 years. Moreover, statin use was associated with heightened type 2 diabetes risk irrespective of which treatment group a patient belonged to. Overall, statin use was associated with a 36 per cent increased risk of type 2 diabetes development compared to those who did not take the drugs. No link was observed between statin potency in diabetes risk, nor in regard to LDL cholesterol. While this was an observational study and no causal link between statin use and diabetes risk can be made, the researchers point to evidence suggesting that statins can impair insulin production. This, they believe, could help explain the diabetes risk. They added, however, that the potential increased risk of diabetes should always be weighed carefully against any benefits of statins, which include reduced risk of a heart attack and stroke in certain groups of people. The findings appear online in the online jo Continue reading >>

Can Cholesterol Drugs Cause Diabetes?

Can Cholesterol Drugs Cause Diabetes?

For every prescription drug that is developed and offers benefits to patients, there are those that also pose significant risks. Physicians must always weigh the benefits to risks in order to make informed decisions as to whether a particular medication should be used for treatment. Recent findings suggest statins, a class of prescription drug used to treat high cholesterol levels, increase the risk of developing diabetes. No one argues the fact that statins are able to prevent major cardiovascular events, such as heart attack and stroke, in patients who have already experienced a previous cardiovascular episode and are very likely to experience another one. But there is cause for concern over the widespread use of statins in patients with a lower risk of cardiovascular disease and the potential for these patients to eventually develop another disease, diabetes. What Do Statins Do Exactly? Elevated blood cholesterol levels, specifically LDL (the bad kind), have been shown to increase a person’s risk of heart attacks and stroke. By testing LDL levels in patients, a fairly accurate prediction can be made of future cardiac events. [1] As more research has been gathered on the role of LDL levels and heart disease, national guidelines have called for optimal LDL cholesterol levels to be lowered. Enter statins. Statins have the ability to block a critical step in the formation of LDL cholesterol within the liver, hence, the overall level of LDL in the blood drops. Because of this, statins are currently the most commonly-prescribed class of drug used to treat high cholesterol. Until very recently, statins were thought to be safe and well tolerated by patients, though some studies reported temporary memory loss that disappeared once medication was switched. Though there is al Continue reading >>

Statin Side Effects: Weigh The Benefits And Risks

Statin Side Effects: Weigh The Benefits And Risks

Statin side effects can be uncomfortable, making it seem like the risks outweigh the benefits of these powerful cholesterol-lowering medications. Doctors often prescribe statins for people with high cholesterol to lower their total cholesterol and reduce their risk of a heart attack or stroke. While statins are highly effective, they have been linked to muscle pain, digestive problems and mental fuzziness in some people and may rarely cause liver damage. Statins include atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Altoprev), pitavastatin (Livalo), pravastatin (Pravachol), rosuvastatin (Crestor) and simvastatin (Zocor). Having too much cholesterol in your blood increases your risk of heart attacks and strokes. Statins block a substance your liver needs to make cholesterol. This causes your liver to remove cholesterol from your blood. If you think you're experiencing side effects from statins, don't just stop taking the pills. Talk to your doctor to see if a change of dosage or even a different type of medication might be helpful. What are statin side effects? Muscle pain and damage One of the most common complaints of people taking statins is muscle pain. You may feel this pain as a soreness, tiredness or weakness in your muscles. The pain can be a mild discomfort, or it can be severe enough to make your daily activities difficult. Oddly enough, most randomized controlled studies of statins indicate that people taking statins develop muscle pain at the same rate as people taking placebo. But up to 29 percent of the people who start taking statins report muscle pain and many discontinue statins because of it. Many of these people do well when they are switched to a different variety of statin. Very rarely, statins can cause life-threatening muscle damage call Continue reading >>

Do Statins Cause Diabetes?

Do Statins Cause Diabetes?

Abstract A wealth of evidence has established that cholesterol-lowering statin drugs, widely used for the prevention of cardiovascular disease, do increase the risk of new-onset diabetes, possibly by impairing pancreatic beta cell function and decreasing peripheral insulin sensitivity. Groups at particular risk include the elderly, women, and Asians. The diabetogenic effect of statins appear directly related to statin dose and the degree of attained cholesterol lowering. Statins can cause hyperinsulinemia even in the absence of hyperglycemia and the potential mitogenic effects and implications of prolonged hyperinsulinemia are discussed. Suggestions are made as to how physicians might avert the hyperinsulinemic and diabetogenic effects of statin therapy in clinical practice, and modulate the detrimental effects of these drugs on exercise performance. Finally, long-term studies are needed to determine if the deleterious hyperinsulinemic and diabetogenic effects of statin therapy undermine the beneficial cardiovascular disease risk outcomes in various segments of the population. Continue reading >>

Statins Increase Diabetes Risk By Up To 50% In Older Women

Statins Increase Diabetes Risk By Up To 50% In Older Women

Statins Increase Diabetes Risk by up to 50% in Older Women Statin therapy increases the risk of new-onset diabetes in elderly women by 33%, and the higher the dose, the greater the risk, a new analysis of the observational Australian Longitudinal Study on Women's Health shows. "Clearly, statins have beneficial effects, including a reduction in the risk of cardiovascular events; however, the dose-response effect we observed suggests that it may be wise to avoid using higher doses of statins in older women," lead author Mark Jones, MD, senior lecturer, school of public health, the University of Queensland, Brisbane, Queensland, told Medscape Medical News in an email. "GPs and their elderly female patients should be aware of the risks," Dr Jones added in a University of Queensland statement, noting that those elderly women taking statins "should be carefully and regularly monitored for increased blood glucose to ensure early detection and management of diabetes." And, he and his colleagues suggest, it may be the case that statins could be stopped altogether in some elderly women. Women Take Statins on Average, for 6.5 Years The new analysis included 8372 Australian women aged between 76 and 82 years at baseline who were followed for 10 years; it is published in the March issue of Drugs and Aging. Dr Jones and colleagues note that the majority of participants in statin trials have been males and that females, especially elderly ones, have been underrepresented. "Our group has expertise and experience in women's health, including being involved with the Australian Longitudinal Study on Women's Health for the past 20 years, and we focused on the older cohort of women [in this study] because we thought this is a population that has generally not been included in clinical tria Continue reading >>

Study Uncovers Why Statins Increase Diabetes Risk And Offers Solution

Study Uncovers Why Statins Increase Diabetes Risk And Offers Solution

Statins are drugs that lower cholesterol in the body by interfering with the production of cholesterol in the liver. Though they lower bad cholesterol and raise good cholesterol, one side effect is that they increase risk of diabetes. Now, researchers have discovered why and offer a way to suppress this side effect. One of the world's most widely used drugs, statins have been hailed by the medical community for their ability to prevent heart disease. Still, the researchers, who have published their findings in the journal Diabetes, were confused as to why diabetes was linked to statin use. "Recently, an increased risk of diabetes has been added to the warning label for statin use," says lead author Jonathan Schertzer, assistant professor of Biochemistry and Biomedical Sciences, and Canadian Diabetes Association Scholar. "This was perplexing to us," he continues, "because if you are improving your metabolic profile with statins you should actually be decreasing the incidence of diabetes with these drugs, yet, the opposite happened." According to the team, around 13 million people could be prescribed a statin drug at some point in their lives. In January of this year, the Food and Drug Administration (FDA) released a Consumer Update outlining some of the risks associated with taking statins, which included an increased risk of raised blood sugar levels and the development of type 2 diabetes. At that time, Dr. Amy G. Egan, deputy director for safety in the FDA's Division of Metabolism and Endocrinology Products, said: Clearly we think that the heart benefits of statins outweighs this small increased risk. But what this means for patients taking statins and the health care professionals prescribing them is that blood-sugar levels may need to be assessed after instituting st Continue reading >>

Statin Medications Can Cause Diabetes, Memory Loss

Statin Medications Can Cause Diabetes, Memory Loss

A few years ago, the Food and Drug Administration (FDA) announced that it’s now going to require makers of cholesterol-lowering statin medications to put new warnings on the label—namely that these drugs can up your risk of developing type 2 diabetes and memory loss. First off, I praise the FDA for finally stepping up and doing the job they should be doing. As I'll mention in a minute, I do recommend statin medications in certain cases, so having the warnings out there is important. But, unfortunately, for many people these warnings are coming way too late. Statin Medications and Diabetes Let’s start with diabetes, an issue that’s been swept under the carpet for far too long! What should have alerted the FDA to take stronger measures earlier was the well-publicized JUPITER study, the one that came out flags waving suggesting that that statin drug Crestor is the heart disease cure-all. At that point, more people were put on statin medications even if they had healthy LDL cholesterol because statins were touted as “primary prevention.” What was lost in the hoopla was that those taking Crestor were developing diabetes at a higher rate than the placebo group. This was followed by several more studies showing the statin-diabetes link. What’s concerning to me is that it took so many years for the FDA to acknowledge the connection and warn the public. Statins Medications and Memory Loss Now, let’s talk about statins and memory loss. This issue has been less publicized, and quite frankly less clear cut. But it’s been bubbling up for quite some time. The reason statin medications can affect the brain is that cholesterol is vital for the formation and function of synapses (the connections between neurons) in the brain that allow you to think and process informat Continue reading >>

Do Statins Really Cause Diabetes?

Do Statins Really Cause Diabetes?

Statins are established drugs for the treatment and management of cardiovascular diseases (CVD) and revolutionized the treatment of high risk patients.1 Statins mainly reduce serum cholesterol content by inhibiting biosynthesis of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase) and isoprenoids.1,2 Other pleiotropic mechanisms of statins facilitating cardioprotective properties include improvement of endothelial dysfunction, increased nitric oxide bioavailability, antioxidant properties, inhibition of inflammatory responses, and stabilization of atherosclerotic plaques.3 Simvastatin and lovastatin are prescribed as lactone pro-drugs that are hydrolyzed enzymatically in vivo to their active hydroxy-acid form.4 Other statins are administered as the active hydroxy acid form.5-7 Focused management strategies for the regulation of higher levels of low density lipoprotein cholesterol (LDL-C) in populations at the risk for coronary heart disease (CHD) have been recommended by the Adult Treatment Panel (ATP) during 1988 (Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults [Adult Treatment Panel II] 1993). Critical limits for risk assessment of LDL-C have been categorized into 3 namely normal people (<3 mmol/l), high-risk people (<2.6 mmol/l) and very high-risk individuals (<1.8 mmol/l). Statins have been identified and employed as first-line therapeutics for treating high cholesterolemia since 1986. Multiple number of statins with variable therapeutic efficacies are available.8 Many clinical trials have demonstrated the safety and tolerability of the statins with appreciable risk/benefit ratio and transient and mild adverse effects such as headache, rashes, and gastrointestinal symptoms.9 However, there is an accumulation of cli Continue reading >>

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