Common Diabetes Drug Metformin Could Cause Thyroid And Heart Problems, Experts Warn
A drug widely prescribed to those with diabetes could cause thyroid, heart and a host of other health problems, a study has warned. Metformin is commonly used to treat type 2 diabetes. It lowers blood sugar levels by reducing glucose production in the liver. But new research, published in the Canadian Medical Association Journal, found the drug is linked to having an underactive thyroid. And the increased risk of producing low levels of the thyroid-stimulating hormone (TSH), can lead to complications, scientists have warned. The condition can cause heart disease, goitre - a lump in the throat caused by a swollen thyroid - pregnancy problems and a life-threatening condition called myxoedema coma. Both men and women can have an underactive thyroid, though the condition is more common in women. In the UK, it affects 15 in every 1,000 women and one in 1,000 men. The condition can also develop in children. The amount of metformin an individual needs to control blood sugar levels is worked out by a person's doctor or diabetes team. However, some previous research has raised concerns that the drug may lower thyroid-stimulating hormone levels. The study, published in Canadian Medical Association Journal, examined data on 74,300 patients who received metformin and sulfonylurea, another common diabetes drug, over a 25-year study period. Of these people, 5,689 were being treated for an underactive thyroid, and 59,937 had normal thyroid function. In the group with an underactive thyroid, there were 495 incidences of low thyroid-stimulating hormone (TSH) (119.7 per 1000) per year compared with 322 in the normal group (4.5 per 1000). In patients with a treated underactive thyroid, metformin was associated with a 55 per cent increased risk of low TSH levels compared with treatment wit Continue reading >>
Will You Have Heart Palpitations With Metformin - From Fda Reports - Ehealthme
A study for a 37 year old woman who takes Accotane NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk. You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088). If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. Continue reading >>
Metformin Side Effects On The Heart
Metformin, sold under the brand name Glucophage, is an anti-hyperglycemic medication used alone or in combination with other medication, such as insulin, to control blood glucose levels in those with Type 2 diabetes. It belongs in the biguanide class of medication. According to Drugs.com, metformin works by decreasing the amount of glucose obtained from food and glucose produced by the liver, lowering blood glucose levels. Video of the Day According to DiabetesNet.com, the chemical structure of metformin resembles that of the French lilac plant, which was used long ago to lower blood sugar but found to be too toxic. Metformin is shorter-acting than French lilac and can in rare cases produce the same toxic reaction, called lactic acidosis. Lactic acidosis--which can be fatal--is a condition in which there is too much lactate in the blood, which lowers the pH. It can occur when metformin levels build up and cannot be cleared from the body. Symptoms of lactic acidosis include slow heartbeat, or bradycardia, and low blood pressure, or hypoptension. Other symptoms include shallow breathing, diarrhea and extreme weakness and fatigue. Alcohol consumption and a reaction with the medication Tagamet can increase the chances for lactic acidosis to develop. Metformin should not be taken by those with congestive heart failure or heart disease. Chest pain is a rare but serious side effect of taking metformin, according to PubMed Health. Notify your physician immediately if you experience any chest pain while taking metformin. Metformin has been well studied in many clinical trials and found to be safe in most instances. The side effects reported by those taking metformin are compared against any side effects experienced by those taking a placebo. It has been determined that taking th Continue reading >>
If You've Had Heart Palpitations, Read This
if you've had heart palpitations, read this If this is your first visit, be sure to check out the FAQ by clicking the link above. You may have to register before you can post: click the register link above to proceed. To start viewing messages, select the forum that you want to visit from the selection below. Did your OB-GYN help or hinder your knowledge about Anti-Mullerian Hormone (AMH) and Follicle Stimulating Hormone (FSH)? Take our Survey here ! if you've had heart palpitations, read this I'm posting this because I just solved a very frustrating medical mystery that had stumped me for seven years. In 1999 (I was 34 and healthy) I started getting heart palpitations. They started out mild and infrequent and they grew more and more frequent over time. In 2002 they were the worst - I was having them daily and sometimes the entire day, without a break. After I quit a very toxic job in 2002 they became better. They still continued, but they were less frequent. I couldn't find much of a pattern except that many mornings I would wake with a palpitating heart and/or flushes. Oh yeah, hot flashes became a constant visitor along with the palpitations from early on. I went to two cardiologists and two MD's. Had all the tests and the only thing they concluded was that I had a heart arythmia (forgot how to spell it). I made them test for Lyme disease, menopause, and thyroid problems, but all checked out. I went on beta blockers and even blood thinners, but they didn't work to stop the palps. I even went to a hypnotist, no success. All this time I've been trying to get pregnant. After seeing my GYN and an RE, I finally decided to see a doctor in St. Louis who specializes in using the Creighton fertility model (understanding your fertility cycles - it's really good, check it out) Continue reading >>
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Diabetes Linked To Irregular Heartbeat
Diabetes is linked to a 40 percent greater risk of developing atrial fibrillation — the most common kind of chronically irregular heartbeat, researchers found in a new study.… The researchers also found that this risk for irregular heartbeat rises even higher the longer people have diabetes and the less controlled their blood sugar is. For three years, the researchers tracked more than 1,400 Group Health patients who had newly recognized atrial fibrillation. They compared these cases with more than 2,200 ‘controls.’ The controls were matched to the cases by age, sex, year, and whether they were treated for high blood pressure; but unlike the cases, they had no atrial fibrillation. Dublin’s study was the first to examine the relationship between atrial fibrillation and the duration of patients’ diabetes and their blood sugar levels. Unlike most prior studies, this one also adjusted for patients’ weight, which is important because both diabetes and atrial fibrillation are more common in heavier people. The researchers found that patients with diabetes were 40 percent more likely to be diagnosed with atrial fibrillation than were people without diabetes. The risk of atrial fibrillation rose by 3 percent for each additional year that patients had diabetes. For patients with high blood pressure (HBA1c more than 9 percent), the risk of atrial fibrillation was twice that for people without diabetes. But patients with well-controlled diabetes (HBA1c 7 percent or less) were about equally likely to have atrial fibrillation as people without diabetes. “When a patient with diabetes has symptoms like heart palpitations, clinicians should have a higher level of suspicion that the reason could be atrial fibrillation. This heart rhythm disturbance is important to diagno Continue reading >>
Chest Pains And Heart Palpitations???
Registration is fast, simple and absolutely free so please,join our community todayto contribute and support the site. This topic is now archived and is closed to further replies. I've been having chest pains the past few days and palpitations and heavy heartbeat. Could just starting back on Janumet do this? What else could cause it other than a heart attack? I'm scared to go to the ER about it as I've had two false alarm visits several years ago and don't want to look stupid or waste money! I think you should go to the ER. I'd rather look foolish than dead I've been having chest pains the past few days and palpitations and heavy heartbeat. Could just starting back on Janumet do this? What else could cause it other than a heart attack? I'm scared to go to the ER about it as I've had two false alarm visits several years ago and don't want to look stupid or waste money! I have been there and know how you feel. Twice I have gone to the ER with like symptoms in the middle of the night. We think my episodes were GERD. My stomach is super sensitive at times and I really have to watch how I take my meds....usually with food. GERD affects your heart beat also. I had a scary one the other night and no matter what I did it would not go away ..... causing irregular heart beats and my pulse went up to 144 with it. I finally got over it but was almost calling 911 once again. It lasted a couple of days. I also have acid reflux at times which causes these feelings you describe. BUT, one never knows ?? I quit taking my potassium for months because it cause stomach upset...upper and lower. I started it up again because of this heart irregularity. Hope it helps me. Is your blood sugar high when this happens? I can always tell when my numbers are high because my heart will beat faster. I Continue reading >>
Heart Palpitations | Diabetes Forum The Global Diabetes Community
Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community I was diagnosed around 2 months ago and the reason I went to my doctors was because of heart palpitations. I have been taking metformin 2 tablets and controlling my diet but my heart palpitations seem to be getting worse not better? Does anyone else has this problem as it is really scary and my doctor says I have to wait for my blood tests which isn't for another month! I suffer these at times and am paralysed, like if I'm tying my shoes or stretching and I have to hold my breath and ride it out. Everything loosens up then and I take take breaths for a while and am ok. It could be fatigue or anxiety. Some people can feel the irregularities and rapidity of heart rate/beat...I can, but I have slow A.F. i) Find your pulse at your wrist and count the number of beats in 30 secs and double it for your heart rate. ii) Also, is your pulse regular at all times as well as fast with the palpitations present? All sorts of problems can cause this; from too much coffee, to anxiety, to thyroid and diet problems etc. Older persons get fast atrial fibrillation where a fast irregular output beat is involved, but you sound young so it is unlikely. (Fewer get slow AF like myself.) It requires medical follow up the doctor needs to work through the possible reasons. I was diagnosed around 2 months ago and the reason I went to my doctors was because of heart palpitations. I have been taking metformin 2 tablets and controlling my diet but my heart palpitations seem to be getting worse not better? Does anyone else has this problem as it is really scary and my doctor says I have to wait for my blood tests which isn't for another month! Continue reading >>
Metformin (glucophage) Side Effects & Complications
The fascinating compound called metformin was discovered nearly a century ago. Scientists realized that it could lower blood sugar in an animal model (rabbits) as early as 1929, but it wasn’t until the late 1950s that a French researcher came up with the name Glucophage (roughly translated as glucose eater). The FDA gave metformin (Glucophage) the green light for the treatment of type 2 diabetes in 1994, 36 years after it had been approved for this use in Britain. Uses of Generic Metformin: Glucophage lost its patent protection in the U.S. in 2002 and now most prescriptions are filled with generic metformin. This drug is recognized as a first line treatment to control blood sugar by improving the cells’ response to insulin and reducing the amount of sugar that the liver makes. Unlike some other oral diabetes drugs, it doesn’t lead to weight gain and may even help people get their weight under control. Starting early in 2000, sales of metformin (Glucophage) were challenged by a new class of diabetes drugs. First Avandia and then Actos challenged metformin for leadership in diabetes treatment. Avandia later lost its luster because it was linked to heart attacks and strokes. Sales of this drug are now miniscule because of tight FDA regulations. Actos is coming under increasing scrutiny as well. The drug has been banned in France and Germany because of a link to bladder cancer. The FDA has also required Actos to carry its strictest black box warning about an increased risk of congestive heart failure brought on by the drug. Newer diabetes drugs like liraglutide (Victoza), saxagliptin (Onglyza) and sitagliptin (Januvia) have become very successful. But metformin remains a mainstay of diabetes treatment. It is prescribed on its own or sometimes combined with the newer d Continue reading >>
Yes I Started On Metformin 3 Days Ago And I've Been Having Rapid Heart Rate And A Lot Of Nervousnes?
Home Q & A Questions Yes I started on Metformin 3... Yes I started on Metformin 3 days ago and I've been having rapid heart rate and a lot of Nervousnes? I am type 2 diabetic and have been on several different diabetic medicines and none of them have worked. So now trying the Metformin, was wondering why I am having rapid heart rate and nervousness and tightening in my chest, I am on 125mcg. of Levothyroxine for my throid, could this be a cause, could someone get bac to me on these questions, I am a female of64 yrs. with a history of heart problems,Liver Transplant and other medical conditions. Thank You JoAnne I have been on Metformin ER for over 5 years. I have been on Synthroid for over 20 years. I go to an endocrinologist to monitor both my thyroid and my diabetes 2 because I learned the hard way that the thyroid levels do indeed need to be watched carefully, especially as we age. I have an excellent primary care doctor, but he does not do this as well as the endocrinologist. My thyroid med has been lowered several times in the past 5 years, but I am 79 years old and this is pretty normal. Too much thyroid med has caused the rapid heart beat and other symptoms you described. It also caused a pounding in my ears when I was lying down. I think you should check this with your doctors. It could be the side effects of the meds that you take, ran a check on the Interactions Checker: MONITOR: The efficacy of oral hypoglycemic agents and insulin may be diminished by certain drugs, including thiazides and other diuretics, corticosteroids, estrogens, progestins, thyroid hormones, human growth hormone, phenothiazines, atypical antipsychotics, sympathomimetic amines, protease inhibitors, phenytoin, megestrol, danazol, isoniazid, asparaginase, pegaspargase, diazoxide, temsiroli Continue reading >>
5 Reasons To Think Twice Before Taking Diabetes Drugs
Australia is facing an avalanche of newly-diagnosed type 2 diabetes cases, brought on by our increasingly toxic food environment and burgeoning obesity epidemic. Depending on the severity of their condition at diagnosis, newly-diagnosed diabetics may either be given a trial of dietary management (which usually fails, because the standard dietary recommendations made to diabetics are laughably inadequate), but the growing trend is to start them on diabetes medication immediately. There’s no denying that diabetes is a dangerous condition that requires urgent treatment. Diabetes damages the eyes, potentially leading to blindness; the kidneys, often resulting in kidney failure; the nerves, frequently resulting in gangrene and limb amputation; and the arteries, worsening atherosclerosis and therefore increasing the risk of heart disease and stroke. In fact, being diabetic raises the risk of dying from ischaemic heart disease (i.e. death due to clogged arteries) by a factor of 3.3 in women, and nearly 2 in men, after adjusting statistically for age, blood pressure, cholesterol, body mass index, and cigarette smoking (1). But all classes of diabetes medication carry serious risks, and dubious benefits: #1. Thiazolidinediones (one of the newest diabetes drugs to hit the market) such as Actos and Avandia, lower blood glucose but raise death rates in diabetics. These drugs (also known as glitazones) were greeted with much enthusiasm by doctors, who were frustrated by the phenomenon of ‘secondary failure’ that dogs the older diabetes drugs: they are initially quite effective at lowering blood glucose, but their effectiveness wanes over time. Avandia was released onto the market in 1999, despite pre-licensing trials demonstrating an 80% higher risk of ischaemic cardiovascular Continue reading >>
Metformin Affects Hearts Of Men And Women Differently
The oral diabetes medicine metformin affects the hearts of men and women differently, according to new research from the Washington University School of Medicine in St. Louis. Metformin is the most widely used diabetes drug in the world, with more than 61 million prescriptions being filled in the United States alone in 2012. Cardiovascular disease is the leading cause of death in people who have diabetes. To determine whether sex has an effect on the heart’s response to diabetes treatments, researchers randomly assigned 43 women and 35 men with Type 2 to one of three groups: The first group received metformin alone, the second received metformin plus rosiglitazone (brand name Avandia), and the third received metformin plus Lovaza, a type of fish oil prescribed to lower blood fats known as triglycerides. At the start of the study and at three months in, each participant had a PET scan to evaluate oxygen levels, blood flow, and glucose and fatty acid uptake in the heart; blood tests to measure glucose and free fatty acid levels; and an echocardiogram to evaluate heart function. Blood glucose levels were well controlled in all three groups. When the groups were compared without separating men and women, no differences were seen in heart metabolism. But when the participants were separated by gender, it became clear that the medicines had different, and sometimes opposite, effects on cardiac function. The biggest difference between men and women was seen in the group taking metformin alone. The drug appeared to improve heart function in women, but it caused the hearts of men to burn less sugar and more fat — a shift that can eventually cause changes in heart muscle, leading to heart failure. “Instead of making heart metabolism more normal in men, metformin alone made Continue reading >>
Does Metformin Cause Heart Palpitations?
Experience: 17 yrs experience in treating OPD & Emergency patients. It is not a common side effect - occurring in between 1-5% of people who take it. But it does occur - this is according to FDA information. Usually this is not serious enough to lead to stopping the medicine - continued use can get over this and sometimes a short period of drugs like beta blockers or alprazolam - discuss this with your doctor. Take care - metformin does cause palpitation though it is not so common - discuss this with your doctor. I hope my answer has helped you. Please click on the green 'accept' button below for accepting this answer if you have been helped (or click on a 'smiley' feedback if there is no accept button). Feedback/Bonus will be appreciated. Do not hesitate to ask further questions if you need more info. Experience: 17 yrs experience in treating OPD & Emergency patients. Dr. P. Jyoti and 87 other Medical Specialists are ready to help you Experience: 17 yrs experience in treating OPD & Emergency patients. A new question is answered every 9 seconds Ask an ExpertExperts are full of valuable knowledge and are ready to help with any question. Credentials confirmed by a Fortune 500 verification firm. Get a Professional AnswerVia email, text message, or notification as you wait on our site. Ask follow up questions if you need to. 100% Satisfaction GuaranteeRate the answer you receive. Ask-a-doc Web sites: If you've got a quick question, you can try to get an answer from sites that say they have various specialists on hand to give quick answers... Justanswer.com. JustAnswer.com...has seen a spike since October in legal questions from readers about layoffs, unemployment and severance. Traffic on JustAnswer rose 14 percent...and had nearly 400,000 page views in 30 days...inquiries Continue reading >>
Can Metformin Cause Palpitations?
Pepcid vs. Prilosec Vestura vs. Yaz Rephresh Pro B Side Effects Lacri Lube Alternative Primolut N Weight Gain Treato does not review third-party posts for accuracy of any kind, including for medical diagnosis or treatments, or events in general. Treato does not provide medical advice, diagnosis or treatment. Usage of the website does not substitute professional medical advice. The side effects featured here are based on those most frequently appearing in user posts on the Internet. The manufacturer's product labeling should always be consulted for a list of side effects most frequently appearing in patients during clinical studies. Talk to your doctor about which medications may be most appropriate for you. The information reflected here is dependent upon the correct functioning of our algorithm. From time-to-time, our system might experience bugs or glitches that affect the accuracy or correct application of mathematical algorithms. We will do our best to update the site if we are made aware of any malfunctioning or misapplication of these algorithms. We cannot guarantee results and occasional interruptions in updating may occur. Please continue to check the site for updated information. Continue reading >>
Drug information provided by: Micromedex Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Abdominal or stomach discomfort cough or hoarseness decreased appetite diarrhea fast or shallow breathing fever or chills general feeling of discomfort lower back or side pain muscle pain or cramping painful or difficult urination sleepiness Less common Anxiety blurred vision chest discomfort cold sweats coma confusion cool, pale skin depression difficult or labored breathing dizziness fast, irregular, pounding, or racing heartbeat or pulse feeling of warmth headache increased hunger increased sweating nausea nervousness nightmares redness of the face, neck, arms, and occasionally, upper chest seizures shakiness shortness of breath slurred speech tightness in the chest unusual tiredness or weakness wheezing Rare Behavior change similar to being drunk difficulty with concentrating drowsiness lack or loss of strength restless sleep unusual sleepiness Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Acid or sour stomach belching bloated excess air or gas in the stomach or intestines full feeling heartburn indigestion loss of appetite metallic taste in the mouth passing of gas stomachache stom Continue reading >>
Metformin And Heart Palpitations?
If this is your first visit, be sure tocheck out the FAQ by clicking thelink above. You may have to register before you can post: click the register link above to proceed. To start viewing messages,select the forum that you want to visit from the selection below. Hi I am Michelle, and I am new to this site. I recently started on Metformin ER for PCOS. I just increased my dose to 1,000 mg. daily. (They would like to see me at 2,000mg. daily). I am considered a "lean" PCOS I guess, and was very anxious to be taking this medication because the Dr. said I had just a mild case of it. I have been experiencing heart palpitations, and even though I've experienced them before in the past, I'm concerned that it is being caused from the medication. I'm thinking that I should maybe stop the metformin, but I am hoping to continue on this to resume regular cycles. (I normally have annovulatory 80+ day cycles that have to be induced with Prometrium). I really just would like to know if heart palpitations are a side effect of the metformin increase and what is usually the highest "effective" dose of metformin to regain ovulatory cycles?? Thank you. I have read that heart palpitations/anxiety can be a side effect of met. This really concerned me and is the reason I put off starting met for such a long time, because I'm always prone to anxiety/depression esp. on meds. But thank God this hasn't been the case for me - (I'm an overweight cyster and really need to be on met due to IR) It is very possible met's the cause of it, if it's disturbing your sleep and really bothering you, talk to the Dr. about it... maybe it just takes a while for your body to get used the met and eventually it'll stop? I was going to ask a similar question. My heart at random has started beating fast and I also f Continue reading >>